Cited by 1,715Stress Responses and CortisolResilience and Mental HealthHealth, psychology, and well-being

The DOI matches its Crossref record; 329 of the 331 references it cites were found in a registry or an index.

Central role of the brain in stress and adaptation: Links to socioeconomic status, health, and disease

Open access

McEwen, Bruce S., Gianaros, Peter J.·2010·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.2009.05331.xPMC PMC2864527

Open this paper in CoChat — free account Open PDF

Abstract

The brain is the key organ of stress reactivity, coping, and recovery processes. Within the brain, a distributed neural circuitry determines what is threatening and thus stressful to the individual. Instrumental brain systems of this circuitry include the hippocampus, amygdala, and areas of the prefrontal cortex. Together, these systems regulate physiological and behavioral stress processes, which can be adaptive in the short‐term and maladaptive in the long‐term. Importantly, such stress processes arise from bidirectional patterns of communication between the brain and the autonomic, cardiovascular, and immune systems via neural and endocrine mechanisms underpinning cognition, experience, and behavior. In one respect, these bidirectional stress mechanisms are protective in that they promote short‐term adaptation ( allostasis ). In another respect, however, these stress mechanisms can lead to a long‐term dysregulation of allostasis in that they promote maladaptive wear‐and‐tear on the body and brain under chronically stressful conditions ( allostatic load ), compromising stress resiliency and health. This review focuses specifically on the links between stress‐related processes embedded within the social environment and embodied within the brain, which is viewed as the central mediator and target of allostasis and allostatic load.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1749-6632.2009.05331.x

Cites

329 of 329 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Stress, appraisal, and coping
Eysenck, H. J. (1985) · Behaviour Research and Therapy · doi:10.1016/0005-7967(85)90087-7 · Cited by 32,038
“Stress: appraisal and coping,”
Folkman, S. (2013) · Encyclopedia of Behavioral Medicine · doi:10.1007/978-1-4419-1005-9_215 · Cited by 27,833
Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States: Results From the National Comorbidity Survey
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
Neighborhoods and Violent Crime: A Multilevel Study of Collective Efficacy
Sampson, R. J., Raudenbush, S. W., & Earls, F. (1997) · Science · doi:10.1126/science.277.5328.918 · Cited by 11,999
Child abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Emotion circuits in the brain
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Conflict monitoring and cognitive control
Botvinick, M. M., Braver, T. S., Barch, D. M., Carter, C. S., & Cohen, J. D. (2001) · Psychological Review · doi:10.1037/0033-295x.108.3.624 · Cited by 7,351
Social Relationships and Health
House, J. S., Landis, K. R., & Umberson, D. (1988) · Science · doi:10.1126/science.3399889 · Cited by 7,073
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733
Self-citation

Show all 331 references

Research works printed but not linked: 10

Lovallo W.R., 2005, Stress and Health: Biological and Psycholocial Interactions
Cannon W.B., 1932, The Wisdome of the Body
10.1210/en.142.7.2796 · DOI
10.1152/physrev.00041.2006 · DOI · Paper page
10.1016/S0169-328X(98)00130-2 · DOI · Paper page
10.1210/edrv-7-3-284 · DOI · Paper page
10.1016/S0006-3223(03)00171-9 · DOI · Paper page
10.1038/sj.mp.4001656 · DOI
10.1037/0033-2909.127.4.472 · DOI · Paper page
Helgeson V.S., 1998, Psychooncology, 99

