The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Microglial Reaction in the Rat Cerebral Cortex Induced by Cortical Spreading Depression
Abstract
The response of microglial cells to cortical spreading depression (CSD) was studied in rat brain by immunocytochemistry. CSD was elicited for one hour by the topical application of 4M potassium chloride solution and the microglial reaction examined immunocytochemically after 4, 16, 24 and 72 hours. CSD was sufficient to induce a microglial reaction throughout the cortex at 24 hours. Activated microglial cells furthermore showed a striking de‐novo expression of major histocompatibility complex class II antigens. In contrast, no microglial reaction was observed in the cortex of sham‐operated animals. This microglial reaction in response to CSD was not associated with histologically detectable neuronal damage. These results support the view that microglial cells are extremely sensitive to changes of the brain microenvironment. Their activation may be related to changes of ion homeostasis in the brain which are not sufficient to trigger neuronal injury.
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Cites
Glia:Neuron index: Review and hypothesis to account for different values in various mammals.
Reichenbach, A. (1989) · Glia · doi:10.1002/glia.440020202 · Cited by 97
Cited by
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
Self-citationStreit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096
Streit, W. J., Xue, Q.-S., Tischer, J., & Bechmann, I. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0142-6 · Cited by 317
Evidence of activated microglia in focal cortical dysplasia
Boer, K., Spliet, W. G. M., van Rijen, P. C., Redeker, S., Troost, D., & Aronica, E. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.01.002 · Cited by 168
Spreading Depression Transiently Disrupts Myelin via Interferon-Gamma Signaling
Pusic, A. D., Mitchell, H. M., Kunkler, P. E., Klauer, N., & Kraig, R. P. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2014.12.001 · Cited by 42
Metadata
- Authors
- Gehrmann, J., Mies, G., Bonnekoh, P., Banati, R., Iijima, T., Kreutzberg, G. W., & Hossmann, K.
- Venue
- Brain Pathology
- Publisher
- Wiley
- Published
- 1993-01
- Volume
- 3
- Issue
- 1
- Pages
- 11-17
- ISSN
- 1015-6305 (ISSN-L)
- 1750-3639
- OpenAlex
- W2070730444
- Cited by
- 160
- References
- 1
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
