Cited by 57Inflammatory Bowel DiseaseProbiotics and Fermented FoodsGut microbiota and health

The effects of probiotics, prebiotics and synbiotics on the reduction of IBD complications, a periodic review during 2009–2020

Darb Emamie, A., Rajabpour, M., Ghanavati, R., Asadolahi, P., Farzi, S., Sobouti, B., Darbandi, A.·2021·Journal of Applied Microbiology

Abstract

AIMS: To perform a systematic review on randomized controlled trials to examine the efficacy of probiotics, prebiotics and synbiotics in the treatment of IBD. METHODS AND RESULTS: PubMed, Web of science, Scopus and Google Scholar were systematically searched from January 2009 to January 2020 using the following keywords: 'Inflammatory Bowel Disease', 'Probiotics' and 'Clinical trial'. The statistical analysis was performed using SPSS software version 24.0. A total of 1832 articles were found during the initial search and 21 clinical trials were eligible. Studies comparing the effects of probiotics and placebo among patients with active ulcerative colitis (UC) showed a significant difference in clinical outcomes. Moreover, probiotics improved the overall induction of remission rates among patients with Crohn's disease (CD). Probiotics significantly decreased the IL-1β, TNF-α and IL-8 levels. Also, the need for systemic steroids, hospitalization, surgery, as well as histological score and disease activity index significantly decreased in patients who used probiotic or pro-/synbiotics. CONCLUSIONS: The use of probiotics, as food supplements, can induce anti-inflammatory reactions, balance the intestinal homeostasis and induce remission in IBD. The efficacy of probiotics on remission induction is more reported in UC rather than CD. Larger well-designed clinical trials are needed to further determine whether probiotics are of clear benefits for remission in IBD.

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Crossref · 10.1111/jam.14907

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Authors
Darb Emamie, A., Rajabpour, M., Ghanavati, R., Asadolahi, P., Farzi, S., Sobouti, B., & Darbandi, A.
Affiliations
  • Department of Pathobiology School of Public Health Tehran University of Medical Sciences Tehran Iran
  • Tehran University of Medical Sciences (IR)
  • Behbahan Faculty of Medical Sciences Behbahan Iran
  • Medical University of Ilam (IR)
  • Shahed University (IR)
  • Iran University of Medical Sciences (IR)
Corresponding author
Darbandi, A.
Venue
Journal of Applied Microbiology
Published
2020-11-16
Volume
130
Issue
6
Pages
1823-1838
ISSN
  • 1364-5072 (ISSN-L)
  • 1365-2672
OpenAlex
W3094477482
Cited by
57
References
75
Citations by year
2026: 6 · 2025: 8 · 2024: 13 · 2023: 9 · 2022: 13 · 2021: 8
FWCI
1.07
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Repository Portal (Ilam University of Medical Sciences) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
probiotics, prebiotics, synbiotics, inflammatory bowel disease, ulcerative colitis, Crohn's disease, remission induction, anti-inflammatory cytokines, TNF-α, IL-1β, interleukin-8, intestinal homeostasis, systemic corticosteroid use, disease activity
MeSH terms
Clinical Trials as Topic, Colitis, Ulcerative, Crohn Disease, Humans, Lactobacillus, Remission Induction, Inflammatory Bowel Diseases, Probiotics, Actinobacteria, Prebiotics, Synbiotics

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