Cited by 116Advanced Glycation End Products researchAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Serum Levels of Advanced Glycation End Products (AGEs) are Independent Correlates of Insulin Resistance in Nondiabetic Subjects

Tahara, Nobuhiro, Yamagishi, Sho‐ichi, Matsui, Takanori, Takeuchi, Masayoshi, Nitta, Yoshikazu, Kodama, Norihiro, Mizoguchi, Minori, Imaizumi, Tsutomu·2012·Cardiovascular Therapeutics

DOI 10.1111/j.1755-5922.2010.00177.x

Open this paper in CoChat — free account

Abstract

SUMMARY: Background: Advanced glycation end products (AGEs) evoke oxidative stress generation and inflammatory reactions, thus being involved in vascular complications in diabetes. Since oxidative stress and inflammation impair insulin actions as well, it is conceivable that AGEs may play some role in insulin resistance. However, there is no clinical study to examine the relationship between serum levels of AGEs and insulin resistance. This study investigated whether serum AGE levels were independent correlates of insulin resistance in humans. Methods: Three hundred twenty‐two nondiabetic Japanese subjects (216 male and 106 female; mean age 61.5 ± 9.1 years) underwent a complete history and physical examination, determinations of blood chemistries, anthropometric and metabolic variables, including AGEs. Serum AGE levels were examined with an enzyme‐linked immunosorbent assay. Results: Mean serum AGE levels were 8.96 ± 2.57 U/mL. In univariate analysis, waist circumference, diastolic blood pressure (BP), mean BP, AGEs, low‐density lipoprotein (LDL) cholesterol, triglycerides, high‐density lipoprotein (HDL) cholesterol (inversely), hemoglobin A1c (GHb), creatinine clearance, uric acid, and high sensitivity C‐reactive protein were significantly associated with insulin resistance evaluated by homeostasis model assessment of insulin resistance (HOMA‐IR) index. After performing multiple regression analysis, waist circumference (P < 0.001), GHb (P < 0.001), triglycerides (P < 0.001), and AGEs (P < 0.01) still remained significant independently. When age‐adjusted HOMA‐IR levels stratified by AGE tertiles were compared using ANCOVA, a significant trend was demonstrated in both males and females. Conclusion: The present study demonstrated for the first time that serum AGE levels were one of the independent correlates of HOMA‐IR index, thus suggesting that AGEs may play some pathological role in insulin resistance in humans.

Integrity signals

Registry

Crossref · 10.1111/j.1755-5922.2010.00177.x

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Obesity and insulin resistance
Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,345
Advanced protein glycosylation in diabetes and aging
Brownlee, M. D. (1995) · Annual Review of Medicine · doi:10.1146/annurev.med.46.1.223 · Cited by 1,312
Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging.
Vlassara, H., Bucala, R., & Striker, L. J. (1994) · PubMed · Cited by 848
Activation of Receptor for Advanced Glycation End Products
Schmidt, A. M., Yan, S. D., Wautier, J., & Stern, D. M. (1999) · Circulation Research · doi:10.1161/01.res.84.5.489 · Cited by 799
Renal Insufficiency and Heart Failure
McAlister, F. A., Ezekowitz, J. A., Tonelli, M. A., & Armstrong, P. W. (2004) · Circulation · doi:10.1161/01.cir.0000116764.53225.a9 · Cited by 702
Circulating Glycotoxins and Dietary Advanced Glycation Endproducts: Two Links to Inflammatory Response, Oxidative Stress, and Aging
Uribarri, J., Cai, W., Peppa, M., Goodman, S., Ferrucci, L., Striker, G., & Vlassara, H. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.4.427 · Cited by 570
Formation of pentosidine during nonenzymatic browning of proteins by glucose. Identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo
Dyer, D. G., Blackledge, J. A., Thorpe, S. R., & Baynes, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99007-1 · Cited by 535
Mechanism of formation of the Maillard protein cross-link pentosidine. Glucose, fructose, and ascorbate as pentosidine precursors
Grandhee, S. K., & Monnier, V. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99006-x · Cited by 459
Diabetic Vascular Complications: Pathophysiology, Biochemical Basis and Potential Therapeutic Strategy
Yamagishi, S., & Imaizumi, T. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612054367300 · Cited by 455
Self-citation
Nonalcoholic Fatty Liver Disease: The Pathogenetic Roles of Insulin Resistance and Adipocytokines
Pοlyzos, S. A., Kountouras, J., & Zavos, C. (2009) · Current Molecular Medicine · doi:10.2174/156652409787847191 · Cited by 333

Show all 37 references

Sorted by citations

Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T. (2015) · Biomolecules · doi:10.3390/biom5010194 · Cited by 1,095
“Insulin resistance was estimated by the homeostatic model assessment index (HOMA-IR) which is based on the calculation of fasting insulin and glucose concentration [76].”
