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Cited by 354

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta‐analysis

Teeuw, Wijnand J., Slot, Dagmar E., Susanto, Hendri, Gerdes, Victor E. A., Abbas, Frank, D'Aiuto, Francesco, Kastelein, John J. P., Loos, Bruno G.·2014·Journal of Clinical Periodontology
DOI 10.1111/jcpe.12171
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Abstract

Aim: Systematic review and meta‐analyses to study the robustness of observations that treatment of periodontitis improves the atherosclerotic profile. Material and Methods: Literature was searched in Medline‐PubMed, Cochrane CENTRAL and EMBASE, based on controlled periodontal intervention trials, including also a non‐intervention group. Data were extracted and meta‐analyses were performed. Results: From 3928 screened studies, 25 trials met the eligibility criteria. These trials enrolled 1748 periodontitis patients. Seven trials enrolled periodontitis patients that were otherwise healthy, 18 trials recruited periodontal patients with various co‐morbidities, such as CVD or diabetes. None of the trials used hard clinical endpoints of CVD. However, improvement of endothelial function has been consistently reported. Meta‐analyses demonstrated significant weighted mean difference (WMD) for hsCRP (−0.50 mg/l, 95% CI:−0.78; −0.22), IL‐6 (−0.48 ng/l, 95% CI: −0.90; −0.06), TNF‐α (−0.75 pg/ml, 95% CI: −1.34; −0.17), fibrinogen (−0.47 g/l, 95% CI: −0.76; −0.17), total cholesterol (−0.11 mmol/l, 95% CI: −0.21; −0.01) and HDL‐C (0.04 mmol/l, 95% CI: 0.03; 0.06) favouring periodontal intervention. Importantly, periodontitis patients with co‐morbidity benefitted most from periodontal therapy; significant WMD were observed for levels of hsCRP (−0.71 mg/l, 95% CI: −1.05; −0.36), IL‐6 (−0.87 ng/l, 95% CI: −0.97; −0.78), triglycerides (−0.24 mmol/l, 95% CI: −0.26; −0.22), total cholesterol (−0.15 mmol/l, 95% CI: −0.29; −0.01), HDL‐C (0.05 mmol/l, 95% CI: 0.03; 0.06) and HbA 1c (−0.43%, 95% CI: −0.60; −0.25). Conclusions: This systematic review and meta‐analyses demonstrate that periodontal treatment improves endothelial function and reduces biomarkers of atherosclerotic disease, especially in those already suffering from CVD and/or diabetes.

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Metadata

Authors
Teeuw, W. J., Slot, D. E., Susanto, H., Gerdes, V. E. A., Abbas, F., D'Aiuto, F., Kastelein, J. J. P., & Loos, B. G.
Venue
Journal of Clinical Periodontology
Publisher
Wiley
Published
2013-10-29
Volume
41
Issue
1
Pages
70-79
ISSN
  • 0303-6979 (ISSN-L)
  • 1600-051X
DOI
10.1111/jcpe.12171
OpenAlex
W2099627050
Cited by
354
References
12
FWCI
3.87
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta‐analysis. https://app.cochat.ai/papers/10.1111/jcpe.12171
The paper
Teeuw, W. J., Slot, D. E., Susanto, H., Gerdes, V. E. A., Abbas, F., D'Aiuto, F., Kastelein, J. J. P., & Loos, B. G. (2014). Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta‐analysis. Journal of Clinical Periodontology. https://doi.org/10.1111/jcpe.12171

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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