Characterization of Thorn‐Shaped Astrocytes in White Matter of Temporal Lobe in A lzheimer's Disease Brains
Open accessAbstract
Thorn‐shaped astrocytes (T s A) are mainly localized in the periventricular white matter of the temporal lobe in a subgroup of aged individuals usually in the context of A lzheimer's disease (AD). Immunohistochemistry of T s A shows 4 R tau deposition, tau phosphorylation at different sites recognized with phosphospecific anti‐tau antibodies T hr181, S er202, S er214, T hr231, S er396, S er422, and clones AT 8 and PHF‐1, and conformational changes revealed with A lz50 and MC‐1 antibodies; T s A are also immunostained with antibodies to active tau kinases MAPK/ERK‐P, SAPK/JNK‐P, p38‐P and GSK‐3β. These findings are common to neurofibrillary tangles in AD. However, T s A are not stained with 3Rtau antibodies, and they are seldom stained or not at all with phosphospecific tau S er262 and with T au‐C 3 antibody, which recognizes the latter tau truncation at aspartic acid 421. Previous studies have shown that tau phosphorylation at S er262 reduces tau binding to microtubules and increases caspase‐3 activity, whereas tau truncation at aspartic acid 421 is associated with tau ubiquitination, and toxic effects of tau. In this line, ubiquitin is not accumulated in T s A, and in situ end‐labeling of nuclear DNA fragmentation shows absence of degeneration in T s A. These observations support the concept that tau lesions in neurons differ from those seen in T s A in AD.
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Astrocytic PHF-tau pathology in CTE is predominantly 4R tau immunopositive and more widely distributed than that reported in the medial temporal lobe in aging and AD.
“Astrocytic PHF-tau pathology in CTE is predominantly 4R tau immunopositive, but more widely distributed than that reported in the medial temporal lobe in aging and AD [103, 114].”
From The neuropathology of sport (2014) · cites this paper as [114]
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Cites
Biernat, J., Gustke, N., Drewes, G., Mandelkow, E., & Mandelkow, E. (1993) · Neuron · doi:10.1016/0896-6273(93)90279-z · Cited by 796 · see citing works
Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down Patients
van Leeuwen, F. W., de Kleijn, D. P. V., van den Hurk, H., Neubauer, A., Sonnemans, M. A. F., Sluijs, J. A., Köycü, S., Ramdjielal, R. D. J., Salehi, A., Martens, G. J. M., et al. (1998) · Science · doi:10.1126/science.279.5348.242 · Cited by 561 · see citing works
Caspase activation precedes and leads to tangles
de Calignon, A., Fox, L. M., Pitstick, R., Carlson, G. A., Bacskai, B. J., Spires-Jones, T. L., & Hyman, B. T. (2010) · Nature · doi:10.1038/nature08890 · Cited by 517 · see citing works
Microtubule-associated Protein/Microtubule Affinity-regulating Kinase (p110mark)
Meyer, H. E., Mandelkow, E.-M., Drewes, G., Trinczek, B., Illenberger, S., Biernat, J., Schmitt-Ulms, G., & Mandelkow, E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7679 · Cited by 388 · see citing works
Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)
Dickson, D. W., Kouri, N., Murray, M. E., & Josephs, K. A. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9589-0 · Cited by 380 · see citing works
Sengupta, A., Kabat, J., Novak, M., Wu, Q., Grundke-Iqbal, I., & Iqbal, K. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0813 · Cited by 363 · see citing works
Ferrer, I., Gómez‐Isla, T., Puig, B., Freixes, M., Ribé, E. M., Dalfó, E., & Ávila, J. (2005) · Current Alzheimer Research · doi:10.2174/1567205052772713 · Cited by 302 · see citing works
Self-citationWidespread cytoskeletal pathology characterizes corticobasal degeneration.
