Autocrine regulation of epithelial permeability by hypoxia: Role for polarized release of tumor necrosis factor α
Open accessAbstract
Background & aims The intestinal mucosa is lined by a monolayer of protective epithelial cells. This barrier is regulated by immune-derived factors such as interferon gamma (IFN-gamma). Because of the high volume of blood flow, the intestine is a primary target for hypoxic damage. We hypothesize that epithelial cytokine responses are regulated by hypoxia.Methods T84 intestinal epithelial cells were used to assess alterations in permeability, major histocompatibility complex class II induction, cytokine receptor expression, and cytokine release in response to combinations of IFN-gamma and cellular hypoxia.Results Hypoxia potentiated the influence of IFN-gamma on epithelial barrier function. Such responses were conferrable in a >/=10-kilodalton conditioned media fraction from hypoxic epithelia. Subsequent experiments identified this factor as epithelium-derived tumor necrosis factor alpha (TNF-alpha). Add-back of recombinant TNF-alpha in combination with IFN-gamma to normoxic epithelia recapitulated hypoxia and identified basolaterally polarized TNF-alpha receptor types I and II on intestinal epithelia. A similar pattern of TNF-alpha-receptor expression was observed on native intestinal epithelia. Specific inhibition of TNF-alpha using neutralizing antibody or alpha-N-phthalimidoglutarimide (thalidomide) resulted in reversal of the hypoxia-evoked responses.Conclusions These studies indicate that during hypoxia, epithelium-derived mediators such as TNF-alpha have the potential to regulate permeability through autocrine pathways.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TNF increases tight junction permeability by decreasing tight junction protein expression and activating myosin light chain kinase.
“TNF increases tight junction permeability by decreasing expression of tight junction proteins as well as by activating myosin light chain kinase (MLCK)147.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [147]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Pathophysiology of Tumor Necrosis Factors
VASSALLI, P. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.002211 · Cited by 1,874 · see citing works
Kindler, V., Sappino, A., Grau, G. E., Piguet, P., & VASSALLI, P. (1989) · Cell · doi:10.1016/0092-8674(89)90676-4 · Cited by 1,239 · see citing works
Jung, H. C., Eckmann, L., Yang, S. K., Panja, A. B., Fierer, J., Morzycka-Wroblewska, E., & Kagnoff, M. F. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117676 · Cited by 1,197 · see citing works
Sampaio, E. P., Sarno, E. N., Gallily, R., Cohn, Z. A., & Kaplan, G. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.3.699 · Cited by 1,191 · see citing works
Two populations of Ia-like molecules on a human B cell line.
Lampson, L. A., & Levy, R. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.125.1.293 · Cited by 1,102 · see citing works
Moreira, A. L., Sampaio, E. P., Zmuidzinas, A., Frindt, P., Smith, K. A., & Kaplan, G. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.6.1675 · Cited by 1,041 · see citing works
Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon
Aggarwal, B. B., Eessalu, T. E., & Hass, P. E. (1985) · Nature · doi:10.1038/318665a0 · Cited by 876 · see citing works
Philip, R., & Epstein, L. B. (1986) · Nature · doi:10.1038/323086a0 · Cited by 762 · see citing works
Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives
Hollander, D., Vadheim, C. M., Brettholz, E., Petersen, G. M., Delahunty, T., & Rotter, J. I. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-6-883 · Cited by 762 · see citing works
Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers.
Madara, J. L., & Stafford, J. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113938 · Cited by 758 · see citing works
Powell, D. W. (1981) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1981.241.4.g275 · Cited by 624 · see citing works
Davies, M. (1979) · Cited by 602 · see citing works
PATHOGENESIS OF CROHN'S DISEASE: MULTIFOCAL GASTROINTESTINAL INFARCTION
Wakefield, A. J., Dhillon, A. P., Rowles, P. M., Sawyerr, A. M., Pittilo, R. M., Lewis, A. A. M., & Pounder, R. E. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91078-7 · Cited by 573 · see citing works
Structural basis for physiological regulation of paracellular pathways in intestinal epithelia
Madara, J., & Pappenheimer, J. R. (1987) · The Journal of Membrane Biology · doi:10.1007/bf02209147 · Cited by 522 · see citing works
Evidence for function of Ia molecules on gut epithelial cells in man.
