The effects of probiotics, prebiotics and synbiotics on the reduction of IBD complications, a periodic review during 2009–2020
Abstract
AIMS: To perform a systematic review on randomized controlled trials to examine the efficacy of probiotics, prebiotics and synbiotics in the treatment of IBD. METHODS AND RESULTS: PubMed, Web of science, Scopus and Google Scholar were systematically searched from January 2009 to January 2020 using the following keywords: 'Inflammatory Bowel Disease', 'Probiotics' and 'Clinical trial'. The statistical analysis was performed using SPSS software version 24.0. A total of 1832 articles were found during the initial search and 21 clinical trials were eligible. Studies comparing the effects of probiotics and placebo among patients with active ulcerative colitis (UC) showed a significant difference in clinical outcomes. Moreover, probiotics improved the overall induction of remission rates among patients with Crohn's disease (CD). Probiotics significantly decreased the IL-1β, TNF-α and IL-8 levels. Also, the need for systemic steroids, hospitalization, surgery, as well as histological score and disease activity index significantly decreased in patients who used probiotic or pro-/synbiotics. CONCLUSIONS: The use of probiotics, as food supplements, can induce anti-inflammatory reactions, balance the intestinal homeostasis and induce remission in IBD. The efficacy of probiotics on remission induction is more reported in UC rather than CD. Larger well-designed clinical trials are needed to further determine whether probiotics are of clear benefits for remission in IBD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several pre-clinical and clinical studies have shown a promising role of probiotics for IBD, particularly for ulcerative colitis and pouchitis.
“Several pre‐clinical and clinical studies have shown the promising role of probiotics for IBD, particularly for UC and pouchitis. 6 , 7”
From Efficacy and safety of probiotics in IBD: An overview of systematic reviews and updated meta-analysis of randomized controlled trials. (2024) · cites this paper as [7]
Six recent meta-analyses showed that probiotic strains induce remission in IBD, with much evidence of efficacy for ulcerative colitis but less evidence for Crohn's disease.
“although six recent meta-analyses [114,115,116,117,118] showed that probiotic strains induce remission in IBD, with much evidence of efficacy for ulcerative colitis (UC) but less evidence for Crohn’s disease (CD) [116,117].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [116]
Cites
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659 · see citing works
Impacts of gut bacteria on human health and diseases
Zhang, Y.-J., Li, S., Gan, R.-Y., Zhou, T., Xu, D.-P., & Li, H.-B. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16047493 · Cited by 1,055 · see citing works
Rachmilewitz, D., Katakura, K., Karmeli, F., Hayashi, T., Reinus, C., Rudensky, B., Akira, S., Takeda, K., Lee, J., Takabayashi, K., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.019 · Cited by 859 · see citing works
The gut microbiota and inflammatory bowel disease
Matsuoka, K., & Kanai, T. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-014-0454-4 · Cited by 804 · see citing works
Khan, I., Ullah, N., Zha, L., Bai, Y., Khan, A., Zhao, T., Che, T., & Zhang, C. (2019) · Pathogens · doi:10.3390/pathogens8030126 · Cited by 771 · see citing works
VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis
Bibiloni, R., Fedorak, R. N., Tannock, G. W., Madsen, K. L., Gionchetti, P., Campieri, M., Simone, C. D., & Sartor, R. B. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41794.x · Cited by 743 · see citing works
Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice
Li, J., Sung, C. Y. J., Lee, N. P. Y., Ni, Y., Pihlajamäki, J., Panagiotou, G., & El-Nezami, H. S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518189113 · Cited by 624 · see citing works
