Leptin Levels Are Dependent on Sleep Duration: Relationships with Sympathovagal Balance, Carbohydrate Regulation, Cortisol, and Thyrotropin
Open accessAbstract
Sleep plays an important role in energy homeostasis. The present study tests the hypothesis that circulating levels of leptin, a hormone that signals energy balance to the brain, are influenced by sleep duration. We also analyzed associations between leptin and sympathovagal balance, cortisol, TSH, glucose, and insulin under different bedtime conditions. Twenty-four-hour hormonal and glucose profiles were sampled at frequent intervals, and sympathovagal balance was estimated from heart rate variability in 11 subjects studied after 6 d of 4-h bedtimes (mean +/- sem of sleep duration during last 2 d: 3 h and 49 +/- 2 min) and after 6 d of 12-h bedtimes (sleep: 9 h and 03 +/- 15 min). A study with 8-h bedtimes was performed 1 yr later (sleep: 6 h and 52 +/- 10 min). Caloric intake and activity levels were carefully controlled in all studies. Mean levels, maximal levels, and rhythm amplitude of leptin were decreased (-19%, -26%, and -20%, respectively) during sleep restriction compared with sleep extension. The decrease in leptin levels was concomitant with an elevation of sympathovagal balance. The effects of sleep duration on leptin were quantitatively associated with alterations of the cortisol and TSH profiles and were accompanied by an elevation of postbreakfast homeostasis model assessment values. Measures of perceived stress were not increased during sleep restriction. During the study with 8-h bedtimes, hormonal and metabolic parameters were intermediate between those observed with 4-h and 12-h bedtimes. In conclusion, sleep modulates a major component of the neuroendocrine control of appetite.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Sleep loss from acute total sleep deprivation or severe recurrent sleep restriction (≤5 h/night) results in elevated evening cortisol levels, often with a slower decline of cortisol concentrations across the day.
“sleep loss, resulting from either acute total sleep deprivation or severe recurrent sleep restriction (≤5, 5 h/ night) resulted in elevated evening cortisol levels, often associated with a slower decline of cortisol concentrations across the day.[8][9][10][11][12][13][14][15][16][17]”
From Effects of Insufficient Sleep on Pituitary–Adrenocortical Response to CRH Stimulation in Healthy Men (2017) · cites this paper as [10]
The Experimental protocol describes six nights with four hours in bed, and the cortisol findings report higher late-afternoon and evening levels and a slower decline during restriction than during sleep extension (page numbers unavailable). The copy does not establish that acute total sleep deprivation produced those cortisol effects; its discussion of acute total deprivation concerns leptin and TSH. (LLM, conf=0.86)
Experimental — accuracy not yet measuredReduced leptin is implicated as a hormonal mechanism by which sleep restriction can worsen insulin sensitivity, increase circulating lipids, and lead to obesity and abdominal obesity via disruption of energy balance and increased cravings for carbohydrate rich foods.
“These data implicate reduced leptin as a hormonal mechanism by which sleep restriction can worsen insulin sensitivity, increase circulating lipids, and lead to obesity and abdominal obesity via disruption of energy balance and increased cravings for carbohydrate rich foods.”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [17]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredSleep restriction is linked with obesity via disruption of leptin and increased cravings for carbohydrate rich foods.
“This prompted the hypothesis that sleep restriction is linked with obesity via disruption of leptin and increased cravings for carbohydrate rich foods [17].”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [17]
The Discussion (page unavailable) reports that sleep restriction lowers leptin and may adversely affect appetite regulation; it also describes the evidence linking shorter sleep with obesity as suggestive. It does not report increased cravings specifically for carbohydrate-rich foods. The carbohydrate-rich meals mentioned in the Experimental protocol were provided to participants, not foods they reported craving. (LLM, conf=0.87)
Experimental — accuracy not yet measuredBoth the hypothalamic-pituitary-adrenal axis and the autonomic nervous system pathways have been proposed as possible mediators of the impairments in glucose tolerance associated with sleep restriction.
“Both these pathways also have been proposed as possible mediators of the impairments in glucose tolerance associated with sleep restriction (22,44–48).”
From Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men (2010) · cites this paper as [47]
The Discussion (page unavailable) reports altered cortisol regulation and sympathovagal balance after sleep restriction, alongside impaired morning glucose tolerance. It does not explicitly propose either pathway as a mediator of the glucose impairment; the reported changes are concomitant. (LLM, conf=0.82)
Experimental — accuracy not yet measuredSevere sleep restriction results in elevated evening cortisol levels.
“Severe sleep restriction results in elevated evening cortisol levels.”