Background
Advanced glycation endproducts in food and their effects on health
Poulsen, M. W., Hedegaard, R. V., Andersen, J. M., de Courten, B., Bügel, S., Nielsen, J., Skibsted, L. H., & Dragsted, L. O. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.052 · Cited by 751
Insulin Resistance: Metabolic Mechanisms and Consequences in the Heart
Abel, E. D., O’Shea, K. M., & Ramasamy, R. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.241984 · Cited by 253
The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction
Sergi, D., Boulestin, H., Campbell, F. M., & Williams, L. M. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900934 · Cited by 194
Advanced Glycation End Products: Building on the Concept of the “Common Soil” in Metabolic Disease
Ruiz, H. H., Ramasamy, R., & Schmidt, A. M. (2019) · Endocrinology · doi:10.1210/endocr/bqz006 · Cited by 186
A review of potential metabolic etiologies of the observed association between red meat consumption and development of type 2 diabetes mellitus
Kim, Y., Keogh, J., & Clifton, P. (2015) · Metabolism · doi:10.1016/j.metabol.2015.03.008 · Cited by 181
“[68] 322 nondiabetic Japanese participants cross-sectional study ⁎Mean serum AGE levels were 8.”
Background
Advanced Glycation End Products: A Molecular Target for Vascular Complications in Diabetes
Yamagishi, S., Nakamura, N., Suematsu, M., Kaseda, K., & Matsui, T. (2015) · Molecular Medicine · doi:10.2119/molmed.2015.00067 · Cited by 179
Self-citation
Advanced glycation endproducts: from precursors to RAGE: round and round we go
Ramasamy, R., Yan, S. F., & Schmidt, A. M. (2010) · Amino Acids · doi:10.1007/s00726-010-0773-2 · Cited by 158
“…Serum : AGEs in type 1 diabetic patients with complications He et al. (2001) Serum : AGEs in nondiabetic subjects with insulin resistance Tahara et al. (2010) Serum : Pentosidine and CML AGEs in type 2 diabetic subjects with diabetic retinopathy Ghanem et al. (2010) Serum : Pentosidine…”
Background
Advanced glycation end-products (AGEs) in foods and their detecting techniques and methods: A review
Wei, Q., Liu, T., & Sun, D. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.09.020 · Cited by 155
Effect of diet-derived advanced glycation end products on inflammation
Kellow, N. J., & Coughlan, M. T. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv030 · Cited by 160
“NF-j B, activated by AGE-RAGE ligation, binds to glyoxalase 1, suppressing its capacity to detoxify dicarbonyls.”
Background
Dietary advanced glycation end-product restriction for the attenuation of insulin resistance, oxidative stress and endothelial dysfunction: a systematic review
Kellow, N. J., & Savige, G. S. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.220 · Cited by 152
Elevated Serum Advanced Glycation Endproducts in Obese Indicate Risk for the Metabolic Syndrome: A Link Between Healthy and Unhealthy Obesity?
Uribarri, J., Cai, W., Woodward, M., Tripp, E., Goldberg, L., Pyzik, R., Yee, K., Tansman, L., Chen, X., Mani, V., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3925 · Cited by 152
“Habitual preference of such foods in excess can result in a modest elevation of sAGEs and inflammation, even without frank obesity (14, 19, 30).”
Background
Glycoxidation of biological macromolecules: A critical approach to halt the menace of glycation
Ahmad, S., Khan, M. S., Akhter, F., Khan, M. S., Khan, M. S., Ashraf, J. M., Pandey, R. P., & Shahab, U. (2014) · Glycobiology · doi:10.1093/glycob/cwu057 · Cited by 133
“More recently, AGEs have been implicated in the pathogenesis of type 2 diabetes by contributing to the development of insulin resistance and low-grade inflammation known to precede the condition (Tahara et al. 2012).”
Background
Glyceraldehyde-derived pyridinium (GLAP) evokes oxidative stress and inflammatory and thrombogenic reactions in endothelial cells via the interaction with RAGE
Matsui, T., Oda, E., Higashimoto, Y., & Yamagishi, S. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-014-0162-3 · Cited by 129
Self-citation
Advanced glycation end products and their receptor in age-related, non-communicable chronic inflammatory diseases; Overview of clinical evidence and potential contributions to disease
Reynaert, N. L., Gopal, P., Rutten, E. P. A., Wouters, E. F. �., & Schalkwijk, C. G. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.06.016 · Cited by 113
Evaluation of tissue accumulation levels of advanced glycation end products by skin autofluorescence: A novel marker of vascular complications in high-risk patients for cardiovascular disease
Yamagishi, S., Fukami, K., & Matsui, T. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.03.167 · Cited by 109
Self-citation
Role of advanced glycation end products and insulin resistance in diabetic nephropathy
Parwani, K., & Mandal, P. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1797106 · Cited by 103
Effect of dietary prebiotic supplementation on advanced glycation, insulin resistance and inflammatory biomarkers in adults with pre-diabetes: a study protocol for a double-blind placebo-controlled randomised crossover clinical trial
Kellow, N. J., Coughlan, M. T., Savige, G. S., & Reid, C. M. (2014) · BMC Endocrine Disorders · doi:10.1186/1472-6823-14-55 · Cited by 93
“Several studies have shown that AGEs are associated with insulin resistance [12,13], and can induce low-grade inflammation [14] and pancreatic beta cell dysfunction [15,16].”
