Periodontitis and blood pressure: the concept of dental hypertension

Tsioufis, Costas; Kasiakogias, Alexandros; Thomopoulos, Costas; Stefanadis, Christodoulos

doi:10.1016/j.atherosclerosis.2011.04.030

Cited by 142Oral microbiology and periodontitis researchBlood Pressure and Hypertension StudiesDental Research and COVID-19

Periodontitis and blood pressure: the concept of dental hypertension

Tsioufis, Costas, Kasiakogias, Alexandros, Thomopoulos, Costas, Stefanadis, Christodoulos·2011·Atherosclerosis

DOI 10.1016/j.atherosclerosis.2011.04.030

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Abstract

Chronic periodontitis is a common inflammatory disorder that is being contemplated as a risk factor for atherosclerotic complications. Current epidemiological evidence also supports its potential association with increases in blood pressure levels and hypertension prevalence. Furthermore, data from cross-sectional studies suggest that in hypertensive subjects periodontitis may enhance the risk and degree of target organ damage. A possible pathogenetic background of an effect of periodontitis on blood pressure should include the systemic generalization of the local oral inflammation, the role of the host immune response, the direct microbial effect on the vascular system and alterations in endothelial function. Inversely, the concept of hypertension unfavorably affecting periodontal tissues cannot be excluded. The two conditions share multiple common risk factors that should be readily controlled for when assessing a possible association. Thoroughly designed prospective and interventional trials are needed in order to determine the impact of periodontitis on blood pressure regulation and incident hypertension and its integration in the clinical approach of both dental and hypertensive patients.

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Several studies appear to support a relationship between severe periodontitis and hypertension.
“Several studies appear to support a relationship between severe periodontitis and hypertension.[24][25][26][27]”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [25]