Mayer, L., & Shlien, R. D. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.166.5.1471 · Cited by 520 · see citing works
McCormick, B. A., Colgan, S. P., Delp-Archer, C., Miller, S. I., & Madara, J. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.4.895 · Cited by 447 · see citing works
Self-citationA human colonic tumor cell line that maintains vectorial electrolyte transport
Dharmsathaphorn, K., McRoberts, J. A., Mandel, K. G., Tisdale, L. D., & Masui, H. (1984) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1984.246.2.g204 · Cited by 398 · see citing works
Rediscovering thalidomide: A review of its mechanism of action, side effects, and potential uses
Tseng, S. S., Pak, G. H., Washenik, K., Pomeranz, M. K., & Shupack, J. L. (1996) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(96)90122-x · Cited by 362 · see citing works
Induction of Interleukin 6 (IL-6) by Hypoxia in Vascular Cells
Yan, S. F., Tritto, I., Pinsky, D. J., Liao, H., Huang, J. G., Fuller, G. M., Brett, J., May, L. T., & Stern, D. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.19.11463 · Cited by 345 · see citing works
Hypoxic induction of interleukin-8 gene expression in human endothelial cells.
Karakurum, M., Shreeniwas, R., Chen, J., Pinsky, D. J., Yan, S. D., Anderson, M., Sunouchi, K., Major, J. A., Hamilton, T. A., & Kuwabara, K. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117135 · Cited by 340 · see citing works
Expression of class II molecules on intestinal epithelial cells in humans
Mayer, L., Eisenhardt, D. J., Salomon, P. F., Bauer, W. M., Plous, R., & Piccinini, L. A. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90575-6 · Cited by 276 · see citing works
Crohn's disease--a permeability disorder of the tight junction?
Hollander, D. (1988) · Gut · doi:10.1136/gut.29.12.1621 · Cited by 271 · see citing works
Hollander, D. (1992) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529209011172 · Cited by 265 · see citing works
Adams, R. B., Planchon, S. M., & Roche, J. K. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.6.2356 · Cited by 242 · see citing works
Quiding, M., Nordström, I., Kilander, A. F., Andersson, G., HANSON, L. Å., Holmgren, J. R., & Czerkinsky, C. C. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115270 · Cited by 229 · see citing works
Parkos, C. A., Colgan, S. P., Liang, T. W., Nusrat, A., Bacarra, A. E., Carnes, D. K., & Madara, J. L. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.132.3.437 · Cited by 216 · see citing works
Self-citationBivic, A. L., Real, F. X., & Rodriguez-Boulan, E. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9313 · Cited by 191 · see citing works
[24] Established intestinal cell lines as model systems for electrolyte transport studies
Dharmsathaphorn, K., & Madara, J. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)92082-o · Cited by 187 · see citing works
IL-4 directly modulates function of a model human intestinal epithelium.
Colgan, S. P., Resnick, M. B., Parkos, C. A., Delp-Archer, C., McGuirk, D., Bacarra, A. E., Weller, P. F., & Madara, J. L. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.5.2122 · Cited by 181 · see citing works
Self-citationColgan, S. P., Parkos, C. A., Delp, C., Arnaout, M. A., & Madara, J. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.3.785 · Cited by 163 · see citing works
Self-citationIntegrative immunophysiology in the intestinal mucosa
Perdue, M. H., & McKay, D. M. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.267.2.g151 · Cited by 163 · see citing works
Parkos, C. A., Colgan, S. P., Diamond, M., Nusrat, A., Liang, T. W., Springer, T. A., & Madara, J. (1996) · Molecular Medicine · doi:10.1007/bf03401908 · Cited by 156 · see citing works
Self-citationWarner-Lambert/Parke-Davis Award lecture. Pathobiology of the intestinal epithelial barrier.
Jl, M. (1990) · PubMed · Cited by 153 · see citing works
Intestinal tissue PO2 and microvascular responses during glucose exposure
Bohlen, H. G. (1980) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1980.238.2.h164 · Cited by 149 · see citing works
Interferon-gamma induces a cell surface phenotype switch on T84 intestinal epithelial cells
Colgan, S. P., Parkos, C., Matthews, J. B., D'Andrea, L., Awtrey, C. S., Lichtman, A. H., Delp-Archer, C., & Madara, J. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.2.c402 · Cited by 134 · see citing works
Self-citationEarly mucosal changes in Crohn's disease.
Sankey, E. A., Dhillon, A. P., Anthony, A., Wakefield, A. J., Sim, R., More, L. J., Hudson, M., Sawyerr, A. M., & Pounder, R. E. (1993) · Gut · doi:10.1136/gut.34.3.375 · Cited by 132 · see citing works
Interleukin-4 and Interleukin-13 Differentially Regulate Epithelial Chloride Secretion
Zünd, G., Madara, J., Dzus, A. L., Awtrey, C. S., & Colgan, S. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.13.7460 · Cited by 130 · see citing works
Self-citationInteraction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-α gene
Newell, C. L., Deisseroth, A., & Lopez‐Berestein, G. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.56.1.27 · Cited by 126 · see citing works
Zwingenberger, K., & Wnendt, S. (1997) · PubMed · Cited by 115 · see citing works
Permeability in Crohn's disease: Altered barrier functions in healthy relatives?
