Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord
Open accessAbstract
Association and relay neurons that are generated in the dorsal spinal cord play essential roles in transducing somatosensory information. During development, these two major neuronal classes are delineated by the expression of the homeodomain transcription factor Lbx1. Lbx1 is expressed in and required for the correct specification of three early dorsal interneuron populations and late-born neurons that form the substantia gelatinosa. In mice lacking Lbx1, cells types that arise in the ventral alar plate acquire more dorsal identities. This results in the loss of dorsal horn association interneurons, excess production of commissural neurons, and disrupted sensory afferent innervation of the dorsal horn. Lbx1, therefore, plays a critical role in the development of sensory pathways in the spinal cord that relay pain and touch.
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The increase in dI4 and dI5 neurons is explained by the expansion of the combined dp4/dp5 progenitor pool in the dorsal spinal cord at these stages and the extended phase of neurogenesis in the dorsal spinal cord that results in late born dI4 and dI5 neurons.
“This is explained by the expansion of the combined dp4/dp5 progenitor pool in the dorsal spinal cord at these stages and the extended phase of neurogenesis in the dorsal spinal cord that results in the formation of late born dI4 and dI5 neurons”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Gross et al., 2002
The decrease in dorsal progenitors at e13.5 is in line with the higher rate of neurogenesis in the dorsal spinal cord at e13.5 and the consequent depletion of progenitors.
“This is in line with the higher rate of neurogenesis in the dorsal spinal cord at e13.5 and the consequent depletion of progenitors”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Gross et al., 2002
A subset of cells from the dorsal dI4.6/dI6 lineages contributed to most ventral inhibitory populations.
“A subset of cells from the dorsal dI4.6/dI6 lineages contributed to most ventral inhibitory populations, which was unexpected though there have been reports of scattered dI4 Ptf1a-derived cells in the embryonic and perinatal ventral horn103,104, and the very small dI6 population is known to be ventrally located105–107.”
From A harmonized atlas of mouse spinal cord cell types and their spatial organization (2021) · cites this paper as [105]
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- Authors
- Gross, M. K., Dottori, M., & Goulding, M.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Goulding, Martyn
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 34
- Issue
- 4
- Pages
- 535-549
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2082785396
- Cited by
- 396
- References
- 39
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 10 · 2023: 21 · 2022: 14 · 2021: 13 · 2020: 15 · 2019: 18 · 2018: 19 · 2017: 15 · 2016: 18 · 2015: 16 · 2014: 17 · 2013: 24 · 2012: 22
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 4095 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- Lbx1, dorsal spinal cord, dorsal horn, substantia gelatinosa, homeodomain transcription factor, neuronal specification, commissural neurons, spinal cord development
- MeSH terms
- Afferent Pathways, Animals, Axons, Cell Differentiation, Cell Movement, Female, Interneurons, Male, Mice, Transgenic, Muscle Proteins, Mutation, Nerve Fibers, Nerve Fibers, Myelinated, Neural Pathways, Nociceptors, Substantia Gelatinosa, Transcription Factors, Apoptosis, Gene Expression Regulation, Developmental, Cell Lineage, Body Patterning, Posterior Horn Cells, Receptor, trkA, Mice
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