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Franek, E., Błach, A., Wituła, A., Kolonko, A., Chudek, J. T., Drugacz, J., & Więcek, A. (2005) · Transplantation · doi:10.1097/01.tp.0000158716.12065.24 · Cited by 39 · see citing works
Blood pressure and left ventricular mass in subjects with type 2 diabetes and gingivitis or chronic periodontitis
Franek, E., Napora, M., Błach, A., Budlewski, T., Gozdowskı, D., Jedynasty, K., Krajewski, J., & Górska, R. (2010) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01613.x · Cited by 36 · see citing works
Experimental-Induced Periodontitis is Exacerbated in Spontaneously Hypertensive Rats
Leite, C. L. A., Redins, C. A., Vasquez, E. C., & Meyrelles, S. S. (2005) · Clinical and Experimental Hypertension · doi:10.1081/ceh-200067688 · Cited by 36 · see citing works
Association between High Blood Pressure and Deep Periodontal Pockets
Engström, S., Gahnberg, L., Högberg, H., & Svärdsudd, K. (2007) · Upsala Journal of Medical Sciences · doi:10.3109/2000-1967-099 · Cited by 36 · see citing works
The effect of full-mouth tooth extraction on glycemic control among patients with type 2 diabetes requiring extraction of all remaining teeth: a randomized clinical trial
Khader, Y. S., Habashneh, R. A., Malalheh, M. A., & Bataineh, A. B. (2010) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2010.01294.x · Cited by 34 · see citing works
Influence of Periodontal Therapy on the Regulation of Soluble Cell Adhesion Molecule Expression in Aggressive Periodontitis Patients
Pischon, N., Hägewald, S., Kunze, M., Heng, N. H. M., Christan, C., Kleber, B., Müller, C., & Bernimoulin, J. (2007) · Journal of Periodontology · doi:10.1902/jop.2007.060286 · Cited by 31 · see citing works
Expression of endothelins and their receptors in cells from human periodontal tissues.
Fujioka, D., Nakamura, S., Yoshino, H., Shinohara, H., Shiba, H., Mizuno, N., Hasegawa, N., Shindoh, N., Uchida, Y., Ogawa, T., et al. (2003) · Journal of Periodontal Research · doi:10.1034/j.1600-0765.2003.00653.x · Cited by 30 · see citing works
ATVB In Focus
Hansson, G. K. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000153139.83149.a2 · Cited by 30 · see citing works
Evaluation of Serum Anti‐Cardiolipin and Oxidized Low‐Density Lipoprotein Levels in Chronic Periodontitis Patients With Essential Hypertension
Türkoğlu, O., Barış, N., Kütükçüler, N., Şenarslan, Ö., Güneri, S., & Atilla, G. (2008) · Journal of Periodontology · doi:10.1902/jop.2008.070321 · Cited by 30 · see citing works
The conjoint detrimental effect of chronic periodontal disease and systemic inflammation on asymmetric dimethyl-arginine in untreated hypertensive subjects
Tsioufis, C. P., Thomopoulos, C., Soldatos, N. K., Syrseloudis, D., Kasiakogias, A., Silvestros, S., Stefanadi, E., Mostratou, E., & Stefanadis, C. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.07.017 · Cited by 26 · see citing works
Self-citation
Studies suggest an association between maternal periodontal disease and pre-eclampsia
Vergnes, J. (2008) · Evidence-Based Dentistry · doi:10.1038/sj.ebd.6400580 · Cited by 26 · see citing works
Inverse association between number of teeth and left ventricular mass in women
Völzke, H., Schwahn, C., Dörr, M., Aumann, N., Felix, S. B., John, U., Rettig, R., Dören, M., Biffar, R., & Kocher, T. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282861fc0 · Cited by 23 · see citing works
Renin–angiotensin gene polymorphisms in relation to severe chronic periodontitis
Gürkan, A., Emingil, G., Saygan, B. H., Atilla, G., Köse, T., Baylas, H., & Berdelı, A. (2009) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2008.01379.x · Cited by 21 · see citing works
Long-term effects of nifedipine on human gingival epithelium: a histopathological and immunohistochemical study
Castro, L. A., Elias, L. S. A., Oton‐Leite, A. F., de Spíndula-Filho, J. V., Leles, C. R., Batista, A. C., & Mendonça, E. F. (2010) · Journal of Oral Science · doi:10.2334/josnusd.52.55 · Cited by 20 · see citing works
Crevicular fluid endothelin-1 levels in periodontal health and disease.
Pradeep, A., Guruprasad, C., Swati, P., & Shikha, C. (2008) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2007.01026.x · Cited by 17 · see citing works
Effect of renovascular hypertension on the morphology of oral blood vessels
Castelli, W. A., Díaz-Pérez, R., Nasjleti, C. E., & Caffesse, R. G. (1978) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(78)90388-2 · Cited by 16 · see citing works
Changes in tooth position in humans in relation to arterial blood pressure
Ioi, H., Nakata, S., Nakasima, A., Counts, A. L., & Nanda, R. S. (2002) · Archives of Oral Biology · doi:10.1016/s0003-9969(01)00110-8 · Cited by 13 · see citing works
Epidemiological Study on the Relationship between Hypertension and Dental Desease in Japanese Factory Workers
OGAWA, Y., Imaki, M., Yoshida, Y., MATSUMOTO, M., & Tanada, S. (1998) · SANGYO EISEIGAKU ZASSHI · doi:10.1539/sangyoeisei.kj00001990681 · Cited by 10 · see citing works
Periodontal Disease Severity and Urinary Albumin Excretion in Middle-Aged Hypertensive Patients
Tsioufis, C. P., Thomopoulos, C., Soldatos, N. K., Kasiakogias, A., Andrikou, I., Kordalis, A., Toutouzas, K., Giamarelos, G., Tousoulis, D., Kallikazaros, I. E., et al. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.08.043 · Cited by 7 · see citing works
Self-citation
Should dental treatment be considered for lowering inflammatory markers in hypertensive patients?
Jastrzębski, M., Zaleska, M., Klocek, M., Stolarz, K., Wojciechowska, W., Olszanecka, A., Czarnecka, D., & Kawecka−Jaszcz, K. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.08.080 · Cited by 3 · see citing works
BACTERIAL DENTAL PLAQUE IS AN INDEPENDANT PREDICTOR OF AORTIC STIFFNESS IN POPULATION-BASED SAMPLE: PP.8.310
Amar, J., Bieler, L., Benguigui, C., Ruidavets, J., Ferrières, J., & Chamontin, B. (2010) · Journal of Hypertension · doi:10.1097/01.hjh.0000378634.97719.0b · Cited by 2 · see citing works