Background
Assessment of the Concentrations of Various Advanced Glycation End-Products in Beverages and Foods That Are Commonly Consumed in Japan
Takeuchi, M., Takino, J.-I., Furuno, S., Shirai, H., Kawakami, M., Muramatsu, M., Kobayashi, Y., & Yamagishi, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118652 · Cited by 85
Self-citation
Positive Association Between Serum Level of Glyceraldehyde-Derived Advanced Glycation End Products and Vascular Inflammation Evaluated by [18F]Fluorodeoxyglucose Positron Emission Tomography
Tahara, N., Yamagishi, S., Takeuchi, M., Honda, A., Tahara, A., Nitta, Y., Kodama, N., Mizoguchi, M., Kaida, H., Ishibashi, M., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0087 · Cited by 81
“In this study, to examine the relationship between serum level of AGEs and vascular inflammation we used an ELISA system that specially recognized glyceraldehyde-derived AGEs because we have recently found that 1) glyceraldehyde-derived AGE levels are increased under inflammatory and/or hyperglycemic conditions (30,32…”
MethodSelf-citation
Association of arterial stiffness and diabetes with triglycerides-to-HDL cholesterol ratio for Japanese men: The Nagasaki Islands Study
Shimizu, Y., Nakazato, M., Sekita, T., Kadota, K., Yamasaki, H., Takamura, N., Aoyagi, K., & Maeda, T. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.03.021 · Cited by 80
“Furthermore, a cross-sectional study conducted in Taiwan reported that AGEs correlate more strongly with TG levels and TG/HDL when compared to glucose or correlation with the degree of insulin resistance [34].”
Background
Increased Arterial Stiffness in Subjects with Impaired Glucose Tolerance and Newly Diagnosed Diabetes But Not Isolated Impaired Fasting Glucose
Li, C., Wu, J., Yang, Y., Shih, C.-C., Lu, F., & Chang, C. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2595 · Cited by 79
“Therefore, IGT, a more pronounced degree of insulin resistance than isolated IFG (15), may not only lead to increased serum levels of AGE (14) but also result in activation of the sympathetic system with subsequent vasoconstriction due to compensatory hyperinsulinemia (16).”
BackgroundInfluential
Role of receptor for advanced glycation end products (RAGE) in liver disease
Yamagishi, S., & Matsui, T. (2015) · European journal of medical research · doi:10.1186/s40001-015-0090-z · Cited by 76
“We have previously shown that serum levels of AGEs are elevated under oxidative stress, inflammatory, and/ or diabetic conditions and correlated with insulin resistance and decreased adiponectin levels, thereby being one of the useful biomarkers for differentiating NASH from simple steatosis [19-24].”
BackgroundSelf-citation
Glycation and Insulin Resistance
Song, F., & Schmidt, A. M. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.241877 · Cited by 74
Potential Clinical Utility of Advanced Glycation End Product Cross-Link Breakers in Age- and Diabetes-Associated Disorders
Yamagishi, S. (2012) · Rejuvenation Research · doi:10.1089/rej.2012.1335 · Cited by 72
“77–79 Therefore, blockade of the AGE–RAGE axis by alagebrium may also be a novel target for the treatment of insulin resistance in type 2 diabetes.”
Self-citation
Pathologic role of dietary advanced glycation end products in cardiometabolic disorders, and therapeutic intervention
Yamagishi, S., & Matsui, T. (2015) · Nutrition · doi:10.1016/j.nut.2015.08.001 · Cited by 73
“metabolic syndrome from simple steatosis [20,102–106].”
BackgroundSelf-citation
Red Meat, Dietary Heme Iron, and Risk of Type 2 Diabetes: The Involvement of Advanced Lipoxidation Endproducts
White, D., & Collinson, A. (2013) · Advances in Nutrition · doi:10.3945/an.113.003681 · Cited by 70
“(81) found mean 6 SD serum AGE concentrations of 8.”
Background
Advanced glycation end products (AGEs) and its receptor, RAGE, modulate age-dependent COVID-19 morbidity and mortality. A review and hypothesis
Sellegounder, D., Zafari, P., Rajabinejad, M., Taghadosi, M., & Kapahi, P. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107806 · Cited by 70
Role of Advanced Glycation Endproduct (AGE)-Receptor for Advanced Glycation Endproduct (RAGE) Axis in Cardiovascular Disease and Its Therapeutic Intervention
Yamagishi, S. (2019) · Circulation Journal · doi:10.1253/circj.cj-19-0618 · Cited by 62
Self-citation
Relationship between Advanced Glycation End Products and Plaque Progression in Patients with Acute Coronary Syndrome: The JAPAN-ACS Sub-study
Fukushima, Y., Daida, H., Morimoto, T., Kasai, T., Miyauchi, K., Yamagishi, S., Takeuchi, M., Hiro, T., Kimura, T., Nakagawa, Y., et al. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-5 · Cited by 60
“They include heterogeneous molecules such as carboxymethyllysine, pentosidine, and glyceraldehyde-derived AGEs [23-25].”
