Cited by 324Tryptophan and brain disordersTreatment of Major DepressionAntioxidant Activity and Oxidative Stress

Markers of Oxidative Stress and Neuroprogression in Depression Disorder

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Vaváková, Magdaléna, Ďuračková, Zdeňka, Trebatická, Jana·2015·Oxidative Medicine and Cellular Longevity

Abstract

Major depression is multifactorial disorder with high prevalence and alarming prognostic in the nearest 15 years. Several mechanisms of depression are known. Neurotransmitters imbalance and imbalance between neuroprogressive and neuroprotective factors are observed in major depression. Depression is accompanied by inflammatory responses of the organism and consequent elevation of proinflammatory cytokines and increased lipid peroxidation are described in literature. Neuropsychiatric disorders including major depression are also associated with telomerase shortening, oxidative changes in nucleotides, and polymorphisms in several genes connected to metabolism of reactive oxygen species. Mitochondrion dysfunction is directly associated with increasing levels of oxidative stress. Oxidative stress plays significant role in pathophysiology of major depression via actions of free radicals, nonradical molecules, and reactive oxygen and nitrogen species. Products of oxidative stress represent important parameters for measuring and predicting of depression status as well as for determining effectiveness of administrated antidepressants. Positive effect of micronutrients, vitamins, and antioxidants in depression treatment is also reviewed.

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  1. [135]Maes M. de Vos N. Pioli R. Lower serum vitamin E concentrations in major depression. Another marker of lowered antioxidant defenses in that illness Journal of Affective Disorders 2000 58 3 241 246 10.1016/s0165-0327(99)00121-4 2-s2.0-0034106884 10802134 · DOI

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Authors
Vaváková, M., Ďuračková, Z., & Trebatická, J.
Affiliations
  • Comenius University Bratislava (SK)
  • University Hospital Bratislava (SK)
Corresponding author
Trebatická, Jana
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2015
Volume
2015
Pages
1-12
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
OpenAlex
W1920770718
Cited by
324
References
139
Citations by year
2026: 13 · 2025: 25 · 2024: 34 · 2023: 47 · 2022: 51 · 2021: 38 · 2020: 34 · 2019: 21 · 2018: 20 · 2017: 23 · 2016: 12 · 2015: 5
FWCI
1.12
Type
journal article
Language
en
Open access
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education of SR (VEGA 1/0703/13)
  • Mind and Health, Civil Association (VEGA 1/0703/13)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
major depressive disorder, oxidative stress, neuroprogression, neuroinflammation, inflammatory cytokines, lipid peroxidation, telomere shortening, mitochondrial dysfunction, reactive oxygen species, reactive nitrogen species, antioxidant micronutrients, antidepressant response, genetic polymorphism
MeSH terms
Antioxidants, Depressive Disorder, DNA Damage, Humans, Mitochondria, Vitamins, Xanthine Oxidase, Oxidative Stress

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