Noncoding RNAs in neurodegeneration
Open accessAbstract
The emerging complexity of the transcriptional landscape poses great challenges to our conventional preconceptions of how the genome regulates brain function and dysfunction. Non-protein-coding RNAs (ncRNAs) confer a high level of intricate and dynamic regulation of various molecular processes in the CNS and they have been implicated in neurodevelopment and brain ageing, as well as in synapse function and cognitive performance, in both health and disease. ncRNA-mediated processes may be involved in various aspects of the pathogenesis of neurodegenerative disorders. Understanding these events may help to develop novel diagnostic and therapeutic tools. Here, we provide an overview of the complex mechanisms that are affected by the diverse ncRNA classes that have been implicated in neurodegeneration.
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Noncoding RNAs can influence the expression of other genes through multiple mechanisms to cause a wide range of disorders.
“they can influence the expression of other genes through multiple mechanisms to cause a wide range of disorders.215–218”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [218]
Earlier reviews have largely focused on global miRNA expression shifts in AD brain tissue, therapeutic miRNA candidates, or body-fluid biomarker signatures, but do not present how miRNA dysfunction propagates across interacting CNS cell types.
“Earlier reviews have largely focused on global miRNA expression shifts in AD brain tissue, therapeutic miRNA candidates, or body-fluid biomarker signatures (Li et al., 2024; Long et al., 2012; Salta and De Strooper, 2017; Samadian et al., 2021; Walgrave et al., 2021b; Wei et al., 2020; Yoon et al., 2022). Although these approaches are valuable, they do not present how miRNA dysfunction propagates”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Salta and De Strooper, 2017
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Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease
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- Authors
- Salta, E., & De Strooper, B.
- Affiliations
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Corresponding author
- Salta, Evgenia
- ORCID
- Salta, Evgenia
- Venue
- Nature Reviews Neuroscience
- Published
- 2017-08-17
- Volume
- 18
- Issue
- 10
- Pages
- 627-640
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2745561846
- Cited by
- 183
- References
- 21
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 23 · 2023: 19 · 2022: 22 · 2021: 19 · 2020: 37 · 2019: 18 · 2018: 15 · 2017: 1
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- green
- discovery.ucl.ac.uk
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Lirias (KU Leuven) (submittedVersion)
- Funders
- Alzheimer's Association
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering
- Medical Research Council (MC_PC_17116)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- non-coding RNA, neurodegenerative diseases, transcriptional regulation, brain aging, brain development, synaptic function, cognitive performance, pathogenesis
- MeSH terms
- Animals, Brain, Gene Expression Regulation, Humans, Models, Genetic, Nerve Tissue Proteins, Neurodegenerative Diseases, RNA, Untranslated
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