BackgroundSelf-citation
Diabetes and cancer: Looking at the multiligand/RAGE axis
Armando Rojas, R. (2011) · World Journal of Diabetes · doi:10.4239/wjd.v2.i7.108 · Cited by 52
Serum Levels of Toxic AGEs (TAGE) May Be a Promising Novel Biomarker for the Onset/Progression of Lifestyle-Related Diseases
Takeuchi, M. (2016) · Diagnostics · doi:10.3390/diagnostics6020023 · Cited by 52
Self-citation
Advanced Glycation End Products in Infant Formulas Do Not Contribute to Insulin Resistance Associated with Their Consumption
Klenovics, K. S., Boor, P., Somoza, V., Celec, P., Fogliano, V., & Šebeková, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053056 · Cited by 52
Advanced-Glycation End-Products Induce Podocyte Injury and Contribute to Proteinuria
Nishad, R., Tahaseen, V., Kavvuri, R., Motrapu, M., Singh, A., Peddi, K., & Pasupulati, A. K. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.685447 · Cited by 50
“While in the American cohort circulating CML levels were associated with insulin resistance (HOMA-IR), in the Japanese cohort, no association was found for CML despite AGEs were associated with the HOMA-IR index (30, 39).”
BackgroundMethod
Toxic AGEs (TAGE) theory: a new concept for preventing the development of diseases related to lifestyle
Takeuchi, M. (2020) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-020-00614-3 · Cited by 50
“Furthermore, we found that circulating TAGE levels were independently correlated with the HOMA-IR index in control subjects without DM [94].”
BackgroundSelf-citation
Clinical and Biochemical Factors Associated With Area and Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT
Tahara, N., Yamagishi, S., Kodama, N., Tahara, A., Honda, A., Nitta, Y., Igata, S., Matsui, T., Takeuchi, M., Kaida, H., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3896 · Cited by 45
Self-citation
Circulating and Extracellular Vesicles Levels of N-(1-Carboxymethyl)-L-Lysine (CML) Differentiate Early to Moderate Alzheimer’s Disease
Haddad, M., Perrotte, M., Landri, S., Page, A. Y. L., Fülöp, T., & Ramassamy, C. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181272 · Cited by 44
Association between habitual dietary and lifestyle behaviours and skin autofluorescence (SAF), a marker of tissue accumulation of advanced glycation endproducts (AGEs), in healthy adults
Kellow, N. J., Coughlan, M. T., & Reid, C. M. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1495-y · Cited by 45
“1 3 blood glucose levels are not essential to enhance the rate of glycation [4].”
Propolis in Metabolic Syndrome and Its Associated Chronic Diseases: A Narrative Review
Zulhendri, F., Ravalia, M., Kripal, K., Chandrasekaran, K., Fearnley, J., & Perera, C. O. (2021) · Antioxidants · doi:10.3390/antiox10030348 · Cited by 52
Relationship between advanced glycation end products and gestational diabetes mellitus
Li, S., & Yang, H. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1449201 · Cited by 42
“found that serum levels of AGEs were independently and positively associated with HOMAIR [29].”
BackgroundInfluential
Elevated Serum Levels of Advanced Glycation End Products and their Monocyte Receptors in Patients with Type 2 Diabetes
Su, X., Shou-she, L. I., Tian, Y., Zhang, Z.-Y., Zhang, G., & Wang, L. (2011) · Archives of Medical Research · doi:10.1016/j.arcmed.2011.11.001 · Cited by 42
Total plasma Nε-(carboxymethyl)lysine and sRAGE levels are inversely associated with a number of metabolic syndrome risk factors in non-diabetic young-to-middle-aged medication-free subjects
Šebeková, K., Krivošíková, Z., & Gajdoš, M. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0879 · Cited by 42
The role of advanced glycation end products in human infertility
Zhu, J., Cai, Y.-Q., Long, S.-L., Chen, Z., & Mo, Z. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117830 · Cited by 44
The AGE-RAGE Axis and Its Relationship to Markers of Cardiovascular Disease in Newly Diagnosed Diabetic Patients
Villegas‐Rodríguez, M. E., Uribarri, J., Solorio, S., Fajardo-Araujo, M. E., Cai, W., Torres‐Graciano, S., Rangel-Salazar, R., Wróbel, K., & Garay‐Sevilla, M. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159175 · Cited by 40
“This has been frequently reported in the literature [31].”
Background
Protective effect of hydrogen sulfide on oxidative stress-induced neurodegenerative diseases
Jeong, N., Jung, J., & Tabassum, R. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.265543 · Cited by 40
“AGEs, ROS, type 2 diabetes October 29, 2010 PubMed English 24.”
Influential
Effects of Toxic AGEs (TAGE) on Human Health
Takeuchi, M., Sakai, A., Takata, T., Takino, J.-I., & Koriyama, Y. (2022) · Cells · doi:10.3390/cells11142178 · Cited by 40
“We previously revealed that serum TAGE levels independently correlated with serum levels of sRAGE [89], low-density lipoprotein cholesterol [90], serum pigment epitheliumderived factor, markers of insulin resistance (IR) [91], the homeostatic model assessment of IR (HOMA-IR) index [92], adiponectin (inversely) [93,94]…”
BackgroundSelf-citation
Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD
Takeuchi, M., Takino, J.-I., Sakai, A., Takata, T., & Tsutsumi, M. (2017) · Nutrients · doi:10.3390/nu9060634 · Cited by 41
Self-citation
The AGE-RAGE Axis and the Pathophysiology of Multimorbidity in COPD
Reynaert, N. L., Vanfleteren, L. E. G. W., & Perkins, T. N. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12103366 · Cited by 40
“However, AGEs are not merely a result of the disease, as circulating AGE levels are also associated with insulin resistance in pre-diabetes [234,235].”
