The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Non‐surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study
Abstract
AIM: To evaluate the effects of non-surgical periodontal treatment on left ventricular mass (LVM), arterial stiffness, systolic and diastolic blood pressure and plasma levels of inflammatory markers (C-reactive protein (CRP), fibrinogen and interleukin-6) in refractory hypertension patients. MATERIAL AND METHODS: This interventional prospective cohort pilot study included 26 patients (53.6 ± 8.0 years old) diagnosed with refractory hypertension and generalized chronic periodontitis. Subjects received non-surgical periodontal treatment according to their needs. Plasma levels of systemic inflammation (CRP; fibrinogen and interleukin-6) and established cardiovascular risk factors [systolic and diastolic blood pressure (SBP and DBP), left ventricular mass (LVM) and arterial stiffness] were assessed at three time points (baseline, 3 months after baseline and 6 months after periodontal therapy). RESULTS: Periodontal therapy significantly reduced all cardiovascular risk markers evaluated. Median values of SBP and DBP were reduced by 12.5 mmHg and 10.0 mmHg, respectively, whereas left ventricular mass (LVM) reduced by 12.9 g and pulse wave velocity reduced by 0.9 m/s (p < 0.01). Levels of CRP, IL-6 and fibrinogen lowered by 0.5 mg/dl, 1.4 pg/dl and 37.5 mg/dl (p < 0.01), respectively, 6 months after periodontal therapy. CONCLUSIONS: Periodontal therapy significantly reduced levels of CRP, IL-6, fibrinogen, blood pressure, LVM and arterial stiffness, lowering cardiovascular risk in refractory hypertensive patients.
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“Limited evidence also suggests that successful periodontal treatment could improve arterial blood pressure.28,29”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [29]
In the citing paper
“the effects of non-surgical periodontal therapy on both systolic and diastolic blood pressure were of greater magnitude of those reported in the other intervention studies.”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [29]
In the citing paper
“We urge caution in interpreting these results especially in view of the limited sample size and inclusion criteria adopted by the authors.29”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [29]
In the citing paper
“This study was a pilot intervention trial including only 26 patients with refractory hypertension and periodontitis”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [29]
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Cites
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000107251.49515.c2 · Cited by 13,271
Development of a Classification System for Periodontal Diseases and Conditions
Armitage, G. C. (1999) · Annals of Periodontology · doi:10.1902/annals.1999.4.1.1 · Cited by 5,110
Laurent, S., Boutouyrie, P., Asmar, R., Gautier, I., Laloux, B., Guize, L., Ducimetiere, P., & Benetos, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.5.1236 · Cited by 3,856
Problems and proposals for recording gingivitis and plaque.
Ainamo, J., & Bay, I. (1975) · PubMed · Cited by 3,022
de Lorgeril, M., Salen, P., Martin, J.-L., Monjaud, I., Delaye, J., & Mamelle, N. (1999) · Circulation · doi:10.1161/01.cir.99.6.779 · Cited by 2,910
Ridker, P. M., Rifai, N., Pfeffer, M. A., Sacks, F. M., Moye, L. A., Goldman, S., Flaker, G. C., & Braunwald, E. (1998) · Circulation · doi:10.1161/01.cir.98.9.839 · Cited by 1,389
Treatment of periodontitis and endothelial function
Tonetti, M. S., D'Aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P., & Deanfield, J. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063186 · Cited by 1,326
Prognostic Significance of Left Ventricular Mass Change During Treatment of Hypertension
Devereux, R. B. (2004) · JAMA · doi:10.1001/jama.292.19.2350 · Cited by 876
Loos, B. G., Craandijk, J., Hoek, F. J., Dillen, P. M. E. W., & van der Velden, U. (2000) · Journal of Periodontology · doi:10.1902/jop.2000.71.10.1528 · Cited by 810
