Effects of raloxifene, hormone therapy, and soy isoflavone on serum high-sensitive C-reactive protein in postmenopausal women
Open accessAbstract
OBJECTIVE: To compare the effects of raloxifene, estradiol valerate plus dienogest, and soy isoflavones (genistein) on serum concentrations of high-sensitive C-reactive protein in healthy postmenopausal women. METHODS: The 80 healthy postmenopausal women enrolled in the study were randomly allocated to receive 60 mg of raloxifene, 2 mg of estradiol valerate plus dienogest, 40 mg of genistein, or placebo (n=20 in each group). Blood samples were collected at the start of the study and at 3 and 6 months. Lipid profile was also determined. RESULTS: Only the group receiving estradiol valerate plus dienogest showed an increase in serum levels of high-sensitive C-reactive protein compared with baseline values and values in the control and other groups. All 3 treatments resulted in an increase in high-density lipoprotein cholesterol levels and a decrease in total, low-density, and very-low-density lipoprotein cholesterol levels. CONCLUSIONS: Estradiol valerate plus dienogest, but not raloxifene and genistein, increase serum high-sensitive C-reactive protein levels. All 3 treatments, however, have an estrogen-like effect on serum lipid profile.
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In that trial, inflammatory markers declined more in the Mediterranean-style diet group even after controlling for weight loss.
“Interestingly, even after controlling for weight loss, the inflammatory markers declined more in subjects following the Mediterranean-style diet.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [284]
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- Authors
- Yildiz, M. F., Kumru, S., Godekmerdan, A., & Kutlu, S.
- Affiliations
- Fırat University (TR)
- Corresponding author
- Kumru, Selahattin
- Venue
- International Journal of Gynecology & Obstetrics
- Publisher
- Wiley
- Published
- 2005-06-20
- Volume
- 90
- Issue
- 2
- Pages
- 128-133
- ISSN
- 0020-6695 (ISSN-L)
- 0020-7292
- OpenAlex
- W2008525533
- Cited by
- 56
- References
- 26
- Citations by year
- 2024: 4 · 2023: 1 · 2021: 6 · 2020: 4 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 1
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- International Journal of Gynecology & Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- DSpace - FIRAT (Fırat University) (submittedVersion, cc-by-nc-nd)
- Funders
- Firat Üniversitesi
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- raloxifene, hormone replacement therapy, soy isoflavones, genistein, high-sensitivity C-reactive protein, postmenopausal women, lipid profile, estrogenic effects
- MeSH terms
- C-Reactive Protein, Cholesterol, Estradiol, Female, Humans, Isoflavones, Lipoproteins, Middle Aged, Nandrolone, Prospective Studies, Glycine max, Estrogen Replacement Therapy, Treatment Outcome, Postmenopause, Raloxifene Hydrochloride
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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