From Effects of Insufficient Sleep on Pituitary–Adrenocortical Response to CRH Stimulation in Healthy Men (2017) · cites this paper as [10]
Some studies showed that sleep restriction significantly increases plasma cortisol levels during the late afternoon to early evening hours.
“Some studies showed that sleep restriction significantly increases plasma cortisol levels during the late afternoon to early evening hours [17], [18], whereas others showed little to no changes [16], [21], [23], [27].”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [17]
Early studies showed sleep restriction decreased leptin levels.
“Early studies investigating the relationship between sleep restriction and leptin showed that sleep restriction decreased leptin levels [17], [19], and increased self-reported appetite and hunger [19].”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [17]
Early experimental studies found leptin decreases after two and six nights of sleep restriction to 4 h TIB.
“Early experimental studies exploring the relationship between sleep restriction and the adipose-derived hormone leptin found decreases after both two [19] and six [17] nights of sleep restriction to 4 h TIB.”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [17]
Several other studies found elevated cortisol in the latter part of the day instead of the usual diurnal decline.
“several others have found elevated cortisol in the latter part of the day instead of the usual diurnal decline [17], [18], [54].”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [17]
Other published findings documented decreases in leptin and increases in hunger and appetite following sleep restriction.
“other published findings in the field which have previously documented decreases in leptin and increases in hunger and appetite following sleep restriction [17], [19].”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [17]
The approximately 30% reduction in adipocyte insulin signaling lies within the range of differences in insulin sensitivity between obese and lean participants and between diabetic and nondiabetic participants.
“The approximate 30% reduction in cellular insulin signaling in adipocytes induced by 4 nights of sleep restriction lies within the range of the difference in insulin sensitivity in adipocytes from obese versus lean participants (30) and from diabetic patients versus nondiabetic participants (31).”
From Impaired Insulin Signaling in Human Adipocytes After Experimental Sleep Restriction: A Randomized, Crossover Study (2012) · cites this paper as [31]
The citation is attached to the obese-versus-lean adipocyte comparison. Our copy studies lean young subjects, and the Postmeal glucose and insulin responses section says HOMA was used to measure meal responses, not insulin sensitivity. Searches for adipocyte insulin sensitivity and obese-versus-lean differences found no passage supporting the comparison; the paper's approximately 30% figure concerns glucose tolerance and insulin response to intravenous glucose, not adipocyte signaling. (LLM, conf=0.74)
Experimental — accuracy not yet measuredMultiple studies have observed that sleep loss, either from acute partial or total sleep deprivation or from recurrent sleep curtailment or insomnia, results in elevated evening cortisol levels.
“Multiple studies have observed that sleep loss, either from acute partial or total sleep deprivation or from recurrent sleep curtailment or insomnia, results in elevated evening cortisol levels (12–19).”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [15]
Consistent with our previous study of 6 nights of sleep restriction, levels of perceived stress in the present study remained low and were not affected by sleep loss.
“Consistent with our previous study of 6 nights of sleep restriction (15), we found that levels of perceived stress in the present study remained low and were not affected by sleep loss.”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [15]
Three studies that enforced similar food intake and measured leptin at more than two time points in normal-weight men all found decreased leptin after sleep loss.
“Three studies assessed leptin at more than 2 time points in a rested sleep condition and in a sleep restriction condition in normal-weight men after similar food intake had been enforced in both conditions. All found decreased levels of anorexigenic leptin after sleep loss [62, 161, 162].”
From Sleep and metabolic function (2012) · cites this paper as [161]
In healthy lean young men under stable caloric intake and activity, six days of 4-, 8-, and 12-h bedtimes produced gradual increases in all characteristics of the 24-h leptin profile from the 4-h to the 12-h condition.
“In a study that assessed the 24-h leptin profiles after 6 days of 4-, 8-, and 12-h bedtimes in healthy lean young men under conditions of stable caloric intake and activity levels, all characteristics of the 24-h leptin profile (overall mean, nocturnal maximum, and amplitude) gradually increased from the 4- to the 12-h bedtime condition [161].”
From Sleep and metabolic function (2012) · cites this paper as [161]
Cortisol evening levels observed under 8-hour bedtime condition were intermediate between those measured under 4-hour and 12-hour bedtime conditions.
“Interestingly, cortisol evening levels observed under 8-hour bedtime condition were intermediate between those measured under 4-hour and 12-hour bedtime conditions [84] (Figure 5).”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [84]
Insufficient sleep duration is associated with weight gain and obesity.
“short sleep duration (6 hours or less), and especially very short sleep duration (less than 5 hours) is associated with increased cardiometabolic morbidity and mortality, including weight gain and obesity, hypertension, hyperlipidemia, and diabetes.”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [30]
Insufficient sleep is linked to lower energy expenditure, altered glucose homeostasis, and alterations in hormones that mediate hunger.
“insufficient sleep has been linked to lower energy expenditure, altered glucose homeostasis and alterations in hormones that mediate hunger(24, 25, 27-31).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [30]
Glucose effectiveness was 30% lower in the state of sleep debt.
“SG was 30% lower in the state of sleep debt.”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [19]
Acute insulin response to glucose was reduced by more than 30% after sleep restriction despite a trend for decreased insulin sensitivity.
“AIRg was reduced by more than 30% after sleep restriction despite a trend for decreased SI.”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [19]
In the first partial sleep deprivation study, glucose tolerance was lower in the sleep-debt condition than in the fully rested condition.
“Glucose tolerance, assessed during an intravenous glucose tolerance test (ivGTT) and a high-carbohydrate breakfast, was lower in the sleep-debt condition than in the fully rested condition.”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [19]
For HOMA, cortisol, GH, leptin and cardiac sympathovagal balance, clear changes are observed in a dose-response relationship with sleep duration after 6 days of 4h, 8h and 12h in bed.
“For all these variables, clear changes are observed in a dose-response relationship with sleep duration.”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [19]
All characteristics of the 24-h leptin profile (overall mean, nocturnal maximum, amplitude) gradually increased from the 4h to the 12h bedtime, signaling the brain an unnecessary need for extra caloric intake in a state of sleep debt.
“For instance, Panels D of Figure 2 show that all characteristics of the 24-h leptin profile (overall mean, nocturnal maximum, amplitude) gradually increased from the 4h to the 12h bedtime, signaling the brain an unnecessary need for extra caloric intake in a state of sleep debt.”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [19]
In a study of healthy lean young men under stable caloric intake and activity, all characteristics of the 24-h leptin profile (overall mean, nocturnal maximum, amplitude) gradually increased from the 4-h to the 12-h bedtime condition.
“In a study that assessed the 24-h leptin profiles after 6 days of 4-h, 8-h, and 12-h bedtimes in healthy lean young men under conditions of stable caloric intake and activity levels, all characteristics of the 24-h leptin profile (overall mean, nocturnal maximum, amplitude) gradually increased from the 4-h to the 12-h bedtime condition [19] (Figure 2; panels D).”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [19]
HOMA levels post-breakfast increased from the 12-h to the 4-h in bed condition, indicating a decrease in glucose tolerance and/or a decrease in insulin sensitivity proportional to the severity of sleep loss.
“HOMA levels post-breakfast increased from the 12-h to the 4-h in bed condition indicating a decrease in glucose tolerance and/or a decrease in SI proportional to the severity of sleep loss (Figure 2; panels A).”
From Role of sleep duration in the regulation of glucose metabolism and appetite (2010) · cites this paper as [19]
Following partial sleep deprivation, mean daytime leptin values are approximately 18% lower than in the rested state.
“Following partial sleep deprivation, mean daytime values of leptin were approximately 18% lower compared to the rested state.104,105”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [105]
After two 4-hour nights, daytime appetite ratings increase by 24%, and sleep deprivation specifically increases appetite for sweet and salty foods.
“After two 4-h nights, there was a 24% increase in daytime appetite ratings;105 in addition, sleep deprivation specifically increased appetite for sweet and salty foods.”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [105]
Four hours in bed per night for 6 days significantly decreased leptin's amplitude by 20% compared with 12 hours in bed per night for 6 nights in 11 lean men.
“Similarly, 4 hours in bed per night for 6 days significantly decreased leptin’s amplitude by 20% when compared with 12 hours in bed per night for 6 nights in 11 lean men [39].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [39]
Obstructive sleep apnea stimulates the sympathetic nervous system.
“obstructive sleep apnea, which stimulates the SNS; 41,43,44”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772 · see citing works
Robust Locally Weighted Regression and Smoothing Scatterplots
Cleveland, W. S. (1979) · Journal of the American Statistical Association · doi:10.1080/01621459.1979.10481038 · Cited by 11,594 · see citing works
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190 · see citing works
Hobson, J. A. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90021-2 · Cited by 5,215 · see citing works
Spectral Analysis and its Applications.
Freiberger, W. F., Jenkins, G. M., & Watts, D. G. (1969) · Journal of the American Statistical Association · doi:10.2307/2286100 · Cited by 5,022 · see citing works
Impact of sleep debt on metabolic and endocrine function
Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,672 · see citing works
Self-citationSympathetic neural mechanisms in obstructive sleep apnea.
Somers, V. K., Dyken, M. E., Clary, M. P., & Abboud, F. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118235 · Cited by 2,527 · see citing works
Taheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010062 · Cited by 2,477 · cited 1× · see citing works
“Preliminary findings from a population study involving 1024 subjects are, however, in complete agreement with our observations, because restricted sleep duration was found to be associated with reduced leptin levels independently of BMI ( 45 ).”
ResultSpiegel, K., Tasali, E., Penev, P., & Cauter, E. V. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-11-200412070-00008 · Cited by 2,459 · see citing works
Self-citationRobust Locally Weighted Regression and Smoothing Scatterplots
Cleveland, W. S. (1979) · Journal of the American Statistical Association · doi:10.2307/2286407 · Cited by 2,063 · see citing works
Mortality Associated With Sleep Duration and Insomnia
Kripke, D. F., Garfinkel, L., Wingard, D. L., Klauber, M. R., & Marler, M. R. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.2.131 · Cited by 1,614 · see citing works
Flier, J. S. (2004) · Cell · doi:10.1016/s0092-8674(03)01081-x · Cited by 1,105 · see citing works
Vgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Mastorakos, G., Vela-Bueno, A., Kales, A., & Chrousos, G. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7778 · Cited by 884 · see citing works
Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects.
Sinha, M. K., Ohannesian, J. P., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Magosin, S., Marco, C. C., & Caro, J. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118551 · Cited by 785 · see citing works
Sleep Loss Results in an Elevation of Cortisol Levels the Next Evening
(1997) · Sleep · doi:10.1093/sleep/20.10.865 · Cited by 745 · cited 1× · see citing works
“vated in subjects submitted to experimental sleep loss (29, 30) Abbreviations: BMI, Body mass index; HOMA, homeostasis model assessment; REM, rapid eye movement; rRR, autocorrelation coefficient of consecutive interbeat intervals; SI, Systeme International (units); SWS, slow wave sleep.”
BackgroundSelf-citationShort and Long Sleep and Sleeping Pills: Is Increased Mortality Associated?
Kripke, D. F. (1979) · Archives of General Psychiatry · doi:10.1001/archpsyc.1979.01780010109014 · Cited by 660 · see citing works
Fos Expression in Orexin Neurons Varies with Behavioral State
Estabrooke, I. V., McCarthy, M. T., Ko, E., Chou, T. C., Chemelli, R. M., Yanagisawa, M., Saper, C. B., & Scammell, T. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01656.2001 · Cited by 654 · see citing works
Human Leptin Levels Are Pulsatile and Inversely Related to Pituitary–Ardenal Function
Licinio, J., Mantzoros, C., Negrão, A. B., Cizza, G., Wong, M.-L., Bongiorno, P. B., Chrousos, G. P., Karp, B., Allen, C., Flier, J. S., et al. (1997) · Nature Medicine · doi:10.1038/nm0597-575 · Cited by 632 · see citing works
Kolaczynski, J. W., Considine, R. V., Ohannesian, J. P., Marco, C. C., Opentanova, I., Nyce, M. R., Myint, M., & Caro, J. F. (1996) · Diabetes · doi:10.2337/diab.45.11.1511 · Cited by 517 · see citing works
Physiological Correlates of Prolonged Sleep Deprivation in Rats
Rechtschaffen, A., Gilliland, M. A., Bergmann, B. M., & Winter, J. B. (1983) · Science · doi:10.1126/science.6857280 · Cited by 487 · see citing works
Havel, P. J. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122601102 · Cited by 476 · see citing works
Effects of Insufficient Sleep on Blood Pressure Monitored by a New Multibiomedical Recorder
Tochikubo, O., Ikeda, A., Miyajima, E., & Ishii, M. (1996) · Hypertension · doi:10.1161/01.hyp.27.6.1318 · Cited by 470 · see citing works
Human leptin: from an adipocyte hormone to an endocrine mediator
Wauters, M., Considine, R. V., & Gaal, L. V. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1430293 · Cited by 458 · see citing works
Yoshida, Y., Fujiki, N., Nakajima, T., Ripley, B. A., Matsumura, H., Yoneda, H., Mignot, E. J.-M., & Nishino, S. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01725.x · Cited by 449 · see citing works
Entrainment of the diurnal rhythm of plasma leptin to meal timing.
Schoeller, D. A., Cella, L. K., Sinha, M. K., & Caro, J. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119717 · Cited by 433 · see citing works
Kamen, P. W., Krum, H., & Tonkin, A. M. (1996) · Clinical Science · doi:10.1042/cs0910201 · Cited by 425 · see citing works
A visual analogue scale technique to measure global vigor and affect
Monk, T. H. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90013-9 · Cited by 418 · see citing works
Sekine, M., Yamagami, T., Handa, K., Saito, T., Nanri, S., Kawaminami, K., Tokui, N., Yoshida, K., & Kagamimori, S. (2002) · Child Care Health and Development · doi:10.1046/j.1365-2214.2002.00260.x · Cited by 418 · see citing works
Effects of glucocorticoids on energy metabolism and food intake in humans
Tataranni, P. A., Larson, D. E., Snitker, S., Young, J. B., Flatt, J. P., & Ravussin, É. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.2.e317 · Cited by 415 · see citing works
Irwin, M. R., Thompson, J., Miller, C., Gillin, J. C., & Ziegler, M. G. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5788 · Cited by 389 · see citing works
Neuroendocrine Regulation and Actions of Leptin
Casanueva, F. F., & Diéguez, C. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0187 · Cited by 381 · see citing works
Time spent watching television, sleep duration and obesity in adults living in Valencia, Spain
Vioqué, J., Torres-Cantero, A. M., & Izquierdo, J. Q. I. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801434 · Cited by 358 · see citing works
Effects of sleep deprivation on neural circulatory control
Kato, M., Phillips, B. G., Sigurdsson, G., Narkiewicz, K., Pesek, C. A., & Somers, V. K. (2000) · Hypertension · doi:10.1161/01.hyp.35.5.1173 · Cited by 348 · see citing works
The Role of Hypocretins (Orexins) in Sleep Regulation and Narcolepsy
Taheri, S., Zeitzer, J. M., & Mignot, E. J.-M. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142826 · Cited by 333 · see citing works
Effects of insufficient sleep on blood pressure in hypertensive patients: a 24-h study
Lusardi, P. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(98)00200-3 · Cited by 331 · see citing works
Diurnal variation in the positive affects
Clark, L. A., Watson, D., & Leeka, J. (1989) · Motivation and Emotion · doi:10.1007/bf00995536 · Cited by 330 · see citing works
Sleep and circadian influences on cardiac autonomic nervous system activity
Burgess, H. J., Trinder, J., Kim, Y., & Luke, D. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.4.h1761 · Cited by 279 · see citing works
Regulation of Leptin Production in Humans
Fried, S. K., Ricci, M. R., Russell, C. D., & Laferrère, B. (2000) · Journal of Nutrition · doi:10.1093/jn/130.12.3127s · Cited by 278 · see citing works
Keim, N., Stern, J. S., & Havel, P. J. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.4.794 · Cited by 272 · see citing works
Risk factors of obesity in a five year old population. Parental versus environmental factors.
Locard, E., MAMELLE, N., Billette, A., Miginiac, M., Munoz, F., & Rey, S. (1992) · PubMed · Cited by 271 · see citing works
Sleep Loss Reduces Diurnal Rhythm Amplitude of Leptin in Healthy Men
Mullington, J. M., Chan, J. L., Van Dongen, H. P. A., Szuba, M. P., Samaras, J., Price, N. J., Meier‐Ewert, H. K., Dinges, D. F., & Mantzoros, C. S. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01069.x · Cited by 261 · see citing works
Sleep deprivation in the rat by the disk-over-water method
Rechtschaffen, A., & Bergmann, B. M. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00020-t · Cited by 253 · see citing works
Regulation of leptin production: sympathetic nervous system interactions
Rayner, D. V., & Trayhurn, P. (2001) · Journal of Molecular Medicine · doi:10.1007/s001090100198 · Cited by 250 · see citing works
Simon, C., Gronfier, C., Schlienger, J. L., & Brandenberger, G. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4864 · Cited by 236 · see citing works
Mantzoros, C. S., Ozata, M., Negrao, A. B., Suchard, M. A., Ziotopoulou, M., Caglayan, S., Elashoff, R. M., Cogswell, R. J., Negro, P., Liberty, V., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.7.3284 · Cited by 229 · see citing works
Sutcliffe, J. G., & de Lecea, L. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20001015)62:2 · Cited by 217 · see citing works
Roles of Leptin and Ghrelin in the Loss of Body Weight Caused by a Low Fat, High Carbohydrate Diet
Weigle, D. S., Cummings, D. E., Newby, P. D., Breen, P. A., Frayo, R. S., Matthys, C. C., Callahan, H. S., & Purnell, J. Q. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021262 · Cited by 212 · see citing works
Prednisolone as an appetite stimulant in patients with cancer.
Willox, J. C., Corr, J., Shaw, J. L., Richardson, M., Calman, K. C., & Drennan, M. (1984) · BMJ · doi:10.1136/bmj.288.6410.27 · Cited by 180 · see citing works
Dependence of sleep on nutrients' availability
Danguir, J., & Nicolaidis, S. (1979) · Physiology & Behavior · doi:10.1016/0031-9384(79)90240-3 · Cited by 164 · see citing works
The role of leptin in the regulation of TSH secretion in the fed state: in vivo and in vitro studies
Ortiga-Carvalho, T. M., Oliveira, K. J., Soares, B., & Pazos-Moura, C. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1740121 · Cited by 154 · see citing works
Functional consequences of sustained sleep deprivation in the rat
Everson, C. A. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00009-i · Cited by 151 · see citing works
Donahoo, W. T., Jensen, D. R., Yost, T. J., & Eckel, R. H. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4434 · Cited by 142 · see citing works
Dose-Dependent Cortisol-Induced Increases in Plasma Leptin Concentration in Healthy Humans
Newcomer, J. W., Selke, G., Melson, A. K., Gross, J., Vogler, G. P., & Dagogo-Jack, S. E. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.11.995 · Cited by 133 · see citing works
Endocrine and other biological rhythms
Cauter, E. V. (2001) · Medical Entomology and Zoology · Cited by 116 · see citing works
Kolaczynski, J. W., Considine, R. V., Ohannesian, J., et al. (1996) · Diabetes · doi:10.2337/diabetes.45.11.1511 · Cited by 111 · see citing works
Regulation of in vivo TSH secretion by leptin
Seoane, L. M., Carro, E., Tovar, S., Casanueva, F. F., & Dieguez, C. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00145-2 · Cited by 109 · see citing works
Lack of effects of circulating thyroid hormone levels on serum leptin concentrations
Corbetta, S., Englaro, P., Giambona, S., Persani, L., Blum, W., & Beck-Peccoz, P. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1370659 · Cited by 90 · see citing works
Effects of 30-h sleep loss on cardiorespiratory functions at rest and in exercise
Chen, H. (1991) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199102000-00008 · Cited by 78 · see citing works
Danguir, J., & Nicolaids, S. (1984) · Brain Research · doi:10.1016/0006-8993(84)90359-7 · Cited by 77 · see citing works
Chin-Chance, C. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2685 · Cited by 69 · see citing works
Burgess, H. J., Penev, P. D., Schneider, R., & Cauter, E. V. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00312-2 · Cited by 64 · see citing works
Self-citation(2003) · PubMed · Cited by 57 · see citing works
Self-citationMüller, H. ‐., Riemann, D. W., Berger, T., & Müller, W. E. G. (1993) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1993.tb03407.x · Cited by 53 · see citing works
Synergistic Effects of Feeding and Dexamethasone on Serum Leptin Levels
Laferrère, B., Fried, S. K., Hough, K., Campbell, S. A., Thornton, J., & Pi-Sunyer, X. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5313 · Cited by 53 · see citing works
Sleep and stressor exposure in relation to circadian rhythms in catecholamine excretion
Åkerstedt, T., & Fröberg, J. E. (1979) · Biological Psychology · doi:10.1016/0301-0511(79)90005-x · Cited by 37 · see citing works
Regulation of leptin by thyroid hormone in humans: Studies in vivo and in vitro
Kristensen, K., Pedersen, S. B., Langdahl, B. L., & Richelsen, B. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90252-4 · Cited by 27 · see citing works
Synergistic Effects of Feeding and Dexamethasone on Serum Leptin Levels
Laferrere, B. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.10.3742 · Cited by 18 · see citing works
Flagged first, then by citations
1 of the 69 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Buxton OM, Spiegel K, Van Cauter E 2002 Chapter 8: Modulation of endocrine function and metabolism by sleep and sleep loss. In: Lee-Chiong TL, Sateia MJ, Carskadon MA, eds. Sleep Medicine. Handley, Philadelphia: Belfus, Inc.; 59 -69
Cited by
Sorted by citations
Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351 · see citing works
Meta-Analysis of Short Sleep Duration and Obesity in Children and Adults
Cappuccio, F. P., Taggart, F. M., Kandala, N.-B., Currie, A., Peile, E., Stranges, S., & Miller, M. A. (2008) · Sleep · doi:10.1093/sleep/31.5.619 · Cited by 2,076 · see citing works
Pathophysiology of migraine: a disorder of sensory processing
Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00034.2015 · Cited by 1,998 · see citing works
Quantity and Quality of Sleep and Incidence of Type 2 Diabetes
Cappuccio, F. P., D'Elia, L., Strazzullo, P., & Miller, M. A. (2010) · Diabetes Care · doi:10.2337/dc09-1124 · Cited by 1,670 · see citing works
Self-Reported and Measured Sleep Duration: How Similar Are They?
Lauderdale, D. S., Knutson, K. L., Yan, L. L., Liu, K., & Rathouz, P. J. (2008) · Epidemiology · doi:10.1097/ede.0b013e318187a7b0 · Cited by 1,565 · see citing works
Behavioral and Physiological Consequences of Sleep Restriction
Banks, S., & Dinges, D. F. (2007) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26918 · Cited by 1,505 · see citing works
Short Sleep Duration and Weight Gain: A Systematic Review
Patel, S. R., & Hu, F. B. (2008) · Obesity · doi:10.1038/oby.2007.118 · Cited by 1,505 · see citing works
Oxidative stress, insulin signaling, and diabetes
Rains, J., & Jain, S. K. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.006 · Cited by 1,444 · see citing works
The metabolic consequences of sleep deprivation
Knutson, K. L., Spiegel, K., Penev, P., & Van Cauter, E. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.01.002 · Cited by 1,365 · see citing works
Self-citationSleep loss: a novel risk factor for insulin resistance and type 2 diabetes
Spiegel, K., Knutson, K., Leproult, R., Tasali, E., & Cauter, E. V. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00660.2005 · Cited by 1,175 · see citing works
Self-citationBesedovsky, L., Lange, T., & Born, J. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1044-0 · Cited by 1,153 · see citing works
Buckley, T. M., & Schatzberg, A. F. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1056 · Cited by 964 · see citing works
Buxton, O. M., Cain, S. W., O’Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A., & Shea, S. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003200 · Cited by 932 · see citing works
Panel, C. C., Watson, N. F., Badr, M. S., Belenky, G., Bliwise, D. L., Buxton, O. M., Buysse, D., Dinges, D. F., Gangwisch, J., Grandner, M. A., et al. (2015) · Sleep · doi:10.5665/sleep.4886 · Cited by 906 · see citing works
Effects of poor and short sleep on glucose metabolism and obesity risk
Spiegel, K., Tasali, E., Leproult, R., & Van Cauter, E. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.23 · Cited by 857 · see citing works
Self-citationBehavioral science at the crossroads in public health: Extending horizons, envisioning the future
Glass, T. A., & McAtee, M. J. (2006) · Social Science & Medicine · doi:10.1016/j.socscimed.2005.08.044 · Cited by 821 · see citing works
Buxton, O. M., & Marcelli, E. (2010) · Social Science & Medicine · doi:10.1016/j.socscimed.2010.05.041 · Cited by 818 · see citing works
Metabolic consequences of sleep and sleep loss
Van Cauter, E., Spiegel, K., Tasali, E., & Leproult, R. (2008) · Sleep Medicine · doi:10.1016/s1389-9457(08)70013-3 · Cited by 812 · see citing works
Self-citationImpact of insufficient sleep on total daily energy expenditure, food intake, and weight gain
Markwald, R. R., Melanson, E. L., Smith, M. R., Higgins, J., Perreault, L., Eckel, R. H., & Wright, K. P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216951110 · Cited by 810 · see citing works
<i>Associations between Sleep Loss and Increased Risk of Obesity and Diabetes</i>
Knutson, K. L., & Van Cauter, E. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.033 · Cited by 810 · see citing works
Is Sleep Duration Associated With Childhood Obesity? A Systematic Review and Meta‐analysis
Chen, X., Beydoun, M. A., & Wang, Y. (2008) · Obesity · doi:10.1038/oby.2007.63 · Cited by 796 · see citing works
Interactions Between Obesity and Obstructive Sleep Apnea
Romero‐Corral, A., Caples, S. M., López-Jiménez, F. A., & Somers, V. K. (2010) · CHEST Journal · doi:10.1378/chest.09-0360 · Cited by 788 · see citing works
Ten Putative Contributors to the Obesity Epidemic
McAllister, E. J., Dhurandhar, N. V., Keith, S. W., Aronne, L. J., Barger, J., Baskin, M., Benca, R. M., Biggio, J., Boggiano, M. M., Eisenmann, J. C., et al. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903372599 · Cited by 710 · see citing works
In search of lost sleep: secular trends in the sleep time of school-aged children and adolescents
Matricciani, L., Olds, T., & Petkov, J. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.03.005 · Cited by 698 · see citing works
Tomiyama, A. J. (2019) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-102936 · Cited by 695 · see citing works
The role of insufficient sleep and circadian misalignment in obesity
Chaput, J., McHill, A. W., Cox, R. C., Broussard, J. L., Dutil, C., da Costa, B. G. G., Sampasa‐Kanyinga, H., & Wright, K. P. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00747-7 · Cited by 689 · see citing works
Obesity and polycystic ovary syndrome
Barber, T., McCarthy, M. I., Wass, J. A. H., & Franks, S. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02587.x · Cited by 655 · see citing works
Putative contributors to the secular increase in obesity: exploring the roads less traveled
Keith, S. W., Redden, D. T., Katzmarzyk, P. T., Boggiano, M. M., Hanlon, E. C., Benca, R. M., Ruden, D. M., Pietrobelli, A., Barger, J. L., Fontaine, K. R., et al. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803326 · Cited by 633 · see citing works
Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men
Buxton, O. M., Pavlova, M., Reid, E. W., Wang, W., Simonson, D. C., & Adler, G. K. (2010) · Diabetes · doi:10.2337/db09-0699 · Cited by 604 · see citing works
“Both these pathways also have been proposed as possible mediators of the impairments in glucose tolerance associated with sleep restriction (22;44-48).”