Safety of Probiotics That Contain Lactobacilli or Bifidobacteria
Borriello, S. P., Hammes, W. P., Holzapfel, W. H., Marteau, P. R., Schrezenmeir, J., Vaara, M., & Valtonen, V. (2003) · Clinical Infectious Diseases · doi:10.1086/368080 · Cited by 550 · see citing works
Immunomodulatory Effects of Probiotics on Cytokine Profiles
Azad, M. A. K., Sarker, M., & Wan, D. (2018) · BioMed Research International · doi:10.1155/2018/8063647 · Cited by 521 · see citing works
Miele, E., Pascarella, F., Giannetti, E., Quaglietta, L., Baldassano, R. N., & Staiano, A. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.118 · Cited by 517 · see citing works
Sood, A., Midha, V., Makharia, G. K., Ahuja, V., Singal, D., Goswami, P., & Tandon, R. K. (2009) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2009.07.016 · Cited by 513 · see citing works
Tursi, A., Brandimarte, G., Papa, A., Giglio, A., Elisei, W., Giorgetti, G. M., Forti, G., Morini, S., Hassan, C., Pistoia, M. A., et al. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.218 · Cited by 489 · cited 2× · see citing works
“Moreover, two trials (Sood et al.2009; Tursi et al.2010) supported the idea that the use of VSL”
BackgroundEfficacy of Lactobacillus GG in maintaining remission of ulcerative colitis
Zocco, M. A., Verme, L. Z. D., Cremonini, F., Piscaglia, A. C., Nista, E. C., Candelli, M., Novi, M., Rigante, D., Cazzato, I. A., Ojetti, V., et al. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02927.x · Cited by 472 · see citing works
Kleerebezem, M., & Vaughan, E. E. (2009) · Annual Review of Microbiology · doi:10.1146/annurev.micro.091208.073341 · Cited by 315 · see citing works
Ganji‐Arjenaki, M., & Rafieian‐Kopaei, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25911 · Cited by 314 · see citing works
Dupont, A. W., Richards, Jelinek, K. A., Krill, J. T., Rahimi, E. F., & Ghouri, Y. A. (2014) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s27530 · Cited by 303 · see citing works
Lammers, K. M., Brigidi, P., Vitali, B., Gionchetti, P., Rizzello, F., Caramelli, E., Matteuzzi, D., & Campieri, M. (2003) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(03)00144-5 · Cited by 282 · see citing works
Oliva, S., Nardo, G. D., Ferrari, F., Mallardo, S., Rossi, P., Patrizi, G., Cucchiara, S., & Stronati, L. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04939.x · Cited by 280 · see citing works
Gastrointestinal effects of prebiotics
Cummings, J. H., & Macfarlane, G. T. (2002) · British Journal Of Nutrition · doi:10.1079/bjn/2002530 · Cited by 280 · see citing works
Gastrointestinal effects of prebiotics
J.H.*, C., & Macfarlane, G. T. (2002) · British Journal Of Nutrition · doi:10.1079/bjnbjn/2002530 · Cited by 278 · see citing works
Steed, H., Macfarlane, G. T., Blackett, K. L., Bahrami, B., Reynolds, N., Walsh, S., Cummings, J. H., & Macfarlane, S. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04417.x · Cited by 247 · see citing works
Technology aspects related to microorganisms in functional foods
Knorr, D. (1998) · Trends in Food Science & Technology · doi:10.1016/s0924-2244(98)00051-x · Cited by 235 · see citing works
Bjarnason, I., Sission, G., & Hayee, B. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00595-4 · Cited by 209 · see citing works
Bienert, M., Plange, N., Remky, A., Arend, O., & Kuerten, D. (2018) · BioMed Research International · doi:10.1155/2018/4756313 · Cited by 207 · see citing works
Takahashi, H., Arimura, Y., Okahara, S., Kodaira, J., Hokari, K., Tsukagoshi, H., Shinomura, Y., & Hosokawa, M. (2015) · BMC Gastroenterology · doi:10.1186/s12876-014-0226-6 · Cited by 205 · see citing works
Probiotics for maintenance of remission in ulcerative colitis
Iheozor‐Ejiofor, Z., Kaur, L., Gordon, M. A., Baines, P. A., Sinopoulou, V., & Akobeng, A. K. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007443.pub3 · Cited by 193 · see citing works