Hollander, D. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90668-3 · Cited by 115 · see citing works
Madara, J., Colgan, S. P., Nusrat, A., Delp, C., & Parkos, C. A. (1992) · Methods in Cell Science · doi:10.1007/bf01409013 · Cited by 108 · see citing works
Self-citationShock: ischemia, reperfusion, and inflammation.
Waxman, K. (1996) · PubMed · Cited by 100 · see citing works
Epithelial exposure to hypoxia modulates neutrophil transepithelial migration.
Colgan, S. P., Dzus, A. L., & Parkos, C. A. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.3.1003 · Cited by 97 · see citing works
Self-citationIntestinal epithelial function: The case for immunophysiological regulation
McKay, D. M., & Perdue, M. H. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01308592 · Cited by 95 · see citing works
Essentials of Mucosal Immunology
(1996) · Elsevier eBooks · doi:10.1016/b978-0-12-394330-9.x5000-5 · Cited by 94 · see citing works
Sanders, S., Madara, J., McGuirk, D., Gelman, D. S., & Colgan, S. P. (1995) · PubMed · Cited by 86 · see citing works
Self-citationIFN-gamma modulates CD1d surface expression on intestinal epithelia
Colgan, S. P., Morales, V. M., Madara, J., Polischuk, J. E., Balk, S. P., & Blumberg, R. S. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.1.c276 · Cited by 78 · see citing works
Self-citationMaeyer, E. D., & Maeyer-Guignard, J. D. (1992) · Current Opinion in Immunology · doi:10.1016/0952-7915(92)90083-q · Cited by 72 · see citing works
Holmgren, J. R., Fryklund, J., & Larsson, H. (1989) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1989.tb02456.x · Cited by 69 · see citing works
Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells.
Zünd, G., Nelson, D. P., Neufeld, E. J., Dzus, A. L., Bischoff, J. E., Mayer, J. E., & Colgan, S. P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7075 · Cited by 66 · see citing works
Self-citationMediators of Inflammation in Chronic Inflammatory Bowel Disease
Nielsen, O. H., & Rask-Madsen, J. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609094569 · Cited by 62 · see citing works
Taylor, C. T., Lisco, S. J., Awtrey, C. S., & Colgan, S. P. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37280-5 · Cited by 43 · see citing works
Self-citationOsborne, M. J., Hudson, M., Piasecki, C., Dhillon, A. P., Lewis, A. A. M., Pounder, R. E., & Wakefield, A. J. (1993) · British journal of surgery · doi:10.1002/bjs.1800800236 · Cited by 33 · see citing works
Perdue, M. H., & Bienenstock, J. (1991) · Current Opinion in Gastroenterology · doi:10.1097/00001574-199106000-00014 · Cited by 29 · see citing works
Hypoxia Enhances the Antiviral Activity of Interferons
Naldini, A., Carraro, F., Fleischmann, W. R., & Bocci, V. A. (1993) · Journal of Interferon Research · doi:10.1089/jir.1993.13.127 · Cited by 26 · see citing works
Tumor Necrosis Factors Alpha and Beta
Palladino, M. A., & Ammann, A. J. (1988) · Humana Press eBooks · doi:10.1007/978-1-4612-4586-5_13 · Cited by 11 · see citing works
Recombinant lymphokines and their receptors
Gillis, S. A. (1987) · M. Dekker eBooks · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 58 references couldn’t be matched to a known paper.
Research works printed but not linked: 6
- Madara JL. Pathobiology of the intestinal epithelial barrier. Am J Pathol 1990;137:1273-1278.
- Colgan SP, Parkos CA, Matthews JB, D'Andrea L, Awtrey CS, Lichtman A, Delp C, Madara JL. Interferon-␥ induces a surface phenotype switch in intestinal epithelia: downregulation of ion transport and upregulation of immune accessory ligands. Am J Physiol 1994;267:C402-C410.
- Adams RB, Planchon SM, Roche JK. IFN-␥ modulation of epithelial barrier function: time course, reversibility, site of cytokine bind- ing. J Immunol 1993;150:2356-2363.