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Diabetes and Hypertension: Is There a Common Metabolic Pathway?
Cheung, B. M. Y., & Li, C. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0227-2 · Cited by 585 · see citing works
Periodontitis is associated with hypertension: a systematic review and meta-analysis
Muñoz Aguilera, E., Suvan, J., Buti, J., Czesnikiewicz-Guzik, M., Barbosa Ribeiro, A., Orlandi, M., Guzik, T. J., Hingorani, A. D., Nart, J., & D’Aiuto, F. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvz201 · Cited by 394 · see citing works
Evaluating All Potential Oral Complications of Diabetes Mellitus
Verhulst, M. J. L., Loos, B. G., Gerdes, V. E. A., & Teeuw, W. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00056 · Cited by 283 · see citing works
Periodontal disease and the metabolic syndrome
Lamster, I. B., & Pagan, M. (2016) · International Dental Journal · doi:10.1111/idj.12264 · Cited by 187 · see citing works
Association between periodontitis and arterial hypertension: a systematic review and meta-analysis
Martin-Cabezas, R., Seelam, N., Petit, C., Agossa, K., Gaertner, S., Tenenbaum, H., Davideau, J.-L., & Huck, O. (2016) · American Heart Journal · doi:10.1016/j.ahj.2016.07.018 · Cited by 183 · see citing works
Metabonomic analysis of saliva reveals generalized chronic periodontitis signature
Aimetti, M., Cacciatore, S., Graziano, A., & Tenori, L. (2011) · Metabolomics · doi:10.1007/s11306-011-0331-2 · Cited by 140 · see citing works
Interrelationship Between Periapical Lesion and Systemic Metabolic Disorders
Sasaki, H., Hirai, K., Martins, C. M., Furusho, H., Battaglino, R. A., & Hashimoto, K. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160216145107 · Cited by 138 · see citing works
Roles of oral microbiota and oral-gut microbial transmission in hypertension
Chen, B., Lin, W.-Z., Li, Y., Bi, C., Du, L., Liu, Y., Zhou, L.-J., Liu, T., Xu, S., Shi, C., et al. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.03.007 · Cited by 124 · see citing works
Is There an Association between Periodontitis and Hypertension?
Paizan, M. L. M., & Vilela-Martin, J. F. (2014) · Current Cardiology Reviews · doi:10.2174/1573403x10666140416094901 · Cited by 120 · see citing works
Non‐surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study
Vidal, F., Cordovil, I., Figueredo, C. M. S., & Fischer, R. G. (2013) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12110 · Cited by 118 · see citing works
Association between Hypertension and Periodontitis: Possible Mechanisms
Leong, X.-F., Ng, C., Baharin, B., & Das, S. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/768237 · Cited by 112 · see citing works
How Periodontal Disease and Presence of Nitric Oxide Reducing Oral Bacteria Can Affect Blood Pressure
Pignatelli, P., Fabietti, G., Ricci, A., Piattelli, A., & Curia, M. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207538 · Cited by 110 · see citing works
Higher Blood Pressure as a Risk Factor for Diseases Other Than Stroke and Ischemic Heart Disease
Kokubo, Y., & Iwashima, Y. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.03480 · Cited by 101 · see citing works
Periodontitis and Hypertension: Is the Association Causal?
Pinto, R. D., Pietropaoli, D., Aguilera, E. M., D’Aiuto, F., Cześnikiewicz‐Guzik, M., Monaco, A., Guzik, T. J., & Ferri, C. (2020) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-020-00392-z · Cited by 98 · see citing works
Poor Oral Health and Blood Pressure Control Among US Hypertensive Adults
Pietropaoli, D., Pinto, R. D., Ferri, C., Wright, J. T., Giannoni, M., Ortu, E., & Monaco, A. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11528 · Cited by 96 · see citing works
