Aggressive behavior in cattle is associated with a polymorphism in the MAOA gene promoter
Abstract
Summary: Molecular mechanisms underlying aggressive behavior are primitive and similar among the subphylum Vertebrata. In humans, a primary goal in the study of aggression is to determine the neurobehavioral molecular factors triggering violence. Although several species have been used to study agonistic responses, researchers are limited by the difficulty of artificially inducing aggression in animals not selected for it. Conversely, the Lidia cattle breed has been selected since the eighteenth century to display agonistic responses based on traits such as aggressiveness, ferocity and mobility, all of them showing significant heritability values. This intensive selection may have driven shifts in specific allele frequencies. In a previous analysis across the autosomes, we revealed long‐term selection regions including genes involved in behavioral development. In the present study, we focus on mapping recent signatures of selection associated with aggressiveness at chromosome X, by comparing Lidia cattle samples with two non‐specialized Spanish breeds showing tamed behavior. The most significant markers peaked around the monoamine oxidase A (MAOA) gene, and thus the associations of three functionally important regions located near the promoter of this gene were further investigated. A polymorphism consisting of a variable number of tandem repeats of the nucleotide ‘C’ (BTX:105,462,494) and displaying lower number of repetitions in the Lidia breed when compared with the tamed breeds was detected. In silico analyses predicted that the g.105,462,494delsinsC variant may code for the Sp1 binding motif, one of the major transcription factors controlling the core promoter and expression of the MAOA gene in humans.
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MAOA is an important locus widely associated with pathological forms of aggression, manifesting in humans in psychiatric conditions such as manic and bipolar disorders and schizophrenia.
“This includes a polymorphism in the promoter of the monoamine oxidase A (MAOA) gene, an important locus widely associated with pathological forms of aggression which, in humans, manifests in a broad spectrum of psychiatric conditions, such as manic and bipolar disorders and schizophrenia, among others [17, 18].”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [18]
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Self-citation
- Authors
- Eusebi, P. G., Sevane, N., Cortés, O., Contreras, E., Cañon, J., & Dunner, S.
- Affiliations
- Universidad Complutense de Madrid (ES)
- Departamento de Producción Animal Facultad de Veterinaria Universidad Complutense de Madrid Avenida Puerta de Hierro, s/n 28040 Madrid Spain
- Corresponding author
- Eusebi, P. G.
- Venue
- Animal Genetics
- Publisher
- Wiley
- Published
- 2019-10-21
- Volume
- 51
- Issue
- 1
- Pages
- 14-21
- ISSN
- 0268-9146 (ISSN-L)
- 1365-2052
- OpenAlex
- W2981649993
- Cited by
- 21
- References
- 62
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 1
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Animal Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- aggression, Lidia cattle, MAOA gene, promoter polymorphism, variable number tandem repeats, X chromosome, selection signatures, cattle breed comparison, monoamine oxidase A, transcriptional regulation
- MeSH terms
- Aggression, Animals, Behavior, Animal, Breeding, Cattle, Monoamine Oxidase, Polymorphism, Genetic, Promoter Regions, Genetic, Selection, Genetic, X Chromosome, Minisatellite Repeats
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