- Colgan SP, Morales VM, Madara JL, Balk SP, Blumberg RS. IFN-␥ modulates CD1d expression on intestinal epithelia. Am J Physiol 1996;271:C276-C283.
- DeMaeyer E, DeMaeyer-Guignard J. Interferon-gamma. Curr Opin Immunol 1992;4:321-326.
- McCormick BA, Colgan SP, Delp-Archer C, Miller SI, Madara JL. Salmonella typhimurium attachment to human intestinal epithe- lial monolayers: transcellular signaling to subepithelial neutro- phils. J Cell Biol 1993;123:895-907.
Cited by
Sorted by citations
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952 · see citing works
Probiotic bacteria enhance murine and human intestinal epithelial barrier function
Madsen, K., Cornish, A. S., Soper, P., McKaigney, C. J., Jijon, H. B., Yachimec, C., Doyle, J. S. G., Jewell, L. D., & Simone, C. D. (2001) · Gastroenterology · doi:10.1053/gast.2001.27224 · Cited by 1,096 · see citing works
Proinflammatory Cytokines Disrupt Epithelial Barrier Function by Apoptosis-Independent Mechanisms
Bruewer, M., Luegering, A., Kucharzik, T. F., Parkos, C. A., Madara, J., Hopkins, A. M., & Nusrat, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6164 · Cited by 897 · see citing works
Tight Junction Pore and Leak Pathways: A Dynamic Duo
Shen, L., Weber, C. R., Raleigh, D. R., Yu, D., & Turner, J. R. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142150 · Cited by 867 · see citing works
(2002) · PubMed · Cited by 840 · see citing works
Self-citationPathological bacterial translocation in liver cirrhosis
Wiest, R., Lawson, M. A., & Geuking, M. B. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.07.044 · Cited by 815 · see citing works
Cummins, E. P., Berra, E., Comerford, K. M., Ginouves, A., Fitzgerald, K. T., Seeballuck, F., Godson, C., Nielsen, J. E., Moynagh, P., Pouyssegur, J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602235103 · Cited by 788 · see citing works
Self-citationWang, F., Graham, W. V., Wang, Y., Witkowski, E. D., Schwarz, B. T., & Turner, J. R. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62264-x · Cited by 692 · see citing works
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
Karhausen, J., Furuta, G. T., Tomaszewski, J. E., Johnson, R. S., Colgan, S. P., & Haase, V. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421086 · Cited by 655 · see citing works
Self-citationThe gut microbiome and liver cancer: mechanisms and clinical translation
Yu, L.-X., & Schwabe, R. F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.72 · Cited by 634 · see citing works
Epithelial Barriers in Homeostasis and Disease
Marchiando, A. M., Graham, W. V., & Turner, J. R. (2010) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092135 · Cited by 612 · see citing works
Immunopathology of inflammatory bowel disease
Wallace, K. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i1.6 · Cited by 581 · see citing works
Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications
Natividad, J. M. M., & Verdu, E. F. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.007 · Cited by 525 · see citing works
A porous defense: the leaky epithelial barrier in intestinal disease
Clayburgh, D. R., Shen, L., & Turner, J. R. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700050 · Cited by 496 · see citing works
Marchiando, A. M., Shen, L., Graham, W. V., Weber, C. R., Schwarz, B. T., Austin, J. R., Raleigh, D. R., Guan, Y., Watson, A. J. M., Montrose, M. H., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200902153 · Cited by 475 · see citing works
Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium
Günther, C., Neumann, H., Neurath, M. F., & Becker, C. (2013) · Gut · doi:10.1136/gutjnl-2011-301364 · Cited by 462 · see citing works
Hypoxia-responsive transcription factors
Cummins, E. P., & Taylor, C. T. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1413-7 · Cited by 462 · see citing works
Self-citationClayburgh, D. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24970 · Cited by 419 · see citing works
The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis
Cummins, E. P., Seeballuck, F., Keely, S. J., Mangan, N. E., Callanan, J. J., Fallon, P. G., & Taylor, C. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.10.012 · Cited by 407 · see citing works
