Cited by 108Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthDrug Transport and Resistance Mechanisms

Scavenger receptor class B type I: A multifunctional receptor

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Valacchi, Giuseppe, Sticozzi, Claudia, Lim, Yunsook, Pecorelli, Alessandra·2011·Annals of the New York Academy of Sciences

Abstract

The scavenger receptor class B type I (SR‐B1) plays an important role in meditating the uptake of HDL‐derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. In addition to being ubiquitous, SR‐B1 is a high‐density lipoprotein (HDL) receptor in many tissues, though the mechanism by which SR‐B1 does this is unclear. Other than its role as an HDL receptor, SR‐B1 is also involved in pathogen recognition; its expression can be modulated by lipopolysaccharide and oxidative stress; and it plays a significant role in the uptake of lipid soluble vitamins, such as vitamin E and carotenoids. In this short review, we have summarized the biological aspects to which SR‐B1 has been thus far associated.

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Crossref · 10.1111/j.1749-6632.2011.06205.x

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  • SCARB1 can serve as a transporter for vitamins, including tocopherols, and carotenoids such as β-carotene and xanthophylls.

    “Additionally, SCARB1 can also serve as a transporter for vitamins, including tocopherols, and carotenoids such as β-carotene and xanthophylls [10,11].”

    From Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye (2021) · cites this paper as [10]

    The “SR-B1 and vitamin E” section (page not provided) states that SR-B1 transports α-tocopherol and is involved in carotenoid uptake. The References list (page not provided) names a study of SR-B1-mediated β-carotene absorption. Our copy does not specifically mention xanthophylls, so that example is not verified by this source. (LLM, conf=0.86)

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Authors
Valacchi, G., Sticozzi, C., Lim, Y., & Pecorelli, A.
Affiliations
  • University of Ferrara (IT)
  • University of Trento (IT)
  • Kyung Hee University (KR)
  • University of Siena (IT)
Corresponding author
Valacchi, Giuseppe
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2011-07
Volume
1229
Issue
1
Pages
E1-7
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W1671549322
Cited by
108
References
82
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 15 · 2016: 6 · 2015: 13 · 2014: 15 · 2013: 6 · 2012: 6
FWCI
1.56
Type
journal article
Language
en
Open access
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Funders
Ministero dell’Istruzione, dell’Università e della Ricerca
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
scavenger receptor class B type I, HDL cholesterol uptake, cholesterol esters, liver, steroidogenic tissues, HDL receptor, pathogen recognition, lipopolysaccharide, oxidative stress, carotenoid uptake, fat-soluble vitamins
MeSH terms
Adrenal Cortex, Animals, Biological Transport, Carotenoids, Cholesterol Esters, Humans, Lipopolysaccharides, Cholesterol, HDL, Liver, Lung, Membrane Proteins, Tissue Distribution, Vitamin E, Mice, Knockout, Oxidative Stress, CD36 Antigens, Mice, Rats, Hep G2 Cells

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