Feany, M. Β., & Dickson, D. W. (1995) · PubMed · Cited by 276 · see citing works
Ferrer, I., Santpere, G., & van Leeuwen, F. W. (2008) · Brain · doi:10.1093/brain/awm305 · Cited by 256 · see citing works
Self-citationFerrer, I., Blanco, R., Carmona, M., Ribera, R., Goutan, E., Puig, B., Rey, M. J., Cardozo, A., Viñals, F., & Ribalta, T. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00387.x · Cited by 239 · see citing works
Self-citationLuna-Muñoz, J., Chávez-Macías, L., García-Sierra, F., & Mena, R. (2007) · Journal of Alzheimer's Disease · doi:10.3233/jad-2007-12410 · Cited by 233 · see citing works
Self-citationTau Cleavage and Dephosphorylation in Cerebellar Granule Neurons Undergoing Apoptosis
Canu, N., Dus, L., Barbato, C., Ciotti, M. T., Brancolini, C., Rinaldi, A. M., Novak, M., Cattaneo, A., Bradbury, A., & Calissano, P. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07061.1998 · Cited by 232 · see citing works
Proapoptotic Effects of Tau Cleavage Product Generated by Caspase-3
Chung, C.-W., Song, Y.-H., Kim, I.-K., Yoon, W. J., Ryu, B. R., Jo, D., Woo, H., Kwon, Y.-K., Kim, H., Gwag, B.-J., et al. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0335 · Cited by 211 · see citing works
Ferrer, I., Blanco, R. E., Carmona, M., & Puig, B. (2001) · Journal of Neural Transmission · doi:10.1007/s007020100016 · Cited by 207 · see citing works
Self-citationWang, Y. P., Biernat, J., Pickhardt, M., Mandelkow�, E., & Mandelkow�, E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703676104 · Cited by 205 · see citing works
Transgenic Mouse Model of Tau Pathology in Astrocytes Leading to Nervous System Degeneration
Forman, M. S., Lal, D., Zhang, B., Dabir, D. V., Swanson, E., Lee, V. M.-Y., & Trojanowski, J. Q. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0081-05.2005 · Cited by 198 · see citing works
Ferrer, I., Barrachina, M., & Puig, B. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0587-8 · Cited by 197 · see citing works
Self-citationFasulo, L., Ugolini, G., Visintin, M., Bradbury, A. M., Brancolini, C., Verzillo, V., Novák, M., & Cattaneo, A. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750624.x · Cited by 195 · see citing works
Conformational changes and truncation of tau protein during tangle evolution in Alzheimer's disease
García-Sierra, F., Ghoshal, N., Quinn, B., Berry, R., & Binder, L. (2003) · Journal of Alzheimer's Disease · doi:10.3233/jad-2003-5201 · Cited by 179 · see citing works
Fischer, D. F., de Vos, R. A. I., van Dijk, R., de Vrij, F. M. S., Proper, E. A., Sonnemans, M. A. F., Verhage, M. C., Sluijs, J. A., Hobo, B., Zouambia, M., et al. (2003) · The FASEB Journal · doi:10.1096/fj.03-0205com · Cited by 153 · see citing works
Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease
Mondragón‐Rodríguez, S., Basurto‐Islas, G., Santa‐María, I., Mena, R., Binder, L. I., Ávila, J., Smith, M. A., Perry, G. L., & García‐Sierra, F. (2008) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2007.00568.x · Cited by 146 · see citing works
Self-citationWang, Y., Garg, S., Mandelkow, E., & Mandelkow�, E. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380955 · Cited by 139 · see citing works
Nishimura, M., Namba, Y., Ikeda, K., & Oda, M. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90227-x · Cited by 120 · see citing works
Thorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles
Ikeda, K., Akiyama, H., Kondo, H., Haga, C., Tanno, E., Tokuda, T., & Ikeda, S. (1995) · Acta Neuropathologica · doi:10.1007/bf00318575 · Cited by 119 · see citing works
Togo, T., & Dickson, D. W. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0569-x · Cited by 115 · see citing works
Glial Tau Pathology in Neurodegenerative Diseases: Their Nature and Comparison with Neuronal Tangles
Ikeda, K., Akiyama, H., Arai, T., & Nishimura, T. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00034-7 · Cited by 110 · see citing works
Luna‐Muñoz, J., García‐Sierra, F., Falcón, V., Menéndez, I., Chávez-Macías, L., & Mena, R. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-8104 · Cited by 107 · see citing works
Self-citationTemporal Sequence of Alzheimer’s Disease-Related Pathology
Braak, H., & Braak, E. (1999) · Cerebral cortex · doi:10.1007/978-1-4615-4885-0_14 · Cited by 94 · see citing works
High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe
Schultz, C., Ghebremedhin, E., Tredici, K. D., Rüb, U., & Braak, H. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00113-1 · Cited by 91 · see citing works
A peculiar constellation of tau pathology defines a subset of dementia in the elderly
Kovács, G. G., Molnár, K., László, L., Ströbel, T., Botond, G., Hönigschnabl, S., Reiner‐Concin, A., Palkovits, M., Fischer, P. A., & Budka, H. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0819-x · Cited by 90 · see citing works
A possible link between astrocyte activation and tau nitration in Alzheimer's disease
Reyes, J. F., Reynolds, M. R., Horowitz, P. M., Fu, Y., Guillozet-Bongaarts, A. L., Berry, R., & Binder, L. I. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.04.005 · Cited by 80 · see citing works
Muñoz, D. G., Woulfe, J., & KERTESZ, A. E. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0266-x · Cited by 77 · see citing works
Ahmed, Z., Doherty, K. A., Silveira‐Moriyama, L., Bandopadhyay, R., Lashley, T., Mamais, A., Hondhamuni, G., Wray, S., Newcombe, J., O’Sullivan, S. S., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0857-4 · Cited by 74 · see citing works
Kováčech, B., & Novák, M. (2010) · Current Alzheimer Research · doi:10.2174/156720510793611556 · Cited by 74 · see citing works
Dementia with Lewy bodies from the perspective of tauopathy
Iseki, E., Togo, T., Suzuki, K., Katsuse, O., Marui, W., de Silva, R., Lees, A. J., Yamamoto, T., & Kosaka, K. (2003) · Acta Neuropathologica · doi:10.1007/s00401-002-0644-3 · Cited by 70 · see citing works
Phosphorylation and cleavage of tau in non-AD tauopathies
Guillozet-Bongaarts, A. L., Glajch, K. E., Libson, E. G., Cahill, M. E., Bigio, E. H., Berry, R. W., & Binder, L. I. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0209-6 · Cited by 65 · see citing works
Ferrer, I., Barrachina, M., Tolnay, M., Rey, M. J., Vidal, N., Carmona, M., Blanco, R., & Puig, B. (2003) · Brain Pathology · doi:10.1111/j.1750-3639.2003.tb00007.x · Cited by 60 · see citing works
Self-citationMondragón‐Rodríguez, S., Mena, R., Binder, L. I., Smith, M. A., Perry, G. L., & García‐Sierra, F. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00853.x · Cited by 58 · see citing works
Self-citationFu, Y., Nishihira, Y., Kuroda, S., Toyoshima, Y., Ishihara, T., Shinozaki, M., Miyashita, A., Piao, Y.-S., Tan, C., Tani, T., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0649-2 · Cited by 55 · see citing works
Ferrer, I. (2004) · Neurotoxicity Research · doi:10.1007/bf03033283 · Cited by 53 · see citing works
Self-citationKatsuse, O., Iseki, E., Arai, T., Akiyama, H., Togo, T., Uchikado, H., Kato, M., de Silva, R., Lees, A. J., & Kosaka, K. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0728-8 · Cited by 46 · see citing works
Žilková, M., Žilka, N., Kováč, A., Kováčech, B., Škrabana, R., Skrabanova, M., & Novák, M. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101434 · Cited by 45 · see citing works
