The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies
Open accessAbstract
In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone consumption. The recent increased intake of soy foods and supplements in the American diet has raised concerns about the possible estrogen-like effects of natural isoflavones and possible promotion or propagation of estrogen-sensitive cancers. These concerns are primarily based on in vitro and rodent data which suggest that genistein aglycone can stimulate tumor cell proliferation and growth in mice having deficient immune systems. In contrast, a recent nested case-control study and meta-analysis of numerous epidemiological studies show an inverse correlation between genistein intake and breast cancer risk. Furthermore, clinical studies in osteopenic and osteoporotic, postmenopausal women support the breast and uterine safety of purified naturally derived genistein administered for up to 3 years. In this review, we summarize the in vitro, preclinical and clinical evidence for the safety of natural genistein.
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Marini, H., Bitto, A., Altavilla, D., Burnett, B. P., Polito, F., Di Stefano, V., Minutoli, L., Atteritano, M., Levy, R. M., D'Anna, R., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1087 · Cited by 167
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The pros and cons of phytoestrogens
Patisaul, H. B., & Jefferson, W. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.03.003 · Cited by 746
The potential health effects of dietary phytoestrogens
Rietjens, I. M. C. M., Louisse, J., & Beekmann, K. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13622 · Cited by 490
Soy food intake and breast cancer survival
Shu, X. O. (2009) · JAMA · doi:10.1001/jama.2009.1783 · Cited by 436
Bioactivity of soy-based fermented foods: A review
Cao, Z.-H., Green-Johnson, J. M., Buckley, N. D., & Lin, Q.-Y. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.12.001 · Cited by 231
Risks and benefits of dietary isoflavones for cancer
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Metadata
- Authors
- Taylor, C. K., Levy, R. M., Elliott, J. C., & Burnett, B. P.
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-07
- Volume
- 67
- Issue
- 7
- Pages
- 398-415
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2126512953
- Cited by
- 216
- References
- 9
- FWCI
- 14.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Taylor, C. K., Levy, R. M., Elliott, J. C., & Burnett, B. P. (2009). The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies. Nutrition Reviews. https://doi.org/10.1111/j.1753-4887.2009.00213.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