Sorted by citations

Items 301–400 of 1,001

Creating probabilistic maps of the face network in the adolescent brain: A multicentre functional MRI study
Tahmasebi, A. M., Eric Artiges, A., Banaschewski, T., Barker, G. J., Brühl, R., Büchel, C., Conrod, P., Flor, H., Garavan, H., Gallinat, J., et al. (2011) · Human Brain Mapping · doi:10.1002/hbm.21261 · Cited by 71
Interferon-α acutely impairs whole-brain functional connectivity network architecture – A preliminary study
Dipasquale, O., Cooper, E. A., Tibble, J. A., Voon, V., Baglio, F., Baselli, G., Cercignani, M., & Harrison, N. A. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.12.011 · Cited by 71
Review on Neural Correlates of Emotion Regulation and Music: Implications for Emotion Dysregulation
Hou, J., Song, B., Chen, A. C. N., Sun, C., Zhou, J., Zhu, H., & Beauchaine, T. P. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00501 · Cited by 85
Brain connectivity and socioeconomic status at birth and externalizing symptoms at age 2 years
Ramphal, B., Whalen, D. J., Kenley, J. K., Yu, Q., Smyser, C. D., Rogers, C. E., & Sylvester, C. M. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100811 · Cited by 70
Socioeconomic Status and Biological Risks for Health and Illness Across the Life Course
Yang, Y. C., Schorpp, K., Boen, C., Johnson, M. P., & Harris, K. M. (2018) · The Journals of Gerontology Series B · doi:10.1093/geronb/gby108 · Cited by 69
Adverse childhood experiences: prevalence and associated factors among South African young adults
Manyema, M., & Richter, L. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e03003 · Cited by 72
Perceived Stress and Low-Back Pain Among Healthcare Workers: A Multi-Center Prospective Cohort Study
Vinstrup, J., Jakobsen, M. D., & Andersen, L. L. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00297 · Cited by 80
The contribution of stress to the social patterning of clinical and subclinical CVD risk factors in African Americans: The Jackson Heart Study
Gebreab, S. Y., Roux, A. V. D., Hickson, D. A., Boykin, S., Sims, M., Sarpong, D. F., Taylor, H. A., & Wyatt, S. B. (2012) · Social Science & Medicine · doi:10.1016/j.socscimed.2012.06.003 · Cited by 75
Early-life stress, microbiota, and brain development: probiotics reverse the effects of maternal separation on neural circuits underpinning fear expression and extinction in infant rats
Cowan, C. S. M., Stylianakis, A. A., & Richardson, R. (2019) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2019.100627 · Cited by 71
Astrocyte plasticity induced by emotional stress: A new partner in psychiatric physiopathology?
Bender, C. L., Calfa, G. D., & Molina, V. A. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.005 · Cited by 70
Socioeconomic disadvantage, neural responses to infant emotions, and emotional availability among first-time new mothers
Kim, P., Capistrano, C. G., Erhart, A., Gray-Schiff, R., & Xu, N. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.001 · Cited by 75
Community Socioeconomic Disadvantage in Midlife Relates to Cortical Morphology via Neuroendocrine and Cardiometabolic Pathways
Gianaros, P. J., Kuan, D. C.-H., Marsland, A. L., Sheu, L. K., Hackman, D. A., Miller, K., & Manuck, S. B. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv233 · Cited by 71
Self-citation
Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals
Jiang, S., Wang, S., Sun, Y., & Zhang, Q. (2014) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-014-5955-5 · Cited by 75
Neural Mechanisms Linking Emotion with Cardiovascular Disease
Kraynak, T. E., Marsland, A. L., & Gianaros, P. J. (2018) · Current Cardiology Reports · doi:10.1007/s11886-018-1071-y · Cited by 70
Self-citation
Risk preferences under acute stress
Cahlíková, J., & Cingl, L. (2016) · Experimental Economics · doi:10.1007/s10683-016-9482-3
Rethinking Addiction
Ewald, D. R., Strack, R. W., & Orsini, M. M. (2019) · Global Pediatric Health · doi:10.1177/2333794x18821943 · Cited by 75
Cumulative stress pathophysiology in schizophrenia as indexed by allostatic load
Nugent, K. L., Chiappelli, J., Rowland, L. M., & Hong, L. E. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.06.009 · Cited by 69
