Cited by 1,715Stress Responses and CortisolResilience and Mental HealthHealth, psychology, and well-being

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Central role of the brain in stress and adaptation: Links to socioeconomic status, health, and disease

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McEwen, Bruce S., Gianaros, Peter J.·2010·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.2009.05331.xPMC PMC2864527

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Abstract

The brain is the key organ of stress reactivity, coping, and recovery processes. Within the brain, a distributed neural circuitry determines what is threatening and thus stressful to the individual. Instrumental brain systems of this circuitry include the hippocampus, amygdala, and areas of the prefrontal cortex. Together, these systems regulate physiological and behavioral stress processes, which can be adaptive in the short‐term and maladaptive in the long‐term. Importantly, such stress processes arise from bidirectional patterns of communication between the brain and the autonomic, cardiovascular, and immune systems via neural and endocrine mechanisms underpinning cognition, experience, and behavior. In one respect, these bidirectional stress mechanisms are protective in that they promote short‐term adaptation ( allostasis ). In another respect, however, these stress mechanisms can lead to a long‐term dysregulation of allostasis in that they promote maladaptive wear‐and‐tear on the body and brain under chronically stressful conditions ( allostatic load ), compromising stress resiliency and health. This review focuses specifically on the links between stress‐related processes embedded within the social environment and embodied within the brain, which is viewed as the central mediator and target of allostasis and allostatic load.

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Stress, appraisal, and coping
Eysenck, H. J. (1985) · Behaviour Research and Therapy · doi:10.1016/0005-7967(85)90087-7 · Cited by 32,038
“Stress: appraisal and coping,”
Folkman, S. (2013) · Encyclopedia of Behavioral Medicine · doi:10.1007/978-1-4419-1005-9_215 · Cited by 27,833
Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States: Results From the National Comorbidity Survey
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
Neighborhoods and Violent Crime: A Multilevel Study of Collective Efficacy
Sampson, R. J., Raudenbush, S. W., & Earls, F. (1997) · Science · doi:10.1126/science.277.5328.918 · Cited by 11,999
Child abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Emotion circuits in the brain
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Conflict monitoring and cognitive control
Botvinick, M. M., Braver, T. S., Barch, D. M., Carter, C. S., & Cohen, J. D. (2001) · Psychological Review · doi:10.1037/0033-295x.108.3.624 · Cited by 7,351
Social Relationships and Health
House, J. S., Landis, K. R., & Umberson, D. (1988) · Science · doi:10.1126/science.3399889 · Cited by 7,073
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733
Self-citation

Show all 331 references

Research works printed but not linked: 10

Lovallo W.R., 2005, Stress and Health: Biological and Psycholocial Interactions
Cannon W.B., 1932, The Wisdome of the Body
10.1210/en.142.7.2796 · DOI
10.1152/physrev.00041.2006 · DOI · Paper page
10.1016/S0169-328X(98)00130-2 · DOI · Paper page
10.1210/edrv-7-3-284 · DOI · Paper page
10.1016/S0006-3223(03)00171-9 · DOI · Paper page
10.1038/sj.mp.4001656 · DOI
10.1037/0033-2909.127.4.472 · DOI · Paper page
Helgeson V.S., 1998, Psychooncology, 99

