Systematic review with meta-analysis: The efficacy of probiotics in inflammatory bowel disease

Derwa, Y.; Gracie, D. J.; Hamlin, P. J.; Ford, A. C.

doi:10.1111/apt.14203

Cited by 393Inflammatory Bowel DiseaseProbiotics and Fermented FoodsGut microbiota and health

Systematic review with meta-analysis: The efficacy of probiotics in inflammatory bowel disease

Derwa, Y., Gracie, D. J., Hamlin, P. J., Ford, A. C.·2017·Alimentary Pharmacology & Therapeutics

DOI 10.1111/apt.14203

Open this paper in CoChat — free account

Abstract

BACKGROUND: Ulcerative colitis (UC) and Crohn's disease (CD) are inflammatory bowel diseases (IBD). Evidence implicates disturbances of the gastrointestinal microbiota in their pathogenesis. AIM: To perform a systematic review and meta-analysis to examine the efficacy of probiotics in IBD. METHODS: MEDLINE, EMBASE, and the Cochrane Controlled Trials Register were searched (until November 2016). Eligible randomised controlled trials (RCTs) recruited adults with UC or CD, and compared probiotics with 5-aminosalicylates (5-ASAs) or placebo. Dichotomous symptom data were pooled to obtain a relative risk (RR) of failure to achieve remission in active IBD, or RR of relapse of disease activity in quiescent IBD, with 95% confidence intervals (CIs). RESULTS: The search identified 12 253 citations. Twenty-two RCTs were eligible. There was no benefit of probiotics over placebo in inducing remission in active UC (RR of failure to achieve remission=0.86; 95% CI=0.68-1.08). However, when only trials of VSL#3 were considered there appeared to be a benefit (RR=0.74; 95% CI=0.63-0.87). Probiotics appeared equivalent to 5-ASAs in preventing UC relapse (RR=1.02; 95% CI=0.85-1.23). There was no benefit of probiotics in inducing remission of active CD, in preventing relapse of quiescent CD, or in preventing relapse of CD after surgically induced remission. CONCLUSIONS: VSL#3 may be effective in inducing remission in active UC. Probiotics may be as effective as 5-ASAs in preventing relapse of quiescent UC. The efficacy of probiotics in CD remains uncertain, and more evidence from RCTs is required before their utility is known.

Integrity signals

Registry

Crossref · 10.1111/apt.14203

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Some systematic reviews and meta-analyses have supported that specific probiotic strains may be effective in certain areas.
“While there is limited evidence around many probiotics, some systematic reviews and meta-analyses have supported that specific strains may be effective in certain areas [43,44,45,46].”
From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [46]

Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials
Sterne, J. A. C., Sutton, A. J., Ioannidis, J. P. A., Terrin, N., Jones, D. R., Lau, J., Carpenter, J., Rucker, G., Harbord, R. M., Schmid, C. H., et al. (2011) · BMJ · doi:10.1136/bmj.d4002 · Cited by 7,709 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1. The Cochrane Collaboration
Higgins, J., Green, S. R., & Higgins, J. (2008) · Cited by 5,544 · see citing works
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
The Treatment-Naive Microbiome in New-Onset Crohn’s Disease
Gevers, D., Kugathasan, S., Denson, L. A., Vázquez-Baeza, Y., Van Treuren, W., Ren, B., Schwager, E., Knights, D., Song, S. J., Yassour, M., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.005 · Cited by 3,220 · see citing works
Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee
Kornbluth, A. A., & Sachar, D. B. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.727 · Cited by 2,019 · see citing works
Predictability of the postoperative course of Crohn's disease
Rutgeerts, P., Geboes, K., Vantrappen, G., Beyls, J., Kerremans, R., & Hiele, M. I. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90613-6 · Cited by 1,814 · see citing works
Proton pump inhibitors affect the gut microbiome
Imhann, F., Bonder, M. J., Vich Vila, A., Fu, J., Mujagic, Z., Vork, L., Tigchelaar, E. F., Jankipersadsing, S. A., Cenit, M. C., Harmsen, H. J. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310376 · Cited by 1,371 · see citing works
Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine
Kruis, W., Frič, P., Pokrotnieks, J., Lukáš, M., Fixa, B., Kaščák, M., Kamm, M. A., Weismueller, J., Beglinger, C., Stolte, M., et al. (2004) · Gut · doi:10.1136/gut.2003.037747 · Cited by 1,285 · see citing works
Management of Crohn's Disease in Adults
Lichtenstein, G. R., Hanauer, S. B., & Sandborn, W. J. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.168 · Cited by 1,184 · see citing works
Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial
Rembacken, B., Snelling, A. M., Hawkey, P. M., Chalmers, D. M., & Axon, A. (1999) · The Lancet · doi:10.1016/s0140-6736(98)06343-0 · Cited by 1,100 · see citing works
The Prevalence and Geographic Distribution of Crohn’s Disease and Ulcerative Colitis in the United States
Kappelman, M. D., Rifas‐Shiman, S. L., KLEINMAN, K. P., Ollendorf, D., Bousvaros, A., Grand, R. J., & Finkelstein, J. A. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.07.012 · Cited by 931 · see citing works
Probiotics and the gut microbiota in intestinal health and disease
Gareau, M. G., Sherman, P. M., & Walker, W. A. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.117 · Cited by 907 · see citing works
Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease
Imhann, F., Vich Vila, A., Bonder, M. J., Fu, J., Gevers, D., Visschedijk, M. C., Spekhorst, L. M., Alberts, R., Franke, L., van Dullemen, H. M., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-312135 · Cited by 788 · see citing works
Double‐blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis
Kruis, W., SCHÜTZ, E., Fric, P., Fixa, B., Judmaier, G., & Stolte, M. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1997.00225.x · Cited by 774 · see citing works
Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis
Ford, A. C., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R., & Moayyedi, P. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.202 · Cited by 747 · cited 2× · see citing works
“probiotics are of proven benefit in other GI disorders, where their use is associated with an improvement in abdominal pain scores and a reduction in the persistence of bowel symptoms.(58) The paucity of data on probiotics for the induction of remission in active CD, and”
Background
Prevalence of symptoms meeting criteria for irritable bowel syndrome in inflammatory bowel disease: systematic review and meta-analysis
Halpin, S. J., & Ford, A. C. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.260 · Cited by 607 · see citing works
Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG
Prantera, C. (2002) · Gut · doi:10.1136/gut.51.3.405 · Cited by 566 · see citing works
The Probiotic Preparation, VSL#3 Induces Remission in Patients With Mild-to-Moderately Active Ulcerative Colitis
Sood, A., Midha, V., Makharia, G. K., Ahuja, V., Singal, D., Goswami, P., & Tandon, R. K. (2009) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2009.07.016 · Cited by 513 · see citing works
Treatment of Relapsing Mild-to-Moderate Ulcerative Colitis With the Probiotic VSL#3 as Adjunctive to a Standard Pharmaceutical Treatment: A Double-Blind, Randomized, Placebo-Controlled Study
Tursi, A., Brandimarte, G., Papa, A., Giglio, A., Elisei, W., Giorgetti, G. M., Forti, G., Morini, S., Hassan, C., Pistoia, M. A., et al. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.218 · Cited by 489 · see citing works
Efficacy of Lactobacillus GG in maintaining remission of ulcerative colitis
Zocco, M. A., Verme, L. Z. D., Cremonini, F., Piscaglia, A. C., Nista, E. C., Candelli, M., Novi, M., Rigante, D., Cazzato, I. A., Ojetti, V., et al. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02927.x · Cited by 472 · see citing works
Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn’s disease: a randomised, double blind, placebo controlled GETAID trial
Marteau, P. R., Lémann, M., Seksik, P., Laharie, D., Colombel, J. F., Bouhnik, Y., Cadiot, G., Soulé, J. C., Bourreille, A., Metman, E.-H., et al. (2005) · Gut · doi:10.1136/gut.2005.076604 · Cited by 412 · see citing works
Crohn's Disease and Escherichia coli
Malchow, H. A. (1997) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199712000-00021 · Cited by 402 · see citing works
Randomized placebo‐controlled trial assessing the effect of bifidobacteria‐fermented milk on active ulcerative colitis
Kato, K., Mizuno, S., Umesaki, Y., Ishii, Y., Sugitani, M., Imaoka, A., Otsuka, M., Hasunuma, O., Kurihara, R., Iwasaki, A., et al. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02268.x · Cited by 397 · see citing works
Antibiotics Associated With Increased Risk of New-Onset Crohn’s Disease But Not Ulcerative Colitis: A Meta-Analysis
Ungaro, R. C., Bernstein, C. N., Gearry, R. B., Hviid, A. P., Kolho, K.-L., Kronman, M. P., Shaw, S. Y., Kruiningen, H. J. V., Colombel, J., & Atreja, A. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.246 · Cited by 383 · see citing works
Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohnʼs Disease, and Pouchitis: Meta-analysis of Randomized Controlled Trials
Shen, J., Zuo, Z.-X., & Mao, A.-P. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000437495.30052.be · Cited by 364 · see citing works
Lactobacillus GG in inducing and maintaining remission of Crohn's disease
Schultz, M., Timmer, A., Herfarth, H. H., Sartor, R. B., Vanderhoof, J. A., & Rath, H. C. (2004) · BMC Gastroenterology · doi:10.1186/1471-230x-4-5 · Cited by 349 · see citing works
Opportunistic Infections With Anti-Tumor Necrosis Factor-α Therapy in Inflammatory Bowel Disease: Meta-Analysis of Randomized Controlled Trials
Ford, A. C., & Peyrin‐Biroulet, L. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.138 · Cited by 342 · see citing works
Chemokine and cytokine levels in inflammatory bowel disease patients
Singh, U. P., Singh, N. P., Murphy, E. A., Price, R. L., Fayad, R., Nagarkatti, M., & Nagarkatti, P. S. (2015) · Cytokine · doi:10.1016/j.cyto.2015.10.008 · Cited by 317 · see citing works
Probiotics are a good choice in remission of inflammatory bowel diseases: a meta analysis and systematic review
Ganji‐Arjenaki, M., & Rafieian‐Kopaei, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25911 · Cited by 314 · see citing works
Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohnʼs disease after ileo-caecal resection
Gossum, A. V., Dewit, O., Louis, E. J., Hertogh, G., Baert, F., Fontaine, F., Devos, M., Enslen, M., Paintin, M., & Franchimont, D. P. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20063 · Cited by 296 · see citing works
Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life -- a double-blind, placebo-controlled study: Randomised clinical trial: B. bifidum MIMBb75 in IBS
Guglielmetti, S., Mora, D., Gschwender, M., & Popp, K. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04633.x · Cited by 287 · see citing works
Patient-reported outcomes as primary end points in clinical trials of inflammatory bowel disease
Williet, N., Sandborn, W. J., & Peyrin–Biroulet, L. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.02.016 · Cited by 260 · cited 8× · see citing works
“These previous systematic reviews also pooled data from RCTs that did not meet our inclusion criteria, including studies that examined the effect of probiotics in children with IBD, and the effect of synbiotics in IBD.28,29 Studies investigating the effect of manipulation of the micro- biome on disease activity in IBD…”
BackgroundInfluential
Probiotics in the Management of Inflammatory Bowel Disease: A Systematic Review of Intervention Studies in Adult Patients
