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Cited by 116Advanced Glycation End Products researchAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Serum Levels of Advanced Glycation End Products (AGEs) are Independent Correlates of Insulin Resistance in Nondiabetic Subjects

Tahara, Nobuhiro, Yamagishi, Sho‐ichi, Matsui, Takanori, Takeuchi, Masayoshi, Nitta, Yoshikazu, Kodama, Norihiro, Mizoguchi, Minori, Imaizumi, Tsutomu·2012·Cardiovascular Therapeutics
DOI 10.1111/j.1755-5922.2010.00177.x
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Abstract

SUMMARY: Background: Advanced glycation end products (AGEs) evoke oxidative stress generation and inflammatory reactions, thus being involved in vascular complications in diabetes. Since oxidative stress and inflammation impair insulin actions as well, it is conceivable that AGEs may play some role in insulin resistance. However, there is no clinical study to examine the relationship between serum levels of AGEs and insulin resistance. This study investigated whether serum AGE levels were independent correlates of insulin resistance in humans. Methods: Three hundred twenty‐two nondiabetic Japanese subjects (216 male and 106 female; mean age 61.5 ± 9.1 years) underwent a complete history and physical examination, determinations of blood chemistries, anthropometric and metabolic variables, including AGEs. Serum AGE levels were examined with an enzyme‐linked immunosorbent assay. Results: Mean serum AGE levels were 8.96 ± 2.57 U/mL. In univariate analysis, waist circumference, diastolic blood pressure (BP), mean BP, AGEs, low‐density lipoprotein (LDL) cholesterol, triglycerides, high‐density lipoprotein (HDL) cholesterol (inversely), hemoglobin A1c (GHb), creatinine clearance, uric acid, and high sensitivity C‐reactive protein were significantly associated with insulin resistance evaluated by homeostasis model assessment of insulin resistance (HOMA‐IR) index. After performing multiple regression analysis, waist circumference (P < 0.001), GHb (P < 0.001), triglycerides (P < 0.001), and AGEs (P < 0.01) still remained significant independently. When age‐adjusted HOMA‐IR levels stratified by AGE tertiles were compared using ANCOVA, a significant trend was demonstrated in both males and females. Conclusion: The present study demonstrated for the first time that serum AGE levels were one of the independent correlates of HOMA‐IR index, thus suggesting that AGEs may play some pathological role in insulin resistance in humans.

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Crossref · 10.1111/j.1755-5922.2010.00177.x

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Metadata

Authors
Tahara, N., Yamagishi, S., Matsui, T., Takeuchi, M., Nitta, Y., Kodama, N., Mizoguchi, M., & Imaizumi, T.
Affiliations
  • Kurume University (JP)
  • Hokuriku University (JP)
Corresponding author
Tahara, Nobuhiro
ORCID
Venue
Cardiovascular Therapeutics
Publisher
Wiley
Published
2012-01-26
Volume
30
Issue
1
Pages
42-48
ISSN
  • 1755-5914 (ISSN-L)
  • 1755-5922
DOI
10.1111/j.1755-5922.2010.00177.x
OpenAlex
W1509582521
Cited by
116
References
37
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 10 · 2020: 14 · 2019: 7 · 2018: 2 · 2017: 6 · 2016: 6 · 2015: 18 · 2014: 5 · 2013: 11 · 2012: 6
FWCI
5.42
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Cardiovascular Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (23591072, 22300264)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
advanced glycation end products, insulin resistance, non-diabetic adults, HOMA-IR, waist circumference, HbA1c, triglycerides, oxidative stress, inflammation, C-reactive protein, uric acid, LDL cholesterol, HDL cholesterol, diastolic blood pressure, creatinine clearance
MeSH terms
Aged, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, Humans, Insulin Resistance, Japan, Male, Middle Aged, Regression Analysis, Risk Factors, Biomarkers, Multivariate Analysis, Glycation End Products, Advanced, Risk Assessment

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