Detection of selection signatures for agonistic behaviour in cattle
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Summary: The identification of genomic regions including signatures of selection produced by domestication and its subsequent artificial selection processes allows the understanding of the evolution of bovine breeds. Although several studies describe the genomic variability among meat or milk production cattle breeds, there are limited studies orientated towards bovine behavioural features. This study is focused on mapping genomic signatures of selection which may provide insights of differentiation between neutral and selected polymorphisms. Their effects are studied in the Lidia cattle traditionally selected for agonistic behaviour compared with Spanish breeds showing tamed behaviour. Two different approaches, BayeScan and SelEstim, were applied using genotypic 50K SNP BeadChip data. Both procedures detected two genomic regions bearing genes previously related to behavioural traits. The frequencies of the selected allele in these two regions in Lidia breed were opposite to those found in the tamed breeds. In these genomic regions, several putative genes associated with enriched metabolic pathways related to the behavioural development were identified, as neurochondrin gene (NCDN) or glutamate ionotropic receptor kainate type subunit 3 (GRIK 3) both located at BTA 3 or leucine‐rich repeat and Ig domain containing 2 (LINGO 2) and phospholipase A2‐activating protein (PLAA) at BTA 8.
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A polymorphism in the promoter of the MAOA gene is among the genomic divergences in the Lidia breed.
“This includes a polymorphism in the promoter of the monoamine oxidase A (MAOA) gene, an important locus widely associated with pathological forms of aggression which, in humans, manifests in a broad spectrum of psychiatric conditions, such as manic and bipolar disorders and schizophrenia, among others [17, 18].”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [16]
A recent study identified significant divergence in genomic regions containing genes associated with aggressive behavior in the Lidia breed.
“A recent study has identified significant divergence in genomic regions containing genes associated with aggressive behavior in the Lidia breed [16].”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [16]
The kainate glutamate receptor GRIK3 is associated with heightened aggression in Lidia cattle.
“Similarly, the kainite glutamate receptor GRIK3 is associated with heightened aggression in Lidia cattle.”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [16]
GRIK3 has been targeted in modern human evolution and in multiple domestication events, including in dogs, sheep, yaks, and across multiple cattle breeds.
“This gene has been targeted in modern human evolution and in multiple domestication events, including in dogs, sheep, yaks, and across multiple cattle breeds [16, 19, 20].”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [16]
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- Authors
- Eusebi, P. G., Cortés, O., Carleos, C., Dunner, S., & Cañon, J.
- Affiliations
- Universidad Complutense de Madrid (ES)
- Universidad de Oviedo (ES)
- Departamento de Producción Animal Facultad de Veterinaria Universidad Complutense de Madrid Madrid Spain
- Corresponding author
- Eusebi, P.G.
- Venue
- Journal of Animal Breeding and Genetics
- Publisher
- Wiley
- Published
- 2018-04-26
- Volume
- 135
- Issue
- 3
- Pages
- 170-177
- ISSN
- 0044-3581 (ISSN-L)
- 0931-2668
- 1439-0388
- OpenAlex
- W2802429197
- Cited by
- 25
- References
- 31
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 3
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Journal of Animal Breeding and Genetics (publishedVersion)
- PubMed (publishedVersion)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- Funders
- Consejo Nacional de Ciencia y Tecnología
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- selection signatures, agonistic behavior, cattle, Lidia cattle, behavioral characteristics, domestication, selective breeding, BayeScan, SNP genotyping, GRIK3, cattle breeds
- MeSH terms
- Selective Breeding, Agonistic Behavior, Animals, Bayes Theorem, Cattle, Genetic Markers, Genotype, Phenotype, Selection, Genetic, Polymorphism, Single Nucleotide, Genetic Association Studies
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