Background
Protective role of sulphoraphane against vascular complications in diabetes
Yamagishi, S., & Matsui, T. (2016) · Pharmaceutical Biology · doi:10.3109/13880209.2016.1138314 · Cited by 39
Self-citation
Effects of Two Different Dietary Patterns on Inflammatory Markers, Advanced Glycation End Products and Lipids in Subjects without Type 2 Diabetes: A Randomised Crossover Study
Kim, Y., Keogh, J. B., & Clifton, P. M. (2017) · Nutrients · doi:10.3390/nu9040336 · Cited by 37
“High levels of AGEs have been implicated in insulin resistance in non-obese, non-diabetic subjects [23,24] and in pancreatic beta cell dysfunction in vitro and in vivo [25,26].”
Background
Plasma Advanced Glycation End Products (AGEs), Receptors for AGEs and Their Correlation with Inflammatory Markers in Middle School-Age Children
Accacha, S. D., Rosenfeld, W., Jacobson, A., Michel, L., Schnurr, F. J., Shelov, S. P., Ten, S., Boucher‐Berry, C., Carey, D. E., Speiser, P., et al. (2013) · Hormone Research in Paediatrics · doi:10.1159/000354831 · Cited by 32
Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies
Takeuchi, M. (2014) · World Journal of Hepatology · doi:10.4254/wjh.v6.i12.880 · Cited by 33
Self-citation
Pigment epithelium-derived factor (PEDF) blocks advanced glycation end products (AGEs)-RAGE-induced suppression of adiponectin mRNA level in adipocytes by inhibiting NADPH oxidase-mediated oxidative stress generation
Maeda, S., Matsui, T., Takeuchi, M., & Yamagishi, S. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.08.043 · Cited by 32
Self-citation
Increased serum levels of advanced glycation end-products is associated with severity of sleep disordered breathing but not insulin sensitivity in non-diabetic men with obstructive sleep apnoea
Lam, J. C. M., Tan, K. C. B., Lai, A. Y. K., Lam, D. C.-L., & Ip, M. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2011.07.015 · Cited by 31
“This finding is contrary to a previous study of 322 non-diabetic Japanese subjects, which found that serum AGE level was one of the independent correlates of insulin resistance [43].”
Result
Psoralea corylifoliaL. Seed Extract Attenuates Methylglyoxal-Induced Insulin Resistance by Inhibition of Advanced Glycation End Product Formation
Truong, C.-S., Seo, E., & Jun, H. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4310319 · Cited by 30
Dietary supplementation of inulin alleviates metabolism disorders in gestational diabetes mellitus mice via RENT/AKT/IRS/GLUT4 pathway
Miao, M., Dai, Y., Rui, C., Fan, Y., Wang, X., Fan, C., Mu, J., Hou, W., Dong, Z., Li, P., et al. (2021) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-021-00768-8 · Cited by 30
“Several studies have shown that AGEs are associated with insulin resistance [34, 35], and can induce low-grade inflammation [36] and pancreatic beta cell dysfunction [37].”
Background
Carboxymethyl lysine, an advanced glycation end product, and incident diabetes: a case–cohort analysis of the ARIC Study
Luft, V. C., Duncan, B. B., Schmidt, M. I., Chambless, L. E., Pankow, J. S., Hoogeveen, R. C., Couper, D. J., & HEISS, G. M. (2015) · Diabetic Medicine · doi:10.1111/dme.12963 · Cited by 29
Behaviour and hormonal status in healthy rats on a diet rich in Maillard reaction products with or without solvent extractable aroma compounds
Šebeková, K., Klenovics, K. S., Boor, P., Celec, P., Behuliak, M., Schieberle, P., Heidland, A., Palkovits, M., & Somoza, V. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.10.004 · Cited by 28
“In humans, high intake of dietary MRPs is associated with decreased insulin sensitivity, and circulating AGE levels are directly related to insulin resistance [18–21].”
Background
Development of a monoclonal antibody-based ELISA system for glyceraldehyde-derived advanced glycation end products
Matsui, T., Joo, H. D., Lee, J. M., Ju, S. M., Tao, W. H., Higashimoto, Y., Fukami, K., & Yamagishi, S. (2015) · Immunology Letters · doi:10.1016/j.imlet.2015.08.008 · Cited by 26
Self-citation
Skin advanced glycation end-product accumulation is negatively associated with calcaneal osteo-sono assessment index among non-diabetic adult Japanese men
Momma, H., Niu, K., Kobayashi, Y., Guan, L., Sato, M., Guo, H., Chujo, M., Otomo, A., Yufei, C., Tadaura, H., et al. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1753-4 · Cited by 25
“In non-diabetic Japanese subjects, serum AGE levels were independently correlated with insulin resistance, which may gradually cause diabetes [15].”
Background
Diabetes Mellitus, Arterial Stiffness and Cardiovascular Disease: Clinical Implications and the Influence of SGLT2i
Lamacchia, O., & Sorrentino, M. R. (2020) · Current Vascular Pharmacology · doi:10.2174/1570161118666200317150359 · Cited by 22
Glycation in Alzheimer’s Disease and Type 2 Diabetes: The Prospect of Dual Drug Approaches for Therapeutic Interventions
Ayoub, S., Arabi, M., Al-Najjar, Y. A., Laswi, I., Outeiro, T. F., & Châari, A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05051-9 · Cited by 23
“This association extends to nondiabetic individuals after adjusting for BMI, waist circumference, and hemoglobin A1C, suggesting that AGEs may inﬂuence insulin resistance and overall metabolic health even in those without diabetes [114].”
