Cited by 116Seaweed-derived Bioactive CompoundsCell death mechanisms and regulationEchinoderm biology and ecology

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Antiproliferative Activity of Fucoidan Was Associated with the Induction of Apoptosis and Autophagy in AGS Human Gastric Cancer Cells

Park, Hyun Soo, Kim, Gi‐Young, Nam, Taek‐Jeong, Deuk Kim, Nam, Hyun Choi, Yung·2011·Journal of Food Science

DOI 10.1111/j.1750-3841.2011.02099.x

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Abstract

Fucoidan, a sulfated polysaccharide purified from brown algae, possesses a variety of pharmacologic effects, including antiinflammatory, antioxidant, and anticancer properties; however, the underlying action mechanisms are not completely understood. This study investigated the possible mechanisms through which fucoidan exerts its antiproliferative action in cultured AGS human gastric adenocarcinoma cells. We found that fucoidan effectively inhibits the growth of AGS cells by inducing autophagy, as well as apoptosis. Apoptosis by fucoidan treatment was associated with the downregulation of antiapoptotic Bcl-2 and Bcl-xL expression, loss of mitochondrial membrane potential, activation of caspases, and concomitant degradation of poly-(ADP-ribose) polymerase protein. In addition, the morphological study indicated a characteristic finding of autophagy, such as the formation of autophagosomes in fucoidan-treated AGS cells. Furthermore, markers of autophagy, namely, the conversion of microtubule-associated protein light chain 3 (LC3)-I to LC3-II and increased beclin-1 accumulation, were observed. Overall, the present data suggest that fucoidan induces apoptotic and autophagic cell death, and both apoptotic and autophagic mechanisms contribute to the fucoidan-induced AGS cell death.

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Authors: Park, H. S., Kim, G., Nam, T., Deuk Kim, N., & Hyun Choi, Y.
Affiliations: Dong-Eui University (KR)
Corresponding author: Park, Hyun Soo
Kim, Gi‐Young
Nam, Taek‐Jeong
ORCID: Park, Hyun Soo
Kim, Gi‐Young
Nam, Taek‐Jeong
Venue: Journal of Food Science
Publisher: Wiley
Published: 2011-04
Volume: 76
Issue: 3
Pages: T77-83
ISSN: 0022-1147 (ISSN-L)
1750-3841
DOI: 10.1111/j.1750-3841.2011.02099.x
OpenAlex: W2172230995
Cited by: 116
References: 36
Citations by year: 2026: 3 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 11 · 2021: 13 · 2020: 15 · 2019: 9 · 2018: 9 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 8 · 2013: 7 · 2012: 3
FWCI: 9.79
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5 d)
Locations: Journal of Food Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
Keywords: fucoidan, sulfated polysaccharides, brown algae, gastric cancer, AGS cells, apoptosis, autophagy, antiproliferative activity, Bcl-2, Bcl-xL, mitochondrial membrane potential, caspase activation, PARP degradation, LC3, Beclin-1, autophagosomes, anticancer activity
MeSH terms: Beclin-1, Adenocarcinoma, Antineoplastic Agents, Autophagy, Cell Survival, Enzyme Activation, Humans, Membrane Proteins, Microtubule-Associated Proteins, Phagosomes, Poly(ADP-ribose) Polymerases, Polysaccharides, Stomach Neoplasms, Biomarkers, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Caspases, Cell Line, Tumor, Cell Proliferation, Apoptosis Regulatory Proteins, bcl-X Protein, Membrane Potential, Mitochondrial

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Antiproliferative Activity of Fucoidan Was Associated with the Induction of Apoptosis and Autophagy in AGS Human Gastric Cancer Cells

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