The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Ammon's Horn Sclerosis: A Maldevelopmental Disorder Associated with Temporal Lobe Epilepsy
Open accessAbstract
Ammon's horn sclerosis (AHS) is the major neuropathological substrate in patients with temporal lobe epilepsy (TLE). Histopathological hallmarks include segmental loss of pyramidal neurons, granule cell dispersion and reactive gliosis. Pathogenetic mechanisms underlying this distinct hippocampal pathology have not yet been identified and it remains to be resolved whether AHS represents the cause or the consequence of chronic seizure activity and pharmacoresistant TLE. Whereas the clinical history indicates an early onset in most patients, ie, occurrence of febrile seizures at a young age, surgical treatment is usually carried out at an end stage of the disease. It has, therefore, been difficult to analyse the sequential development of hippocampal pathology in TLE patients. Recent molecular neuropathological studies focusing on developmental aspects of hippocampal organization revealed 2 intriguing findings in AHS specimens: i) The persistence of Cajal‐Retzius cells in AHS patients points towards an early insult and an altered Reelin signaling pathway and ii) increased neurogenesis in and abnormal architectural organization of the dentate granule cell layer can be observed in young patients with early hippocampal seizure onset. These findings would be compatible with a model that involves a neurodevelopmental component in the formation of AHS. Its association with a lowered seizure threshold and an increased susceptibility for segmental cell loss in the hippocampus during the long course of the disease may constitute additional elements in a pathogenic cascade.
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Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,511
CNS stem cells express a new class of intermediate filament protein
Lendahl, U., Zimmerman, L. B., & McKay, R. D. G. (1990) · Cell · doi:10.1016/0092-8674(90)90662-x · Cited by 3,151
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Learning enhances adult neurogenesis in the hippocampal formation
Gould, E., Beylin, A., Tanapat, P., Reeves, A., & Shors, T. J. (1999) · Nature Neuroscience · doi:10.1038/6365 · Cited by 2,157
Parent, J. M., Yu, T. W., Leibowitz, R. T., Geschwind, D. H., Sloviter, R. S., & Lowenstein, D. H. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03727.1997 · Cited by 1,871
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
D'Arcangelo, G., G. Miao, G., Chen, S.-C., Scares, H. D., Morgan, J. I., & Curran, T. (1995) · Nature · doi:10.1038/374719a0 · Cited by 1,748
Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
Cameron, H. A., & Mckay, R. D. G. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1040 · Cited by 1,585
Neurogenesis in the Neocortex of Adult Primates
Gould, E., Reeves, A. J., Graziano, M. S. A., & Gross, C. G. (1999) · Science · doi:10.1126/science.286.5439.548 · Cited by 1,262
Altman, J., & Bayer, S. A. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.903010304 · Cited by 819
Cited by
Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis
Compiled by Heinz‐Gregor Wieser for the ILAE Commission on Neurosurgery of Epilepsy (2004) · Epilepsia · doi:10.1111/j.0013-9580.2004.09004.x · Cited by 773
Walton, E., Hass, J., Liu, J., Roffman, J. L., Bernardoni, F., Roessner, V., Kirsch, M., Schackert, G., Calhoun, V., & Ehrlich, S. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv074 · Cited by 286
The kainic acid models of temporal lobe epilepsy
Rusina, E., Bernard, C., & Williamson, A. (2021) · eneuro · doi:10.1523/eneuro.0337-20.2021 · Cited by 225
An organotypic brain slice preparation from adult patients with temporal lobe epilepsy
Eugène, E., Cluzeaud, F., Cifuentes-Diaz, C., Fricker, D., Le Duigou, C., Clemenceau, S., Baulac, M., Poncer, J.-C., & Miles, R. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.07.009 · Cited by 101
Reelin deficiency causes granule cell dispersion in epilepsy
Haas, C. A., & Frotscher, M. (2010) · Experimental Brain Research · doi:10.1007/s00221-009-1948-5 · Cited by 96
Metadata
- Authors
- MD, I. B., MRCPath, M. T., & Wiestler, O. D.
- Venue
- Brain Pathology
- Publisher
- Wiley
- Published
- 2002-04
- Volume
- 12
- Issue
- 2
- Pages
- 199-211
- ISSN
- 1015-6305 (ISSN-L)
- 1750-3639
- OpenAlex
- W2089126506
- Cited by
- 373
- References
- 86
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- green
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