The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Antiproliferative Activity of Fucoidan Was Associated with the Induction of Apoptosis and Autophagy in AGS Human Gastric Cancer Cells
Abstract
Fucoidan, a sulfated polysaccharide purified from brown algae, possesses a variety of pharmacologic effects, including antiinflammatory, antioxidant, and anticancer properties; however, the underlying action mechanisms are not completely understood. This study investigated the possible mechanisms through which fucoidan exerts its antiproliferative action in cultured AGS human gastric adenocarcinoma cells. We found that fucoidan effectively inhibits the growth of AGS cells by inducing autophagy, as well as apoptosis. Apoptosis by fucoidan treatment was associated with the downregulation of antiapoptotic Bcl-2 and Bcl-xL expression, loss of mitochondrial membrane potential, activation of caspases, and concomitant degradation of poly-(ADP-ribose) polymerase protein. In addition, the morphological study indicated a characteristic finding of autophagy, such as the formation of autophagosomes in fucoidan-treated AGS cells. Furthermore, markers of autophagy, namely, the conversion of microtubule-associated protein light chain 3 (LC3)-I to LC3-II and increased beclin-1 accumulation, were observed. Overall, the present data suggest that fucoidan induces apoptotic and autophagic cell death, and both apoptotic and autophagic mechanisms contribute to the fucoidan-induced AGS cell death.
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“While using AGS human gastric adenocarcinoma cells and fucoidan from Fucus vesiculosus, it was established that treatment with fucoidan resulted not only in apoptosis of these cells, but also in autophagy with the formation of autophagosomes in fucoidan-treated cells, the conversion of microtubule-associated protein light chain 3 to light chain 3-II and the increase of beclin-1 level [35].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [35]
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Metadata
- Authors
- Park, H. S., Kim, G., Nam, T., Deuk Kim, N., & Hyun Choi, Y.
- Affiliations
- Dong-Eui University (KR)
- Corresponding author
- Park, Hyun Soo
- Kim, Gi‐Young
- Nam, Taek‐Jeong
- Venue
- Journal of Food Science
- Publisher
- Wiley
- Published
- 2011-04
- Volume
- 76
- Issue
- 3
- Pages
- T77-83
- ISSN
- 0022-1147 (ISSN-L)
- 1750-3841
- OpenAlex
- W2172230995
- Cited by
- 116
- References
- 36
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 11 · 2021: 13 · 2020: 15 · 2019: 9 · 2018: 9 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 8 · 2013: 7 · 2012: 3
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Food Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
- Keywords
- fucoidan, sulfated polysaccharides, brown algae, gastric cancer, AGS cells, apoptosis, autophagy, antiproliferative activity, Bcl-2, Bcl-xL, mitochondrial membrane potential, caspase activation, PARP degradation, LC3, Beclin-1, autophagosomes, anticancer activity
- MeSH terms
- Beclin-1, Adenocarcinoma, Antineoplastic Agents, Autophagy, Cell Survival, Enzyme Activation, Humans, Membrane Proteins, Microtubule-Associated Proteins, Phagosomes, Poly(ADP-ribose) Polymerases, Polysaccharides, Stomach Neoplasms, Biomarkers, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Caspases, Cell Line, Tumor, Cell Proliferation, Apoptosis Regulatory Proteins, bcl-X Protein, Membrane Potential, Mitochondrial
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