Sex differences of oxidative stress markers in young healthy subjects are marker-specific in plasma but not in saliva
Tóthová, Ľ., Ostatníková, D., Šebeková, K., Celec, P., & Hodosy, J. (2013) · Annals of Human Biology · doi:10.3109/03014460.2012.754495 · Cited by 21
Serum Levels of sRAGE Are Associated with Body Measurements, but Not Glycemic Parameters in Patients with Prediabetes
Güçlü, M., Ali, A., Eroglu, D. U., Oral, S., Cander, S., & Ocak, N. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0078 · Cited by 20
“For example, Tahara et al. 55 have reported independent correlation be-tween IR and AGEs levels in nondiabetic subjects.”
Association between Advanced Glycation End Products and Impaired Fasting Glucose: Results from the SALIA Study
Teichert, T., Hellwig, A., Peßler, A., Hellwig, M., Vossoughi, M., Sugiri, D., Vierkötter, A., Schulte, T., Freund, J., Roden, M., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0128293 · Cited by 20
Association between the tissue accumulation of advanced glycation end products and exercise capacity in cardiac rehabilitation patients
Kunimoto, M., Shimada, K., Yokoyama, M. N., Matsubara, T., Aikawa, T., Ouchi, S., Shimizu, M., Fukao, K., Miyazaki, T., Kadoguchi, T., et al. (2020) · BMC Cardiovascular Disorders · doi:10.1186/s12872-020-01484-3 · Cited by 19
Correlation among soluble receptors for advanced glycation end-products, soluble vascular adhesion protein-1/semicarbazide-sensitive amine oxidase (sVAP-1) and cardiometabolic risk markers in apparently healthy adolescents: a cross-sectional study
Gurecká, R., Koborová, I., Csongová, M., Šebek, J., & Šebeková, K. (2016) · Glycoconjugate Journal · doi:10.1007/s10719-016-9696-9 · Cited by 18
Phosphatidylglycerol to Treat Chronic Skin Wounds in Diabetes
Luo, Y., Marrero, E. V., Choudhary, V., & Bollag, W. B. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051497 · Cited by 17
“[31] independently conducted clinical studies of 207 (97 males, 110 females) non-obese, non-diabetic subjects and 322 (216 males, 106 females) nondiabetic Japanese subjects, respectively.”
Association of hemoglobin glycation index and its interaction with obesity/family history of hypertension on hypertension risk: a community-based cross-sectional survey
Mi, J., Song, J. H., Zhao, Y., & Wu, X. (2020) · BMC Cardiovascular Disorders · doi:10.1186/s12872-020-01762-0 · Cited by 16
Advanced glycation end products and insulin resistance in diabetic nephropathy
Parwani, K., & Mandal, P. (2024) · Vitamins and hormones · doi:10.1016/bs.vh.2024.02.007 · Cited by 19
Personalized diet study of dietary advanced glycation end products (AGEs) and fatty acid desaturase 2 (FADS2) genotypes in obesity
Mahmoudinezhad, M., Farhangi, M. A., Kahroba, H., & Dehghan, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-99077-3 · Cited by 17
Plant Foods, Healthy Plant-Based Diets, and Type 2 Diabetes: A Review of the Evidence
del Carmen Fernández-Fígares Jiménez, M. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuad099 · Cited by 20
Empagliflozin ameliorates renal and metabolic derangements in obese type 2 diabetic mice by blocking advanced glycation end product–receptor axis
Matsui, T., Sotokawauchi, A., Nishino, Y., Koga, Y., & Yamagishi, S.-I. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01138-0 · Cited by 15
“…the formation of AGEs, while AGE-RAGE-evoked NADPH oxidase-mediated ROS generation further enhances RAGE expression in various tissues (Kaida et al. 2013; Yamagishi and Imaizumi 2005; Yamag-ishi and Matsui 2018; Ide et al. 2010; Tan et al. 2010; Tahara et al. 2010, 2012; Yoshida et al. 2006).”
Self-citation
Advanced glycation end products activated endothelial-to-mesenchymal transition in pancreatic islet endothelial cells and triggered islet fibrosis in diabetic mice
Tsai, P.-S., Chiu, C., Sheu, M., Yang, C., Lan, K., & Liu, S. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109562 · Cited by 15
Distinctive effects of different types of advanced glycation end-products (AGEs) on liver glucose metabolism
Fan, L., Yu, W., Zhang, B., Cao, B., Wang, M., & Hu, X. (2022) · Food & Function · doi:10.1039/d2fo01974d · Cited by 15
Determinants of concentrations of N(ε)-carboxymethyl-lysine and soluble receptor for advanced glycation end products and their associations with risk of pancreatic cancer.
Duan, Z., Chen, G., Chen, L., Stolzenberg‐Solomon, R. Z., Weinstein, S. J., Männistö, S., White, D. L., Albanes, D., & Jiao, L. (2014) · PubMed Central · Cited by 15
Blood and Tissue Advanced Glycation End Products as Determinants of Cardiometabolic Disorders Focusing on Human Studies
Kim, Y. (2023) · Nutrients · doi:10.3390/nu15082002 · Cited by 16
“The association between higher blood circulating AGEs levels and higher insulin resistance was observed [2,3], while other studies [4–6] showed the association between lower blood circulating AGEs levels and higher insulin resistance.”
Result
Effects of sleep restriction on food intake and appetite under free-living conditions: A randomized crossover trial
Tajiri, E., Yoshimura, E., Tobina, T., Yamashita, T., Kume, K., Hatamoto, Y., & Shimoda, S. (2023) · Appetite · doi:10.1016/j.appet.2023.106998 · Cited by 16
Antioxidant and antiglycation activities of traditional plants and identification of bioactive compounds from extracts of Hordeum vulgare by LC–MS and GC–MS
Asif, A., Zeeshan, N., & Mehmood, S. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13381 · Cited by 15
Association of α-Dicarbonyls and Advanced Glycation End Products with Insulin Resistance in Non-Diabetic Young Subjects: A Case-Control Study
Csongová, M., Scheijen, J. L. J. M., van de Waarenburg, M. P. H., Gurecká, R., Koborová, I., Tábi, T., Szökő, É., Schalkwijk, C. G., & Šebeková, K. (2022) · Nutrients · doi:10.3390/nu14224929 · Cited by 12
Mild Chronic Kidney Disease Associated with Greater Risk of Arterial Stiffness in Elderly Adults
Liu, I.-T., Wu, J., Yang, Y., Huang, Y., Lu, F., & Chang, C. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12445 · Cited by 12
“Individuals with diabetes mellitus and prediabetes mellitus have greater insulin resistance,(23) which is positively correlated with the amount of advanced glycation end products.(24) In addition, hyperglycemia itself results in arterial stiffness through the effects of activated proinflammatory transcription factors…”
Background
Increased Arterial Stiffness in Prediabetic Subjects Recognized by Hemoglobin A1c with Postprandial Glucose but Not Fasting Glucose Levels
Li, C., Lu, F.-H., Yang, Y., Wu, J., & Chang, C. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050603 · Cited by 11
“Furthermore, the serum levels of AGEs are positive correlates of insulin resistance [27], which is related to the reduced production of nitric oxide and its related vasodilation [28], post-load hyperinsulinemia-induced oxidative stress [29], decreased endothelial progenitor cells with impaired vascular repair qualitie…”
Background
Impact of Androgen and Dietary Advanced Glycation End Products on Female Rat Liver
Palioura, E., Palimeri, S., Piperi, C., Sakellariou, S., Kandaraki, E., Sergentanis, T. Ν., Levidou, G., Agrogiannis, G. D., Papalois, A. E., Korkolopoulou, P. A., et al. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430400 · Cited by 12
Oral administration of spa-derived green alga improves insulin resistance in overweight subjects: Mechanistic insights from fructose-fed rats
Kaseda, K., Kai, Y., Tajima, M., Suematsu, M., Iwata, S., Miyata, M., Mifude, C., Yamashita, N., Seiryu, W. A., Fukada, M., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104633 · Cited by 11
Self-citation
A Novel Approach: Investigating the Intracellular Clearance Mechanism of Glyceraldehyde-Derived Advanced Glycation End-Products Using the Artificial Checkpoint Kinase 1 d270KD Mutant as a Substrate Model
Takeda, K., Sakai, A., Kajinami, K., & Takeuchi, M. (2023) · Cells · doi:10.3390/cells12242838 · Cited by 10
Self-citation
From diabetes to renal aging: the therapeutic potential of adiponectin
Karamian, M., Moossavi, M., & Hemmati, M. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00790-4 · Cited by 9
Skin Autofluorescence and Carotid Intima-Media Thickness Evaluation Following Bariatric Surgery in Patients with Severe Obesity
Yavuz, D. G., Apaydın, T., İmre, E., Uygur, M. M., & Yazıcı, D. (2020) · Obesity Surgery · doi:10.1007/s11695-020-05077-z · Cited by 9
Serum advanced glycation end products are associated with insulin resistance in male nondiabetic patients with obstructive sleep apnea
Xu, J., Cai, W., Sun, J.-F., Liao, W.-J., Liu, Y., Xiao, J.-R., Zhu, L., Liu, J., & Zhang, W. (2015) · Sleep And Breathing · doi:10.1007/s11325-014-1100-z · Cited by 9
“Several studies in humans showed that serum AGEs were associated with homeostasis model assessment index (HOMA-IR) in subjects with or without diabetes [17, 18].”
