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Cited by 345Barrier Structure and Function StudiesGastrointestinal motility and disordersCell Adhesion Molecules Research

Myosin light chain kinase: pulling the strings of epithelial tight junction function

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Cunningham, Kevin E., Turner, Jerrold R.·2012·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.2012.06526.xPMC PMC3384706
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Abstract

Dynamic regulation of paracellular permeability is essential for physiological epithelial function, while dysregulated permeability is common in disease. The recent elucidation of the molecular composition of the epithelial tight junction complex has been accompanied by characterization of diverse intracellular mediators of paracellular permeabiltiy. Myosin light chain kinase (MLCK), which induces contraction of the perijunctional actomyosin ring through myosin II regulatory light chain phosphorylation, has emerged as a key regulator of tight junction permeability. Examination of the regulation and role of MLCK in tight junction dysfunction has helped to define pathological processes and characterize the role of barrier loss in disease pathogenesis, and may provide future therapeutic targets to treat intestinal disease.

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Crossref · 10.1111/j.1749-6632.2012.06526.x

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  • The mechanisms underlying junctional positioning and coupling to the contractile actomyosin network to provide tensile strength to the barrier have been mostly explored in simple epithelia in lower organisms or in cell culture.

    “The mechanisms underlying junctional positioning and coupling to the contractile actomyosin network to provide tensile strength to the barrier have been mostly explored in simple epithelia in lower organisms or in cell culture32, 33.”

    From E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning (2017) · cites this paper as [33]

    The Introduction (page unavailable) describes junctional positioning, attachment to perijunctional actomyosin, and their roles in structural integrity and barrier function. The Myosin light chain kinase section (page unavailable) says cultured epithelial monolayers enabled mechanistic investigation that intact tissue could not, but it does not establish that these mechanisms were mostly explored in lower organisms or simple epithelia. (LLM, conf=0.82)

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Cited by

Sorted by citations

Authors
Cunningham, K. E., & Turner, J. R.
Affiliations
University of Chicago (US)
Corresponding author
Turner, Jerrold R.
ORCID
Turner, Jerrold R.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2012-06-25
Volume
1258
Issue
1
Pages
34-42
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.2012.06526.x
PMC
PMC3384706
OpenAlex
W1608259439
Cited by
345
References
4
Citations by year
2026: 25 · 2025: 20 · 2024: 21 · 2023: 17 · 2022: 35 · 2021: 31 · 2020: 32 · 2019: 28 · 2018: 22 · 2017: 33 · 2016: 25 · 2015: 28 · 2014: 17 · 2013: 9 · 2012: 1
FWCI
1.64
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • University of Chicago
  • National Cancer Institute (P30‐CA14599, P30CA014599)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK61931, P01DK067887, R01DK-68271, R01DK068271, R01DK061931)
  • National Center for Research Resources (UL1RR024999)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
myosin light chain kinase, epithelial tight junctions, paracellular permeability, tight junction permeability, actomyosin ring, tight junction dysfunction, intestinal diseases, therapeutic target
MeSH terms
Animals, Crohn Disease, Humans, Intestinal Mucosa, Myosin-Light-Chain Kinase, Tumor Necrosis Factor-alpha, Disease Progression, Tight Junctions

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