Self-citationZolotarevsky, Y., Hecht, G. A., Koutsouris, A., Gonzalez, D. E., Quan, C., Tom, J., Mrsny, R. J., & Turner, J. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.34235 · Cited by 385 · see citing works
Wu, H., Xie, S., Miao, J., Li, Y., Wang, Z., Wang, M., & Yu, Q. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1734423 · Cited by 377 · see citing works
Myosin light chain kinase: pulling the strings of epithelial tight junction function
Cunningham, K. E., & Turner, J. R. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06526.x · Cited by 345 · see citing works
Epithelial Cell Shedding and Barrier Function
Williams, J. M., Duckworth, C. A., Burkitt, M. D., Watson, A. J. M., Campbell, B. J., & Pritchard, D. M. (2014) · Veterinary Pathology · doi:10.1177/0300985814559404 · Cited by 332 · see citing works
Sappington, P. L., Yang, R., Yang, H., Tracey, K. J., Delude, R. L., & Fink, M. P. (2002) · Gastroenterology · doi:10.1053/gast.2002.35391 · Cited by 319 · see citing works
Hypoxia and gastrointestinal disease
Taylor, C. T., & Colgan, S. P. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0277-z · Cited by 313 · see citing works
Self-citationGronert, K., Maheshwari, N., Khan, N. A., Hassan, I., Dunn, M. W., & Schwartzman, M. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410638200 · Cited by 308 · see citing works
Wang, F., Schwarz, B. T., Graham, W. V., Wang, Y., Su, L., Clayburgh, D. R., Abraham, C., & Turner, J. R. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.08.022 · Cited by 305 · see citing works
Blair, S. A., Kane, S. V., Clayburgh, D. R., & Turner, J. R. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700373 · Cited by 298 · see citing works
Weber, C. R., Raleigh, D. R., Su, L., Shen, L., Sullivan, E. A., Wang, Y., & Turner, J. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.064808 · Cited by 296 · see citing works
Fink, M. P. (2003) · Current Opinion in Critical Care · doi:10.1097/00075198-200304000-00011 · Cited by 221 · see citing works
Endogenous PPARγ mediates anti-inflammatory activity in murine ischemia-reperfusion injury
Nakajima, A., Wada, K., Miki, H., Kubota, N., Nakajima, N., Terauchi, Y., Ohnishi, S., Saubermann, L. J., Kadowaki, T., Blumberg, R. S., et al. (2001) · Gastroenterology · doi:10.1053/gast.2001.21191 · Cited by 215 · see citing works
Intestinal Barrier and Permeability in Health, Obesity and NAFLD
Portincasa, P., Bonfrate, L., Khalil, M., Angelis, M. D., Calabrese, F. M., D’Amato, M., Wang, D. Q. ‐., & Ciaula, A. D. (2021) · Biomedicines · doi:10.3390/biomedicines10010083 · Cited by 212 · see citing works
Cytokine regulation of epithelial permeability and ion transport
McKay, D. M., & Baird, A. W. (1999) · Gut · doi:10.1136/gut.44.2.283 · Cited by 201 · see citing works
The role of molecular remodeling in differential regulation of tight junction permeability
Turner, J. R., Buschmann, M. M., Romero-Calvo, I., Sailer, A., & Shen, L. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.09.022 · Cited by 200 · see citing works
Buschmann, M. M., Shen, L., Rajapakse, H., Raleigh, D. R., Wang, Y., Wang, Y., Lingaraju, A., Zha, J., Abbott, E., McAuley, E. M., et al. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-09-0688 · Cited by 192 · see citing works
Modulation of tight junction structure and function by cytokines
Walsh, S. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00048-x · Cited by 188 · see citing works
Comerford, K. M., Leonard, M. O., Karhausen, J., Carey, R., Colgan, S. P., & Taylor, C. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337412100 · Cited by 185 · see citing works
Self-citationHan, X., Fink, M. P., & Delude, R. L. (2003) · Shock · doi:10.1097/00024382-200303000-00006 · Cited by 184 · see citing works
Schwarz, B. T., Wang, F., Shen, L., Clayburgh, D. R., Su, L., Wang, Y., Fu, Y., & Turner, J. R. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.052 · Cited by 178 · see citing works
The Role of NF‐κB in Hypoxia‐Induced Gene Expression
Taylor, C. T., & Cummins, E. P. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05024.x · Cited by 175 · see citing works