A systematic review and meta‐analyses on C‐reactive protein in relation to periodontitis
Paraskevas, S., Huizinga, J. D., & Loos, B. G. (2008) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2007.01173.x · Cited by 757
Effect of nonsurgical periodontal therapy
Badersten, A., Nilvéus, R., & Egelberg, J. H. (1984) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1984.tb01309.x · Cited by 721
O’Brien, E., Asmar, R. G., Beilin, L. J., Imai, Y., Mancia, G., Mengden, T., Myers, M. G., Padfield, P. L., Palatini, P., Parati, G., et al. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000163132.84890.c4 · Cited by 720
Fichtlscherer, S., Rosenberger, G., Walter, D. H., Breuer, S., Dimmeler, S., & Zeiher, A. M. (2000) · Circulation · doi:10.1161/01.cir.102.9.1000 · Cited by 665
Vlachopoulos, C., Dima, I., Aznaouridis, K., Vasiliadou, C., Ioakeimidis, N., Aggeli, C., Toutouza, M., & Stefanadis, C. (2005) · Circulation · doi:10.1161/circulationaha.105.535435 · Cited by 492
D'Aiuto, F., Parkar, M., Nibali, L., Suvan, J., Lessem, J., & Tonetti, M. S. (2006) · American Heart Journal · doi:10.1016/j.ahj.2005.06.018 · Cited by 332
Verdecchia, P. (2003) · American Journal of Hypertension · doi:10.1016/s0895-7061(03)01018-5 · Cited by 310
Impact of oral health on the life quality of periodontal patients
Needleman, I. G., McGrath, C. P. J., Floyd, P. D., & Biddle, A. (2004) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2004.00498.x · Cited by 300
Low‐Grade Inflammation in Chronic Infectious Diseases
Moutsopoulos, N. M., & Madianos, P. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1366.032 · Cited by 298
Offenbacher, S., Beck, J. D., MOSS, K. L., Mendoza, L., Paquette, D. W., Barrow, D. A., Couper, D. J., Stewart, D., Falkner, K. L., Graham, S., et al. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.080007 · Cited by 262
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Seinost, G., Wimmer, G., Skerget, M., Thaller, E., Brodmann, M., Gasser, R. N. A., Bratschko, R. O., & Pilger, E. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.09.059 · Cited by 253
Higashi, Y., Goto, C., Jitsuiki, D., Umemura, T., Nishioka, K., Hidaka, T., Takemoto, H., Nakamura, S., Soga, J., Chayama, K., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.101535 · Cited by 250
Ide, M., McPartlin, D., Coward, P. Y., Crook, M. A., Lumb, P. J., & Wilson, R. F. (2003) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2003.00282.x · Cited by 231
Holmlund, A., Holm, G., & Lind, L. (2006) · Journal of Periodontology · doi:10.1902/jop.2006.050233 · Cited by 215
Vidal, F., Figueredo, C. M., Cordovil, I., & Fischer, R. G. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.080471 · Cited by 204
Self-citationThe Effect of Periodontal Treatment on Serum Leptin, Interleukin‐6, and C‐Reactive Protein
Shimada, Y., Komatsu, Y., 池澤, 育., 田井, 秀., Sugita, N., & Yoshie, H. (2010) · Journal of Periodontology · doi:10.1902/jop.2010.090741 · Cited by 193
Yamazaki, K., Honda, T., Oda, T., Ueki‐Maruyama, K., Nakajima, T. E., Yoshie, H., & Seymour, G. J. (2004) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2004.00772.x · Cited by 188
Iwamoto, Y., Nishimura, F., Soga, Y., Takeuchi, K., Kurihara, M., Takashiba, S., & Murayama, Y. (2003) · Journal of Periodontology · doi:10.1902/jop.2003.74.8.1231 · Cited by 171
Marcaccini, A. M., Meschiari, C. A., Sorgi, C. A., Saraiva, M. D. C. P., de Souza, A. M., Faccioli, L. H., Tanus-Santos, J. E., Novaes, A. B., & Gerlach, R. F. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.080561 · Cited by 158
Higashi, Y., Goto, C., Hidaka, T., Soga, J., Nakamura, S., Fujii, Y., Hata, T., Idei, N., Fujimura, N., Chayama, K., et al. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.03.037 · Cited by 157
Urinary Electrolyte Excretion in 24 Hours and Blood Pressure in the INTERSALT Study
Dyer, A. R., Elliott, P., & Shipley, M. J. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117100 · Cited by 153
Periodontitis and atherogenesis: causal association or simple coincidence?