Jonkers, D., Penders, J., Masclee, A., & Pierik, M. (2012) · Drugs · doi:10.2165/11632710-000000000-00000 · Cited by 240 · see citing works
The Probiotic VSL#3 Has Anti-inflammatory Effects and Could Reduce Endoscopic Recurrence After Surgery for Crohn's Disease
Fedorak, R. N., Feagan, B. G., Hotte, N., Leddin, D., Dieleman, L. A., Petrunia, D. M., Enns, R. A., Bitton, A., Chiba, N., Paré, P., et al. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.10.031 · Cited by 230 · see citing works
Microbial diversity of inflamed and noninflamed gut biopsy tissues in inflammatory bowel disease
Sepehri, S., Kotłowski, R., Bernstein, C. N., & Krause, D. O. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20101 · Cited by 225 · see citing works
Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double‐blinded, placebo‐controlled multicenter trial
Tamaki, H., Nakase, H., Inoue, S., Kawanami, C., Itani, T., Ohana, M., Kusaka, T., Uose, S., Hisatsune, H., Tojo, M., et al. (2016) · Digestive Endoscopy · doi:10.1111/den.12553 · Cited by 214 · see citing works
The association between the gut microbiota and the inflammatory bowel disease activity: a systematic review and meta-analysis
Prosberg, M. V., Bendtsen, F., Vind, I., Petersen, A. M., & Gluud, L. L. (2016) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2016.1216587 · Cited by 210 · see citing works
Effects of probiotic on intestinal mucosa of patients with ulcerative colitis
Cui, H.-H. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i10.1521 · Cited by 209 · see citing works
Clinical trial: probiotic treatment of acute distal ulcerative colitis with rectally administered Escherichia coli Nissle 1917 (EcN)
Matthes, H., Krummenerl, T., Giensch, M., Wolff, C., & Schulze, J. (2010) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-10-13 · Cited by 207 · see citing works
Interventions for prevention of post-operative recurrence of Crohn's disease
Doherty, G. A., Bennett, G., Patil, S. A., Cheifetz, A. S., & Moss, A. C. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006873.pub2 · Cited by 202 · see citing works
The influence of proton pump inhibitors and other commonly used medication on the gut microbiota
Imhann, F., Vila, A. V., Bonder, M. J., Manosalva, A. G. L., Koonen, D. P. Y., Fu, J., Wijmenga, C., Zhernakova, A., & Weersma, R. K. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1284732 · Cited by 195 · see citing works
Saccharomyces boulardii Does Not Prevent Relapse of Crohn's Disease
Bourreille, A., Cadiot, G., Dréau, G. L., Laharie, D., Beaugerie, L., Dupas, J., Marteau, P. R., Rampal, P., Moyse, D., Saleh, A., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.02.021 · Cited by 186 · see citing works
A Meta-Analysis on the Efficacy of Probiotics for Maintenance of Remission and Prevention of Clinical and Endoscopic Relapse in Crohn’s Disease
Rahimi, R., Nikfar, S., Rahimi, F. C., Elahi, B., Derakhshani, S., Vafaie, M., & Abdollahi, M. R. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-0171-0 · Cited by 173 · see citing works
Systematic review with meta‐analysis: malignancies with anti‐tumour necrosis factor‐α therapy in inflammatory bowel disease
Williams, C. J. M., Peyrin‐Biroulet, L., & Ford, A. C. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12624 · Cited by 171 · see citing works
Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis
Ng, S. C., Plamondon, S., Kamm, M. A., Hart, A. L., Al-Hassi, H. O., Guenther, T., Stagg, A. J., & Knight, S. C. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21222 · Cited by 147 · see citing works
A Randomized, Double-blind, Placebo-controlled Multicenter Trial of Saccharomyces boulardii in Irritable Bowel Syndrome: Effect on Quality of Life
Choi, C. H., Jo, S. Y., Park, H. J., Chang, S. K., Byeon, J.-S., & Myung, S.-J. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318204593e · Cited by 144 · cited 1× · see citing works
“drome, where beneficial effects on abdominal pain and quality of life have been observed with some species and strains.(58,62,63) Given that”
Background
A randomised double-blind placebo-controlled trial with Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp. lactis BB-12 for maintenance of remission in ulcerative colitis
Wildt, S., Nordgaard, I., Hansen, U., Brockmann, E., & Rumessen, J. J. (2011) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2010.11.004 · Cited by 141 · see citing works
Probiotic Mix VSL#3 Is Effective Adjunctive Therapy for Mild to Moderately Active Ulcerative Colitis
Mardini, H. E., & Grigorian, A. Y. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000084 · Cited by 140 · see citing works
Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis
Yoshimatsu, Y., Yamada, A., Furukawa, R., Sono, K., Osamura, A., Nakamura, K., Aoki, H., Tsuda, Y., Hosoe, N., Takada, N., et al. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i19.5985 · Cited by 137 · see citing works
Untitled work
Rogler (2015) · doi:10.1097/mib.0000000000000229 · Cited by 137 · see citing works
Ciprofloxacin and probiotic Escherichia coli Nissle add-on treatment in active ulcerative colitis: A double-blind randomized placebo controlled clinical trial
Petersen, A. M., Mirsepasi‐Lauridsen, H. C., Halkjær, S. I., Mortensen, E. M., Nordgaard-Lassen, I., & Krogfelt, K. A. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.06.001 · Cited by 136 · see citing works
Probiotics for maintenance of remission in ulcerative colitis
Naidoo, K., Gordon, M. A., Fagbemi, A. O., Thomas, A. G., & Akobeng, A. K. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007443.pub2 · Cited by 136 · see citing works
Remission induction and maintenance effect of probiotics on ulcerative colitis: A meta-analysis
Sang, L.-X. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i15.1908 · Cited by 133 · see citing works
Negative Effects on Psychological Health and Quality of Life of Genuine Irritable Bowel Syndrome–type Symptoms in Patients With Inflammatory Bowel Disease
Gracie, D., Williams, C. J., Sood, R., Mumtaz, S., Bholah, H., Hamlin, J., & Ford, A. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.05.012 · Cited by 118 · see citing works
Escherichia coli Nissle 1917 in Ulcerative Colitis Treatment: Systematic Review and Meta-analysis
Losurdo, G., Iannone, A., Contaldo, A., Ierardi, E., Leo, A. D., & Principi, M. (2015) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld.2014.1121.244.ecn · Cited by 109 · see citing works
Probiotic treatments for induction and maintenance of remission in inflammatory bowel diseases: a meta-analysis of randomized controlled trials
Fujiya, M., Ueno, N., & Kohgo, Y. (2013) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-013-0440-8 · Cited by 87 · see citing works
Systematic review and meta‐analysis: opportunistic infections and malignancies during treatment with anti‐integrin antibodies in inflammatory bowel disease
Luthra, P., Peyrin‐Biroulet, L., & Ford, A. C. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13215 · Cited by 82 · see citing works
Probiotics for maintenance of remission in ulcerative colitis
Naidoo, K., Gordon, M. A., Fagbemi, A. A., Thomas, A. G., & Akobeng, A. K. (2010) · Archives of Disease in Childhood · doi:10.1136/adc.2010.186338.123 · Cited by 65 · see citing works
Meta‐analysis: the effect and adverse events of Lactobacilli versus placebo in maintenance therapy for Crohn disease
Shen, J., Ran, H. Z., Yin, M. H., Zhou, T., & Xiao, D. (2008) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2008.01791.x · Cited by 59 · see citing works
Production Conditions Affect the In Vitro Anti-Tumoral Effects of a High Concentration Multi-Strain Probiotic Preparation
Cinque, B., Torre, C. L., Lombardi, F., Palumbo, P., der Rest, M. V., & Cifone, M. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163216 · Cited by 41 · see citing works
Methodological Quality Assessment of Meta-Analyses and Systematic Reviews of Probiotics in Inflammatory Bowel Disease and Pouchitis
Dong, J., Teng, G., Tiantong, W., Gao, W. H., & Wang, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168785 · Cited by 39 · see citing works
Interventions for prevention of post-operative recurrence of Crohn's disease
Patil, S. A., Bennett, G., Cheifetz, A. S., & Moss, A. C. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006873 · Cited by 37 · see citing works
A meta-analysis of the benefit of probiotics in maintaining remission of human ulcerative colitis: evidence for prevention of disease relapse and maintenance of remission
Rahimi, R., Nikfar, S., Rezaie, A. R., & Abdollahi, M. R. (2008) · Archives of Medical Science · Cited by 33 · see citing works
T1235 Randomised, Double-Blinded, Placebo-Controlled Study of VSL#3 Versus Placebo in the Maintenance of Remission in Crohns Disease
Willert, R. P., Peddi, K., Ombiga, J., Bampton, P. A., & Lawrance, I. C. (2010) · Gastroenterology · doi:10.1016/s0016-5085(10)62390-6 · Cited by 21 · see citing works