Self-citationColgan, S. P., Hershberg, R. M., Furuta, G. T., & Blumberg, R. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13938 · Cited by 173 · see citing works
Self-citationOxygen metabolism and barrier regulation in the intestinal mucosa
Glover, L. E., Lee, J. S., & Colgan, S. P. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84429 · Cited by 172 · see citing works
Self-citationNicoletti, A., Ponziani, F. R., Biolato, M., Valenza, V., Marrone, G., Sganga, G., Gasbarrini, A., Miele, L., & Grieco, A. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i33.4814 · Cited by 170 · see citing works
Onizawa, M., Nagaishi, T., Kanai∥, T., Nagano, K.-I., Oshima, S., Nemoto, Y., Yoshioka, A., Totsuka, T., Okamoto, R., Nakamura, T., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00071.2008 · Cited by 164 · see citing works
Ciaula, A. D., Baj, J., Garruti, G., Celano, G., Angelis, M. D., Wang, H. H., Palo, D. M. D., Bonfrate, L., Wang, D. Q. ‐., & Portincasa, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082648 · Cited by 164 · see citing works
Rotavirus alters paracellular permeability and energy metabolism in Caco-2 cells
Dickman, K. G., Hempson, S. J., Anderson, J., Lippe, S., Zhao, L., Burakoff, R. B., & Shaw, R. D. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.4.g757 · Cited by 162 · see citing works
Synergistic effects of interferon γ and tumour necrosis factor α on T84 cell function
Fish, S. M., Proujansky, R., & Reenstra, W. W. (1999) · Gut · doi:10.1136/gut.45.2.191 · Cited by 161 · see citing works
Du, J., Chen, Y., Shi, Y., Liu, T., Cao, Y., Tang, Y., Ge, X., Nie, H., Zheng, C.-Q., & Li, Y. C. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000526 · Cited by 157 · see citing works
Leonard, M. O., Cottell, D. C., Godson, C., Brady, H. R., & Taylor, C. T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302560200 · Cited by 151 · see citing works
Self-citationMechanisms and Functional Implications of Intestinal Barrier Defects
Shen, L., Su, L., & Turner, J. R. (2009) · Digestive Diseases · doi:10.1159/000233282 · Cited by 149 · see citing works
Moriez, R., Salvador–Cartier, C., Théodorou, V., Fioramonti, J., Eutamène, H., & Bueno, L. P. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61196-0 · Cited by 149 · see citing works
Parassol, N., Freitas, M., Thoreux, K., Dalmasso, G., Bourdet‐Sicard, R., & Rampal, P. (2004) · Research in Microbiology · doi:10.1016/j.resmic.2004.09.013 · Cited by 146 · see citing works
Denning, T. L., Takaishi, H., Crowe, S. E., Boldogh, I. R., Jevnikar, A. M., & Ernst, P. B. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01141-3 · Cited by 144 · see citing works
Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation
Mazzon, E., & Cuzzocrea, S. (2007) · Respiratory Research · doi:10.1186/1465-9921-8-75 · Cited by 143 · see citing works
Ponziani, F. R., Zocco, M. A., Cerrito, L., Gasbarrini, A., & Pompili, M. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1481747 · Cited by 139 · see citing works
Taylor, C. T., Furuta, G. T., Synnestvedt, K., & Colgan, S. P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220211797 · Cited by 130 · see citing works
Self-citationMechanism ofClostridium difficileToxin A–Induced Apoptosis in T84 Cells
Brito, G. A. D. C., Fujji, J., Carneiro‐Filho, B. A., Lima, A. Â. M., Obrig, T. G., & Guerrant, R. L. (2002) · The Journal of Infectious Diseases · doi:10.1086/344729 · Cited by 127 · see citing works
Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD
Welden, S. V., Selfridge, A. C., & Hindryckx, P. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.101 · Cited by 124 · see citing works
Hypoxia Activates NF-κB–Dependent Gene Expression Through the Canonical Signaling Pathway
Oliver, K. M., Garvey, J., Ng, C. T., Veale, D. J., Fearon, U., Cummins, E. P., & Taylor, C. T. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2400 · Cited by 120 · see citing works
Self-citationCorridoni, D., Pastorelli, L., Mattioli, B., Locovei, S., Ishikawa, D., Arseneau, K. O., Chieppa, M., Cominelli, F., & Pizarro, T. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042067 · Cited by 118 · see citing works
Mesenteric lymph: the bridge to future management of critical illness.