Allostatic Load and the Assessment of Cumulative Biological Risk in Biobehavioral Medicine
Gallo, L. C., Fortmann, A. L., & Mattei, J. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000095 · Cited by 68
Examining brain structures associated with perceived stress in a large sample of young adults via voxel-based morphometry
Li, H., Li, W., Wei, D., Chen, Q., Jackson, T., Zhang, Q., & Qiu, J. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.01.044 · Cited by 70
Allostatic load is associated with psychotic symptoms and decreases with antipsychotic treatment in patients with schizophrenia and first-episode psychosis
Berger, M., Juster, R., Westphal, S., Amminger, G. P., Bogerts, B., Schiltz, K., Bahn, S., Steiner, J. H., & Sarnyai, Z. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.02.001 · Cited by 74
Impact of Chronic Stress on Attention Control: Evidence from Behavioral and Event-Related Potential Analyses
Liu, Q., Liu, Y., Leng, X., Han, J., Xia, F., & Chen, H. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00549-9 · Cited by 70
Effect of Early Adversity and Childhood Internalizing Symptoms on Brain Structure in Young Men
Jensen, S. K. G., Dickie, E. W., Schwartz, D. H., Evans, C. J., Dumontheil, I., Paus, T., & Barker, E. D. (2015) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2015.1486 · Cited by 66
Burden on Caregivers of Children with Cerebral Palsy: Predictors and Related Factors
Marrón, E. M., Redolar-Ripoll, E., Boixadós, M., Nieto, R., Guillamón, N., Encuentra, E. H., & Gómez, B. B. (2013) · Universitas Psychologica · doi:10.11144/javeriana.upsy12-3.bccc · Cited by 66
Adolescent girls’ neural response to reward mediates the relation between childhood financial disadvantage and depression
Romens, S. E., Casement, M. D., McAloon, R. L., Keenan, K. E., Hipwell, A. E., Guyer, A. E., & Forbes, E. E. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12410 · Cited by 70
A gene expression atlas for different kinds of stress in the mouse brain
Flati, T., Gioiosa, S., Chillemi, G., Mele, A., Oliverio, A., Mannironi, C., Rinaldi, A., & Castrignanò, T. (2020) · Scientific Data · doi:10.1038/s41597-020-00772-z · Cited by 65
Association of Allostatic Load with All-Cause and Cancer Mortality by Race and Body Mass Index in the REGARDS Cohort
Akinyemiju, T., Wilson, L. E., Deveaux, A. E., Aslibekyan, S. W., Cushman, M., Gilchrist, S. C., Safford, M. M., Judd, S. E., & Howard, V. J. (2020) · Cancers · doi:10.3390/cancers12061695 · Cited by 65
Neurobiological Implications of Chronic Stress and Metabolic Dysregulation in Inflammatory Bowel Diseases
Sic, A., Cvetkovic, K., Manchanda, E., & Knezevic, N. N. (2024) · Diseases · doi:10.3390/diseases12090220 · Cited by 65
Stress and Anxiety
Bystritsky, A., & Kronemyer, D. (2014) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2014.08.002 · Cited by 107
The Roadmap for Resilience: The California Surgeon General's Report on Adverse Childhood Experiences, Toxic Stress, and Health
Bhushan, D., Kotz, K. J., McCall, J., Wirtz, S., Gilgoff, R., Dube, S. R., Powers, C., Olson-Morgan, J., Galeste, M., Patterson, K., et al. (2020) · doi:10.48019/peam8812 · Cited by 79
Health Neuroscience
Erickson, K. I., Creswell, J. D., Verstynen, T., & Gianaros, P. J. (2014) · Current Directions in Psychological Science · doi:10.1177/0963721414549350 · Cited by 69
Self-citation
Being “on Point”: Exploring the Stress-related Experiences of Incarceration
Porter, L. C. (2018) · Society and Mental Health · doi:10.1177/2156869318771439 · Cited by 70
Testing, Stress, and Performance: How Students Respond Physiologically to High-Stakes Testing
Heissel, J. A., Adam, E. K., Doleac, J. L., Figlio, D., & Meer, J. (2019) · Education Finance and Policy · doi:10.1162/edfp_a_00306 · Cited by 64
Involvement of NR1, NR2A different expression in brain regions in anxiety-like behavior of prenatally stressed offspring
Sun, H., Jia, N., Guan, L., Su, Q., Wang, D., Li, H., & Zhu, Z. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.044 · Cited by 64
Insulin dysfunction and allostatic load in bipolar disorder
