Aryl hydrocarbon receptor activation modulates intestinal epithelial barrier function by maintaining tight junction integrity
Open accessAbstract
experiments, Caco-2 cells were treated with tumour necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ) for 48 h, with or without FICZ. AhR activation prevented TNF-α/IFN-γ-induced decrease in TER and morphological disruption of the TJs in Caco-2 monolayers. It also inhibited TNF-α/IFN-γ-induced increase in MLCK expression and MLC phosphorylation by suppression of NF-κB p65 signaling pathway. Thus, AhR-activating factors might have potential as therapeutic agents for the treatment of patients with IBD.
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AhR activation by FICZ was therapeutic in the dextran sodium sulfate-induced mouse colitis model in which FICZ treatment upregulated tight junction protein expression in inflamed mouse colons.
“AhR activation by FICZ was therapeutic in the dextran sodium sulfate (DSS)–induced mouse colitis model in which FICZ treatment upregulated TJ protein expression in inflamed mouse colons.92,93”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [92]
FICZ prevented a TNF-α/interferon gamma-induced decrease in transepithelial electrical resistance and disruption of tight junction proteins in Caco-2 monolayers.
“In addition, FICZ also prevented a TNF-α/interferon gamma–induced decrease in transepithelial electrical resistance (TEER) and disruption of TJ proteins in Caco-2 monolayers.92”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [92]
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- Authors
- Yu, M., Wang, Q., Ma, Y., Li, L., Yu, K., Zhang, Z., Chen, G., Li, X., Xiao, W., Xu, P., & Yang, H.
- Affiliations
- Army Medical University (CN)
- Kunming Medical University (CN)
- Corresponding author
- Yang, Hua
- ORCID
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2018
- Volume
- 14
- Issue
- 1
- Pages
- 69-77
- ISSN
- 1449-2288 (ISSN-L)
- PMC
- PMC5821050
- OpenAlex
- W2790048761
- Cited by
- 274
- References
- 47
- Citations by year
- 2026: 51 · 2025: 43 · 2024: 45 · 2023: 41 · 2022: 36 · 2021: 22 · 2020: 22 · 2019: 9 · 2018: 5
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- International Journal of Biological Sciences (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (IRT 13050, 81501661, 81770524, 81470803, 81330013)
- Ministry of Education of the People's Republic of China
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- aryl hydrocarbon receptor, intestinal epithelial barrier, tight junction integrity, FICZ, TNF-α/IFN-γ, transepithelial electrical resistance, myosin light chain kinase, myosin light chain phosphorylation, NF-κB p65 signaling, inflammatory bowel disease, Caco-2 cells
- MeSH terms
- Animals, Colitis, Fluorescent Antibody Technique, Humans, Immunohistochemistry, Interferon-gamma, Intestinal Mucosa, Mice, Inbred C57BL, Phosphorylation, Tumor Necrosis Factor-alpha, Blotting, Western, Inflammatory Bowel Diseases, Signal Transduction, Dextran Sulfate, Receptors, Aryl Hydrocarbon, Microscopy, Confocal, Caco-2 Cells, Myosin Light Chains, Tight Junctions, Mice
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