Fanous, M., Phillips, A. J., & Windsor, J. A. (2007) · PubMed · Cited by 118 · see citing works
Hartmann, P., Haimerl, M., Mazagova, M., Brenner, D. A., & Schnabl, B. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.099 · Cited by 118 · see citing works
Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium
Sharkey, K. A., Beck, P. L., & McKay, D. M. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0051-4 · Cited by 116 · see citing works
Matrix Metalloproteinases in Renal Diseases: A Critical Appraisal
Zakiyanov, O., Kalousová, M., Zima, T., & Tesař, V. (2019) · Kidney & Blood Pressure Research · doi:10.1159/000499876 · Cited by 114 · see citing works
Scharl, M. M., Paul, G., Barrett, K. E., & McCole, D. F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.046292 · Cited by 110 · see citing works
Barreau, F., Madre, C., Meinzer, U., Berrebi, D. D., Dussaillant, M., Merlin, F., Eckmann, L., Karin, M., Sterkers, G., Bonacorsi, S., et al. (2009) · Gut · doi:10.1136/gut.2008.171546 · Cited by 109 · see citing works
Interferon-γ Regulation of Intestinal Epithelial Permeability
Beaurepaire, C., Smyth, D. R., & McKay, D. M. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2008.0057 · Cited by 102 · see citing works
Relationship between Intestinal Permeability and Calprotectin Concentration in Gut Lavage Fluid
Berstad, G. A. A. (2000) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655200750024551 · Cited by 102 · see citing works
Nemeth, Z. H., Deitch, E. A., Szabó, C., & Haskó, G. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64259-9 · Cited by 99 · see citing works
The role of the intestine in the pathophysiology and management of severe acute pancreatitis
Flint, R. S., & Windsor, J. A. (2003) · HPB · doi:10.1080/13651820310001108 · Cited by 98 · see citing works
Clark, E. C., Patel, S. D., Chadwick, P. R., Warhurst, G., Curry, A., & Carlson, G. (2003) · Gut · doi:10.1136/gut.52.2.224 · Cited by 97 · see citing works
Yue, Y., Wu, S., Li, Z., Li, J., Li, X., Xiang, J., & Ding, H. (2015) · Food & Function · doi:10.1039/c5fo00378d · Cited by 94 · see citing works
Restore Intestinal Barrier Integrity: An Approach for Inflammatory Bowel Disease Therapy
Chen, K., Yang, M., Yue, N., Zhang, Y., Tian, C., Wei, D., Shi, R., Yao, J., Wang, L., & Li, D. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s470520 · Cited by 94 · see citing works
Stimulus-induced reorganization of tight junction structure: The role of membrane traffic
Yu, D., & Turner, J. R. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.027 · Cited by 93 · see citing works
Hypoxia. Regulation of NFκB signalling during inflammation: the role of hydroxylases
Oliver, K. M., Taylor, C. T., & Cummins, E. P. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2575 · Cited by 91 · see citing works
Self-citationLive F aecalibacterium prausnitzii in an apical anaerobic model of the intestinal epithelial barrier
Ulluwishewa, D., Anderson, R. C., Young, W., McNabb, W. C., van Baarlen, P., Moughan, P. J., Wells, J. M., & Roy, N. C. (2014) · Cellular Microbiology · doi:10.1111/cmi.12360 · Cited by 90 · see citing works
Azo compounds in colon-specific drug delivery
Roldo, M., Barbu, E., Brown, J. F., Laight, D. W., Smart, J. D., & Tsibouklis, J. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.4.5.547 · Cited by 90 · see citing works
Utrilla, M. P., Peinado, M. J., Ruiz, R., Rodríguez‐Nogales, A., Algieri, F., Rodríguez‐Cabezas, M. E., Clemente, A., Gálvez, J., & Rubio, L. A. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400630 · Cited by 86 · see citing works
Taylor, C. T., Fueki, N., Agah, A., Hershberg, R. M., & Colgan, S. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19447 · Cited by 86 · see citing works
Self-citationBurhans, W. S., Rossiter-Burhans, C. A., & Baumgard, L. H. (2022) · Journal of Dairy Science · doi:10.3168/jds.2021-21080 · Cited by 85 · see citing works
Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice
Nakamoto, N., Amiya, T., Aoki, R., Taniki, N., Koda, Y., Miyamoto, K., Teratani, T., Suzuki, T., Chiba, S., Chu, P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.022 · Cited by 79 · see citing works
Cytokine responses and epithelial function in the intestinal mucosa
Onyiah, J. C., & Colgan, S. P. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2289-8 · Cited by 77 · see citing works
Self-citationThe role of mucosal barriers in human gut health
Seo, K., Seo, J.-M., Yeun, J., Choi, H., Kim, Y., & Chang, S.-Y. (2021) · Archives of Pharmacal Research · doi:10.1007/s12272-021-01327-5 · Cited by 75 · see citing works