Background
The inhibitory effects of endophytic metabolites on glycated proteins under non-communicable disease conditions: A review
Nawaz, M., Afridi, M. N., Ullah, I., Khan, I. A., Ishaq, M. S., Su, Y., Rizwan, H. M., Cheng, K., Zhou, Q., & Wang, M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131869 · Cited by 8
Relationship among urinary advanced glycation‐end products, skeletal muscle mass and physical performance in community‐dwelling older adults
Yang, C., Li, C., Liu, C.-S., Lin, C., Lin, W., Li, T., & Lin, C. (2019) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13762 · Cited by 8
Glyceraldehyde-Derived Pyridinium Evokes Renal Tubular Cell Damage via RAGE Interaction
Sotokawauchi, A., Nakamura, N., Matsui, T., Higashimoto, Y., & Yamagishi, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072604 · Cited by 8
Self-citation
Wasabi leaf supplementation had antioxidant, anti-glycation, and improved skin melanin, spot and moisture
Chiang, H., Lyu, J.-L., Lu, M., Lin, Y.-H., Chan, S.-T., Lin, Y.-K., & Chiang, C. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105398 · Cited by 7
Serum levels of pigment epithelium-derived factor, a novel marker of insulin resistance, are independently associated with fasting apolipoprotein B48 levels in humans
Tahara, N., Yamagishi, S., Tahara, A., Takeuchi, M., & Imaizumi, T. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.07.095 · Cited by 7
Self-citation
Co-treatment with azelinidipine and olmesartan inhibits advanced glycation end products (AGEs) elicited down-regulation of adiponectin mRNA levels in cultured adipocytes partly via its anti-oxidative property
Maeda, S., Matsui, T., Takeuchi, M., & Yamagishi, S. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.10.073 · Cited by 7
Self-citation
Habitual intake of advanced glycation endproducts is not associated with worse insulin sensitivity, worse beta cell function, or presence of prediabetes or type 2 diabetes: The Maastricht Study
Linkens, A. M. A., Eussen, S. J. P. M., Houben, A. J. H. M., Mari, A., Dagnelie, P. C., Stehouwer, C. D. A., & Schalkwijk, C. G. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.05.021 · Cited by 6
Assessment of Total Sugar and Glucose Concentrations in Commonly Consumed Beverages in Japan
Takeuchi, M. (2016) · Nutrition and Food Technology Open Access · doi:10.16966/2470-6086.106 · Cited by 6
“We recently indicated that serum levels of TAGE, but not those of hemoglobin A1c (HbA1c), glucose-derived AGEs (Glu-AGEs), or Nε(carboxymethyl)lysine (CML), a representative AGE compound found in food, may be used as a biomarker to predict the progression of lifestylerelated diseases [21-25].”
BackgroundResultSelf-citation
The contribution of adiponectin to diabetic retinopathy progression: Association with the AGEs-RAGE pathway
Fu, M., Zhengran, L., Li, Y., Tong, W., Liyang, C., Xi, G., Yang, X., Cao, M., & Yi, G. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36111 · Cited by 5
“RAGE exists in two other forms: a soluble form that circulates in the blood and an alternatively spliced isoform known as endogenous secreted RAGE (esRAGE), which lacks the NF-κ B domain and acts as a decoy receptor rather than inducing inflammation [14,15].”
Background
Altered Inflammatory Mediators in Fibromyalgia
García, J. J., Gil, J. C., Olea, A. H., & Gómez-Galán, R. (2017) · Journal of Ancient Diseases & Preventive Remedies · doi:10.4172/2329-8731.1000215 · Cited by 5
26. Advanced glycation end products in infant formulas
Šebeková, K., Klenovics, K. S., & Šebeková, K. (2014) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-223-8_26 · Cited by 5
Gallstone disease associated with increased risk of arterial stiffness in a Taiwanese population
Wang, J.-Y., Lu, F.-H., Sun, Z.-J., Wu, J.-S., Yang, Y.-C., Lee, C. T., & Chang, C.-J. (2017) · Journal of Human Hypertension · doi:10.1038/jhh.2017.43 · Cited by 5

Authors: Tahara, N., Yamagishi, S., Matsui, T., Takeuchi, M., Nitta, Y., Kodama, N., Mizoguchi, M., & Imaizumi, T.
Affiliations: Kurume University (JP)
Hokuriku University (JP)
Corresponding author: Tahara, Nobuhiro
ORCID: Tahara, Nobuhiro
Yamagishi, Sho‐ichi
Matsui, Takanori
Takeuchi, Masayoshi
Venue: Cardiovascular Therapeutics
Publisher: Wiley
Published: 2012-01-26
Volume: 30
Issue: 1
Pages: 42-48
ISSN: 1755-5914 (ISSN-L)
1755-5922
DOI: 10.1111/j.1755-5922.2010.00177.x
OpenAlex: W1509582521
Cited by: 116
References: 37
Citations by year: 2026: 2 · 2025: 2 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 10 · 2020: 14 · 2019: 7 · 2018: 2 · 2017: 6 · 2016: 6 · 2015: 18 · 2014: 5 · 2013: 11 · 2012: 6
FWCI: 5.42
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Cardiovascular Therapeutics (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science (23591072, 22300264)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: advanced glycation end products, insulin resistance, non-diabetic adults, HOMA-IR, waist circumference, HbA1c, triglycerides, oxidative stress, inflammation, C-reactive protein, uric acid, LDL cholesterol, HDL cholesterol, diastolic blood pressure, creatinine clearance
MeSH terms: Aged, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, Humans, Insulin Resistance, Japan, Male, Middle Aged, Regression Analysis, Risk Factors, Biomarkers, Multivariate Analysis, Glycation End Products, Advanced, Risk Assessment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Serum Levels of Advanced Glycation End Products (AGEs) are Independent Correlates of Insulin Resistance in Nondiabetic Subjects

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks