Glia:Neuron index: Review and hypothesis to account for different values in various mammals.
Abstract
The present paper proposes a hypothesis to account for different values of the glia:neuron index in comparable central nervous system tissues of various mammals. This hypothesis assumes that K+ ions released by active neurons are a mitogenic signal for glial cells. The thicker the tissue (for example, the brain wall), the more difficult is efficient K+ clearance, and more perinatal glial cell proliferation should occur. Thus, this hypothesis accounts for higher glia:neuron indices in mammals with thicker brain walls.
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The fixed energy budget per neuron across brain sizes disputes the traditional view that the ratio between numbers of glial and neuronal cells is related to increased metabolic needs of larger neurons.
“Moreover, the fixed energy budget per neuron across brain sizes disputes the traditional view that the ratio between numbers of glial and neuronal cells is related to increased metabolic needs of larger neurons [42]; instead, the glia/neuron ratio may be determined simply by the addition of glial cells of a relatively constant size to neuronal parenchyma consisting of small or large neurons during”
From Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution (2011) · cites this paper as [42]
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- Authors
- Reichenbach, A.
- Affiliations
- Leipzig University (DE)
- Corresponding author
- Reichenbach, Andreas
- ORCID
- Reichenbach, Andreas
- Venue
- Glia
- Publisher
- Wiley
- Published
- 1989-01
- Volume
- 2
- Issue
- 2
- Pages
- 71-77
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W1998794365
- Cited by
- 97
- References
- 84
- Citations by year
- 2026: 2 · 2025: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 6 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Glia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- glial cell proliferation, potassium ions, mitogenic signaling, potassium clearance, perinatal development, central nervous system, cross-species comparison, mammals
- MeSH terms
- Aging, Animals, Brain, Cell Division, Central Nervous System, Models, Neurological, Neuroglia, Neurons
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