D’Aiuto, F., Parkar, M., Andreou, G., Brett, P., Ready, D. R., & Tonetti, M. S. (2004) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2004.00580.x · Cited by 152
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Tsioufis, C., Kasiakogias, A., Thomopoulos, C., & Stefanadis, C. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.04.030 · Cited by 142
Tsakos, G., Sabbah, W., Hingorani, A. D., Netuveli, G., Donos, N., Watt, R. G., & D'Aiuto, F. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32833e0fe1 · Cited by 134
Montebugnoli, L., Servidio, D., MIATON, R. A., Prati, C., Tricoci, P., Melloni, C., & Melandri, G. (2005) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2005.00641.x · Cited by 131
Association Between Periodontal Disease and Left Ventricle Mass in Essential Hypertension
Angeli, F., Verdecchia, P., Pellegrino, C., Pellegrino, R. G., Pellegrino, G., Prosciutti, L., Giannoni, C., Cianetti, S., & Bentivoglio, M. (2003) · Hypertension · doi:10.1161/01.hyp.0000056525.17476.d7 · Cited by 124
Bokhari, S. A. H., Khan, A. A., Butt, A. K., Azhar, M., Hanif, M., Izhar, M., & Tatakis, D. N. (2012) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2012.01942.x · Cited by 119
Mercanoğlu, F., Oflaz, H., Öz, O., Gokbuget, A. Y., Gençhellaç, H., Sezer, M., Nişancí, Y., & Umman, S. (2004) · Journal of Periodontology · doi:10.1902/jop.2004.75.12.1694 · Cited by 114
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Peres, M. A., Tsakos, G., Barbato, P. R., Silva, D. A. S., & Peres, K. G. (2012) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2012.01916.x · Cited by 81
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Blum, A., Kryuger, K., Eizenberg, M. M., Tatour, S., Vigder, F., Laster, Z., & Front, E. (2007) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2006.12.003 · Cited by 80
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Rusak, E. J., Bellido, C. A., Iavı́coli, O. R., Vázquez, S. T., Duarte, M., & Lerman, J. (2010) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2010.00292.x · Cited by 13
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Metadata
- Authors
- Vidal, F., Cordovil, I., Figueredo, C. M. S., & Fischer, R. G.
- Affiliations
- Universidade do Estado do Rio de Janeiro (BR)
- Instituto Nacional de Cardiologia (BR)
- Corresponding author
- Fischer, Ricardo Guimarães
- Venue
- Journal Of Clinical Periodontology
- Publisher
- Wiley
- Published
- 2013-05-03
- Volume
- 40
- Issue
- 7
- Pages
- 681-687
- ISSN
- 0303-6979 (ISSN-L)
- 1600-051X
- OpenAlex
- W1992216876
- Cited by
- 118
- References
- 53
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 14 · 2023: 18 · 2022: 5 · 2021: 18 · 2020: 13 · 2019: 10 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 6
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal Of Clinical Periodontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- non-surgical periodontal therapy, resistant hypertension, chronic periodontitis, cardiovascular risk, left ventricular mass, arterial stiffness, pulse wave velocity, C-reactive protein, fibrinogen, interleukin-6, systemic inflammation, blood pressure reduction
- MeSH terms
- Arteries, Blood Flow Velocity, Blood Pressure, C-Reactive Protein, Cardiovascular Diseases, Dental Plaque Index, Fibrinogen, Follow-Up Studies, Gingival Hemorrhage, Humans, Hypertension, Middle Aged, Oral Hygiene, Periodontal Index, Periodontal Pocket, Pilot Projects, Prospective Studies, Risk Factors, Dental Scaling, Cohort Studies, Interleukin-6, Ventricular Function, Left, Periodontal Attachment Loss, Chronic Periodontitis, Periodontal Debridement
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