Effect of intensive periodontal therapy on blood pressure and endothelial microparticles in patients with prehypertension and periodontitis: a randomized controlled trial
Zhou, Q., Xia, W., Ren, J., Yu, B., Tong, X., Chen, Y., Chen, S., Feng, L., Dai, J., Tao, J., et al. (2017) · Journal of Periodontology · doi:10.1902/jop.2017.160447 · Cited by 89 · see citing works
Interplay between periodontitis and chronic kidney disease
Chapple, I., Hirschfeld, J., Cockwell, P., Dietrich, T., & Sharma, P. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00910-5 · Cited by 79 · see citing works
Oral Health and Blood Pressure: The IPC Cohort
Darnaud, C., Thomas, F., Pannier, B., Danchin, N., & Bouchard, P. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv025 · Cited by 79 · see citing works
Relationship Between Prehypertension/Hypertension and Periodontal Disease: A Prospective Cohort Study
Kawabata, Y., Ekuni, D., Miyai, H., Kataoka, K., Yamane, M., Mizutani, S., Irie, K., Azuma, T., Tomofuji, T., Iwasaki, Y., et al. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv117 · Cited by 71 · see citing works
Periodontitis, Blood Pressure, and the Risk and Control of Arterial Hypertension: Epidemiological, Clinical, and Pathophysiological Aspects—Review of the Literature and Clinical Trials
Surma, S., Romańczyk, M., Witalińska-Łabuzek, J., Czerniuk, M. R., Łabuzek, K., & Filipiak, K. J. (2021) · Current Hypertension Reports · doi:10.1007/s11906-021-01140-x · Cited by 70 · see citing works
Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal.
Carra, M., Rangé, H., Caligiuri, G., & Bouchard, P. (2023) · Periodontology 2000 · doi:10.1111/prd.12528 · Cited by 83 · see citing works
Salivary DNA and markers of oxidative stress in patients with chronic periodontitis
Baňasová, L., Kamodyová, N., Janšáková, K., Tóthová, Ľ., Stanko, P., Turňa, J., & Celec, P. (2014) · Clinical Oral Investigations · doi:10.1007/s00784-014-1236-z · Cited by 65 · see citing works
The association of periodontitis and metabolic syndrome.
Gurav, A. N. (2014) · Europe PMC (PubMed Central) · doi:10.4103/1735-3327.127175 · Cited by 60 · see citing works
Diet-Induced Overweight and Obesity and Periodontitis Risk: An Application of the Parametric G-Formula in the 1982 Pelotas Birth Cohort
Nascimento, G., Peres, M., Mittinty, M., Peres, K., Do, L., Horta, B., Gigante, D., Corrêa, M., & Demarco, F. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kww187 · Cited by 54 · see citing works
Association between tooth loss and hypertension: A systematic review and meta-analysis
Xu, K., Yu, W., Li, Y., Li, Y., Wan, Q., Chen, L., Dong, Y., Tay, F. R., & Niu, L. (2022) · Journal of Dentistry · doi:10.1016/j.jdent.2022.104178 · Cited by 58 · see citing works
The interrelationship between periodontal disease and systemic health
Tattar, R., da Costa, B. D. C., & Neves, V. C. M. (2025) · BDJ · doi:10.1038/s41415-025-8642-2 · Cited by 50 · see citing works
Associations among oral hygiene behavior and hypertension prevalence and control: the 2008 to 2010 Korea National Health and Nutrition Examination Survey
Choi, H. M., Han, K., Park, Y., & Park, J. (2015) · Journal of Periodontology · doi:10.1902/jop.2015.150025 · Cited by 49 · see citing works
Molecular inflammation and oxidative stress are shared mechanisms involved in both myocardial infarction and periodontitis
Díaz, C. M., Bullón, B., Ruiz-Salmeron, R. J., Riejos, P. F., Fernández-Palacín, A., Battino, M. A., Cordero, M. D., Quiles, J. L., Varela‐López, A., & Bullón, P. (2020) · Journal of Periodontal Research · doi:10.1111/jre.12739 · Cited by 46 · see citing works