Hindryckx, P., De Vos, M., Jacques, P., Ferdinande, L., Peeters, H., Olievier, K., Bogaert, S., Brinkman, B., Vandenabeele, P., Elewaut, D., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002541 · Cited by 73 · see citing works
HIF‐dependent induction of apical CD55 coordinates epithelial clearance of neutrophils
Louis, N. A., Hamilton, K. E., Kong, T., & Colgan, S. P. (2005) · The FASEB Journal · doi:10.1096/fj.04-3251com · Cited by 71 · see citing works
Self-citationTight Junctions and the Intestinal Barrier
Ma, T. Y., Anderson, J. M., & Turner, J. R. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00038-5 · Cited by 67 · see citing works
Saccharomyces boulardii prevents TNF-α-induced apoptosis in EHEC-infected T84 cells
Dalmasso, G., Loubat, A., Dahan, S., Calle, G., Rampal, P., & Czerucka, D. (2006) · Research in Microbiology · doi:10.1016/j.resmic.2005.11.007 · Cited by 66 · see citing works
Role of TNF-α in ileum tight junction alteration in mouse model of restraint stress
Mazzon, E., & Cuzzocrea, S. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00014.2008 · Cited by 66 · see citing works
Rehman, A., John, P. C. L., & Bhatti, A. (2021) · Nanomaterials · doi:10.3390/nano11082005 · Cited by 65 · see citing works
Regulation of the intestinal epithelial paracellular barrier
Daugherty, A. L., & Mrsny, R. J. (1999) · Pharmaceutical Science & Technology Today · doi:10.1016/s1461-5347(99)00170-4 · Cited by 65 · see citing works
Kim, Y., Yi, E.-J., Kim, Y., Lee, A. R., Chung, J., Ha, H. C., Cho, J. M., Kim, S.-R., Ko, H., Cheon, J. H., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.609689 · Cited by 57 · see citing works
Suzuki, M., Nagaishi, T., Yamazaki, M., Onizawa, M., Watabe, T., Sakamaki, Y., Ichinose, S., Totsuka, M., Oshima, S., Okamoto, R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088369 · Cited by 54 · see citing works
Bax is downregulated in inflamed colonic mucosa of ulcerative colitis
Iimura, M., Nakamura, T., Shinozaki, S., Iizuka, B., Inoue, Y., Suzuki, S., & Hayashi, N. (2000) · Gut · doi:10.1136/gut.47.2.228 · Cited by 53 · see citing works
Lu, P., Paassen, N. B., van der Sluis, M., Witte‐Bouma, J., Kerckaert, J., van Goudoever, J. B., SEUNINGEN, I. V., & Renes, I. B. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21592 · Cited by 52 · see citing works
Chapman, J. C., Liu, Y., Zhu, L., & Rhoads, J. M. (2012) · Pediatric Research · doi:10.1038/pr.2012.137 · Cited by 52 · see citing works
TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction
Hauwermeiren, F. V., Vandenbroucke, R. E., Grine, L., Lodens, S., Wonterghem, E. V., Rycke, R. M. D., Geest, N. D., Hassan, B. A., & Libert, C. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.112 · Cited by 51 · see citing works
Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner
O’Reilly, S. M., Leonard, M. O., Kieran, N. E., Comerford, K. M., Cummins, E. P., Pouliot, M., Lee, S. B., & Taylor, C. T. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00278.2005 · Cited by 51 · see citing works
Self-citationWallimann, T., Hall, C. H. T., Colgan, S. P., & Glover, L. E. (2021) · Nutrients · doi:10.3390/nu13051429 · Cited by 50 · see citing works
Self-citationMetabolic regulation of intestinal epithelial barrier during inflammation
Colgan, S. P., Curtis, V. F., Lanis, J. M., & Glover, L. E. (2014) · Tissue Barriers · doi:10.4161/21688362.2014.970936 · Cited by 49 · see citing works
Self-citationBeyond Ussing's chambers: contemporary thoughts on integration of transepithelial transport
Herrmann, J. R., & Turner, J. R. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00348.2015 · Cited by 49 · see citing works
- Authors
- Taylor, C. T., Dzus, A. L., & Colgan, S. P.
- Affiliations
- Brigham and Women's Hospital (US)
- ORCID
- Taylor, Cormac T.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1998-04
- Volume
- 114
- Issue
- 4
- Pages
- 657-668
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2042606716
- Cited by
- 188
- References
- 58
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 11 · 2014: 9 · 2013: 7 · 2012: 9
- FWCI
- 9.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (F32DK009699, DK09699, DK-50189)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- intestinal epithelial permeability, hypoxia, TNF-α, autocrine regulation, interferon-gamma, intestinal barrier function, thalidomide, MHC class II induction, cytokine receptor expression, T84 cells
- MeSH terms
- Cells, Cultured, Interferon-gamma, Intestinal Mucosa, Ischemia, Permeability, Thalidomide, Tumor Necrosis Factor-alpha, Cell Hypoxia, Cell Polarity, Receptors, Tumor Necrosis Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review