Effect of Sleep Extension on the Subsequent Testosterone, Cortisol and Prolactin Responses to Total Sleep Deprivation and Recovery
Abstract
Total sleep deprivation (TSD) in humans is associated with altered hormonal levels, which may have clinical relevance. Less is known about the effect of an extended sleep period before TSD on these hormonal changes. Fourteen subjects participated in two experimental counterbalanced conditions (randomised cross‐over design): extended sleep (21.00–07.00 h time in bed, EXT) and habitual sleep (22.30–07.00 h time in bed, HAB). For each condition, subjects performed two consecutive phases: six nights of either EXT or HAB. These nights were followed by 3 days in the sleep laboratory with blood sampling at 07.00 and 17.00 h at baseline (B‐07.00 and B‐17.00), after 24 and 34 h of continuous awakening (24 h‐CA, 34 h‐CA) and after one night of recovery sleep (R‐07.00 and R‐17.00) to assess testosterone, cortisol, prolactin and catecholamines concentrations. At 24 h of awakening, testosterone, cortisol and prolactin concentrations were significantly lower compared to B‐07.00 and recovered basal levels after recovery sleep at R‐07.00 (P < 0.001 for all). However, no change was observed at 34 h of awakening compared to B‐17.00. No effect of sleep extension was observed on testosterone, cortisol and catecholamines concentrations at 24 and 34 h of awakening. However, prolactin concentration was significantly lower in EXT at B‐07.00 and R‐07.00 compared to HAB (P < 0.05, P < 0.001, respectively). In conclusion, 24 h of awakening inhibited gonadal and adrenal responses in healthy young subjects and this was not observed at 34 h of awakening. Six nights of sleep extension is not sufficient to limit decreased concentrations of testosterone and cortisol at 24 h of awakening but may have an impact on prolactin concentration.
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Sleep loss and lower sleep duration are associated with lower morning, afternoon, and 24-h testosterone.
“When epidemiological and interventional studies are considered collectively, sleep loss and lower sleep duration are associated with lower morning, afternoon and 24-h testosterone; as well as higher afternoon, but not morning or 24-h cortisol.”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [46]
All in-laboratory studies when collectively examined show that sleep restriction decreases testosterone.
“All studies when collectively examined show that sleep restriction decreases testosterone.”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [46]
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- Authors
- Arnal, P. J., Drogou, C., Sauvet, F., Regnauld, J., Dispersyn, G., Faraut, B., Millet, G. Y., Leger, D., Gomez‐Merino, D., & Chennaoui, M.
- Affiliations
- Université Paris Descartes (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- University of Calgary (CA)
- Hôtel Dieu EA7330 VIFASOM (Vigilance Fatigue et Sommeil) Université Paris Descartes Paris France
- Unité Fatigue et Vigilance Département Neurosciences et Contraintes Opérationnelles Institut de Recherche Biomédicale des Armées (IRBA) Brétigny sur Orge France
- Corresponding author
- Chennaoui, M.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2016-02
- Volume
- 28
- Issue
- 2
- Pages
- 12346-12346
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2194654717
- Cited by
- 55
- References
- 12
- Citations by year
- 2025: 6 · 2024: 1 · 2023: 7 · 2022: 4 · 2021: 11 · 2020: 3 · 2019: 8 · 2018: 5 · 2017: 6 · 2016: 4
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Direction Générale de l’Armement (14Ca703, PDH‐1‐SMO‐2‐508)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- total sleep deprivation, sleep extension, recovery sleep, testosterone, cortisol, prolactin, catecholamines, awakening, gonadal axis, adrenal axis, sleep deprivation recovery
- MeSH terms
- Adult, Catecholamines, Humans, Hydrocortisone, Male, Prolactin, Sleep, Sleep Deprivation, Testosterone, Wakefulness, Cross-Over Studies, Young Adult, Healthy Volunteers
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