Brietzke, E. M., Kapczinski, F. P., Grassi‐Oliveira, R., Grande, I., Vieta, E., & McIntyre, R. S. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.185 · Cited by 64
What Is the Brain-Cancer Connection?
Cao, L., & During, M. J. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150546 · Cited by 63
Double-jeopardy: The joint impact of neighborhood disadvantage and low social cohesion on cumulative risk of disease among African American men and women in the Jackson Heart Study
Barber, S., Hickson, D. A., Kawachi, I. I., Subramanian, S. V., & Earls, F. J. (2016) · Social Science & Medicine · doi:10.1016/j.socscimed.2016.02.001 · Cited by 70
Chronic stress accelerates the development of endometriosis in mouse through adrenergic receptor β2
Long, Q., Liu, X., Qi, Q.-M., & Guo, S. (2016) · Human Reproduction · doi:10.1093/humrep/dew237 · Cited by 68
Stress Controversies: Post-Traumatic Stress Disorder, Hippocampal Volume, Gastroduodenal Ulceration*
Fink, G. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02089.x · Cited by 66
Abnormal Stress Responsivity in a Rodent Developmental Disruption Model of Schizophrenia
Zimmerman, E. C., Bellaire, M., Ewing, S. G., & Grace, A. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.110 · Cited by 66
Translating Developmental Science to Address Childhood Adversity
Garner, A. S., Forkey, H. C., & Szilagyi, M. A. (2015) · Academic Pediatrics · doi:10.1016/j.acap.2015.05.010 · Cited by 67
Multiple Vulnerabilities to Health Disparities and Incident Heart Failure Hospitalization in the REGARDS Study
Pinheiro, L. C., Reshetnyak, E., Sterling, M. R., Levitan, E. B., Safford, M. M., & Goyal, P. (2020) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.119.006438 · Cited by 63
Functional brain connectivity in ex utero premature infants compared to in utero fetuses
De Asis-Cruz, J., Kapse, K., Basu, S. K., Said, M., Scheinost, D., Murnick, J., Chang, T., du Plessis, A., & Limperopoulos, C. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117043 · Cited by 63
Historical trauma and substance use among American Indian people with current substance use problems.
Gameon, J. A., & Skewes, M. C. (2021) · Psychology of Addictive Behaviors · doi:10.1037/adb0000729 · Cited by 64
Do positive or negative stressful events predict the development of new brain lesions in people with multiple sclerosis?
Burns, M. N., Nawacki, E., Kwasny, M., Pelletier, D., & Mohr, D. C. (2013) · Psychological Medicine · doi:10.1017/s0033291713000755 · Cited by 60
Intelligence and socioeconomic position in childhood in relation to frailty and cumulative allostatic load in later life: the Lothian Birth Cohort 1936
Gale, C. R., Booth, T., Starr, J. M., & Deary, I. J. (2016) · Journal of Epidemiology and Community Health · doi:10.1136/jech-2015-205789 · Cited by 64
Women’s socioeconomic position in ontogeny is associated with improved immune function and lower stress, but not with height
Rubika, A., Luoto, S., Krama, T., Trakimas, G., Rantala, M. J., Moore, F. R., Skrinda, I., Elferts, D., Krams, R., Contreras-Garduño, J. A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-68217-6 · Cited by 63
Antidepressant mechanisms of ketamine: a review of actions with relevance to treatment-resistance and neuroprogression
Lullau, A. P. M., Haga, E. M. W., Ronold, E. H., & Dwyer, G. E. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1223145 · Cited by 65
Functional magnetic resonance imaging study reveals differences in the habituation to psychological stress in patients with Crohn’s disease versus healthy controls
Agostini, A., Filippini, N., Benuzzi, F., Bertani, A., Scarcelli, A., Leoni, C., Farinelli, V., Riso, D., Tambasco, R., Calabrese, C., et al. (2012) · Journal of Behavioral Medicine · doi:10.1007/s10865-012-9441-1 · Cited by 63
Stress and Obesity as Risk Factors in Cardiovascular Diseases: A Neuroimmune Perspective
Ippoliti, F., Canitano, N., & Businaro, R. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9432-6 · Cited by 63
Stress and the healthy adolescent brain: Evidence for the neural embedding of life events
Ganzel, B. L., Kim, P., Gilmore, H. M., Tottenham, N., & Temple, E. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000242 · Cited by 66
