Markers of Oxidative Stress and Neuroprogression in Depression Disorder
Open accessAbstract
Major depression is multifactorial disorder with high prevalence and alarming prognostic in the nearest 15 years. Several mechanisms of depression are known. Neurotransmitters imbalance and imbalance between neuroprogressive and neuroprotective factors are observed in major depression. Depression is accompanied by inflammatory responses of the organism and consequent elevation of proinflammatory cytokines and increased lipid peroxidation are described in literature. Neuropsychiatric disorders including major depression are also associated with telomerase shortening, oxidative changes in nucleotides, and polymorphisms in several genes connected to metabolism of reactive oxygen species. Mitochondrion dysfunction is directly associated with increasing levels of oxidative stress. Oxidative stress plays significant role in pathophysiology of major depression via actions of free radicals, nonradical molecules, and reactive oxygen and nitrogen species. Products of oxidative stress represent important parameters for measuring and predicting of depression status as well as for determining effectiveness of administrated antidepressants. Positive effect of micronutrients, vitamins, and antioxidants in depression treatment is also reviewed.
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Increased oxidative damage occurs quite often in anxiety.
“anxiety [9, 10]”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [9]
Increased oxidative damage occurs quite often in depression.
“increased oxidative damage occurs quite often in depression [7–9]”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [9]
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Research works printed but not linked: 1
- [135]Maes M. de Vos N. Pioli R. Lower serum vitamin E concentrations in major depression. Another marker of lowered antioxidant defenses in that illness Journal of Affective Disorders 2000 58 3 241 246 10.1016/s0165-0327(99)00121-4 2-s2.0-0034106884 10802134 · DOI
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“These studies further corroborate the association between energy impairment, inflammation and myelin loss during MDD. Non-responders to depressive treatment have shown increased baseline inflammation and oxidative stress (Strawbridge et al., 2015; Vaváková et al., 2015).”
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“In this way, one of these aspects is oxidative stress status, which seems to be implicated in most of the different affective disorders, since it has been shown that increased oxidative damage occurs quite often in depression [7–9], anxiety [9, 10], bipolar disorder (BD) [10–14], panic disorder (PD) [15, 16], and also…”
BackgroundCecerska-Heryć, E., Polikowska, A., Serwin, N., Roszak, M., Grygorcewicz, B., Heryć, R., Michalczyk, A., & Dołęgowska, B. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2021.105269 · Cited by 68 · see citing works
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- Authors
- Vaváková, M., Ďuračková, Z., & Trebatická, J.
- Affiliations
- Comenius University Bratislava (SK)
- University Hospital Bratislava (SK)
- Corresponding author
- Trebatická, Jana
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-12
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC4453280
- OpenAlex
- W1920770718
- Cited by
- 324
- References
- 139
- Citations by year
- 2026: 13 · 2025: 25 · 2024: 34 · 2023: 47 · 2022: 51 · 2021: 38 · 2020: 34 · 2019: 21 · 2018: 20 · 2017: 23 · 2016: 12 · 2015: 5
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Education of SR (VEGA 1/0703/13)
- Mind and Health, Civil Association (VEGA 1/0703/13)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- major depressive disorder, oxidative stress, neuroprogression, neuroinflammation, inflammatory cytokines, lipid peroxidation, telomere shortening, mitochondrial dysfunction, reactive oxygen species, reactive nitrogen species, antioxidant micronutrients, antidepressant response, genetic polymorphism
- MeSH terms
- Antioxidants, Depressive Disorder, DNA Damage, Humans, Mitochondria, Vitamins, Xanthine Oxidase, Oxidative Stress
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