Mitochondrial pathways governing stress resistance, life, and death in the fungal aging model Podospora anserina
Abstract
Work from more than 50 years of research has unraveled a number of molecular pathways that are involved in controlling aging of the fungal model system Podospora anserina. Early research revealed that wild-type strain aging is linked to gross reorganization of the mitochondrial DNA. Later it was shown that aging of P. anserina does also take place, although at a slower pace, when the wild-type specific mitochondrial DNA rearrangements do not occur. Now it is clear that a network of different pathways is involved in the control of aging. Branches of these pathways appear to be connected and constitute a hierarchical system of responses. Although cross talk between the individual pathways seems to be fundamental in the coordination of the overall system, the precise underlying interactions remain to be unraveled. Such a systematic approach aims at a holistic understanding of the process of biological aging, the ultimate goal of modern systems biology.
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For several genotypes the Podospora anserina culture will grow for 3-5 weeks and then enter senescence marked by mitochondrial DNA instabilities, increased ROS, mitochondrial fission, accumulation of pigment and cell death.
“For several genotypes the culture will grow for 3-5 weeks and then enter senescence marked by mitochondrial DNA instabilities, increased ROS, mitochondrial fission, accumulation of pigment and cell death (Gredilla et al., 2006; Osiewacz et al., 2010).”
From Programmed cell death in aging (2015) · cites this paper as Osiewacz et al., 2010
Cites
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082 · see citing works
Antioxidant and Prooxidant Behavior of Flavonoids: Structure-Activity Relationships
Cao, G., Sofic, E., & Prior, R. L. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00351-6 · Cited by 2,415 · see citing works
Molecular Chaperones and Protein Quality Control
Bukau, B., Weissman, J. S., & Horwich, A. L. (2006) · Cell · doi:10.1016/j.cell.2006.04.014 · Cited by 1,556 · see citing works
Rhee, S. G., Chae, H. Z., & Kim, K. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.026 · Cited by 1,409 · see citing works
The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells
Maxwell, D. P., Wang, Y., & McIntosh, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8271 · Cited by 1,113 · see citing works
The Photochemistry of Carotenoids
Frank, H. A., Cogdell, R. J., Britton, G., & Young, A. J. (1999) · Advances in photosynthesis and respiration · doi:10.1007/0-306-48209-6 · Cited by 772 · see citing works
Robertson, A. B., Klungland, A., Rognes, T., & Leiros, I. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-8736-z · Cited by 652 · see citing works
Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism
Bota, D. A., & Davies, K. J. A. (2002) · Nature Cell Biology · doi:10.1038/ncb836 · Cited by 557 · see citing works
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
Van Raamsdonk, J. M., & Hekimi, S. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000361 · Cited by 511 · see citing works
Doonan, R., McElwee, J., Matthijssens, F., Walker, G. A., Houthoofd, K., Back, P., Matscheski, A., Vanfleteren, J. R., & Gems, D. (2008) · Genes & Development · doi:10.1101/gad.504808 · Cited by 480 · see citing works
Mitochondrial filaments and clusters as intracellular power-transmitting cables
Skulachev, V. P. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01735-7 · Cited by 477 · see citing works
Nakada, K., Inoue, K., Ono, T., Isobe, K., Ogura, A., Goto, Y., Nonaka, I., & Hayashi, J. (2001) · Nature Medicine · doi:10.1038/90976 · Cited by 430 · see citing works
Ono, T., Isobe, K., Nakada, K., & Hayashi, J.-I. (2001) · Nature Genetics · doi:10.1038/90116 · Cited by 420 · see citing works
Bohr, V. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00787-6 · Cited by 380 · see citing works
The genome sequence of the model ascomycete fungus Podospora anserina
Espagne, E., Lespinet, O., Malagnac, F., Silva, C. D., Jaillon, O., Porcel, B. M., Couloux, A., Aury, J., Segurens, B., Poulain, J., et al. (2008) · Genome biology · doi:10.1186/gb-2008-9-5-r77 · Cited by 349 · see citing works
Stahl, W., Junghans, A., de Boer, B., Driomina, E. S., Briviba, K., & Sies, H. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00434-7 · Cited by 347 · see citing works
Scheckhuber, C. Q., Erjavec, N., Tinazli, A., Hamann, A., Nyström, T., & Osiewacz, H. D. (2007) · Nature Cell Biology · doi:10.1038/ncb1524 · Cited by 344 · see citing works
Self-citationRequirement for the Yeast Gene LON in Intramitochondrial Proteolysis and Maintenance of Respiration
Suzuki, C. K., Suda, K., Wang, N., & Schatz, G. (1994) · Science · doi:10.1126/science.8146662 · Cited by 272 · see citing works
Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease
Nicholls, D. G. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00077-8 · Cited by 246 · see citing works
Zhu, B. T., Ezell, E. L., & Liehr, J. G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42348-9 · Cited by 237 · see citing works
Bota, D. A., Ngo, J. K., & Davies, K. J. A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.017 · Cited by 203 · see citing works
Everett, S. A., Dennis, M. F., Patel, K. B., Maddix, S. P., Kundu, S. C., & WILLSON, R. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.3988 · Cited by 201 · see citing works
The mitochondrial plasmid of Podospora anserina: A mobile intron of a mitochondrial gene
Osíewacz, H. D., & Esser, K. (1984) · Current Genetics · doi:10.1007/bf00419728 · Cited by 199 · see citing works
Evidence for plasmid like DNA in a filamentous fungus, the ascomycete Podospora anserina
Ståhl, U., Lemke, P. A., Tudzynski, P., Kück, U., & Esser, K. (1978) · Molecular and General Genetics MGG · doi:10.1007/bf00268860 · Cited by 182 · see citing works
A causal link between respiration and senescence in Podospora anserina
Dufour, É., Boulay, J., Rincheval, V., & Sainsard‐Chanet, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.070501997 · Cited by 170 · see citing works
Roles for the Human ATP-dependent Lon Protease in Mitochondrial DNA Maintenance
Lü, B., Yadav, S. S., Shah, P. G., Liu, T., Tian, B., Pukszta, S., Villaluna, N., Kutějová, E., Newlon, C. S., Santos, J. H., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611540200 · Cited by 148 · see citing works
Apoptosis pathways in fungal growth, development and ageing
Hamann, A., Brust, D., & Osiewacz, H. D. (2008) · Trends in Microbiology · doi:10.1016/j.tim.2008.03.003 · Cited by 143 · see citing works
Self-citationPinan‐Lucarré, B., Paoletti, M., Dementhon, K., Salin, B., & Clavé, C. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03208.x · Cited by 141 · see citing works
Iron accumulation in aging: modulation by dietary restriction
Cook, C. I., & Yu, B. P. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00005-0 · Cited by 137 · see citing works
Increasing organismal healthspan by enhancing mitochondrial protein quality control
Luce, K., & Osiewacz, H. D. (2009) · Nature Cell Biology · doi:10.1038/ncb1893 · Cited by 133 · see citing works
Self-citationMitochondrial DNA from Podospora anserina
Cummings, D. J., Belcour, L., & Grandchamp, C. (1979) · Molecular and General Genetics MGG · doi:10.1007/bf00267577 · Cited by 127 · see citing works
Erratum: Livermore Faces Forces of Change
Anderson, C. (1994) · Science · doi:10.1126/science.8178144 · Cited by 125 · see citing works
Krause, F., Scheckhuber, C. Q., Werner, A., Rexroth, S., Reifschneider, N. H., Dencher, N. A., & Osiewacz, H. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402756200 · Cited by 118 · see citing works
Self-citationAccelerated Cell Death in Podospora Autophagy Mutants
Pinan‐Lucarré, B., Balguerie, A., & Clavé, C. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.11.1765-1774.2005 · Cited by 118 · see citing works
Copper-Modulated Gene Expression and Senescence in the Filamentous Fungus Podospora anserina
Borghouts, C., Werner, A., Elthon, T., & Osiewacz, H. D. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.2.390-399.2001 · Cited by 109 · see citing works
Self-citationGenes, mitochondria and aging in filamentous fungi
Osiewacz, H. D. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00010-7 · Cited by 106 · see citing works
Self-citationAntioxidative properties of lycopene and other carotenoids from tomatoes: Synergistic effects
Shi, J., Kakuda, Y., & Yeung, D. L. (2004) · BioFactors · doi:10.1002/biof.552210141 · Cited by 94 · see citing works
Gruszecki, W. I. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48209-6_20 · Cited by 87 · see citing works
Groebe, K., Krause, F., Kunstmann, B., Unterluggauer, H., Reifschneider, N. H., Scheckhuber, C. Q., Sastri, C., Stegmann, W., Woźny, W., Schwall, G., et al. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.07.001 · Cited by 86 · see citing works
Self-citationHamann, A., Brust, D., & Osiewacz, H. D. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05839.x · Cited by 86 · see citing works
Self-citationRigas, S., Δάρας, Γ., Laxa, M., Marathias, N., Fasseas, C., Sweetlove, L. J., & Hatzopoulos, P. (2008) · New Phytologist · doi:10.1111/j.1469-8137.2008.02701.x · Cited by 85 · see citing works
Yanase, S., Onodera, A., Tedesco, P., Johnson, T. E., & Ishii, N. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp020 · Cited by 82 · see citing works
The phenoloxidases of the ascomycete Podospora anserina
Prillinger, H., & Esser, K. (1977) · Molecular and General Genetics MGG · doi:10.1007/bf00267190 · Cited by 80 · see citing works
Gredilla, R., Grief, J., & Osiewacz, H. D. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.01.010 · Cited by 79 · see citing works
Self-citationMitochondrial metabolism and aging in the filamentous fungus Podospora anserina
Lorin, S., Dufour, É., & Sainsard‐Chanet, A. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.03.005 · Cited by 73 · see citing works
Borghouts, C., & Osiewacz, H. D. (1998) · Molecular and General Genetics MGG · doi:10.1007/s004380050922 · Cited by 72 · see citing works
Self-citationZatta, P. F., Drago, D., Zambenedetti, P., Bolognin, S., Nogara, E., Peruffo, A., & Cozzi, B. (2008) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2008.02.008 · Cited by 71 · see citing works
Mitochondrial functions and aging
Osiewacz, H. D. (2002) · Gene · doi:10.1016/s0378-1119(01)00804-6 · Cited by 70 · see citing works
Self-citationAging in fungi: role of mitochondria in Podospora anserina
Osiewacz, H. D. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00421-3 · Cited by 70 · see citing works
Self-citationStumpferl, S. W., Stephan, O., & Osiewacz, H. D. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.1.200-211.2004 · Cited by 70 · see citing works
Self-citationLorin, S., Dufour, É., Boulay, J., Begel, O., Marsy, S., & Sainsard‐Chanet, A. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02690.x · Cited by 68 · see citing works
Schulte, E., Kück, U., & Esser, K. (1988) · Molecular and General Genetics MGG · doi:10.1007/bf00330614 · Cited by 65 · see citing works
Busch, K. B., Bereiter-Hahn, J., Wittig, I., Schägger, H., & Jendrach, M. (2006) · Molecular Membrane Biology · doi:10.1080/09687860600877292 · Cited by 64 · see citing works
Podospora anserina: a model organism to study mechanisms of healthy ageing
Scheckhuber, C. Q., & Osiewacz, H. D. (2008) · Molecular Genetics and Genomics · doi:10.1007/s00438-008-0378-6 · Cited by 61 · see citing works
Self-citationBorghouts, C., Scheckhuber, C. Q., Stephan, O., & Osiewacz, H. D. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00078-x · Cited by 60 · see citing works
Self-citationMortensen, A., & Skibsted, L. H. (1996) · Free Radical Research · doi:10.3109/10715769609149073 · Cited by 54 · see citing works
Kunstmann, B., & Osiewacz, H. D. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00412.x · Cited by 50 · see citing works
Self-citationRespiration, copper availability and SOD activity in P. anserina strains with different lifespan
Borghouts, C., Scheckhuber, C. Q., Werner, A., et al. (2002) · Biogerontology · doi:10.1023/a:1015696404723 · Cited by 49 · see citing works
Self-citationOsiewacz, H., Skaletz, A., & Esser, K. (1991) · Applied Microbiology and Biotechnology · doi:10.1007/bf00180633 · Cited by 47 · see citing works
Self-citationExpression of multiple catechol‐o‐methyltransferase (COMT) mRNA variants in human brain
Tunbridge, E. M., Lane, T. A., & Harrison, P. J. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30539 · Cited by 45 · see citing works
Mitochondrial-nuclear interactions and lifespan control in fungi
Osiewacz, H. D., & Kimpel, E. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00063-7 · Cited by 45 · see citing works
Self-citationKunstmann, B., & Osiewacz, H. D. (2009) · Aging · doi:10.18632/aging.100029 · Cited by 43 · see citing works
Self-citationOsiewacz, H. D. (1994) · Current Genetics · doi:10.1007/bf00326309 · Cited by 42 · see citing works
Self-citationAverbeck, N., Jensen, O. N., Mann, M., Schägger, H., & Osiewacz, H. D. (2000) · Current Genetics · doi:10.1007/s002940050520 · Cited by 42 · see citing works
Self-citationElectrophoretic karyotype of the ascomycete Podospora anserina
Osiewacz, H. D., Clairmont, A., & Huth, M. (1990) · Current Genetics · doi:10.1007/bf00309921 · Cited by 38 · see citing works
Self-citationImpact of ROS on ageing of two fungal model systems: Saccharomyces cerevisiae and Podospora anserina
Osiewacz, H. D., & Scheckhuber, C. Q. (2006) · Free Radical Research · doi:10.1080/10715760600921153 · Cited by 36 · see citing works
Self-citationCopper-dependence of mitochondrial DNA rearrangements in Podospora anserina
Borghouts, C., Kerschner, S., & Osiewacz, H. D. (2000) · Current Genetics · doi:10.1007/s002940050528 · Cited by 36 · see citing works
Self-citationStrobel, I., Breitenbach, J., Scheckhuber, C. Q., et al. (2009) · Current Genetics · doi:10.1007/s00294-009-0235-0 · Cited by 31 · see citing works
Self-citationA two-step protocol for efficient deletion of genes in the filamentous ascomycete Podospora anserina
Hamann, A., Krause, K., Werner, A., et al. (2005) · Current Genetics · doi:10.1007/s00294-005-0018-1 · Cited by 30 · see citing works
Self-citationAntioxidant and prooxidant effects of quercetin on glyceraldehyde-3-phosphate dehydrogenase
Schmalhausen, E. V., Zhlobek, E. B., Shalova, I. N., Firuzi, O., Saso, L., & Muronetz, V. I. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.04.015 · Cited by 28 · see citing works
Silar, P., Barreau, C., Debuchy, R., et al. (2003) · Fungal Genetics and Biology · doi:10.1016/s1087-1845(03)00025-2 · Cited by 26 · see citing works
Soerensen, M., Gredilla, R., Mueller-Ohldach, M., Werner, A., Bohr, V. A., Osiewacz, H. D., & Stevnsner, T. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.05.003 · Cited by 21 · see citing works
Self-citationScheckhuber, C. Q., Rödel, E., & Wüstehube‐Lausch, J. (2008) · Biotechnology Journal · doi:10.1002/biot.200800010 · Cited by 18 · see citing works
Self-citationImpact of Mitochondrial Dynamics on Organismic Aging
Scheckhuber, C. Q. (2009) · The Scientific World JOURNAL · doi:10.1100/tsw.2009.33 · Cited by 9 · see citing works
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Programmed cell death in aging
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- Authors
- Osiewacz, H. D., Brust, D., Hamann, A., Kunstmann, B., Luce, K., Müller‐Ohldach, M., Scheckhuber, C. Q., Servos, J., & Strobel, I.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Osiewacz, Heinz D.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2010-06
- Volume
- 1197
- Issue
- 1
- Pages
- 54-66
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1513192819
- Cited by
- 33
- References
- 75
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Podospora anserina, fungal aging, mitochondrial genome rearrangement, stress tolerance, life and death, aging pathways, pathway crosstalk
- MeSH terms
- Aging, Biochemical Phenomena, DNA, Mitochondrial, Mitochondria, Models, Biological, Podospora
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