Early-life adversity and adolescent depression: mechanisms involving the ventral striatum
Goff, B., & Tottenham, N. (2014) · CNS Spectrums · doi:10.1017/s1092852914000674 · Cited by 62
Stress, Sleep, and Performance on Standardized Tests: Understudied Pathways to the Achievement Gap
Heissel, J. A., Levy, D. J., & Adam, E. K. (2017) · AERA Open · doi:10.1177/2332858417713488 · Cited by 74
Commentary: childhood exposure to environmental adversity and the well‐being of people with intellectual disabilities
Emerson, E. (2012) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2012.01577.x · Cited by 62
Association of gray matter volumes with general and specific dimensions of psychopathology in children
Durham, E. L., Jeong, H. J., Moore, T. M., Dupont, R. M., Cardenas‐Iniguez, C., Cui, Z., Stone, F. E., Berman, M. G., Lahey, B. B., & Kaczkurkin, A. N. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-00952-w · Cited by 65
Growth delay as an index of allostatic load in young children: Predictions to disinhibited social approach and diurnal cortisol activity
Johnson, A. E., Bruce, J., Tarullo, A. R., & Gunnar, M. R. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000356 · Cited by 66
Socioeconomic and Other Social Stressors and Biomarkers of Cardiometabolic Risk in Youth: A Systematic Review of Less Studied Risk Factors
Slopen, N. B., Goodman, E., Koenen, K. C., & Kubzansky, L. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064418 · Cited by 59
Neural Control of Vascular Function in Skeletal Muscle
Shoemaker, J. K., Badrov, M. B., Al‐Khazraji, B. K., & Jackson, D. N. (2015) · Comprehensive physiology · doi:10.1002/cphy.c150004 · Cited by 59
Is the Association of ADHD with Socio-Economic Disadvantage Explained by Child Comorbid Externalizing Problems or Parent ADHD?
Miller, L. L., Gustafsson, H., Tipsord, J. M., Song, M., Nousen, E. K., Dieckmann, N. F., & Nigg, J. T. (2017) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-017-0356-8 · Cited by 59
Human social genomics: Concepts, mechanisms, and implications for health
Slavich, G. M., Mengelkoch, S., & Cole, S. W. (2023) · Lifestyle Medicine · doi:10.1002/lim2.75 · Cited by 63
Environmental stress and transposon transcription in the mammalian brain
Hunter, R. G., McEwen, B. S., & Pfaff, D. W. (2013) · Mobile Genetic Elements · doi:10.4161/mge.24555 · Cited by 58
Self-citation
The social transmission of risk: Maternal stress physiology, synchronous parenting, and well-being mediate the effects of war exposure on child psychopathology.
Halevi, G., Djalovski, A., Kanat‐Maymon, Y., Yirmiya, K., Zagoory‐Sharon, O., Koren, L., & Feldman, R. (2017) · Journal of Abnormal Psychology · doi:10.1037/abn0000307 · Cited by 62
Brain histamine modulates recognition memory: possible implications in major cognitive disorders
Provensi, G., Costa, A., Izquierdo, I., Blandina, P., & Passani, M. B. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14478 · Cited by 61
Ghosts from the past? The association between childhood interpersonal trauma, attachment and anxiety and depression in late life
Assche, L. V., de Ven, L. V., Vandenbulcke, M., & Luyten, P. (2019) · Aging & Mental Health · doi:10.1080/13607863.2019.1571017 · Cited by 58
POVERTY POISONS THE BRAIN
Lende, D. H. (2012) · Annals of Anthropological Practice · doi:10.1111/j.2153-9588.2012.01099.x · Cited by 57
Long-term health consequences of violence exposure in adolescence: a 26–year prospective study
Olofsson, N., Lindqvist, K., Shaw, B. A., & Danielsson, I. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-411 · Cited by 57
The Central Role of Relationships With Trauma-Informed Integrated Care for Children and Youth
Brown, J. D., King, M. A., & Wissow, L. S. (2017) · Academic Pediatrics · doi:10.1016/j.acap.2017.01.013 · Cited by 61
How stress physically re-shapes the brain: Impact on brain cell shapes, numbers and connections in psychiatric disorders
Kaul, D., Schwab, S. G., Mechawar, N., & Matosin, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.025 · Cited by 58
