The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Cytokine‐Induced Sickness Behavior: Mechanisms and Implications
Abstract
A bstract: Sickness behavior refers to a coordinated set of behavioral changes that develop in sick individuals during the course of an infection. At the molecular level, these changes are due to the brain effects of proinflammatory cytokines such as interleukin‐1 (IL‐1) and tumor necrosis factor alpha (TNFα). Peripherally released cytokines act on the brain via a fast transmission pathway involving primary afferent nerves innervating the bodily site of inflammation and a slow transmission pathway involving cytokines originating from the choroid plexus and circumventricular organs and diffusing into the brain parenchyma by volume transmission. At the behavioral level, sickness behavior appears to be the expression of a central motivational state that reorganizes the organism priorities to cope with infectious pathogens. There is evidence that the sickness motivational state can interact with other motivational states and respond to nonimmune stimuli probably by way of sensitization and/or classical conditioning. However, the mechanisms that are involved in plasticity of the sickness motivational state are not yet understood.
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Cites
Biological basis of the behavior of sick animals
Hart, B. L. (1988) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(88)80004-6 · Cited by 2,223
Species-specific defense reactions and avoidance learning
Bolles, R. C. (1970) · Psychological Review · doi:10.1037/h0028589 · Cited by 1,610
Sawchenko, P. E., & Swanson, L. W. (1982) · Brain Research Reviews · doi:10.1016/0165-0173(82)90010-8 · Cited by 1,140
Sickness behavior as a new target for drug development
Kent, S., Bluthé, R.-M., Kelley, K. W., & Dantzer, R. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90012-u · Cited by 863
Self-citationEricsson, A., Kovacs, K., & Sawchenko, P. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-02-00897.1994 · Cited by 683
Endotoxin produces a depressive-like episode in rats
Yirmiya, R. (1996) · Brain Research · doi:10.1016/0006-8993(95)01415-2 · Cited by 604
Layé, S., Parnet, P., Goujon, E., & Dantzer, R. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90197-x · Cited by 500
Self-citationGoehler, L. E., Gaykema, R. P. A., Nguyen, K. T., Lee, J. E., Tilders, F. J. H., Maier, S. F., & Watkins, L. R. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02799.1999 · Cited by 355
van Dam, A.-M., Brouns, M., Louisse, S., & Berkenbosch, F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91588-6 · Cited by 333
Neural and biochemical mediators of endotoxin and stress-induced c-fos expression in the rat brain
Wan, W., Wetmore, L., Sorensen, C. M., Greenberg, A. H., & Nance, D. M. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90179-1 · Cited by 326
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Schiepers, O. J. G., Wichers, M. C., & Maes, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.003 · Cited by 1,235
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Self-citationReview: microglia of the aged brain: primed to be activated and resistant to regulation
Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792
Regulation of learning and memory by meningeal immunity: a key role for IL-4
Derecki, N. C., Cardani, A. N., Yang, C. H., Quinnies, K. M., Crihfield, A., Lynch, K. R., & Kipnis, J. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091419 · Cited by 800
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Metadata
- Authors
- Dantzer, R.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2001-03
- Volume
- 933
- Issue
- 1
- Pages
- 222-234
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2005474456
- Cited by
- 801
- References
- 58
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dantzer, R. (2001). Cytokine‐Induced Sickness Behavior: Mechanisms and Implications. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2001.tb05827.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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