Yılmaz, İ., Dolar, M. E., & Özpınar, H. (2019) · Turkish Journal of Gastroenterology · doi:10.5152/tjg.2018.18227 · Cited by 193 · see citing works
Saccharomyces boulardii Does Not Prevent Relapse of Crohn's Disease
Bourreille, A., Cadiot, G., Dréau, G. L., Laharie, D., Beaugerie, L., Dupas, J., Marteau, P. R., Rampal, P., Moyse, D., Saleh, A., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.02.021 · Cited by 186 · see citing works
The Antimicrobial Properties of Different Strains of Lactobacillus spp. Isolated from Kefir
Santos, A., San Mauro, M., Sanchez, A., Torres, J. M., & Marquina, D. (2003) · Systematic and Applied Microbiology · doi:10.1078/072320203322497464 · Cited by 183 · see citing works
Shen, B., Brzezinski, A., Fazio, V. W., Remzi, F. H., Achkar, J.-P., Bennett, A. E., Sherman, K. K., & Lashner, B. A. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02642.x · Cited by 173 · see citing works
Probiotic Modulation of Innate Cell Pathogen Sensing and Signaling Events
Llewellyn, A., & Foey, A. (2017) · Nutrients · doi:10.3390/nu9101156 · Cited by 171 · see citing works
Probiotics for prevention of Clostridium difficile infection
Mills, J., Rao, K. K., & Young, V. B. (2017) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000410 · Cited by 162 · see citing works
Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders
Currò, D., Ianiro, G., Pecere, S., Bibbò, S., & Cammarota, G. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13632 · Cited by 160 · see citing works
Drug Insight: aminosalicylates for the treatment of IBD
Nielsen, O. H., & Munck, L. K. (2007) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0696 · Cited by 158 · see citing works
Probiotics for induction of remission in ulcerative colitis
Kaur, L., Gordon, M. A., Baines, P. A., Iheozor‐Ejiofor, Z., Sinopoulou, V., & Akobeng, A. K. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005573.pub3 · Cited by 148 · see citing works
Huynh, H. Q., deBruyn, J. C. C., Guan, L. L., Díaz, H., Li, M., Girgis, S., Turner, J. M., Fedorak, R. N., & Madsen, K. L. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20816 · Cited by 147 · see citing works
Ng, S. C., Plamondon, S., Kamm, M. A., Hart, A. L., Al-Hassi, H. O., Guenther, T., Stagg, A. J., & Knight, S. C. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21222 · Cited by 147 · see citing works
Wildt, S., Nordgaard, I., Hansen, U., Brockmann, E., & Rumessen, J. J. (2011) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2010.11.004 · Cited by 141 · see citing works
Yoshimatsu, Y., Yamada, A., Furukawa, R., Sono, K., Osamura, A., Nakamura, K., Aoki, H., Tsuda, Y., Hosoe, N., Takada, N., et al. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i19.5985 · Cited by 137 · see citing works
The long-term effects of probiotics in the therapy of ulcerative colitis: A clinical study
Palumbo, V. D., Romeo, M., Marino, A., Carini, F., Damiani, P., Damiano, G., Buscemi, S., Monte, A. I. L., Geagea, A. G., Jurjus, A. R., et al. (2016) · Biomedical Papers · doi:10.5507/bp.2016.044 · Cited by 130 · see citing works
Efficacy of Bifidobacterium breve fermented milk in maintaining remission of ulcerative colitis
Matsuoka, K., Uemura, Y., Kanai, T., Kunisaki, R., Suzuki, Y., Yokoyama, K., Yoshimura, N., & Hibi, T. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-4946-2 · Cited by 128 · see citing works
I.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life
Lorenzo‐Zúñiga, V. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i26.8709 · Cited by 120 · see citing works
Immunomodulatory effects of probiotics: Can they be used to treat allergies and autoimmune diseases?
Dargahi, N., Johnson, J., Donkor, O. N., Vasiljevic, T., & Apostolopoulos, V. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.11.002 · Cited by 118 · see citing works
Animal models of IBD: linkage to human disease
Mizoguchi, A., & Mizoguchi, E. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.05.007 · Cited by 114 · see citing works
Probiotic viability–does it matter?
Lahtinen, S. J. (2012) · Microbial Ecology in Health & Disease · doi:10.3402/mehd.v23i0.18567 · Cited by 107 · see citing works
Renata D'Incà, Barollo, M., Scarpa, M., Grillo, A. R., Brun, P., Vettorato, M. G., Castagliuolo, I., & Sturniolo, G. C. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1384-1 · Cited by 99 · see citing works
Shadnoush, M., Hosseini, R. S., Khalilnezhad, A., Navai, L., Goudarzi, H., & Vaezjalali, M. (2015) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2015.65.4.215 · Cited by 98 · see citing works
Enhanced anti-inflammatory effects of a nitric oxide–releasing derivative of mesalamine in rats
Wallace, J. L., Vergnolle, N., Muscará, M. N., Asfaha, S., Chapman, K., McKnight, W., Soldato, P. D., Morelli, A., & Fiorucci, S. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70448-8 · Cited by 96 · see citing works
Bengmark, S. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.05.002 · Cited by 86 · see citing works
Mezzasalma, V., Manfrini, E., Ferri, E., Sandionigi, A., La Ferla, B., Schiano, I., Michelotti, A., Nobile, V., Labra, M., & Di Gennaro, P. (2016) · BioMed Research International · doi:10.1155/2016/4740907 · Cited by 81 · see citing works
Shadnoush, M., Hosseini, R. S., Mehrabi, Y., Delpisheh, A., Alipoor, E., Faghfoori, Z., Mohammadpour, N., & Zaringhalam, J. (2013) · Europe PMC (PubMed Central) · Cited by 80 · see citing works
Prebiotics and Synbiotics in Clinical Medicine
Bengmark, S., & Martindale, R. G. (2005) · Nutrition in Clinical Practice · doi:10.1177/0115426505020002244 · Cited by 72 · see citing works
Joeres-Nguyen-Xuan, T. H., Böhm, S., Joeres, L., Schulze, J., & Kruis, W. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21042 · Cited by 52 · see citing works
Darbandi, A., Mirshekar, M., Shariati, A., Moghadam, M. T., Lohrasbi, V., Asadollahi, P., & Talebi, M. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.11.008 · Cited by 50 · see citing works
Carter, G. M., Esmaeili, A., Shah, H. M., Indyk, D., Johnson, M., Andreae, M. H., & Sacks, H. S. (2016) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofw164 · Cited by 49 · see citing works
Kelsen, J. R., Dawany, N. B., Martinez, A., Grochowski, C. M., Maurer, K., Rappaport, E. F., Piccoli, D. A., Baldassano, R. N., Mamula, P., Sullivan, K. E., et al. (2015) · BMC Gastroenterology · doi:10.1186/s12876-015-0394-z · Cited by 47 · see citing works
Acute Interstitial Nephritis Associated with the Use of Mesalazine in Inflammatory Bowel Disease
Frandsen, N. E., Saugmann, S., & Marcussen, N. (2002) · The Nephron journals/Nephron journals · doi:10.1159/000064461 · Cited by 43 · see citing works
Dore, M. P., Rocchi, C., Longo, N. P., Scanu, A. M., Vidili, G., Padedda, F., & Pes, G. M. (2019) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-019-9517-0 · Cited by 43 · see citing works
Alternative and Replacement Foods
(2018) · Elsevier eBooks · doi:10.1016/c2016-0-00621-6 · Cited by 43 · see citing works
Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn’s Disease and Ulcerative Colitis
Dobre, M., Milanesi, E., Manuc, T. E., Arsene, D. E., Ţieranu, C. G., Maj, C., Becheanu, G., & Mănuc, M. (2018) · Journal of Immunology Research · doi:10.1155/2018/9208274 · Cited by 42 · see citing works
Indications for 5-aminosalicylate in inflammatory bowel disease: Is the body of evidence complete
Bodegraven, A. A. V. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i38.6115 · Cited by 41 · see citing works
Bae, J.-M. (2018) · Epidemiology and Health · doi:10.4178/epih.e2018043 · Cited by 37 · see citing works
Amiriani, T., Rajabli, N., Faghani, M., Besharat, S., Roshandel, G., Tabib, A. A., & Joshaghani, H. (2019) · Middle East Journal of Digestive Diseases · doi:10.15171/mejdd.2020.160 · Cited by 37 · see citing works
Antibiotics, Probiotics and Prebiotics in IBD
Bernstein, C. N. (2014) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000360713 · Cited by 36 · see citing works
Common misconceptions about 5-aminosalicylates and thiopurines in inflammatory bowel disease
Gisbert, J. P. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i30.3467 · Cited by 34 · see citing works
Diculescu, M. M., Manuc, T. E., & Mănuc, M. (2016) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s53381 · Cited by 33 · see citing works
Tsampalieros, A. K., Berkenstock, M., Zemel, B. S., Griffin, L. M., Justine Shults, A., Burnham, J. M., Baldassano, R. N., & Leonard, M. B. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2701-x · Cited by 20 · see citing works
Manuc, T. E., Mănuc, M., & Diculescu, M. M. (2016) · Dove Medical Press (Taylor and Francis Group) · Cited by 18 · see citing works
Park, K. T., Perez, F. D., Tsai, R., Honkanen, A. A., Bass, D. M., & Garber, A. M. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3182293a5e · Cited by 17 · see citing works
Nonclassic Inflammatory Bowel Disease in Young Infants
Chandrakasan, S., Venkateswaran, S., & Kugathasan, S. (2016) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2016.08.010 · Cited by 17 · see citing works
Lewis, J. D. (2014) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000360664 · Cited by 14 · see citing works
Ferguson, L. R. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00467 · Cited by 14 · see citing works
Meczker, Á., Mikó, A., Gede, N., Szentesi, A., Párniczky, A., Gódi, S., & Hegyi, P. (2019) · Pancreas · doi:10.1097/mpa.0000000000001297 · Cited by 14 · see citing works
Shadnoush, M., Hosseini, R. S., Mehrabi, Y., et al. (2013) · Research Repository Portal (Ilam University of Medical Sciences) · Cited by 11 · see citing works
IL-10 Producing Lactococcus lactis for the Treatment of Crohn's Disease
Braat, H., Rottiers, P., Huyghebaert, N., Remaut, E., Remon, J., van Deventer, S. J. H., Neirynck, S., Peppelenbosch, M. P., Steidler, L., & Hommes, D. W. (2006) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200604002-00063 · Cited by 8 · see citing works
Tomasello, G., Margiotta, G., Noto, M., Sinagra, E., Accardo, M. F., Damiani, P., Arculeo, V. M., Guarneri, F., Sanfilippo, A., Cappello, F., et al. (2015) · Medical Science and Technology · doi:10.12659/mst.895438 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review
Zhao, M., Chu, J., Feng, S., Guo, C., Xue, B., He, K., & Li, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114985 · Cited by 466 · see citing works
The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381 · see citing works
Zhang, X.-F., Guan, X.-X., Tang, Y.-J., Sun, J.-F., Wang, X.-K., Wang, W.-D., & Fan, J.-M. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02503-5 · Cited by 193 · see citing works
The emerging role of the gut microbiota and its application in inflammatory bowel disease
Xiu, W., Peng, J., Cai, P., Xia, Y., Yi, C., Shang, A., Akanyibah, F. A., & Mao, F. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117302 · Cited by 105 · see citing works
Gut microbiota in pathophysiology, diagnosis, and therapeutics of inflammatory bowel disease
Pandey, H., Jain, D., Tang, D. W. T., Wong, S. H., & Lal, D. (2023) · Intestinal Research · doi:10.5217/ir.2023.00080 · Cited by 89 · see citing works
Iyer, N. R., & Corr, S. C. (2021) · Nutrients · doi:10.3390/nu13124259 · Cited by 80 · see citing works
Estevinho, M. M., Yuan, Y., Rodríguez‐Lago, I., Sousa‐Pimenta, M., Dias, C. C., Barreiro‐de Acosta, M., Jairath, V., & Magro, F. (2024) · United European gastroenterology journal · doi:10.1002/ueg2.12636 · Cited by 74 · see citing works
“6,7 The mechanisms underlying these outcomes are variable but most likely attributable to the production of butyrate, immunoglobulin A (IgA) and short ‐ chain fatty acid (SCFA, known to be trophic factors), upregulation of defensins and mucin ‐ 2 expression, and downregulation of pro ‐ inflammatory…”
Haque, M., Kaminsky, L., Abdulqadir, R. F., Engers, J., Kovtunov, E., Rawat, M., Al-Sadi, R., & Ma, T. Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1348010 · Cited by 71 · see citing works
Selvamani, S., Mehta, V. K., Enshasy, H. A. E., Thevarajoo, S., Adawi, H. E., Zeini, I. M., Pham, K. T., Varzakas, T. H., & Abomoelak, B. (2022) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2022.02.044 · Cited by 56 · see citing works
Yarahmadi, A., Afkhami, H., Javadi, A., & Kashfi, M. (2024) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-024-01561-z · Cited by 59 · see citing works
Gut Microbiome as a Target of Intervention in Inflammatory Bowel Disease Pathogenesis and Therapy
Hetta, . F., Ramadan, Y. N., Alharbi, A. A., Alsharif, S. M., Alkindy, T. T., Alkhamali, A., Albalawi, A. S., & El‐Amin, H. (2024) · Immuno · doi:10.3390/immuno4040026 · Cited by 50 · see citing works
Hu, Y., Ye, Z., Wu, M., She, Y., Li, L., Xu, Y.-J., Qin, K., Hu, Z., Yang, M., Lu, F., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.766126 · Cited by 44 · see citing works
Wang, J., Su, L., Zhang, L., Zeng, J., Chen, Q., Deng, R., Wang, Z., Kuang, W., Jin, X., Gui, S., et al. (2022) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2100988 · Cited by 43 · see citing works
Huang, Z., Li, Y., Park, H., Ho, M., Bhardwaj, K., Sugimura, N., Lee, H. W., Meng, H., Ebert, M. P., Chao, K., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2237645 · Cited by 41 · see citing works
The Gut Microbiome in Human Obesity: A Comprehensive Review
Borrego-Ruiz, A., & Borrego, J. J. (2025) · Biomedicines · doi:10.3390/biomedicines13092173 · Cited by 45 · see citing works
Alsharairi, N. A. (2022) · Nutrients · doi:10.3390/nu14194113 · Cited by 37 · see citing works
Bretto, E., Caviglia, G. P., Saracco, G. M., Bugianesi, E., & Ribaldone, D. G. (2025) · Biomedicines · doi:10.3390/biomedicines13081807 · Cited by 38 · see citing works
Lê, A., Mantel, M., Marchix, J., Bodinier, M., Jan, G., & Rolli‐Derkinderen, M. (2022) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00002.2022 · Cited by 30 · see citing works
Noda, M., Danshiitsoodol, N., Kanno, K., Uchida, T., & Sugiyama, M. (2021) · Microorganisms · doi:10.3390/microorganisms9112243 · Cited by 29 · see citing works
Gan, J., Liu, Y., Sun, L., Ma, W., Chen, G., Zhao, C., Wen, L., Zhao, Y., & Sun, L. (2021) · Applied Materials Today · doi:10.1016/j.apmt.2021.101231 · Cited by 26 · see citing works
Komura, T., Takemoto, A., Kosaka, H., Suzuki, T., & Nishikawa, Y. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00454-21 · Cited by 23 · see citing works
Hu, Y., Ye, Z., She, Y., Li, L., Wu, M., Qin, K., Li, Y., He, H., Hu, Z., Yang, M., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.844961 · Cited by 23 · see citing works
Gill Jenkins, P. M. (2022) · Food & Nutrition Journal · doi:10.29011/2575-7091.100245 · Cited by 21 · see citing works
Bugajewski, M., Angerhoefer, N., Pączek, L., & Kaleta, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073320 · Cited by 21 · see citing works
Modulation of intestinal epithelial cell proliferation and apoptosis by Lactobacillus gasseri SF1183
Luccia, B. D., Acampora, V., Saggese, A., Calabrò, V., Vivo, M., Angrisano, T., Baccigalupi, L., Ricca, E., & Pollice, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-24483-0 · Cited by 21 · see citing works
Hirose, M., Sekar, P., Eladham, M. W., Albataineh, M. T., Rahmani, M., & Ibrahim, S. M. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02381-w · Cited by 21 · see citing works
Farah, A., Paul, P., Khan, A. S., Sarkar, A., Laws, S., & Châari, A. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1435030 · Cited by 23 · see citing works
Xue, Z., Li, R., Liu, J., Zhou, J., Zhang, X., Zhang, T., Zhang, M., Yang, Y., & Chen, H. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12173 · Cited by 17 · see citing works
The proteolytic activity in inflammatory bowel disease: insight from gut microbiota
Hou, J., Ding, L., Yang, T., Yang, Y.-F., Jin, Y., Zhang, X., Ma, A.-H., & Qin, Y. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106560 · Cited by 20 · see citing works
Changes of intestinal microbiota and microbiota-based treatments in IBD
Li, Q., Zhou, S., Wang, Y., & Cong, J. (2022) · Archives of Microbiology · doi:10.1007/s00203-022-03069-4 · Cited by 15 · see citing works
Highlights on two decades with microbiota and inflammatory bowel disease from etiology to therapy
Hussein, I. H., Dosh, L., Qassab, M. A., Jurjus, R. A., Masri, J. E., Nader, C. A., Rappa, F., Leone, A., & Jurjus, A. R. (2023) · Transplant Immunology · doi:10.1016/j.trim.2023.101835 · Cited by 15 · see citing works
El‐Saadony, M. T., Saad, A. M., Sitohy, M. Z., Alkafaas, S. S., Dladla, M., Ghosh, S., Mohammed, D. M., Ibrahim, E. H., Fahmy, M. A., Elkelish, A., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1713426 · Cited by 13 · see citing works
Microbiome and bladder cancer: the role of probiotics in treatment
Dadgar-Zankbar, L., Mokhtaryan, M., Bafandeh, E., Javanmard, Z., Asadollahi, P., Darbandi, T., Afifirad, R., Dashtbin, S., Darbandi, A., & Ghanavati, R. (2024) · Future Microbiology · doi:10.1080/17460913.2024.2414671 · Cited by 15 · see citing works
Nori, W., Al-kaabi, M. M., Akram, N. N., Kassim, M. A. K., & Pantazi, A. C. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673314861240429072352 · Cited by 9 · see citing works
Ottria, R., Xynomilakis, O., Casati, S., & Ciuffreda, P. (2024) · Microorganisms · doi:10.3390/microorganisms12081582 · Cited by 9 · see citing works
Lu, X., Sun, Y., Zhang, Z., Sun, Z., Wang, S., & Xu, E. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1573684 · Cited by 9 · see citing works
Probiotics in IBD: Evidence and Perspectives on Patient Health and Disease Management
Hijová, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189065 · Cited by 9 · see citing works
Monzani, R., Gagliardi, M., Clemente, N., Saverio, V., Pańczyszyn, E., Santoro, C., Yissachar, N., Visciglia, A., Pane, M., Amoruso, A., et al. (2022) · Biology · doi:10.3390/biology11111574 · Cited by 7 · see citing works
Zhang, P., Su, L., Ma, F., Ji, X., Su, Y., Yue, Q., Zhao, C., Zhang, S., Sun, X., & Zhao, L. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12568 · Cited by 6 · see citing works
Weissman, S. I., Fung, B. M., Bangolo, A., Rashid, A., Khan, B. F., Tirumala, A. K. G., Nagpaul, S., Cornwell, S., Karamthoti, P., Murugan, V., et al. (2023) · International Journal of Colorectal Disease · doi:10.1007/s00384-023-04404-x · Cited by 6 · see citing works
Vincenzi, A., Goettert, M. I., & de Souza, C. F. V. (2023) · Journal of Applied Microbiology · doi:10.1093/jambio/lxad168 · Cited by 6 · see citing works
Kushkevych, I. V., & Jampílek, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00016-7 · Cited by 5 · see citing works
Zhu, B., Wu, H., Han, Z., Song, Q., Xiao, Y., & Yu, B. (2025) · iScience · doi:10.1016/j.isci.2025.112763 · Cited by 4 · see citing works
Selected Aspects of Nutrition in the Prevention and Treatment of Inflammatory Bowel Disease
Panufnik, P., Więcek, M., Kaniewska, M. A., Lewandowski, K., Szwarc, P., & Rydzewska, G. M. (2022) · Nutrients · doi:10.3390/nu14234965 · Cited by 4 · see citing works
Vaghela, P., Dave, B. P., Dabhade, A., Deshmukh, R., Prajapati, B. G., Alsaidan, O. A., Patel, S., Mehta, A., Singh, A., & Dudhat, K. R. (2026) · Antonie van Leeuwenhoek · doi:10.1007/s10482-026-02254-5 · Cited by 3 · see citing works
Alhalabi, M. M. (2023) · Medicine · doi:10.1097/md.0000000000033061 · Cited by 2 · see citing works
Maćków, M., Kozioł-Kozakowska, A., Szeląg, M., Pytrus, T., Raczkowska, E., Neubauer, K., Zawiślak, I., Gajda, R., Habánová, M., & Stawarski, A. (2024) · Nutrients · doi:10.3390/nu16162762 · Cited by 1 · see citing works
Khodadoostan, M., Marnani, M. A., Moravejolahkami, A. R., Askari, G., & Iraj, B. (2022) · Nutrition & Food Science · doi:10.1108/nfs-06-2022-0195 · Cited by 1 · see citing works
Probiotics in Inflammatory Bowel Diseases
Singh, B., Mal, G., Kalra, R. S., & Marotta, F. (2024) · Springer eBooks · doi:10.1007/978-3-031-65459-6_8 · Cited by 1 · see citing works
Gut Microbiota and Inflammatory Bowel Diseases
Jacob, A., & Mathew, J. (2023) · doi:10.1002/9781119904786.ch10
Huerta, M. C. C. C., Antunez‐Mojica, M., Plascencia, H. M., & Molina, A. I. B. (2024) · Revista Argentina de Microbiología · doi:10.1016/j.ram.2024.02.002
Rahi, A., Azizian, R., Mohammadi, M. R., Namadiyam, N., Azimi, A., & Hamidi, M. (2025) · The Open Microbiology Journal · doi:10.2174/01187428582701202627012026
黄兴宗 (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.162522
Role of the gut microbiome in the pathogenesis of inflammatory bowel disease
Banerjee, S., Adhikary, P., De, D., Kalam, A., Chowdhury, S., & Mal, C. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40483-2.00021-2
Diet and complementary medicine in IBD: myths and realities
Crucillà, S., Mourad, F. H., & Hashash, J. G. (2026) · Frontline Gastroenterology · doi:10.1136/flgastro-2024-103001
Microbiome and Gut Immunity: T Cells
Palatella, M., Wagner, S., Busch, D. H., & Huehn, J. (2026) · Springer eBooks · doi:10.1007/978-3-032-26410-7_9
- Authors
- Darb Emamie, A., Rajabpour, M., Ghanavati, R., Asadolahi, P., Farzi, S., Sobouti, B., & Darbandi, A.
- Affiliations
- Department of Pathobiology School of Public Health Tehran University of Medical Sciences Tehran Iran
- Tehran University of Medical Sciences (IR)
- Behbahan Faculty of Medical Sciences Behbahan Iran
- Medical University of Ilam (IR)
- Shahed University (IR)
- Iran University of Medical Sciences (IR)
- Corresponding author
- Darbandi, A.
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-11-16
- Volume
- 130
- Issue
- 6
- Pages
- 1823-1838
- ISSN
- 1364-5072 (ISSN-L)
- 1365-2672
- OpenAlex
- W3094477482
- Cited by
- 57
- References
- 75
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 13 · 2023: 9 · 2022: 13 · 2021: 8
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Research Repository Portal (Ilam University of Medical Sciences) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, prebiotics, synbiotics, inflammatory bowel disease, ulcerative colitis, Crohn's disease, remission induction, anti-inflammatory cytokines, TNF-α, IL-1β, interleukin-8, intestinal homeostasis, systemic corticosteroid use, disease activity
- MeSH terms
- Clinical Trials as Topic, Colitis, Ulcerative, Crohn Disease, Humans, Lactobacillus, Remission Induction, Inflammatory Bowel Diseases, Probiotics, Actinobacteria, Prebiotics, Synbiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review