Is periodontitis a risk factor for ischaemic stroke, coronary artery disease and subclinical atherosclerosis? A Mendelian randomization study
Bell, S., Gibson, J. T., Harshfield, E. L., & Markus, H. S. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.09.029 · Cited by 44 · see citing works
The relationship between tooth loss and hypertension: a systematic review and meta-analysis
Tada, A., Tano, R., & Miura, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-17363-0 · Cited by 43 · see citing works
Docosahexaenoic Acid, Inflammation, and Bacterial Dysbiosis in Relation to Periodontal Disease, Inflammatory Bowel Disease, and the Metabolic Syndrome
Tabbaa, M., Golubić, M., Roizen, M. F., & Bernstein, A. (2013) · Nutrients · doi:10.3390/nu5083299 · Cited by 43 · see citing works
The association of hypertension with periodontitis is highlighted in female adults: results from the Fourth Korea National Health and Nutrition Examination Survey
Ahn, Y., Shin, M., Byun, J.-S., & Kim, H. (2015) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12471 · Cited by 43 · see citing works
Association between the number of teeth and hypertension in a study based on 13,561 participants
Shin, H. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0413 · Cited by 41 · see citing works
Association between obstructive sleep apnea and comorbidities with periodontal disease in adults
Otero, L., Latorre, C., Arregocés, F. M. E., Porras, J. V., Rubiano, D., & Martínez, P. H. (2018) · Journal of Indian Society of Periodontology · doi:10.4103/jisp.jisp_38_18 · Cited by 40 · see citing works
Is the Oral Microbiome Associated with Blood Pressure in Older Women?
Gordon, J. H., LaMonte, M. J., Genco, R. J., Zhao, J., Li, L., Hovey, K. M., Tsompana, M., Buck, M. J., Andrews, C., McSkimming, D. I., et al. (2019) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-019-00322-8 · Cited by 39 · see citing works
Periodontal Disease in Diabetes Mellitus: A Case–Control Study in Smokers and Non-Smokers
Battancs, E., Gheorghita, D., Nyiraty, S., Lengyel, C., Eördegh, G., Baráth, Z., Várkonyi, T. T., & Antal, M. Á. (2020) · Diabetes Therapy · doi:10.1007/s13300-020-00933-8 · Cited by 39 · see citing works
Hypertension favors the inflammatory process in rats with experimentally induced periodontitis
Bonato, C. F., do Amaral, C. C. F., Belini, L., Salzedas, ‪. M. P., & Oliveira, S. H. P. (2012) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2012.01496.x · Cited by 39 · see citing works
Association of clinical measures of periodontal disease with blood pressure and hypertension among postmenopausal women
Gordon, J. H., LaMonte, M. J., Genco, R. J., Zhao, J., Cimato, T. R., Hovey, K. M. O., & Wactawski‐Wende, J. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0562 · Cited by 34 · see citing works
Correlation between periodontitis and chronic kidney disease in Korean adults
Han, S. S., Shin, N., Lee, S. M., Lee, H., Kim, D. K., & Kim, Y. S. (2013) · Kidney Research and Clinical Practice · doi:10.1016/j.krcp.2013.09.001 · Cited by 30 · see citing works
Additive Interaction of Oral Health Disorders on Risk of Hypertension in a Japanese Urban Population: The Suita Study
Iwashima, Y., Kokubo, Y., Ono, T., Yoshimuta, Y., Kida, M., Kosaka, T., Maeda, Y., Kawano, Y., & Miyamoto, Y. (2013) · American Journal of Hypertension · doi:10.1093/ajh/hpt227 · Cited by 30 · see citing works
Obesity and Periodontal Outcomes: A Population‐Based Cohort Study in Brazil
Nascimento, G. G., Peres, K. G., Mittinty, M., Mejía, G. C., Silva, D. A. S., González‐Chica, D. A., & Peres, M. A. (2016) · Journal of Periodontology · doi:10.1902/jop.2016.160361 · Cited by 29 · see citing works