Flagged first, then by citations

Sorted by citations

The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases
Parada Venegas, D., De la Fuente, M. K., Landskron, G., González, M. J., Quera, R., Dijkstra, G., Harmsen, H. J. M., Faber, K. N., & Hermoso, M. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00277 · Cited by 3,820 · see citing works
ACG Clinical Guideline: Ulcerative Colitis in Adults
Rubin, D. T., Ananthakrishnan, A. N., Siegel, C. A., Sauer, B. G., & Long, M. D. (2019) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000152 · Cited by 1,594 · see citing works
Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body
Cristofori, F., Dargenio, V. N., Dargenio, C., Miniello, V. L., Barone, M., & Francavilla, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.578386 · Cited by 958 · see citing works
Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration
Leeming, E. R., Johnson, A. J., Spector, T. D., & Le Roy, C. I. (2019) · Nutrients · doi:10.3390/nu11122862 · Cited by 817 · see citing works
Postbiotics—A Step Beyond Pre- and Probiotics
Żółkiewicz, J., Marzec, A., Ruszczyński, M., & Feleszko, W. (2020) · Nutrients · doi:10.3390/nu12082189 · Cited by 797 · see citing works
Treatment of Inflammatory Bowel Disease: A Comprehensive Review
Cai, Z., Wang, S., & Li, J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.765474 · Cited by 697 · see citing works
Effects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial
Cox, S. R., Lindsay, J. O., Fromentin, S., Stagg, A. J., McCarthy, N. E., Galleron, N., Ibraim, S. B., Roume, H., Levenez, F., Pons, N., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.09.024 · Cited by 386 · see citing works
Thirty Years of Lactobacillus rhamnosus GG
Capurso, L. (2019) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001170 · Cited by 384 · see citing works
Prebiotics and Probiotics in Digestive Health
Quigley, E. M. M. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.09.028 · Cited by 387 · see citing works
The influence of the brain–gut axis in inflammatory bowel disease and possible implications for treatment
Gracie, D. J., Hamlin, P. J., & Ford, A. C. (2019) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(19)30089-5 · Cited by 358 · see citing works
Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections
Ney, L.-M., Wipplinger, M., Grossmann, M., Engert, N., Wegner, V. D., & Mosig, A. S. (2023) · Open Biology · doi:10.1098/rsob.230014 · Cited by 337 · see citing works
The microbiome in inflammatory bowel diseases: from pathogenesis to therapy
Liu, S., Zhao, W., Lan, P., & Mou, X. (2020) · Protein & Cell · doi:10.1007/s13238-020-00745-3 · Cited by 266 · see citing works
Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis
Fairbrass, K. M., Costantino, S. J., Gracie, D. J., & Ford, A. C. (2020) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(20)30300-9 · Cited by 265 · see citing works
Effectiveness of probiotics, prebiotics, and prebiotic‐like components in common functional foods
Peng, M., Tabashsum, Z., Anderson, M., Truong, A., Houser, A., Padilla, J., Akmel, A., Bhatti, J., Rahaman, S. O., & Biswas, D. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12565 · Cited by 258 · see citing works
Chemically and Biologically Engineered Bacteria‐Based Delivery Systems for Emerging Diagnosis and Advanced Therapy
Li, Z., Wang, Y., Liu, J., Rawding, P. A., Bu, J., Hong, S., & Hu, Q. (2021) · Advanced Materials · doi:10.1002/adma.202102580 · Cited by 243 · see citing works
The Role of Gut Microbiota Biomodulators on Mucosal Immunity and Intestinal Inflammation
Amoroso, C., Perillo, F., Strati, F., Fantini, M. C., Caprioli, F., & Facciotti, F. (2020) · Cells · doi:10.3390/cells9051234 · Cited by 243 · see citing works
Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics
Lynch, J. P., Goers, L., & Lesser, C. F. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.02.002 · Cited by 235 · see citing works
Intestinal microbiome and fitness in kidney disease
Meijers, B. K. I., Evenepoel, P., & Anders, H. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0172-1 · Cited by 223 · see citing works
Leveraging diet to engineer the gut microbiome
Wolter, M., Grant, E. T., Boudaud, M., Steimle, A., Pereira, G. V., Martens, E. C., & Desai, M. S. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00512-7 · Cited by 211 · see citing works
ACG Clinical Guideline Update: Ulcerative Colitis in Adults
Rubin, D. T., Ananthakrishnan, A. N., Siegel, C. A., Barnes, E. L., & Long, M. D. (2025) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003463 · Cited by 226 · see citing works
Probiotics in Autoimmune and Inflammatory Disorders
Liu, Y., Alookaran, J. J., & Rhoads, J. M. (2018) · Nutrients · doi:10.3390/nu10101537 · Cited by 199 · see citing works
Clinical effects and gut microbiota changes of using probiotics, prebiotics or synbiotics in inflammatory bowel disease: A systematic review and meta-analysis
Zhang, X.-F., Guan, X.-X., Tang, Y.-J., Sun, J.-F., Wang, X.-K., Wang, W.-D., & Fan, J.-M. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02503-5 · Cited by 193 · see citing works
Microbial-Based and Microbial-Targeted Therapies for Inflammatory Bowel Diseases
Oka, A., & Sartor, R. B. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06090-z · Cited by 185 · see citing works
Diet, Gut Microbiome and Epigenetics: Emerging Links with Inflammatory Bowel Diseases and Prospects for Management and Prevention
Aleksandrova, K., Romero-Mosquera, B., & Hernández, V. (2017) · Nutrients · doi:10.3390/nu9090962 · Cited by 169 · see citing works
Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis
Yang, Z., Liu, F., Zhu, X., Suo, F., Jia, Z., & Yao, S. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i24.3609 · Cited by 146 · see citing works
The role of topical probiotics in skin conditions: A systematic review of animal and human studies and implications for future therapies
Knackstedt, R. W., Knackstedt, T., & Gatherwright, J. R. (2019) · Experimental Dermatology · doi:10.1111/exd.14032 · Cited by 147 · see citing works
European Crohn’s and Colitis Organisation Topical Review on Complementary Medicine and Psychotherapy in Inflammatory Bowel Disease
Torres, J., Ellul, P., Langhorst, J., Mikocka‐Walus, A. A., Acosta, M. B., Basnayake, C., Ding, N. S., Gilardi, D., Katsanos, K. H., Moser, G., et al. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz051 · Cited by 137 · see citing works
Combination of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Shows a Stronger Anti-Inflammatory Effect than Individual Strains in HT-29 Cells
Li, S., Hsu, W.-F., Chang, J., & Shih, C. (2019) · Nutrients · doi:10.3390/nu11050969 · Cited by 137 · see citing works
Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults
Zhang, C., Jiang, J., Tian, F., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.01.005 · Cited by 131 · see citing works
Probiotics Efficacy on Oxidative Stress Values in Inflammatory Bowel Disease: A Randomized Double-Blinded Placebo-Controlled Pilot Study
Ballini, A., Santacroce, L., Cantore, S., Bottalico, L., Dipalma, G., Topi, S., Saini, R., Vito, D. D., & Inchingolo, F. (2018) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530319666181221150352 · Cited by 132 · see citing works
Vitamin D administration leads to a shift of the intestinal bacterial composition in Crohn's disease patients, but not in healthy controls
Schäffler, H., Herlemann, D. P. R., Klinitzke, P., Berlin, P., Kreikemeyer, B., Jaster, R., & Lamprecht, G. (2018) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12591 · Cited by 131 · see citing works
AGA Technical Review on the Role of Probiotics in the Management of Gastrointestinal Disorders
Preidis, G. A., Weizman, A. V., Kashyap, P., & Morgan, R. L. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.060 · Cited by 135 · see citing works
Probiotics, Nutrition, and the Small Intestine
Judkins, T. C., Archer, D. L., Kramer, D. C., & Solch-Ottaiano, R. J. (2020) · Current Gastroenterology Reports · doi:10.1007/s11894-019-0740-3 · Cited by 128 · see citing works
Probiotics, Prebiotics and Synbiotics in Inflammatory Bowel Diseases
Akutko, K., & Stawarski, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112466 · Cited by 125 · see citing works
Meta-Analysis of Fecal Microbiota and Metabolites in Experimental Colitic Mice during the Inflammatory and Healing Phases
