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Cited by 118Oral microbiology and periodontitis researchCardiovascular Health and Disease PreventionBlood Pressure and Hypertension Studies

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Non‐surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study

Vidal, Fábio, Cordovil, Ivan, Figueredo, Carlos Marcelo Silva, Fischer, Ricardo Guimarães·2013·Journal Of Clinical Periodontology
DOI 10.1111/jcpe.12110
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Abstract

AIM: To evaluate the effects of non-surgical periodontal treatment on left ventricular mass (LVM), arterial stiffness, systolic and diastolic blood pressure and plasma levels of inflammatory markers (C-reactive protein (CRP), fibrinogen and interleukin-6) in refractory hypertension patients. MATERIAL AND METHODS: This interventional prospective cohort pilot study included 26 patients (53.6 ± 8.0 years old) diagnosed with refractory hypertension and generalized chronic periodontitis. Subjects received non-surgical periodontal treatment according to their needs. Plasma levels of systemic inflammation (CRP; fibrinogen and interleukin-6) and established cardiovascular risk factors [systolic and diastolic blood pressure (SBP and DBP), left ventricular mass (LVM) and arterial stiffness] were assessed at three time points (baseline, 3 months after baseline and 6 months after periodontal therapy). RESULTS: Periodontal therapy significantly reduced all cardiovascular risk markers evaluated. Median values of SBP and DBP were reduced by 12.5 mmHg and 10.0 mmHg, respectively, whereas left ventricular mass (LVM) reduced by 12.9 g and pulse wave velocity reduced by 0.9 m/s (p < 0.01). Levels of CRP, IL-6 and fibrinogen lowered by 0.5 mg/dl, 1.4 pg/dl and 37.5 mg/dl (p < 0.01), respectively, 6 months after periodontal therapy. CONCLUSIONS: Periodontal therapy significantly reduced levels of CRP, IL-6, fibrinogen, blood pressure, LVM and arterial stiffness, lowering cardiovascular risk in refractory hypertensive patients.

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Crossref · 10.1111/jcpe.12110

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Metadata

Authors
Vidal, F., Cordovil, I., Figueredo, C. M. S., & Fischer, R. G.
Affiliations
  • Universidade do Estado do Rio de Janeiro (BR)
  • Instituto Nacional de Cardiologia (BR)
Corresponding author
Fischer, Ricardo Guimarães
ORCID
Venue
Journal Of Clinical Periodontology
Publisher
Wiley
Published
2013-05-03
Volume
40
Issue
7
Pages
681-687
ISSN
  • 0303-6979 (ISSN-L)
  • 1600-051X
DOI
10.1111/jcpe.12110
OpenAlex
W1992216876
Cited by
118
References
53
Citations by year
2026: 5 · 2025: 6 · 2024: 14 · 2023: 18 · 2022: 5 · 2021: 18 · 2020: 13 · 2019: 10 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 6
FWCI
6.89
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal Of Clinical Periodontology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
non-surgical periodontal therapy, resistant hypertension, chronic periodontitis, cardiovascular risk, left ventricular mass, arterial stiffness, pulse wave velocity, C-reactive protein, fibrinogen, interleukin-6, systemic inflammation, blood pressure reduction
MeSH terms
Arteries, Blood Flow Velocity, Blood Pressure, C-Reactive Protein, Cardiovascular Diseases, Dental Plaque Index, Fibrinogen, Follow-Up Studies, Gingival Hemorrhage, Humans, Hypertension, Middle Aged, Oral Hygiene, Periodontal Index, Periodontal Pocket, Pilot Projects, Prospective Studies, Risk Factors, Dental Scaling, Cohort Studies, Interleukin-6, Ventricular Function, Left, Periodontal Attachment Loss, Chronic Periodontitis, Periodontal Debridement

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