Occupational Status Moderates the Association Between Current Perceived Stress and High Blood Pressure
Wiernik, E., Pannier, B., Czernichow, S., Nabi, H., Hanon, O., Simon, T., Simon, J.-M., Thomas, F., Bean, K., Consoli, S. M., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00302 · Cited by 57
Heart rate variability can clarify students’ level of stress during nursing simulation
Nakayama, N., Arakawa, N., Ejiri, H., Matsuda, R., & Makino, T. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195280 · Cited by 56
Race/Ethnicity, Socioeconomic Characteristics, Coethnic Social Ties, and Health: Evidence From the National Jewish Population Survey
Pearson, J. A., & Geronimus, A. T. (2010) · American Journal of Public Health · doi:10.2105/ajph.2009.190462 · Cited by 58
6. The Social Determinants of Chronic Disease
Hood, C. M., Pillai, P., & Lantz, P. M. (2016) · American Public Health Association eBooks · doi:10.2105/9780875532783ch06 · Cited by 55
Effects of group singing versus group music listening on hospitalized children and adolescents with mental disorders: A pilot study
Grebosz‐Haring, K., & Thun‐Hohenstein, L. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e01014 · Cited by 58
Relationship between effort–reward imbalance and hair cortisol concentration in female kindergarten teachers
Qi, X., Zhang, J., Liu, Y., Ji, S., Chen, Z., Sluiter, J. K., & Deng, H. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.01.008 · Cited by 55
Recent advances in the role of cortisol and metabolic syndrome in age-related degenerative diseases
Martocchia, A., Stefanelli, M., Falaschi, G. M., Toussan, L., Ferri, C., & Falaschi, P. (2015) · Aging Clinical and Experimental Research · doi:10.1007/s40520-015-0353-0 · Cited by 54
Neurostructural Heterogeneity in Youth with Internalizing Symptoms
Kaczkurkin, A., Sotiras, A., Baller, E. B., Barzilay, R., Calkins, M., Chand, G., Cui, Z., Erus, G., Fan, Y., Gur, R., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.005 · Cited by 50
An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responses
Witt, S. H., Buchmann, A. F., Blomeyer, D., Nieratschker, V., Treutlein, J., Esser, G., Schmidt, M. H., Bidlingmaier, M., Wiedemann, K., Rietschel, M., et al. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.12.015 · Cited by 54
What are the links between maternal social status, hippocampal function, and HPA axis function in children?
Sheridan, M. A., How, J., Araujo, M., Schamberg, M. A., & Nelson, C. A. (2013) · Developmental Science · doi:10.1111/desc.12087 · Cited by 57
Association of N‐cadherin levels and downstream effectors of Rho GTPases with dendritic spine loss induced by chronic stress in rat hippocampal neurons
Castañeda, P., Muñoz, M., García‐Rojo, G., Ulloa, J. L., Bravo, J. A., Márquez, R., García-Pérez, M. A., Arancibia, D., Araneda, K., Rojas, P. S., et al. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23602 · Cited by 56
Perceived stress is associated with smaller hippocampal volume in adolescence
Piccolo, L. D. R., Noble, K. G., & for the Pediatric Imaging, N. (2017) · Psychophysiology · doi:10.1111/psyp.13025 · Cited by 61
Sex and gender differences in risk scores for dementia and Alzheimer's disease among cisgender, transgender, and non-binary adults
Brady, B., Zheng, L., Kootar, S., & Anstey, K. J. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13317 · Cited by 54
Dimensions of Early-Life Adversity Are Differentially Associated With Patterns of Delayed and Accelerated Brain Maturation
Beck, D., Whitmore, L. B., MacSweeney, N., Brieant, A. E., Karl, V., de Lange, A. G., Westlye, L. T., Mills, K. L., & Tamnes, C. K. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.07.019 · Cited by 59
Sex-specific interaction effects of age, occupational status, and workplace stress on psychiatric symptoms and allostatic load among healthy Montreal workers
Juster, R., Moskowitz, D. S., Lavoie, J., & D’Antono, B. (2013) · Stress · doi:10.3109/10253890.2013.835395 · Cited by 58
Sex differences in chronic stress responses and Alzheimer's disease
Yan, Y., Dominguez, S., Fisher, D. W., & Dong, H. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.03.002 · Cited by 56