Association of Periodontal Disease and Edentulism With Hypertension Risk in Postmenopausal Women
Gordon, J. H., LaMonte, M. J., Zhao, J., Genco, R. J., Cimato, T. R., Hovey, K. M. O., Allison, M., Mouton, C. P., & Wactawski‐Wende, J. (2018) · American Journal of Hypertension · doi:10.1093/ajh/hpy164 · Cited by 26 · see citing works
Periodontal Disease Is Associated With Increased Risk of Hypertension: A Cross-Sectional Study
Zhao, M.-J., Qiao, Y.-X., Wu, L., Huang, Q. Y., Li, B., & Zeng, X. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00440 · Cited by 26 · see citing works
Association between periodontitis and systemic medication intake: A case‐control study
Wang, I., Askar, H., Ghassib, I. H., Wang, C., & Wang, H. (2020) · Journal of Periodontology · doi:10.1002/jper.19-0593 · Cited by 25 · see citing works
Oral health in patients treated by positive airway pressure for obstructive sleep apnea: a population-based case–control study
Carra, M. C., Thomas, F., Schmitt, A., Pannier, B., Danchin, N., & Bouchard, P. (2015) · Sleep And Breathing · doi:10.1007/s11325-015-1239-2 · Cited by 25 · see citing works
Association between indices of clinically‐defined periodontitis and self‐reported history of systemic medical conditions
Chrysanthakopoulos, N. A., & Chrysanthakopoulos, P. A. (2014) · Journal of Investigative and Clinical Dentistry · doi:10.1111/jicd.12119 · Cited by 25 · see citing works
A Study on the Relationship between Reflux Esophagitis and Periodontitis
Adachi, K., Mishiro, T., Tanaka, S., Yoshikawa, H., & Kinoshita, Y. (2016) · Internal Medicine · doi:10.2169/internalmedicine.55.6898 · Cited by 24 · see citing works
Effects of age, sex, and blood pressure on the blood flow velocity in dental pulp measured by Doppler ultrasound technique
Kim, D., & Park, S. H. (2016) · Microcirculation · doi:10.1111/micc.12302 · Cited by 23 · see citing works
Association between periodontal condition and hypertension in a non‐smoking population aged 30–49 years: results of the Health 2000 Survey in Finland
Ollikainen, E., Saxlin, T., Tervonen, T., Suominen, A. L., Knuuttila, M. L. E., Jula, A., & Ylöstalo, P. (2014) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12316 · Cited by 22 · see citing works
Gingival fluid inflammatory biomarkers and hypertension in African Americans
Khocht, A., Rogers, T., Janal, M. N., & Brown, M. (2017) · JDR Clinical & Translational Research · doi:10.1177/2380084417694335 · Cited by 21 · see citing works
Rosuvastatin promotes benefits on induced periodontitis in hypertensive rats
Messora, M. R., Vieira, G. H. A., Vanderlei, J. M. T. M. M., Mariguela, V. C., Fernandes, P. G., Palioto, D. B., de Souza, S. L. S., Novaes, A. B., Furlaneto, F. A. C., & Taba, M. (2017) · Journal of Periodontal Research · doi:10.1111/jre.12442 · Cited by 21 · see citing works
The place of periodontal examination and referral in general medicine
Chan, S., Pasternak, G. M., & West, M. (2017) · Periodontology 2000 · doi:10.1111/prd.12199 · Cited by 21 · see citing works
A review of the association between oral bacterial flora and obstructive sleep apnea–hypopnea syndrome comorbid with cardiovascular disease
Zeng, Y., Hu, A., Su, H., & Ko, C. (2019) · Sleep And Breathing · doi:10.1007/s11325-019-01962-9 · Cited by 21 · see citing works
Diabetes or hypertension as risk indicators for missing teeth experience: An exploratory study in a sample of Mexican adults
Medina‐Solís, C. E., Delgado-Pérez, V. J., de la Rosa-Santillana, R., Márquez-Corona, M., Ávila-Burgos, L., Islas-Granillo, H., Minaya‐Sánchez, M., & Medina-Solís, G. (2017) · Nigerian Journal of Clinical Practice · doi:10.4103/njcp.njcp_52_17 · Cited by 20 · see citing works
