Cited by 31Natural Antidiabetic Agents StudiesSeaweed-derived Bioactive CompoundsMedicinal Plant Research

Antihyperglycemic, Antioxidant and Antimicrobial Activities of the Butanol Extract from S pirulina Platensis: Antihyperglycemic Effect of Spirulina

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Mallikarjun Gouda, K.G., Kavitha, M.D., Sarada, R.·2015·Journal of Food Biochemistry

Abstract

The butanol extract of Spirulina was found to have potent α-glucosidase inhibitory activity with an IC50 value of 23.0 ± 0.4 μg/mL. Total phenolic and flavonoid contents were estimated to be 121.0 ± 3.5 mg gallic acid equivalent/100 g and 27.4 ± 1.2 mg rutin equivalent/100 g of Spirulina biomass. The butanol extract also exhibited rat intestinal α-glucosidase inhibitory activity with IC50 value of 37.5 ± 2.8 μg/mL. The butanol extract had showed antioxidant activities with DPPH (1, 1-diphenyl-1-picrylhydrazyl radical), reducing power, hydroxyl radical and nitric oxide scavenging activity and showed antimicrobial activity against gram-positive and gram-negative bacteria. The present results indicate that Spirulina can be used for nutraceutical applications. Practical Application Spirulina has Generally Recognized as Safe (GRAS) status and FDA approval for dietary supplement; therefore, it can be used as food supplement for health benefits. The therapeutic approach for preventing diabetes mellitus is to retard the absorption of glucose through inhibition of α-glucosidase.

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Authors
Mallikarjun Gouda, K. G., Kavitha, M. D., & Sarada, R.
Affiliations
  • Plant Cell Biotechnology Department; CSIR-Central Food Technological Research Institute; Mysore Karnataka 570020 India
  • Central Food Technological Research Institute (IN)
Corresponding author
Sarada, R.
Venue
Journal of Food Biochemistry
Publisher
Wiley
Published
2015-07-14
Volume
39
Issue
5
Pages
594-602
ISSN
0145-8884 (ISSN-L)
OpenAlex
W1915737366
Cited by
31
References
48
Citations by year
2026: 4 · 2025: 5 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2
FWCI
1.45
Type
journal article
Language
en
Open access
Locations
Journal of Food Biochemistry (publishedVersion)
Funders
CSIR, Govt. of India
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
Spirulina platensis, n-butanol extract, antidiabetic activity, α-glucosidase inhibition, antioxidant activity, antimicrobial activity, phenolic content, flavonoid content, DPPH radical scavenging, nitric oxide scavenging, hydroxyl radical scavenging, diabetes prevention, nutraceuticals, dietary supplements, Spirulina

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