Understanding Embodiment in Place-Health Research: Approaches, Limitations, and Opportunities
Petteway, R. J., Mujahid, M. S., & Allen, A. M. (2019) · Journal of Urban Health · doi:10.1007/s11524-018-00336-y · Cited by 59
Association Between Speed of Multimorbidity Accumulation in Old Age and Life Experiences: A Cohort Study
Dekhtyar, S., Vetrano, D. L., Marengoni, A., Wang, H., Pan, K., Fratiglioni, L., & Calderón‐Larrañaga, A. (2019) · American Journal of Epidemiology · doi:10.1093/aje/kwz101 · Cited by 57
Felon Disenfranchisement in the United States: A Health Equity Perspective
Purtle, J. (2012) · American Journal of Public Health · doi:10.2105/ajph.2012.300933 · Cited by 52
Adverse Childhood Experiences and Amygdalar Reduction: High-Resolution Segmentation Reveals Associations With Subnuclei and Psychiatric Outcomes
Oshri, A., Gray, J. C., Owens, M. M., Liu, S., Duprey, E. B., Sweet, L. H., & MacKillop, J. (2019) · Child Maltreatment · doi:10.1177/1077559519839491 · Cited by 50
Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models
Scheich, B., Gaszner, B., Kormos, V., László, K., Ádori, C., Borbély, É., Hajna, Z., Tékus, V., Bölcskei, K., Ábrahám, I. M., et al. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.09.021 · Cited by 53
Regulating emotion to improve physical health through the amygdala
Song, Y., Lu, H., Hu, S., Xu, M., Li, X., & Liu, J. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu083 · Cited by 60
The impact of childhood stressful life events on health and behavior in at-risk youth
Roberts, Y. H., English, D., Thompson, R., & White, C. R. (2017) · Children and Youth Services Review · doi:10.1016/j.childyouth.2017.11.029 · Cited by 52
Trajectories of family poverty and children's mental health: Results from the Danish National Birth Cohort
Pryor, L., Strandberg‐Larsen, K., Andersen, A. N., Rod, N. H., & Melchior, M. (2018) · Social Science & Medicine · doi:10.1016/j.socscimed.2018.10.023 · Cited by 53
Toward Sustainable Development through Nurturing Diversity
Jackson, L., Meiring, D., van de Vijver, F. J. R., Idemudia, E. S., & Gabrenya, W. K. (2014) · ScholarWorks - GVSU (Grand Valley State University) · doi:10.4087/cjxs1591 · Cited by 52
Cumulative stress and autonomic dysregulation in a community sample
Lampert, R., Tuit, K., Hong, K.-I., Donovan, T., Lee, F., & Sinha, R. (2016) · Stress · doi:10.1080/10253890.2016.1174847 · Cited by 51
Cost of resilience: Childhood poverty, mental health, and chronic physiological stress
France, K. D., Evans, G. W., Brody, G. H., & Doan, S. N. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105872 · Cited by 64
Cysteamine Attenuates the Decreases in TrkB Protein Levels and the Anxiety/Depression-Like Behaviors in Mice Induced by Corticosterone Treatment
Kutiyanawalla, A., Terry, A. V., & Pillai, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026153 · Cited by 54
Childhood cumulative risk and later allostatic load: Mediating role of substance use.
Doan, S. N., Dich, N., & Evans, G. W. (2013) · Health Psychology · doi:10.1037/a0034790 · Cited by 51
Social regulation of allostasis: Commentary on “Mentalizing homeostasis: The social origins of interoceptive inference” by Fotopoulou and Tsakiris
Atzil, S., & Barrett, L. F. (2017) · Neuropsychoanalysis · doi:10.1080/15294145.2017.1295214 · Cited by 58
The ROCK Inhibitor Fasudil Prevents Chronic Restraint Stress-Induced Depressive-Like Behaviors and Dendritic Spine Loss in Rat Hippocampus
García‐Rojo, G., Fresno, C., Vilches, N., Díaz‐Véliz, G., Mora, S., Aguayo, F. I., Pacheco, A., Parra-Fiedler, N. A., Parra, C. S., Rojas, P. S., et al. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw108 · Cited by 51
Adverse childhood experiences, post-traumatic stress disorder symptoms, and self-reported stress among traditional and nontraditional college students
Kalmakis, K. A., Chiodo, L. M., Kent, N. M., & Meyer, J. S. (2019) · Journal of American College Health · doi:10.1080/07448481.2019.1577860 · Cited by 62
Gene–environment interdependence
Rutter, M. L. (2012) · European Journal of Developmental Psychology · doi:10.1080/17405629.2012.661174 · Cited by 49

