Circulating Glycotoxins and Dietary Advanced Glycation Endproducts: Two Links to Inflammatory Response, Oxidative Stress, and Aging
Open accessAbstract
BACKGROUND: Oxidative stress (OS) and inflammatory mediators increase with aging. The levels of advanced glycation endproducts (AGEs), prooxidant factors linked to chronic diseases such as diabetes, cardiovascular disease, and renal disease, also increase with aging. AGEs are readily derived from heat-treated foods. We propose that the excess consumption of certain AGEs via the diet enhances OS and inflammatory responses in healthy adults, especially in elderly persons. METHODS: We examined 172 young (<45 years old) and older (>60 years old) healthy individuals to determine whether the concentration of specific serum AGEs (N(epsilon)-carboxymethyl-lysine [CML] or methylglyoxal [MG] derivatives) were higher in older compared to younger persons and whether, independent of age, they correlated with the intake of dietary AGEs, as well as with circulating markers of OS and inflammation. RESULTS: Body weight, body mass index (BMI), and serum AGE, CML, and MG derivatives were higher in older participants, independent of gender. Serum CML correlated with levels of 8-isoprostanes (r = 0.448, p =.0001) as well as with Homeostasis Model Assessment index (HOMA), an index of insulin resistance (r = 0.247, p =.044). The consumption of dietary AGEs, but not of calories, correlated independently with circulating AGEs (CML: r = 0.415, p =.0001 and MG: r = 0.282, p =.002) as well as with high sensitivity C-reactive protein (hsCRP) (r = 0.200, p =.042). CONCLUSIONS: Circulating indicators of AGEs (CML and MG derivatives), although elevated in older participants, correlate with indicators of inflammation and OS across all ages. Indicators of both AGEs and OS are directly influenced by the intake of dietary AGEs, independent of age or energy intake. Thus, reduced consumption of these oxidants may prove a safe economic policy to prevent age-related diseases, especially in an aging population.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The pathological implications of AGEs are ascribed to their ability to promote oxidative stress, inflammation, and apoptosis.
“The pathological implications of AGEs are ascribed to their ability to promote oxidative stress, inflammation, and apoptosis.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [3]
The amounts of AGEs in exogenous sources are usually much higher than those of endogenously produced AGEs.
“The amounts of AGEs in exogenous sources are usually much higher than those of endogenously produced AGEs2–4,24.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [3]
Intake of foods and/or beverages with high levels of exogenous AGEs likely creates more health problems than endogenously produced AGEs.
“Thus, it is likely that the intake of foods and/or beverages with high levels of exogenous AGEs create more health problems than endogenously produced AGEs, although both exogenous and endogenous AGEs are similar in their biological functions and potentially act synergistically to stimulate oxidative stress, inflammation, and cellular damage, contributing to detrimental pathophysiology2–4,24.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [3]
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,769 · see citing works
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315 · see citing works
Gupta, A., & Uribarri, J. (2016) · Hormone Research in Paediatrics · doi:10.1159/000444053 · Cited by 4,019 · see citing works
Self-citationInflammation in Atherosclerosis
Libby, P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179705 · Cited by 3,748 · see citing works
Assessing Kidney Function — Measured and Estimated Glomerular Filtration Rate
Stevens, L. A., Coresh, J., Greene, T., & Levey, A. S. (2006) · New England Journal of Medicine · doi:10.1056/nejmra054415 · Cited by 2,952 · see citing works
Stadtman, E. R. (1992) · Science · doi:10.1126/science.1355616 · Cited by 2,701 · see citing works
Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
Baynes, J. W., & Thorpe, S. R. (1999) · Diabetes · doi:10.2337/diabetes.48.1.1 · Cited by 2,441 · see citing works
Advanced Glycation End Products: Sparking the Development of Diabetic Vascular Injury
Goldin, A., Beckman, J. A., Schmidt, A. M., & Creager, M. A. (2006) · Circulation · doi:10.1161/circulationaha.106.621854 · Cited by 2,261 · see citing works
Keaney, J. F., Larson, M. G., Vasan, R. S., Wilson, P. W. F., Lipinska, I., Corey, D., Massaro, J. M., Sutherland, P., Vita, J. A., & Benjamin, E. J. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000058402.34138.11 · Cited by 1,304 · see citing works
Pickup, J. C., Mattock, M. B., Chusney, G. D., & Burt, D. J. (1997) · Diabetologia · doi:10.1007/s001250050822 · Cited by 1,241 · see citing works
Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE
Wautier, M., Chappey, O., Corda, S., Stern, D. M., Schmidt, A. M., & Wautier, J. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e685 · Cited by 1,076 · see citing works
Stadtman, E. R. (2006) · Free Radical Research · doi:10.1080/10715760600918142 · Cited by 1,056 · see citing works
Protein Glycation, Diabetes, and Aging
Ulrich, P. C. (2001) · Recent Progress in Hormone Research · doi:10.1210/rp.56.1.1 · Cited by 810 · see citing works
Koschinsky, T., He, C.-J., Mitsuhashi, T., Bucala, R., Liu, C., Buenting, C., Heitmann, K., & Vlassara, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6474 · Cited by 792 · see citing works
Self-citationAdvanced glycoxidation end products in commonly consumed foods
Goldberg, T., Cai, W., Peppa, M., Dardaine, V., Baliga, B. S., Uribarri, J., & Vlassara, H. (2004) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2004.05.214 · Cited by 744 · see citing works
Self-citationVlassara, H., Cai, W., Crandall, J., Goldberg, T., Oberstein, R., Dardaine, V., Peppa, M., & Rayfield, E. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242407999 · Cited by 668 · see citing works
Self-citationGlycoxidation and lipoxidation in atherogenesis
Baynes, J., & Thorpe, S. R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00228-8 · Cited by 515 · see citing works
Yan, S. F., Ramasamy, R., Naka, Y., & Schmidt, A. M. (2003) · Circulation Research · doi:10.1161/01.res.0000103862.26506.3d · Cited by 513 · see citing works
Immunochemical detection of advanced glycosylation end products in vivo.
Makita, Z., Vlassara, H., Cerami, A., & Bucala, R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42741-x · Cited by 491 · see citing works
Self-citationNutritional and toxicological aspects of the Maillard browning reaction in foods
O'Brien, J., Morrissey, P. A., & Ames, J. M. (1989) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398909527499 · Cited by 477 · see citing works
Gopaul, N. K., Änggård, E. E., Mallet, A. I., Betteridge, D. J., Wolff, S. P., & Nourooz-Zadeh, J. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00649-t · Cited by 390 · see citing works
Methylglyoxal Modification of Protein
Oya, T., Hattori, N., Mizuno, Y., Miyata, S., Maeda, S., Osawa, T., & Uchida, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18492 · Cited by 374 · see citing works
Uribarri, J., Peppa, Μ., Cai, W., Goldberg, T., Lu, M. M., He, C., & Vlassara, H. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000051593.41395.b9 · Cited by 331 · see citing works
Self-citationTHORPE SR ROLE OF OXIDATIVE STRESS IN DIABETIC COMPLICATIONS: A NEW PERSPECTIVE ON AN OLD PARADIGM
Baynes, J. (1999) · Cited by 326 · see citing works
Hofmann, S. M., Dong, H. H., Li, Z., Cai, W., Altomonte, J., Thung, S. N., Zeng, F., Fisher, E. A. A., & Vlassara, H. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2082 · Cited by 296 · see citing works
Self-citationStirban, A. O., Negrean, M., Stratmann, B., Gawlowski, T., Horstmann, T., Götting, C., Kleesiek, K., Müller-Rösel, M., Koschinsky, T., Uribarri, J., et al. (2006) · Diabetes Care · doi:10.2337/dc06-0531 · Cited by 258 · see citing works
Self-citationCai, W., Gao, Q.-D., Zhu, L., Peppa, Μ., He, C., & Vlassara, H. (2002) · Molecular Medicine · doi:10.1007/bf03402014 · Cited by 235 · see citing works
Self-citationDiabetes, Hyperglycemia, and Inflammation in Older Individuals
de Rekeneire, N., Peila, R., Ding, J., Colbert, L. H., Visser, M., Shorr, R. I., Kritchevsky, S. B., Kuller, L. H., Strotmeyer, E. S., Schwartz, A. V., et al. (2006) · Diabetes Care · doi:10.2337/dc05-2327 · Cited by 230 · see citing works
Glycation and oxidation: A role in the pathogenesis of atherosclerosis
Lyons, T. J. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90142-y · Cited by 221 · see citing works
Insulin Resistance and Type 2 Diabetes in High-Fat–Fed Mice Are Linked to High Glycotoxin Intake
Sandu, O. A., Song, K., Cai, W., Zheng, F., Uribarri, J., & Vlassara, H. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2314 · Cited by 213 · see citing works
Self-citationReviewIsoprostanes: Novel Bioactive Products of Lipid Peroxidation
Basu, S. (2003) · Free Radical Research · doi:10.1080/10715760310001646895 · Cited by 211 · see citing works
Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products
Zheng, F., He, C., Cai, W., Hattori, M., Steffes, M. W., & Vlassara, H. (2002) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.283 · Cited by 207 · see citing works
Self-citationCouillard, C., Ruel, G., Archer, W., Pomerleau, S., Bergeron, J., Couture, P., Lamarche, B., & Bergeron, N. (2005) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2004-2438 · Cited by 204 · see citing works
Overview: Renal Physiology and Pathophysiology of Aging
Lindeman, R. D. (1990) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)80002-3 · Cited by 193 · see citing works
He, C., Sabol, J., Mitsuhashi, T., & Vlassara, H. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1308 · Cited by 191 · see citing works
Cai, W., He, J. C., Zhu, L., Peppa, M., Lu, C., Uribarri, J., & Vlassara, H. (2004) · Circulation · doi:10.1161/01.cir.0000135587.92455.0d · Cited by 177 · see citing works
Self-citationReduced Oxidant Stress and Extended Lifespan in Mice Exposed to a Low Glycotoxin Diet
Cai, W., He, C., Zhu, L., Chen, X., Wallenstein, S. R., Striker, G. E., & Vlassara, H. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061281 · Cited by 175 · see citing works
Self-citationAdverse effects of dietary glycotoxins on wound healing in genetically diabetic mice
Peppa, M., Brem, H., Ehrlich, P., Zhang, J.-G., Cai, W., Li, Z., Croitoru, A., Thung, S., & Vlassara, H. (2003) · Diabetes · doi:10.2337/diabetes.52.11.2805 · Cited by 153 · see citing works
Self-citationAhmed, N., & Thornalley, P. J. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311417 · Cited by 152 · see citing works
Hyperinsulinemia: the missing link among oxidative stress and age-related diseases?
Facchini, F. S., Hua, N. W., Reaven, G. M., & Stoohs, R. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00438-x · Cited by 134 · see citing works
Fetal or Neonatal Low-Glycotoxin Environment Prevents Autoimmune Diabetes in NOD Mice
Peppa, Μ., He, C., Hattori, M., McEvoy, R. C., Zheng, F., & Vlassara, H. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1441 · Cited by 129 · see citing works
Self-citationKilhovd, B. K., Juutilainen, A., Lehto, S., Rönnemaa, T., Torjesen, P. A., Birkeland, K. I., Berg, T. J., Hanssen, K. F., & Laakso, M. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000158380.44231.fe · Cited by 122 · see citing works
Historical Perspective of the Maillard Reaction in Food Science
Finot, P. A. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.001 · Cited by 121 · see citing works
Glycoxidation and inflammation in renal failure patients
Peppa, Μ., Uribarri, J., Cai, W., Lu, M. M., & Vlassara, H. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2003.11.022 · Cited by 117 · see citing works
Self-citationLin, R.-Y., Reis, E. D., Dore, A. T., Lu, M., Ghodsi, N., Fallon, J. T., Fisher, E. A., & Vlassara, H. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00008-4 · Cited by 109 · see citing works
Self-citationDiabetes, Inflammation, and Functional Decline in Older Adults
Figaro, M. K., Kritchevsky, S. B., Resnick, H. E., Shorr, R. I., Butler, J., Shintani, A., Penninx, B. W. J. H., Simonsick, E. M., Goodpaster, B. H., Newman, A. B., et al. (2006) · Diabetes Care · doi:10.2337/dc06-0245 · Cited by 91 · see citing works
Katoh, S., Lehtovirta, M., Kaprio, J. A., Harjutsalo, V., Koskenvuo, M. J., Eriksson, J. G., Tajima, N., & Tuomilehto, J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2471 · Cited by 25 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Advanced glycation end products in foods and a practical guide to their reduction in the diet
Uribarri, J., Woodruff, S., Goodman, S., Cai, W., Chen, X., Pyzik, R., Yong, A., Striker, G. E., & Vlassara, H. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.03.018 · Cited by 1,289 · see citing works
Self-citationDietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T. (2015) · Biomolecules · doi:10.3390/biom5010194 · Cited by 1,095 · see citing works
Advanced glycation endproducts in food and their effects on health
Poulsen, M. W., Hedegaard, R. V., Andersen, J. M., de Courten, B., Bügel, S., Nielsen, J., Skibsted, L. H., & Dragsted, L. O. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.052 · Cited by 751 · see citing works
Advanced Glycation End Products (AGE) and Diabetes: Cause, Effect, or Both?
Vlassara, H., & Uribarri, J. (2014) · Current Diabetes Reports · doi:10.1007/s11892-013-0453-1 · Cited by 594 · see citing works
Self-citationPerrone, A., Giovino, A., Benny, J., & Martinelli, F. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3818196 · Cited by 459 · see citing works
Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works
“Ethanol metabolism primarily occurs in the liver in three major steps: (1) ethanol oxidation to acetaldehyde, (2) acetaldehyde metabolism to acetate, and (3) acetate catabolism to H2O and CO2 .”
BackgroundDietary Advanced Glycation End Products and Aging
Luevano-Contreras, C., & Chapman-Novakofski, K. (2010) · Nutrients · doi:10.3390/nu2121247 · Cited by 396 · see citing works
The western diet and lifestyle and diseases of civilization
Carrera-Bastos, P., Fontes, O'Keefe, Lindeberg, & Cordain (2011) · Research Reports in Clinical Cardiology · doi:10.2147/rrcc.s16919 · Cited by 342 · see citing works
AGE restriction in diabetes mellitus: a paradigm shift
Vlassara, H., & Striker, G. E. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.74 · Cited by 277 · see citing works
Self-citationDietary advanced glycation end products and their relevance for human health
Nowotny, K., Schröter, D., Schreiner, M., & Grune, T. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.06.005 · Cited by 255 · see citing works
Donato, A. J., Black, A. D., Jablonski, K. L., Gano, L. B., & Seals, D. R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00438.x · Cited by 237 · see citing works
The human tri-peptide GHK and tissue remodeling
Pickart, L. (2008) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856208784909435 · Cited by 218 · see citing works
Fernando, D. H., Forbes, J. M., Angus, P. W., & Herath, C. B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205037 · Cited by 184 · see citing works
Kumar Pasupulati, A., Chitra, P. S., & Reddy, G. B. (2016) · Biomolecular Concepts · doi:10.1515/bmc-2016-0021 · Cited by 163 · see citing works
Inhibition of Protein Glycation by Extracts of Culinary Herbs and Spices
Dearlove, R. P., Greenspan, P., Hartle, D. K., Swanson, R. B., & Hargrove, J. L. (2008) · Journal of Medicinal Food · doi:10.1089/jmf.2007.536 · Cited by 157 · see citing works
Yacoub, R., Nugent, M., Cai, W., Nadkarni, G. N., Chaves, L. D., Abyad, S., Honan, A. M., Thomas, S. A., Zheng, W., Valiyaparambil, S. A., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0184789 · Cited by 139 · see citing works
Self-citationRole of advanced glycation end products in carcinogenesis and their therapeutic implications
Schröter, D., & Höhn, A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190130145549 · Cited by 126 · see citing works
Tahara, N., Yamagishi, S., Matsui, T., Takeuchi, M., Nitta, Y., Kodama, N., Mizoguchi, M., & Imaizumi, T. (2012) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00177.x · Cited by 116 · see citing works
Serum advanced glycation end products (AGEs) are associated with insulin resistance
Tan, K. C. B., Shiu, S. W. M., Wong, Y., & Tam, X. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1188 · Cited by 111 · see citing works
Nutrition and AGE‐ing: Focusing on Alzheimer’s Disease
Abate, G., Marziano, M., Rungratanawanich, W., Memo, M., & Uberti, D. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7039816 · Cited by 103 · see citing works
Coenzyme Q<sub>10</sub>: From bench to clinic in aging diseases, a translational review
Gutierrez-Mariscal, F. M., Yubero-Serrano, E. M., Villalba, J. M., & Lopez-Miranda, J. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1442316 · Cited by 92 · see citing works
Dietary glycotoxins exacerbate progression of experimental fatty liver disease
Leung, C., Herath, C. B., Jia, Z., Goodwin, M., Mak, K. Y., Watt, M. J., Forbes, J. M., & Angus, P. W. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.11.033 · Cited by 88 · see citing works
Hoeijmakers, L., Heinen, Y., van Dam, A.-M., Lucassen, P. J., & Korosi, A. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00398 · Cited by 85 · see citing works
Plasma advanced glycation end products are decreased in obese children compared with lean controls
Šebeková, K., Somoza, V., Jarčušková, M., Heidland, A., & Podracká, L. (2009) · International Journal of Pediatric Obesity · doi:10.1080/17477160802248039 · Cited by 82 · see citing works
Maternally Transmitted and Food-Derived Glycotoxins
Mericq, V., Piccardo, C., Cai, W., Chen, X., Zhu, L., Striker, G. E., Vlassara, H., & Uribarri, J. (2010) · Diabetes Care · doi:10.2337/dc10-1058 · Cited by 82 · see citing works
Self-citationRaghav, A., Ahmad, J., & Alam, K. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.07.033 · Cited by 15 · see citing works
- Authors
- Uribarri, J., Cai, W., Peppa, M., Goodman, S., Ferrucci, L., Striker, G., & Vlassara, H.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- National Institutes of Health (US)
- Corresponding author
- Uribarri, J.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04-01
- Volume
- 62
- Issue
- 4
- Pages
- 427-433
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC2645629
- OpenAlex
- W2095847921
- Cited by
- 570
- References
- 50
- Citations by year
- 2026: 14 · 2025: 33 · 2024: 37 · 2023: 37 · 2022: 39 · 2021: 34 · 2020: 27 · 2019: 27 · 2018: 39 · 2017: 33 · 2016: 33 · 2015: 32 · 2014: 30 · 2013: 30 · 2012: 27
- FWCI
- 15.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 AG999999)
- National Institute on Aging (AG23188, R37AG023188, AG09453, R01AG009453)
- National Center for Research Resources (M01RR000071)
- NIH Clinical Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- advanced glycation end products, dietary AGEs, carboxymethyllysine, methylglyoxal, oxidative stress, inflammation, aging, insulin resistance, C-reactive protein, 8-isoprostane, heat-treated foods, older adults, age-related diseases
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, C-Reactive Protein, Energy Intake, Diet, Female, Humans, Inflammation, Insulin Resistance, Lysine, Male, Middle Aged, Pyruvaldehyde, Dinoprost, Glycation End Products, Advanced, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