Osaka, T., Moriyama, E., Arai, S., Date, Y., Yagi, J., Kikuchi, J., & Tsuneda, S. (2017) · Nutrients · doi:10.3390/nu9121329 · Cited by 121 · see citing works
The gut microbiome as a target for IBD treatment: are we there yet
Knox, N. C., Forbes, J. D., Van Domselaar, G., & Bernstein, C. N. (2019) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-019-00221-w · Cited by 117 · see citing works
Current understanding of microbiota- and dietary-therapies for treating inflammatory bowel disease
Eom, T.-K., Kim, Y. S., Choi, C. H., Sadowsky, M. J., & Unno, T. (2018) · The Journal of Microbiology · doi:10.1007/s12275-018-8049-8 · Cited by 116 · see citing works
The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases
Peppas, S., Pansieri, C., Piovani, D., Danese, S., Peyrin‐Biroulet, L., Tsantes, A. G., Brunetta, E., Tsantes, A. Ε., & Bonovas, S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030377 · Cited by 114 · see citing works
The Efficacy of Probiotics, Prebiotic Inulin-Type Fructans, and Synbiotics in Human Ulcerative Colitis: A Systematic Review and Meta-Analysis
Astó, E., Méndez, I., Audivert, S., Farrán-Codina, A., & Espadaler, J. (2019) · Nutrients · doi:10.3390/nu11020293 · Cited by 109 · see citing works
Gut microbial DL-endopeptidase alleviates Crohn’s disease via the NOD2 pathway
Gao, J., Zhao, X., Hu, S., Huang, Z., Hu, M., Jin, S., Lu, B., Sun, K., Wang, Z., Fu, J., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.08.002 · Cited by 103 · see citing works
Gut Microbiota as a Therapeutic Target to Ameliorate the Biochemical, Neuroanatomical, and Behavioral Effects of Traumatic Brain Injuries
Rice, M. W., Pandya, J. D., & Shear, D. A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00875 · Cited by 89 · see citing works
The role of the gut microbiota in the treatment of inflammatory bowel diseases
Aggeletopoulou, I., Konstantakis, C., Assimakopoulos, S. F., & Triantos, C. K. (2019) · Microbial Pathogenesis · doi:10.1016/j.micpath.2019.103774 · Cited by 101 · see citing works
The role of diet in the prevention and treatment of Inflammatory Bowel Diseases.
Reddavide, R., Rotolo, O., Caruso, M. G., Stasi, E., Notarnicola, M., Miraglia, C., Nouvenne, A., Meschi, T., Angelis, G. L. D., Mario, F. D., et al. (2018) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v89i9-s.7952 · Cited by 100 · see citing works
Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders
Shahbazi, R., Yasavoli‐Sharahi, H., Alsadi, N., Ismail, N., & Matar, C. (2020) · Molecules · doi:10.3390/molecules25214891 · Cited by 101 · see citing works
Nutritional Treatment in Crohn’s Disease
Caio, G., Lungaro, L., Caputo, F., Zoli, E., Giancola, F., Chiarioni, G., GIORGIO, R. D., & Zoli, G. (2021) · Nutrients · doi:10.3390/nu13051628 · Cited by 100 · see citing works
Bacteria and bacterial derivatives as delivery carriers for immunotherapy
Kang, S., Nguyen, D.-H., Yoo, S. W., & Min, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114085 · Cited by 99 · see citing works
Perioperative dietary therapy in inflammatory bowel disease.
Adamina, M., Gerasimidis, K., Sigall-Boneh, R., Zmora, O., van Overstraeten, A. D. B., Campmans-Kuijpers, M., Ellul, P., Katsanos, K., Kotze, P., Noor, N., et al. (2019) · Journal of Crohn's & Colitis · doi:10.1093/ecco-jcc/jjz160 · Cited by 86 · see citing works
Longitudinal impact of IBS-type symptoms on disease activity, healthcare utilization, psychological health, and quality of life in inflammatory bowel disease
Gracie, D. J., Hamlin, P. J., & Ford, A. C. (2018) · The American Journal of Gastroenterology · doi:10.1038/s41395-018-0021-z · Cited by 97 · see citing works
Recent advances in the design and fabrication of probiotic delivery systems to target intestinal inflammation
Jiang, Z., Li, M., McClements, D. J., Liu, X., & Liu, F. (2021) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2021.107438 · Cited by 95 · see citing works
Yogurt starter cultures of Streptococcus thermophilus and Lactobacillus bulgaricus ameliorate symptoms and modulate the immune response in a mouse model of dextran sulfate sodium-induced colitis
Wasilewska, E. M., Złotkowska, D., & Wróblewska, B. (2018) · Journal of Dairy Science · doi:10.3168/jds.2018-14520 · Cited by 94 · see citing works
Therapeutic, Prophylactic, and Functional Use of Probiotics: A Current Perspective
Aponte, M., Murru, N., & Shoukat, M. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.562048 · Cited by 92 · see citing works
Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation
Zeng, W., Shen, J., Bo, T., Peng, L., Xu, H., Nasser, M. I., Zhuang, Q., & Zhao, M. (2019) · Journal of Immunology Research · doi:10.1155/2019/1603758 · Cited by 89 · see citing works
Antioxidant Therapy in Inflammatory Bowel Diseases
Dziąbowska-Grabias, K., Sztanke, M., Zając, P., Celejewski, M., Kurek, K., Szkutnicki, S., Korga, P., Bulikowski, W., & Sztanke, K. (2021) · Antioxidants · doi:10.3390/antiox10030412 · Cited by 89 · see citing works
Bifidobacterium and Lactobacillus improve inflammatory bowel disease in zebrafish of different ages by regulating the intestinal mucosal barrier and microbiota
Ni, Y., Zhang, Y., Zheng, L., Rong, N., Yang, Y., Gong, P., Yang, Y. M., Siwu, X., Zhang, C., Zhu, L., et al. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121699 · Cited by 89 · see citing works
Role of short chain fatty acids in gut health and possible therapeutic approaches in inflammatory bowel diseases
Caetano, M. A. F., & Castelucci, P. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i28.9985 · Cited by 88 · see citing works
Fructooligosaccharides on inflammation, immunomodulation, oxidative stress, and gut immune response: a systematic review
Costa, G. T., Vasconcelos, Q. D. J. S., & Aragão, G. F. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab115 · Cited by 86 · see citing works
Side Effects Associated with Probiotic Use in Adult Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Dore, M. P., Bibbò, S., Fresi, G., Bassotti, G., & Pes, G. M. (2019) · Nutrients · doi:10.3390/nu11122913 · Cited by 83 · see citing works
Role of food proteins and bioactive peptides in inflammatory bowel disease
Fernández‐Tomé, S., Hernández‐Ledesma, B., Chaparro, M., Indiano‐Romacho, P., Bernardo, D., & Gisbert, J. P. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.03.017 · Cited by 82 · see citing works
Gut microbiome and autoimmune disorders
Shaheen, W., Quraishi, M. N., & Iqbal, T. H. (2022) · Clinical & Experimental Immunology · doi:10.1093/cei/uxac057 · Cited by 85 · see citing works
Design of synthetic microbial consortia for gut microbiota modulation
Vázquez-Castellanos, J. F., Biclot, A., Vrancken, G., Huys, G. R. B., & Raes, J. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.07.005 · Cited by 81 · see citing works
Functional foods modulating inflammation and metabolism in chronic diseases: a systematic review
Luvián‐Morales, J., Varela-Castillo, F. O., Flores-Cisneros, L. A., Cetina, L., & Castro-Eguiluz, D. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1875189 · Cited by 81 · see citing works
Aktualisierte S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn“ der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – August 2021 – AWMF-Registernummer: 021-004
Sturm, A., Stallmach, A., Atreya, R. N., Bettenworth, D., Bokemeyer, B., Dignass, A. U., Ehehalt, R., Germer, C. T., Grunert, P., Helwig, U., et al. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1713-3941 · Cited by 77 · see citing works
Probiotics and prebiotics in clinical tests: an update
Brüssow, H. (2019) · F1000Research · doi:10.12688/f1000research.19043.1 · Cited by 78 · see citing works
Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome
Camara-Lemarroy, C. R., Metz, L. M., & Yong, V. W. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i37.4217 · Cited by 75 · see citing works
Vitamin D Axis in Inflammatory Bowel Diseases: Role, Current Uses and Future Perspectives
Pinto, R. D., Ferri, C., & Cominelli, F. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112360 · Cited by 73 · see citing works
Efficacy and safety of probiotics in IBD: An overview of systematic reviews and updated meta-analysis of randomized controlled trials.
Estevinho, M. M., Yuan, Y., Rodríguez‐Lago, I., Sousa‐Pimenta, M., Dias, C. C., Barreiro‐de Acosta, M., Jairath, V., & Magro, F. (2024) · United European gastroenterology journal · doi:10.1002/ueg2.12636 · Cited by 74 · see citing works
Probiotics: A Dietary Factor to Modulate the Gut Microbiome, Host Immune System, and Gut–Brain Interaction
Hori, T., Matsuda, K., & Oishi, K. (2020) · Microorganisms · doi:10.3390/microorganisms8091401 · Cited by 75 · see citing works
British Dietetic Association consensus guidelines on the nutritional assessment and dietary management of patients with inflammatory bowel disease
Lomer, M. C. E., Wilson, B., & Wall, C. L. (2022) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.13054 · Cited by 70 · see citing works
Probiotic-Based Intervention in the Treatment of Ulcerative Colitis: Conventional and New Approaches
Štofilová, J., Kvaková, M., Kamlárová, A., Hijová, E., Bertková, I., & Guľašová, Z. (2022) · Biomedicines · doi:10.3390/biomedicines10092236 · Cited by 74 · see citing works
Probiotics in the Treatment of Inflammatory Bowel Disease
Guandalini, S., & Sansotta, N. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_319 · Cited by 70 · see citing works
Feline chronic enteropathy
Marsilio, S. (2021) · Journal of Small Animal Practice · doi:10.1111/jsap.13332 · Cited by 69 · see citing works
IRT5 Probiotics Changes Immune Modulatory Protein Expression in the Extraorbital Lacrimal Glands of an Autoimmune Dry Eye Mouse Model
Choi, S. H., Oh, J., Ryu, J. S., Kim, H. M., Im, S., Kim, K. P., & Kim, M. K. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.3.42 · Cited by 69 · see citing works
New avenues for Parkinson's disease therapeutics: disease-modifying strategies based on the gut microbiota
Lorente-Picón, M., & Laguna, A. (2021) · Biomolecules · doi:10.3390/biom11030433 · Cited by 69 · see citing works
Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa: A proof-of-concept study
Pagnini, C., Corleto, V. D., Martorelli, M., Lanini, C., D’Ambra, G., Giulio, E. D., & Fave, G. D. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i41.4652 · Cited by 67 · see citing works
Recent advances in modulating the microbiome
Quigley, E. M. M., & Gajula, P. (2020) · F1000Research · doi:10.12688/f1000research.20204.1 · Cited by 68 · see citing works
The Use of Complementary and Alternative Medicine in Patients With Inflammatory Bowel Disease.
Lin, S. C., & Cheifetz, A. S. (2018) · Europe PMC (PubMed Central) · Cited by 66 · see citing works
Probiotic Lactobacillus and Bifidobacterium Strains Counteract Adherent-Invasive Escherichia coli (AIEC) Virulence and Hamper IL-23/Th17 Axis in Ulcerative Colitis, but Not in Crohn’s Disease
Leccese, G., Bibi, A., Mazza, S., Facciotti, F., Caprioli, F., Landini, P., & Paroni, M. (2020) · Cells · doi:10.3390/cells9081824 · Cited by 66 · see citing works
Reviewing the potential of probiotics, prebiotics and synbiotics: advancements in treatment of ulcerative colitis
Jadhav, A., Jagtap, S., Vyavahare, S., Sharbidre, A., & Kunchiraman, B. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1268041 · Cited by 58 · see citing works
The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts
Hov, J., & Karlsen, T. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1608801 · Cited by 65 · see citing works
Connecting the Dots Between Inflammatory Bowel Disease and Metabolic Syndrome: A Focus on Gut-Derived Metabolites
Verdugo‐Meza, A., Ye, J., Dadlani, H., Ghosh, S., & Gibson, D. L. (2020) · Nutrients · doi:10.3390/nu12051434 · Cited by 69 · see citing works
Guía GETECCU 2020 para el tratamiento de la colitis ulcerosa. Elaborada con metodología GRADE
Sicilia, B., García‐López, S., González‐Lama, Y., Zabana, Y., Hinojosa, J., & Gomollón, F. (2020) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2020.07.001 · Cited by 63 · see citing works
Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis
Layunta, E., Buey, B., Mesonero, J. E., & Latorre, E. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.748254 · Cited by 67 · see citing works
Inter-kingdom effect on epithelial cells of the N-Acyl homoserine lactone 3-oxo-C12:2, a major quorum-sensing molecule from gut microbiota
Landman, C., Grill, J.-P., Mallet, J., Marteau, P. R., Humbert, L., Balc’h, E. L., Maubert, M.-A., Pérez, K., Chaara, W., Brot, L., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202587 · Cited by 62 · see citing works
Immunological mechanisms underpinning faecal microbiota transplantation for the treatment of inflammatory bowel disease
Quraishi, M. N., Shaheen, W., Oo, Y. H., & Iqbal, T. H. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13397 · Cited by 62 · see citing works
Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis
Ashique, S., Mishra, N., Garg, A., Sibuh, B. Z., Taneja, P., Rai, G., Djearamane, S., Wong, L. S., Al‐Dayan, N., Roychoudhury, S., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1126579 · Cited by 58 · see citing works
Gut microbiota: impacts on gastrointestinal cancer immunotherapy
Lau, H. C.-H., Sung, J. J. �., & Yu, J. Q. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1869504 · Cited by 56 · see citing works
Exploring the interaction and impact of probiotic and commensal bacteria on vitamins, minerals and short chain fatty acids metabolism
Bermúdez‐Humarán, L. G., Chassaing, B., & Langella, P. (2024) · Microbial Cell Factories · doi:10.1186/s12934-024-02449-3 · Cited by 56 · see citing works
Forty-five-year evolution of probiotic therapy
Puebla-Barragan, S., & Reid, G. (2019) · Microbial Cell · doi:10.15698/mic2019.04.673 · Cited by 59 · see citing works
May ChatGPT be a tool producing medical information for common inflammatory bowel disease patients' questions? An evidence-controlled analysis
Gravina, A. G., Pellegrino, R., Cipullo, M., Palladino, G., Imperio, G., Ventura, A., Auletta, S., Ciamarra, P., & Federico, A. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i1.17 · Cited by 56 · see citing works
“This is because of the often disproportionate and misguided use of supplements in patients with IBD[38] and the poorly defined evidence on the benefits of consuming specific probiotics[39-41].”
Diet and inflammatory bowel disease: the Asian Working Group guidelines
Sood, A., Ahuja, V., Kedia, S., Midha, V., Mahajan, R., Mehta, V., Sudhakar, R., Singh, A., Kumar, A., Puri, A. S., et al. (2019) · Indian Journal of Gastroenterology · doi:10.1007/s12664-019-00976-1 · Cited by 54 · see citing works
Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine
Darby, T. M., Owens, J. A., Saeedi, B. J., Luo, L., Matthews, J. D., Robinson, B. S., Naudin, C. R., & Jones, R. M. (2019) · iScience · doi:10.1016/j.isci.2019.01.030 · Cited by 54 · see citing works
Using Twitter to Understand the Human Bowel Disease Community: Exploratory Analysis of Key Topics
Pérez‐Pérez, M., Rodríguez, G. P., Fdez‐Riverola, F., & Lourenço, A. M. G. (2019) · Journal of Medical Internet Research · doi:10.2196/12610 · Cited by 54 · see citing works
Beneficial effects of nutritional supplements on intestinal epithelial barrier functions in experimental colitis modelsin vivo
Vargas‐Robles, H., Castro-Ochoa, K. F., Citalán‐Madrid, A. F., & Michael Schnoor, A. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i30.4181 · Cited by 54 · see citing works
Gut Microbiota and Dietary Factors as Modulators of the Mucus Layer in Inflammatory Bowel Disease
Fernández‐Tomé, S., Moreno, L. O., Chaparro, M., & Gisbert, J. P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910224 · Cited by 53 · see citing works
Probiotics for people with cystic fibrosis
Coffey, M. J., Garg, M., Homaira, N., Jaffé, A., & Ooi, C. Y. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012949.pub2 · Cited by 53 · see citing works
Intestinal Microbes in Autoimmune and Inflammatory Disease
Wu, W.-J. H., Zegarra-Ruiz, D. F., & Diehl, G. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.597966 · Cited by 53 · see citing works
Searching for a Consensus Among Inflammatory Bowel Disease Studies: A Systematic Meta-Analysis
Abdel-Rahman, L. I. H., & Morgan, X. C. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac194 · Cited by 51 · see citing works
Redox Role of Lactobacillus casei Shirota Against the Cellular Damage Induced by 2,2′-Azobis (2-Amidinopropane) Dihydrochloride-Induced Oxidative and Inflammatory Stress in Enterocytes-Like Epithelial Cells
Finamore, A., Ambra, R., Nobili, F., Garaguso, I., Raguzzini, A., & Serafini, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01131 · Cited by 52 · see citing works
The Microbiota and the Immune Response: What Is the Chicken and What Is the Egg?
Fritsch, J., & Abreu, M. T. (2019) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2019.02.005 · Cited by 52 · see citing works

P622 Efficacy of probiotics in inflammatory bowel disease: systematic review and meta-analysis
Derwa, Y. H., Gracie, D. J., Hamlin, P. J., & Ford, A. C. (2017) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjx002.746 · Cited by 7 · see citing works
P793 Efficacy and safety of probiotics in inflammatory bowel disease: an umbrella review and updated meta-analysis of randomized controlled trials
Estevinho, M. M., Rodríguez–Lago, I., Dias, C. C., Acosta, M. B., & Magro, F. (2024) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjad212.0923 · Cited by 3 · see citing works
Efficacy and safety of probiotics in IBD: An overview of systematic reviews and updated meta-analysis of randomized controlled trials.
Estevinho, M. M., Yuan, Y., Rodríguez‐Lago, I., Sousa‐Pimenta, M., Dias, C. C., Barreiro‐de Acosta, M., Jairath, V., & Magro, F. (2024) · United European gastroenterology journal · doi:10.1002/ueg2.12636 · Cited by 74 · see citing works
Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohnʼs Disease, and Pouchitis: Meta-analysis of Randomized Controlled Trials
Shen, J., Zuo, Z.-X., & Mao, A.-P. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000437495.30052.be · Cited by 364 · see citing works
Efficacy and safety of probiotics in the induction and maintenance of inflammatory bowel disease remission: A systematic review and meta-analysis
Chen, M., Feng, Y., & Liu, W. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-21-2996 · Cited by 35 · see citing works

