The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.
Oxytocin: Its Mechanism of Action and Receptor Signalling in the Myometrium
Abstract
Oxytocin is a nonapeptide hormone that has a central role in the regulation of parturition and lactation. In this review, we address oxytocin receptor (OTR) signalling and its role in the myometrium during pregnancy and in labour. The OTR belongs to the rhodopsin‐type (C lass 1) of the G‐protein coupled receptor superfamily and is regulated by changes in receptor expression, receptor desensitisation and local changes in oxytocin concentration. Receptor activation triggers a number of signalling events to stimulate contraction, primarily by elevating intracellular calcium (C a 2+). This includes inositol‐tris‐phosphate‐mediated store calcium release, store‐operated C a 2+ entry and voltage‐operated C a 2+ entry. We discuss each mechanism in turn and also discuss C a 2+‐independent mechanisms such as C a 2+ sensitisation. Because oxytocin induces contraction in the myometrium, both the activation and the inhibition of its receptor have long been targets in the management of dysfunctional and preterm labours, respectively. We discuss current and novel OTR agonists and antagonists and their use and potential benefit in obstetric practice. In this regard, we highlight three clinical scenarios: dysfunctional labour, postpartum haemorrhage and preterm birth.
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Cites
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Cited by
The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation
Napso, T., Yong, H. E. J., Lopez-Tello, J., & Sferruzzi-Perri, A. N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01091 · Cited by 470
FIGO recommendations on the management of postpartum hemorrhage 2022
Escobar, M. F., Nassar, A. H., Theron, G., Barnea, E. R., Nicholson, W., Ramasauskaite, D., Lloyd, I., Chandraharan, E., Miller, S., Burke, T., et al. (2022) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.14116 · Cited by 406
Is oxytocin “nature’s medicine”
Carter, C. S., Kenkel, W. M., MacLean, E. L., Wilson, S. R., Perkeybile, A. M., Yee, J. R., Ferris, C. F., Nazarloo, H. P., Porges, S. W., Davis, J. M., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019398 · Cited by 394
Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism
Parker, K. J., Oztan, O., Libove, R. A., Sumiyoshi, R. D., Jackson, L. P., Karhson, D. S., Summers, J. E., Hinman, K. E., Motonaga, K. S., Phillips, J. M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705521114 · Cited by 349
Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers
Leng, G., & Sabatier, N. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12413 · Cited by 237
“Oxytocin and vasopressin act at four receptors: the oxytocin receptor (22); the V2 receptor, which accounts for the antidiuretic actions of vasopressin (23,24); the V1b receptor (25), which accounts for vasopressin effects on adrenocorticotrophin release; and the V1a receptor, which accounts for…”
Background
Metadata
- Authors
- Arrowsmith, S., & Wray, S.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2014-05-29
- Volume
- 26
- Issue
- 6
- Pages
- 356-369
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W1970338647
- Cited by
- 290
- References
- 156
- FWCI
- 15.88
- Type
- journal article
- Language
- en
- Open access
- closed
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