LINC01116 promotes proliferation and migration of endometrial stromal cells by targeting FOXP1 via sponging miR-9-5p in endometriosis
Open accessAbstract
Endometriosis is a common multi-factorial gynaecological disease. Recent studies have revealed that long non-coding RNAs (lncRNAs) are involved in the pathogenesis of endometriosis. In the present study, the expression profiles of lncRNAs in 6 pairs of endometriosis ectopic endometrium (ecEM) and eutopic endometrium (euEM) tissues were analysed by RNA sequencing. From the profiles, LINC01116 was found to be up-regulated in ecEM tissues compared to euEM tissues and was verified by quantitative real-time PCR (qRT-PCR). Then, functional experiments demonstrated that LINC01116 promoted the proliferation and migration of ectopic primary endometrial stromal cells (ESCs), while miR-9-5p exerted the opposite effects. Dual-luciferase reporter assays verified that LINC01116 directly sponged miR-9-5p and relieved the suppression of its target, Forkhead box protein P1 (FOXP1). Rescue experiments further demonstrated that LINC01116 could promote proliferation and migration of ESCs by targeting FOXP1 via sponging miR-9-5p. Overall, our study illuminates that LINC01116 promotes the progression of endometriosis through the miR-9-5p/FOXP1 axis. This finding provides a novel therapeutic target for patients with endometriosis.
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LINC01116 promotes the progression of endometriosis through the miR-9-5p/FOXP1 axis, providing a new therapeutic target for endometriosis patients.
“A study by the Cui et al. team explains that LINC01116 promotes the progression of endometriosis through the miR-9-5p/FOXP1 axis. This discovery provides a new therapeutic target for endometriosis patients [174].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [174]
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Smolarz, B., Szyłło, K., & Romanowicz, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910554 · Cited by 560 · see citing works
- Authors
- Cui, L., Chen, S., Wang, D., & Yang, Q.
- Affiliations
- China Medical University (CN)
- Corresponding author
- Yang, Qing
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2020-12-28
- Volume
- 25
- Issue
- 4
- Pages
- 2000-2012
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- PMC
- PMC7882988
- OpenAlex
- W3115408500
- Cited by
- 38
- References
- 51
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 8 · 2021: 6 · 2020: 1
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-05-07)
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Cellular and Molecular Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81872125)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- LINC01116, endometriosis, miR-9-5p, FOXP1, long non-coding RNA, endometrial stromal cells, cell proliferation, cell migration, ectopic endometrium, microRNA sponging, therapeutic target
- MeSH terms
- Adult, Cell Movement, Disease Susceptibility, Endometriosis, Female, Gene Expression Regulation, Humans, Repressor Proteins, Stromal Cells, Computational Biology, Gene Expression Profiling, RNA Interference, MicroRNAs, Cell Proliferation, Forkhead Transcription Factors, Young Adult, High-Throughput Nucleotide Sequencing, Transcriptome
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