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Cited by 34Smoking Behavior and CessationSubstance Abuse Treatment and OutcomesNicotinic Acetylcholine Receptors Study

A Longer Course of Varenicline Therapy Improves Smoking Cessation Rates

Lee, John H., Jones, Philip G., Bybee, Kevin, O’Keefe, James H.·2008·Preventive Cardiology
DOI 10.1111/j.1751-7141.2008.00003.x
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Abstract

Smoking exerts strong dose‐dependent increases in cardiovascular risk and mortality, and quitting can profoundly decrease these risks. Varenicline attenuates nicotine addiction by reducing withdrawal symptoms and cravings. A meta‐analysis performed addressed whether a longer duration of varenicline is associated with better abstinence rates than shorter courses of treatment. For this meta‐analysis, a literature search was performed to identify randomized controlled trials investigating the efficacy of the smoking cessation agent varenicline. The association between abstinence and duration of treatment was analyzed using fixed‐effect meta‐regression. Five randomized controlled trials were identified and included in this meta‐analysis. A highly significant relationship (P<.001) was found between the length of exposure to varenicline and abstinence rate. Cessation rates were approximately twice as high with varenicline treatment of 24 weeks compared to 6 weeks. In conclusion, a meta‐analysis of randomized controlled trials suggests that longer duration of varenicline therapy improves long‐term abstinence rates.

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Authors
Lee, J. H., Jones, P. G., Bybee, K., & O’Keefe, J. H.
Affiliations
University of Missouri–Kansas City (US)
Corresponding author
O’Keefe, James H.
ORCID
Venue
Preventive Cardiology
Publisher
Wiley
Published
2008-09
Volume
11
Issue
4
Pages
210-214
ISSN
  • 1520-037X (ISSN-L)
  • 1751-7141
DOI
10.1111/j.1751-7141.2008.00003.x
OpenAlex
W2001751389
Cited by
34
References
20
Citations by year
2025: 1 · 2023: 5 · 2022: 1 · 2019: 5 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 1
FWCI
1.81
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 44 d)
Locations
  • Preventive Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
varenicline, smoking cessation, treatment duration, abstinence rates, nicotine dependence, nicotine withdrawal symptoms, nicotine craving, cardiovascular risk reduction
MeSH terms
Varenicline, Smoking Prevention, Benzazepines, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Male, Patient Compliance, Quinoxalines, Receptors, Nicotinic, Randomized Controlled Trials as Topic, Smoking Cessation, Treatment Outcome, Clinical Trials, Phase II as Topic, Clinical Trials, Phase III as Topic, Risk Assessment, Maximum Tolerated Dose

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