Vascular Degeneration in P arkinson's Disease
Open accessAbstract
Vascular degeneration plays a significant role in contributing to neurodegenerative conditions such as Alzheimer's disease. Our understanding of the vascular components in Parkinson's disease (PD) is however limited. We have examined the vascular morphology of human brain tissue from both PD and the control cases using immunohistochemical staining and image analysis. The degenerative morphology seen in PD cases included the formation of endothelial cell "clusters," which may be contributed by the fragmentation of capillaries. When compared to the control cases, the capillaries of PDs were less in number (P < 0.001), shorter in length (P < 0.001) and larger in diameter (P < 0.01) with obvious damage to the capillary network evidenced by less branching (P < 0.001). The level of degeneration seen in the caudate nucleus was also seen in the age-matched control cases. Vessel degeneration associated with PD was, however, found in multiple brain regions, but particularly in the substantia nigra, middle frontal cortex and brain stem nuclei. The data suggest that vascular degeneration could be an additional contributing factor to the progression of PD. Thus, treatments that prevent vascular degeneration and improve vascular remodeling may be a novel target for the treatment of PD.
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Inflammatory responses in the gut might signal to specific parts of the brain systemically and through dysfunctional blood brain barrier structures as seen in Parkinson's disease patients.
“It is also possible that these inflammatory responses in the gut might signal to specific parts of the brain systemically and through dysfunctional blood brain barrier structures as seen in PD patients (Guan et al., 2013).”
From The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies (2017) · cites this paper as Guan et al., 2013
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- Authors
- Guan, J., Pavlovic, D., Dalkie, N., Waldvogel, H. J., O'Carroll, S. J., Green, C. R., & Nicholson, L. F. B.
- Affiliations
- University of Auckland (NZ)
- Centre for Brain Research, and the Department of Anatomy with Radiology, Faculty of Medicine and Health Science University of Auckland Auckland New Zealand
- Corresponding author
- Guan, Jian
- Venue
- Brain Pathology
- Publisher
- Wiley
- Published
- 2012-09-13
- Volume
- 23
- Issue
- 2
- Pages
- 154-164
- ISSN
- 1015-6305 (ISSN-L)
- 1750-3639
- PMC
- PMC8029297
- OpenAlex
- W1621325175
- Cited by
- 191
- References
- 42
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 17 · 2023: 17 · 2022: 17 · 2021: 25 · 2020: 24 · 2019: 7 · 2018: 13 · 2017: 10 · 2016: 9 · 2015: 12 · 2014: 7 · 2013: 1
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- Parkinson's disease, vascular degeneration, capillary damage, caudate nucleus, substantia nigra, brainstem nuclei, middle frontal cortex, vascular remodeling, neurodegeneration
- MeSH terms
- Aged, Aged, 80 and over, Brain, Caudate Nucleus, Endothelium, Vascular, Female, Humans, Male, Nerve Degeneration, Parkinson Disease, Endothelial Cells
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