Authors: Derwa, Y., Gracie, D. J., Hamlin, P. J., & Ford, A. C.
Affiliations: University of Leeds (GB)
St James's University Hospital (GB)
Corresponding author: Gracie, D. J.
ORCID: Derwa, Y.
Gracie, D. J.
Ford, A. C.
Venue: Alimentary Pharmacology & Therapeutics
Publisher: Wiley
Published: 2017-06-27
Volume: 46
Issue: 4
Pages: 389-400
ISSN: 0269-2813 (ISSN-L)
1365-2036
DOI: 10.1111/apt.14203
OpenAlex: W2733524369
Cited by: 393
References: 67
Citations by year: 2026: 22 · 2025: 26 · 2024: 37 · 2023: 47 · 2022: 39 · 2021: 62 · 2020: 57 · 2019: 50 · 2018: 45 · 2017: 8
FWCI: 5.63
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alimentary Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: probiotics, inflammatory bowel disease, ulcerative colitis, Crohn's disease, VSL#3, 5-aminosalicylates, remission induction, relapse prevention, quiescent disease, surgical remission, gut microbiota
MeSH terms: Adult, Colitis, Ulcerative, Crohn Disease, Humans, Remission Induction, Randomized Controlled Trials as Topic, Treatment Outcome, Mesalamine, Probiotics, Secondary Prevention

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Systematic review with meta-analysis: The efficacy of probiotics in inflammatory bowel disease

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks