Scavenger receptor class B type I: A multifunctional receptor
Open accessAbstract
The scavenger receptor class B type I (SR‐B1) plays an important role in meditating the uptake of HDL‐derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. In addition to being ubiquitous, SR‐B1 is a high‐density lipoprotein (HDL) receptor in many tissues, though the mechanism by which SR‐B1 does this is unclear. Other than its role as an HDL receptor, SR‐B1 is also involved in pathogen recognition; its expression can be modulated by lipopolysaccharide and oxidative stress; and it plays a significant role in the uptake of lipid soluble vitamins, such as vitamin E and carotenoids. In this short review, we have summarized the biological aspects to which SR‐B1 has been thus far associated.
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SCARB1 can serve as a transporter for vitamins, including tocopherols, and carotenoids such as β-carotene and xanthophylls.
“Additionally, SCARB1 can also serve as a transporter for vitamins, including tocopherols, and carotenoids such as β-carotene and xanthophylls [10,11].”
From Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye (2021) · cites this paper as [10]
The “SR-B1 and vitamin E” section (page not provided) states that SR-B1 transports α-tocopherol and is involved in carotenoid uptake. The References list (page not provided) names a study of SR-B1-mediated β-carotene absorption. Our copy does not specifically mention xanthophylls, so that example is not verified by this source. (LLM, conf=0.86)
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Université de Poitiers Faculté de Médecine et Pharmacie
Couderc, E. (2014)
29 Immunoglobulin-Like Domain Containing Receptor Mediates Fat-Stimulated Cholecystokinin Secretion
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- Authors
- Valacchi, G., Sticozzi, C., Lim, Y., & Pecorelli, A.
- Affiliations
- University of Ferrara (IT)
- University of Trento (IT)
- Kyung Hee University (KR)
- University of Siena (IT)
- Corresponding author
- Valacchi, Giuseppe
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2011-07
- Volume
- 1229
- Issue
- 1
- Pages
- E1-7
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1671549322
- Semantic Scholar
- 8d8aa42c23deabac7c734ebce862fbf1ccf9108b
- Cited by
- 108
- References
- 82
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 15 · 2016: 6 · 2015: 13 · 2014: 15 · 2013: 6 · 2012: 6
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- scavenger receptor class B type I, HDL cholesterol uptake, cholesterol esters, liver, steroidogenic tissues, HDL receptor, pathogen recognition, lipopolysaccharide, oxidative stress, carotenoid uptake, fat-soluble vitamins
- MeSH terms
- Adrenal Cortex, Animals, Biological Transport, Carotenoids, Cholesterol Esters, Humans, Lipopolysaccharides, Cholesterol, HDL, Liver, Lung, Membrane Proteins, Tissue Distribution, Vitamin E, Mice, Knockout, Oxidative Stress, CD36 Antigens, Mice, Rats, Hep G2 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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