Antihyperglycemic, Antioxidant and Antimicrobial Activities of the Butanol Extract from S pirulina Platensis: Antihyperglycemic Effect of Spirulina
Open accessAbstract
The butanol extract of Spirulina was found to have potent α-glucosidase inhibitory activity with an IC50 value of 23.0 ± 0.4 μg/mL. Total phenolic and flavonoid contents were estimated to be 121.0 ± 3.5 mg gallic acid equivalent/100 g and 27.4 ± 1.2 mg rutin equivalent/100 g of Spirulina biomass. The butanol extract also exhibited rat intestinal α-glucosidase inhibitory activity with IC50 value of 37.5 ± 2.8 μg/mL. The butanol extract had showed antioxidant activities with DPPH (1, 1-diphenyl-1-picrylhydrazyl radical), reducing power, hydroxyl radical and nitric oxide scavenging activity and showed antimicrobial activity against gram-positive and gram-negative bacteria. The present results indicate that Spirulina can be used for nutraceutical applications. Practical Application Spirulina has Generally Recognized as Safe (GRAS) status and FDA approval for dietary supplement; therefore, it can be used as food supplement for health benefits. The therapeutic approach for preventing diabetes mellitus is to retard the absorption of glucose through inhibition of α-glucosidase.
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Intestinal α-glucosidases inhibitors are important in controlling diabetes because they lower postprandial blood glucose levels.
“Intestinal α-glucosidases inhibitors are important in controlling diabetes because they lower postprandial blood glucose levels [32].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [32]
The polyphenol-rich butanol extract of Arthrospira platensis is a potent α-glucoside inhibitor (IC50 23 μg/mL).
“The polyphenol-rich butanol extract of the alga is a potent α-glucoside inhibitor (IC50 23 µg/mL).”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [32]
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Ramos-Romero, S., Torrella, J. R., Pagès, T., Viscor, G., & Torres, J. L. (2021) · Nutrients · doi:10.3390/nu13020563 · Cited by 134 · see citing works
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“Intestinal α-glucosidases inhibitors are important in controlling diabetes because they lower postprandial blood glucose levels [32].”
BackgroundPiovan, A., Battaglia, J., Filippini, R., Dalla Costa, V., Facci, L., Argentini, C., Pagetta, A., Giusti, P., & Zusso, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.724993 · Cited by 31 · see citing works
- Authors
- Mallikarjun Gouda, K. G., Kavitha, M. D., & Sarada, R.
- Affiliations
- Plant Cell Biotechnology Department; CSIR-Central Food Technological Research Institute; Mysore Karnataka 570020 India
- Central Food Technological Research Institute (IN)
- Corresponding author
- Sarada, R.
- ORCID
- Sarada, R.
- Venue
- Journal of Food Biochemistry
- Publisher
- Wiley
- Published
- 2015-07-14
- Volume
- 39
- Issue
- 5
- Pages
- 594-602
- ISSN
- 0145-8884 (ISSN-L)
- OpenAlex
- W1915737366
- Cited by
- 31
- References
- 48
- Citations by year
- 2026: 4 · 2025: 5 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Food Biochemistry (publishedVersion)
- Funders
- CSIR, Govt. of India
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Spirulina platensis, n-butanol extract, antidiabetic activity, α-glucosidase inhibition, antioxidant activity, antimicrobial activity, phenolic content, flavonoid content, DPPH radical scavenging, nitric oxide scavenging, hydroxyl radical scavenging, diabetes prevention, nutraceuticals, dietary supplements, Spirulina
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