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The Medial Prefrontal Cortex: Coordinator of Autonomic, Neuroendocrine and Behavioural Responses to Stress
Open accessAbstract
Responding to real or potential threats in the environment requires the coordination of autonomic, neuroendocrine and behavioural processes to promote adaptation and survival. These diverging systems necessitate input from the limbic forebrain to integrate and modulate functional output in accordance with contextual demand. In the present review, we discuss the potential role of the medial prefrontal cortex (m PFC ) as a coordinator of behavioural and physiological stress responses across multiple temporal and contextual domains. Furthermore, we highlight converging evidence from rodent and human research indicating the necessity of the m PFC for modulating physiological energetic systems to mobilise or limit energetic resources as needed to ultimately promote behavioural adaptation in the face of stress. We review the literature indicating that glucocorticoids act as one of the primary messengers in the reallocation of energetic resources having profound effects locally within the m PFC , as well as shaping how the m PFC acts within a network of brain structures to modulate responses to stress. Finally, we discuss how both rodent and human studies point toward a critical role of the m PFC in the coordination of anticipatory responses to stress and why this distinction is an important one to make in stress neurobiology.
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“A large body of evidence indicates that stress and anxiety negatively affect several aspects of cognitive flexibility (McKlveen et al 2015, Park & Moghaddam 2017)”
From Prefrontal cortex executive processes affected by stress in health and disease (2018) · cites this paper as McKlveen et al 2015
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Metadata
- Authors
- McKlveen, J. M., Myers, B., & Herman, J. P.
- Affiliations
- University of Cincinnati (US)
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2015-05-26
- Volume
- 27
- Issue
- 6
- Pages
- 446-456
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- PMC
- PMC4580281
- OpenAlex
- W2092831348
- Cited by
- 273
- References
- 120
- Citations by year
- 2026: 27 · 2025: 29 · 2024: 24 · 2023: 26 · 2022: 21 · 2021: 26 · 2020: 25 · 2019: 36 · 2018: 27 · 2017: 18 · 2016: 12 · 2015: 2
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (MH097430, MH069860, MH049698.B, HL122454)
- American Heart Association (17070152)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- medial prefrontal cortex, stress response, glucocorticoids, autonomic responses, neuroendocrine response, behavioral adaptation, anticipatory stress, limbic forebrain, contextual modulation
- MeSH terms
- Adaptation, Psychological, Animals, Autonomic Nervous System, Behavior, Humans, Neurosecretory Systems, Stress, Psychological, Prefrontal Cortex
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