Cited by 33Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and PathologyFungal and yeast genetics research

Mitochondrial pathways governing stress resistance, life, and death in the fungal aging model Podospora anserina

Osiewacz, Heinz D., Brust, Diana, Hamann, Andrea, Kunstmann, Birgit, Luce, Karin, Müller‐Ohldach, Mathis, Scheckhuber, Christian Q., Servos, Jörg +1 more·2010·Annals of the New York Academy of Sciences

Abstract

Work from more than 50 years of research has unraveled a number of molecular pathways that are involved in controlling aging of the fungal model system Podospora anserina. Early research revealed that wild-type strain aging is linked to gross reorganization of the mitochondrial DNA. Later it was shown that aging of P. anserina does also take place, although at a slower pace, when the wild-type specific mitochondrial DNA rearrangements do not occur. Now it is clear that a network of different pathways is involved in the control of aging. Branches of these pathways appear to be connected and constitute a hierarchical system of responses. Although cross talk between the individual pathways seems to be fundamental in the coordination of the overall system, the precise underlying interactions remain to be unraveled. Such a systematic approach aims at a holistic understanding of the process of biological aging, the ultimate goal of modern systems biology.

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Crossref · 10.1111/j.1749-6632.2010.05190.x

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  • For several genotypes the Podospora anserina culture will grow for 3-5 weeks and then enter senescence marked by mitochondrial DNA instabilities, increased ROS, mitochondrial fission, accumulation of pigment and cell death.

    “For several genotypes the culture will grow for 3-5 weeks and then enter senescence marked by mitochondrial DNA instabilities, increased ROS, mitochondrial fission, accumulation of pigment and cell death (Gredilla et al., 2006; Osiewacz et al., 2010).”

    From Programmed cell death in aging (2015) · cites this paper as Osiewacz et al., 2010

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Authors
Osiewacz, H. D., Brust, D., Hamann, A., Kunstmann, B., Luce, K., Müller‐Ohldach, M., Scheckhuber, C. Q., Servos, J., & Strobel, I.
Affiliations
Goethe University Frankfurt (DE)
Corresponding author
Osiewacz, Heinz D.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2010-06
Volume
1197
Issue
1
Pages
54-66
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W1513192819
Cited by
33
References
75
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 4
FWCI
0.42
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
Podospora anserina, fungal aging, mitochondrial genome rearrangement, stress tolerance, life and death, aging pathways, pathway crosstalk
MeSH terms
Aging, Biochemical Phenomena, DNA, Mitochondrial, Mitochondria, Models, Biological, Podospora

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