Serum levels of vitamin D and chronic periodontitis in patients with chronic kidney disease
Bastos, J. D. A., de Andrade, L. C. F., Ferreira, A. P., Barroso, E. D. A., Daibert, P. D. C., Barreto, P. L. D. S., Vilela, E. M., Marcaccini, A. M., Colugnati, F. A. B., & Bastos, M. G. (2013) · Brazilian Journal of Nephrology · doi:10.5935/0101-2800.20130004 · Cited by 19 · see citing works
Periodontal disease as a potential factor of migraine chronification
Ameijeira, P., Leira, Y., Blanco, J., & Leira, R. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.03.019 · Cited by 18 · see citing works
Endothelin-1 is a surrogate biomarker link severe periodontitis and endothelial dysfunction in hypertensive patients: The potential nexus
Al-Kuraishy, H. M., Kadhim, S., Al-Windy, S., & Al-Gareeb, A. I. (2019) · Journal of international oral health · doi:10.4103/jioh.jioh_158_19 · Cited by 18 · see citing works
Hypertension Undermines Mineralization-inducing Capacity of and Tissue Response to Mineral Trioxide Aggregate Endodontic Cement
Martins, C. M., Gomes‐Filho, J. E., Queiroz, Í. O. D. A., Ervolino, E., & Cintra, L. T. Â. (2016) · Journal of Endodontics · doi:10.1016/j.joen.2016.01.003 · Cited by 18 · see citing works
Inhibition of angiotensin II receptor I prevents inflammation and bone loss in periodontitis
Li, J., Xiao, X., Wei, W., Ding, H., Yue, Y., Tian, Y., Nabar, N. R., Liu, Z., Zheng, Y., & Wang, M. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0753 · Cited by 17 · see citing works
Self-reported periodontal health and incident hypertension: longitudinal evidence from the NutriNet-Santé e-cohort
Carra, M. C., Fessi, S., Detzen, L., Darnaud, C., Julia, C., Herçberg, S., Touvier, M., Andreeva, V. A., & Bouchard, P. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000002941 · Cited by 17 · see citing works
Arterial Hypertension Perpetuates Alveolar Bone Loss
Vanderlei, J. M. T. M. D. M., Messora, M. R., Fernandes, P. G., Novaes, A. B., Palioto, D. B., Grisi, M. F. D. M., de Souza, S. L. S., Gerlach, R. F., Antoniali, C., & Taba, M. (2012) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2012.683969 · Cited by 17 · see citing works
Specific periodontopathic bacterial infection affects hypertension in male cardiovascular disease patients
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Authors: Tsioufis, C., Kasiakogias, A., Thomopoulos, C., & Stefanadis, C.
Affiliations: National and Kapodistrian University of Athens (GR)
Corresponding author: Tsioufis, Costas
ORCID: Kasiakogias, Alexandros
Thomopoulos, Costas
Stefanadis, Christodoulos
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 2011-11
Volume: 219
Issue: 1
Pages: 1-9
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/j.atherosclerosis.2011.04.030
OpenAlex: W2119224792
Cited by: 142
References: 98
Citations by year: 2026: 5 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 15 · 2021: 11 · 2020: 11 · 2019: 11 · 2018: 9 · 2017: 9 · 2016: 10 · 2015: 8 · 2014: 8 · 2013: 14 · 2012: 7
FWCI: 1.57
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
Keywords: chronic periodontitis, hypertension, blood pressure, systemic inflammation, host immune response, endothelial function, target organ damage
MeSH terms: Animals, Blood Pressure, Humans, Hypertension, Inflammation, Insulin Resistance, Periodontitis, Periodontium, Risk Factors, Hypertrophy, Left Ventricular, Oxidative Stress, Inflammation Mediators, Atherosclerosis, Vascular Stiffness

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Periodontitis and blood pressure: the concept of dental hypertension

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