Tolnay, M., & Probst, A. (2008) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)01251-1 · Cited by 41 · see citing works
Ferrer, I., Barrachina, M., & Puig, B. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0600-2 · Cited by 36 · see citing works
Self-citationGarcía‐Sierra, F., Jarero-Basulto, J. J., Krištofíková, Z., Majer, E., Binder, L. I., & Řı́pová, D. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00525.x · Cited by 34 · see citing works
Distribution of tuft-shaped astrocytes in the cerebral cortex in progressive supranuclear palsy
Iwasaki, Y., Yoshida, M., Hattori, M., et al. (2004) · Acta Neuropathologica · doi:10.1007/s00401-004-0904-5 · Cited by 27 · see citing works
Tuft-shaped astrocytes in Lewy body disease
Hishikawa, N., Hashizume, Y., Yoshida, M., Niwa, J.-I., Tanaka, F., & Sobue, G. (2005) · Acta Neuropathologica · doi:10.1007/s00401-004-0967-3 · Cited by 26 · see citing works
Sakai, K., Piao, Y.-S., Kikugawa, K., Ohara, S., Hasegawa, M., Takano, H., Fukase, M., Nishizawa, M., Kakita, A., & Takahashi, H. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0093-5 · Cited by 26 · see citing works
Glial fibrillary tangles in diffuse neurofibrillary tangles with calcification
Hashimoto, N., Takeuchi, T., Ishihara, R., et al. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0715-0 · Cited by 23 · see citing works
Spinal cord tau pathology in cervical spondylotic myelopathy
Shimizu, H., Kakita, A., & Takahashi, H. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0321-7 · Cited by 19 · see citing works
Ito, K., Arai, K., Yoshiyama, Y., Kashiwado, K., Sakakibara, Y., & Hattori, T. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0378-y · Cited by 15 · see citing works
Filipčík, P., Cente, M., Krajciova, G., Vanický, I., & Novák, M. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9372-8 · Cited by 14 · see citing works
Neuropathology of Hereditary Forms of Frontotemporal Dementia and Parkinsonism
Muñoz, D. G., & Ferrer, I. (2008) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)01237-7 · Cited by 13 · see citing works
Self-citationMena, R., & Luna‐Muñoz, J. (2009) · Springer eBooks · doi:10.1007/978-0-387-87995-6_7 · Cited by 8 · see citing works
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- Authors
- López‐González, I., Carmona, M., Blanco, R., Luna‐Muñoz, J., Martínez‐Mandonado, A., Mena, R., & Ferrer, I.
- Affiliations
- Bellvitge University Hospital (ES)
- Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
- CIBERNED (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas), Institut de Neuropatologia, IDIBELL‐Hospital Universitari de Bellvitge Universitat de Barcelona Hospitalet de Llobregat Spain
- Venue
- Brain Pathology
- Publisher
- Wiley
- Published
- 2012-09-13
- Volume
- 23
- Issue
- 2
- Pages
- 144-153
- ISSN
- 1015-6305 (ISSN-L)
- 1750-3639
- PMC
- PMC8028879
- OpenAlex
- W2117283190
- Cited by
- 28
- References
- 54
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 3 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- European Commission
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, tau phosphorylation, 4R tau, tau conformation, neurofibrillary tangles, MAPK/ERK pathway, SAPK/JNK, p38 MAPK, GSK3β, tau truncation, caspase-3, periventricular white matter, temporal lobe, astrocyte degeneration
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Aged, Aged, 80 and over, Alzheimer Disease, Astrocytes, Axons, Female, Humans, Male, Nerve Fibers, Myelinated, Neurons, Phosphorylation, Temporal Lobe, Neurofibrillary Tangles, tau Proteins, Glycogen Synthase Kinase 3, Mitogen-Activated Protein Kinase 8, Cell Shape, Caspase 3
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