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Self-citation
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Oyola, M. G., & Handa, R. J. (2017) · Stress · doi:10.1080/10253890.2017.1369523 · Cited by 710
“These responses are known to be adaptive and have effects that influence future HPA axis responses (McEwen & Gianaros, 2010).”
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Self-citation
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Self-citation
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Self-citation
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“Research also indicates that exposure to chronic stress during early development has lasting effects on stress responses (see McEwen & Gianaros 2010 for a review).”
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Self-citation
Trauma-Informed Care
Forkey, H. C., Szilagyi, M. A., Kelly, E. T., Duffee, J. H., Springer, S. H., Fortin, K., Jones, V. F., Greiner, M. B. V., Ochs, T. J., Partap, A. N., et al. (2021) · PEDIATRICS · doi:10.1542/peds.2021-052580 · Cited by 247
Acute stress and episodic memory retrieval: neurobiological mechanisms and behavioral consequences
Gagnon, S. A., & Wagner, A. D. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12996 · Cited by 255
Associations Between Socioeconomic Status and Allostatic Load: Effects of Neighborhood Poverty and Tests of Mediating Pathways
Schulz, A. J., Mentz, G. B., Lachance, L., Johnson, J. L., Gaines, C., & Israel, B. A. (2012) · American Journal of Public Health · doi:10.2105/ajph.2011.300412 · Cited by 244
Understanding Rural–Urban Differences in Depressive Symptoms Among Older Adults in China
Li, L., Liu, J., Xu, H., & Zhang, Z. (2015) · Journal of Aging and Health · doi:10.1177/0898264315591003 · Cited by 221
Social deprivation stress is a triggering factor for the emergence of anxiety- and depression-like behaviours and leads to reduced brain BDNF levels in C57BL/6J mice
Berry, A., Bellisario, V., Capoccia, S., Tirassa, P., Calza, A., Alleva, E., & Cirulli, F. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.09.007 · Cited by 229
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[Chronic non-communicable diseases in Brazil: priorities for disease management and research].
Duncan, B. B., Chor, D., Aquino, E. M. L., Benseñor, I. M., Mill, J. G., Schmidt, M. I., Lotufo, P. A., Vigo, Á., & Barreto, S. M. (2012) · PubMed · doi:10.1590/s0034-89102012000700017 · Cited by 62
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Puglisi‐Allegra, S., & Andolina, D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.052 · Cited by 213
Ageism as a Risk Factor for Chronic Disease
Allen, J. O. (2015) · The Gerontologist · doi:10.1093/geront/gnu158 · Cited by 205
Manganese Exposure from Drinking Water and Children’s Classroom Behavior in Bangladesh
Khan, K., Factor-Litvak, P. R., Wasserman, G. A., Liu, X., Ahmed, E., Parvez, F., Slavkovich, V. N., Levy, D., Mey, J. L., van Geen, A., et al. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1003397 · Cited by 202
Early childhood growth failure and the developmental origins of adult disease: do enteric infections and malnutrition increase risk for the metabolic syndrome?
DeBoer, M. D., Lima, A. A., Oría, R. B., Scharf, R. J., Moore, S. R., Luna, M. A., & Guerrant, R. L. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00543.x · Cited by 196
Socioeconomic disparities in neurocognitive development in the first two years of life
Noble, K. G., Engelhardt, L. E., Brito, N. H., Mack, L. J., Nail, E. J., Angal, J., Barr, R., Fifer, W. P., & Elliott, A. J. (2015) · Developmental Psychobiology · doi:10.1002/dev.21303 · Cited by 200
Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory
Krugers, H. J., Hoogenraad, C. C., & Groc, L. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2913 · Cited by 197
The nuts and bolts of animal emotion
Kremer, L., Holkenborg, S. E. J. K., Reimert, I., Bolhuis, J. E., & Webb, L. E. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.028 · Cited by 219
Social status predicts wound healing in wild baboons
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Behavior genetics and postgenomics
Charney, E. (2012) · Behavioral and Brain Sciences · doi:10.1017/s0140525x11002226 · Cited by 215
Socioeconomic status and the brain: prospects for neuroscience-informed policy
Farah, M. J. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0023-2 · Cited by 201
The accelerated aging phenotype: The role of race and social determinants of health on aging
Hooten, N. N., Pacheco, N. L., Smith, J. T., & Evans, M. K. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101536 · Cited by 199

Authors: McEwen, B. S., & Gianaros, P. J.
Affiliations: Rockefeller University (US)
University of Pittsburgh (US)
Corresponding author: McEwen, Bruce S.
ORCID: McEwen, Bruce S.
Gianaros, Peter J.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2010-02
Volume: 1186
Issue: 1
Pages: 190-222
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.2009.05331.x
PMC: PMC2864527
OpenAlex: W1686749590
Cited by: 1,715
References: 331
Citations by year: 2026: 99 · 2025: 117 · 2024: 91 · 2023: 101 · 2022: 135 · 2021: 120 · 2020: 138 · 2019: 109 · 2018: 98 · 2017: 117 · 2016: 102 · 2015: 111 · 2014: 100 · 2013: 89 · 2012: 95
FWCI: 7.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 15 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: John D. and Catherine T. MacArthur Foundation
National Institutes of Health (MH41256, MH58911)
National Heart, Lung, and Blood Institute (R01HL089850)
National Institute of Mental Health (5P01 MH58911, K01MH070616, R01 MH41256, P50MH058911, R01MH041256)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
Health Sciences › Health Professions › General Health Professions › Health, psychology, and well-being
Keywords: stress, allostasis, allostatic load, socioeconomic status, stress reactivity, coping, hippocampus, amygdala, prefrontal cortex, stress resilience, neuroimmune interactions, chronic stress, health and disease, social environment
MeSH terms: Adaptation, Physiological, Amygdala, Brain, Health Status, Hippocampus, Humans, Social Class, Stress, Physiological, Allostasis

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Central role of the brain in stress and adaptation: Links to socioeconomic status, health, and disease

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