Cited by 273Stress Responses and CortisolMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

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The Medial Prefrontal Cortex: Coordinator of Autonomic, Neuroendocrine and Behavioural Responses to Stress

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McKlveen, J. M., Myers, B., Herman, J. P.·2015·Journal of Neuroendocrinology

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Abstract

Responding to real or potential threats in the environment requires the coordination of autonomic, neuroendocrine and behavioural processes to promote adaptation and survival. These diverging systems necessitate input from the limbic forebrain to integrate and modulate functional output in accordance with contextual demand. In the present review, we discuss the potential role of the medial prefrontal cortex (m PFC ) as a coordinator of behavioural and physiological stress responses across multiple temporal and contextual domains. Furthermore, we highlight converging evidence from rodent and human research indicating the necessity of the m PFC for modulating physiological energetic systems to mobilise or limit energetic resources as needed to ultimately promote behavioural adaptation in the face of stress. We review the literature indicating that glucocorticoids act as one of the primary messengers in the reallocation of energetic resources having profound effects locally within the m PFC , as well as shaping how the m PFC acts within a network of brain structures to modulate responses to stress. Finally, we discuss how both rodent and human studies point toward a critical role of the m PFC in the coordination of anticipatory responses to stress and why this distinction is an important one to make in stress neurobiology.

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Authors: McKlveen, J. M., Myers, B., & Herman, J. P.
Affiliations: University of Cincinnati (US)
ORCID: McKlveen, J. M.
Myers, B.
Herman, J. P.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2015-05-26
Volume: 27
Issue: 6
Pages: 446-456
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1111/jne.12272
PMC: PMC4580281
OpenAlex: W2092831348
Cited by: 273
References: 120
Citations by year: 2026: 27 · 2025: 29 · 2024: 24 · 2023: 26 · 2022: 21 · 2021: 26 · 2020: 25 · 2019: 36 · 2018: 27 · 2017: 18 · 2016: 12 · 2015: 2
FWCI: 1.53
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (MH097430, MH069860, MH049698.B, HL122454)
American Heart Association (17070152)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: medial prefrontal cortex, stress response, glucocorticoids, autonomic responses, neuroendocrine response, behavioral adaptation, anticipatory stress, limbic forebrain, contextual modulation
MeSH terms: Adaptation, Psychological, Animals, Autonomic Nervous System, Behavior, Humans, Neurosecretory Systems, Stress, Psychological, Prefrontal Cortex

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The Medial Prefrontal Cortex: Coordinator of Autonomic, Neuroendocrine and Behavioural Responses to Stress

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