Authors: McEwen, B. S., & Gianaros, P. J.
Affiliations: Rockefeller University (US)
University of Pittsburgh (US)
Corresponding author: McEwen, Bruce S.
ORCID: McEwen, Bruce S.
Gianaros, Peter J.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2010-02
Volume: 1186
Issue: 1
Pages: 190-222
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.2009.05331.x
PMC: PMC2864527
OpenAlex: W1686749590
Cited by: 1,715
References: 331
Citations by year: 2026: 99 · 2025: 117 · 2024: 91 · 2023: 101 · 2022: 135 · 2021: 120 · 2020: 138 · 2019: 109 · 2018: 98 · 2017: 117 · 2016: 102 · 2015: 111 · 2014: 100 · 2013: 89 · 2012: 95
FWCI: 7.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 15 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: John D. and Catherine T. MacArthur Foundation
National Institutes of Health (MH41256, MH58911)
National Heart, Lung, and Blood Institute (R01HL089850)
National Institute of Mental Health (5P01 MH58911, K01MH070616, R01 MH41256, P50MH058911, R01MH041256)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
Health Sciences › Health Professions › General Health Professions › Health, psychology, and well-being
Keywords: stress, allostasis, allostatic load, socioeconomic status, stress reactivity, coping, hippocampus, amygdala, prefrontal cortex, stress resilience, neuroimmune interactions, chronic stress, health and disease, social environment
MeSH terms: Adaptation, Physiological, Amygdala, Brain, Health Status, Hippocampus, Humans, Social Class, Stress, Physiological, Allostasis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Central role of the brain in stress and adaptation: Links to socioeconomic status, health, and disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks