The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Folate, Vitamin B12, and Neuropsychiatric Disorders
Abstract
Folate and vitamin B12 are required both in the methylation of homocysteine to methionine and in the synthesis of S-adenosylmethionine. S-adenosylmethionine is involved in numerous methylation reactions involving proteins, phospholipids, DNA, and neurotransmitter metabolism. Both folate and vitamin B12 deficiency may cause similar neurologic and psychiatric disturbances including depression, dementia, and a demyelinating myelopathy. A current theory proposes that a defect in methylation processes is central to the biochemical basis of the neuropsychiatry of these vitamin deficiencies. Folate deficiency may specifically affect central monoamine metabolism and aggravate depressive disorders. In addition, the neurotoxic effects of homocysteine may also play a role in the neurologic and psychiatric disturbances that are associated with folate and vitamin B12 deficiency.
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Cites
Enhancement of recovery from psychiatric illness by methylfolate
Godfrey, P. S. A., Toone, B. K., Bottiglien, T., Laundy, M., Reynolds, E. H., Carney, M. W. P., Flynn, T. G., & Chanarin, I. (1990) · The Lancet · doi:10.1016/0140-6736(90)91942-4 · Cited by 389
Cited by
Liew, S.-C., & Gupta, E. D. (2015) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2014.10.004 · Cited by 466
Markers of Oxidative Stress and Neuroprogression in Depression Disorder
Vaváková, M., Ďuračková, Z., & Trebatická, J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/898393 · Cited by 324
The Controversial Role of Homocysteine in Neurology: From Labs to Clinical Practice
Moretti, R., & Caruso, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010231 · Cited by 248
Bottiglieri, T. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.1151s · Cited by 286
Self-citationPetridou, E. T., Kousoulis, A. A., Michelakos, T., Papathoma, P., Dessypris, N., Papadopoulos, F. C., & Stefanadis, C. (2016) · Aging & Mental Health · doi:10.1080/13607863.2015.1049115 · Cited by 112
dos Santos, E. F., Busanello, E. N. B., Miglioranza, A., Zanatta, Â., Barchak, A. G., Vargas, C. R., Saute, J., Rosa, C., Carrion, M. J., Camargo, D., et al. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-009-9139-4 · Cited by 76
Vitamin B12, folate, homocysteine and dementia: are they really related?
Arioğul, S., Cankurtaran, M., Dağli, N., Khalil, M., & Yavuz, B. (2005) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2004.07.005 · Cited by 51
Metadata
- Authors
- Bottiglieri, T.
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04-27
- Volume
- 54
- Issue
- 12
- Pages
- 382-390
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2111057102
- Cited by
- 356
- References
- 1
- FWCI
- 13.10
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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