The DOI matches its Crossref record; 239 of the 239 references it cites were found in a registry or an index.
Signal Transducer and Activator of Transcription‐3, Inflammation, and Cancer: How Intimate Is the Relationship?
Open accessAbstract
Signal transducer and activator of transcription‐3 (STAT‐3) is one of six members of a family of transcription factors. It was discovered almost 15 years ago as an acute‐phase response factor. This factor has now been associated with inflammation, cellular transformation, survival, proliferation, invasion, angiogenesis, and metastasis of cancer. Various types of carcinogens, radiation, viruses, growth factors, oncogenes, and inflammatory cytokines have been found to activate STAT‐3. STAT‐3 is constitutively active in most tumor cells but not in normal cells. Phosphorylation of STAT‐3 at tyrosine 705 leads to its dimerization, nuclear translocation, DNA binding, and gene transcription. The phosphorylation of STAT‐3 at serine 727 may regulate its activity negatively or positively. STAT‐3 regulates the expression of genes that mediate survival (survivin, bcl‐xl, mcl‐1, cellular FLICE‐like inhibitory protein), proliferation (c‐fos, c‐myc, cyclin D1), invasion (matrix metalloproteinase‐2), and angiogenesis (vascular endothelial growth factor). STAT‐3 activation has also been associated with both chemoresistance and radioresistance. STAT‐3 mediates these effects through its collaboration with various other transcription factors, including nuclear factor‐κB, hypoxia‐inducible factor‐1, and peroxisome proliferator activated receptor‐γ. Because of its critical role in tumorigenesis, inhibitors of this factor's activation are being sought for both prevention and therapy of cancer. This has led to identification of small peptides, oligonucleotides, and small molecules as potential STAT‐3 inhibitors. Several of these small molecules are chemopreventive agents derived from plants. This review discusses the intimate relationship between STAT‐3, inflammation, and cancer in more detail.
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Citations
Cites
2 retracted
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RetractedOpposite Regulation of Myc and p21 Transcription by STAT3 Proteins
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A family of cytokine-inducible inhibitors of signalling
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SOCS proteins, cytokine signalling and immune regulation
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Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
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Cited by
Yang, L., Moss, T., Mangala, L. S., Marini, J., Zhao, H., Wahlig, S., Armaiz‐Pena, G., Jiang, D., Achreja, A., Win, J., et al. (2014) · Molecular Systems Biology · doi:10.1002/msb.20134892 · Cited by 326
Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314
“Like most proteins, STAT3 also becomes conjugated to ubiquitin and undergoes proteasomal degradation through the ubiquitin–proteasome pathway (Aggarwal et al., 2009).”
BackgroundPhospholipase signalling networks in cancer
Park, J. B., Lee, C. S., Jang, J.-H., Ghim, J., Kim, Y.-J., You, S., Hwang, D., Suh, P.-G., & Ryu, S. H. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3379 · Cited by 276
Cancer cell signaling pathways targeted by spice-derived nutraceuticals
Sung, B., Prasad, S., Yadav, V. R., & Aggarwal, B. B. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.630551 · Cited by 204
Self-citationPleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2
Li, Y., Cai, L., Wang, H., Wu, P., Gu, W., Chen, Y., Hao, H., Tang, K., Yi, P., Liu, M., et al. (2011) · Oncogene · doi:10.1038/onc.2011.112 · Cited by 192
Metadata
- Authors
- Aggarwal, B. B., Kunnumakkara, A. B., Harikumar, K. B., Gupta, S. R., Tharakan, S. T., Koca, C., Dey, S., & Sung, B.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2009-08
- Volume
- 1171
- Issue
- 1
- Pages
- 59-76
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2003681585
- Cited by
- 649
- References
- 239
- FWCI
- 19.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Aggarwal, B. B., Kunnumakkara, A. B., Harikumar, K. B., Gupta, S. R., Tharakan, S. T., Koca, C., Dey, S., & Sung, B. (2009). Signal Transducer and Activator of Transcription‐3, Inflammation, and Cancer: How Intimate Is the Relationship? Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2009.04911.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