BackgroundSleep influences on obesity, insulin resistance, and risk of type 2 diabetes
Reutrakul, S., & Van Cauter, E. (2018) · Metabolism · doi:10.1016/j.metabol.2018.02.010 · Cited by 584 · see citing works
Objectively Measured Sleep Characteristics among Early-Middle-Aged Adults
Lauderdale, D. S., Knutson, K. L., Yan, L. L., Rathouz, P. J., Hulley, S. B., Sidney, S., & Liu, K. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj199 · Cited by 581 · see citing works
Fatima, Y., Doi, S. A. R., & Mamun, A. A. (2015) · Obesity Reviews · doi:10.1111/obr.12245 · Cited by 577 · see citing works
Watson, N. F., Badr, M. S., Belenky, G., Bliwise, D. L., Buxton, O. M., Buysse, D., Dinges, D. F., Gangwisch, J., Grandner, M. A., Kushida, C., et al. (2015) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.4950 · Cited by 568 · see citing works
The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
Oster, H., Challet, E., Ott, V., Arvat, E., de Kloet, E. R., Dijk, D.-J., Lightman, S., Vgontzas, A., & Van Cauter, E. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1080 · Cited by 548 · see citing works
(2013) · PubMed · Cited by 538 · see citing works
Landsberg, L., Aronne, L. J., Beilin, L. J., Burke, V., Igel, L. I., Lloyd‐Jones, D., & Sowers, J. (2013) · The Journal of Clinical Hypertension · doi:10.1111/jch.12049 · Cited by 528 · see citing works
Interactions between sleep, stress, and metabolism: From physiological to pathological conditions
Hirotsu, C., Tufik, S., & Andersen, M. L. (2015) · Sleep Science · doi:10.1016/j.slsci.2015.09.002 · Cited by 527 · see citing works
Sleep duration and cardiometabolic risk: A review of the epidemiologic evidence
Knutson, K. L. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.07.001 · Cited by 520 · see citing works
Lovesick: How Couples’ Relationships Influence Health
Kiecolt‐Glaser, J. K., & Wilson, S. J. (2017) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032816-045111 · Cited by 520 · see citing works
The link between short sleep duration and obesity: we should recommend more sleep to prevent obesity
Taheri, S. (2006) · Archives of Disease in Childhood · doi:10.1136/adc.2005.093013 · Cited by 510 · see citing works
Beccuti, G., & Pannain, S. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3283479109 · Cited by 507 · see citing works
Haus, E. L., & Smolensky, M. H. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.08.003 · Cited by 499 · see citing works
Correlates of Long Sleep Duration
Patel, S. R., Malhotra, A., Gottlieb, D. J., White, D. P., & Hu, F. B. (2006) · Sleep · doi:10.1093/sleep/29.7.881 · Cited by 490 · see citing works
Metabolic Consequences of Sleep and Circadian Disorders
Depner, C. M., Stothard, E. R., & Wright, K. P. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0507-z · Cited by 480 · see citing works
Sleep patterns, diet quality and energy balance
Chaput, J. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.09.006 · Cited by 466 · see citing works
St-Onge, M.-P., Roberts, A. L., Chen, J., Kelleman, M., O’Keeffe, M., RoyChoudhury, A., & Jones, P. J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.013904 · Cited by 463 · see citing works
Spaeth, A. M., Dinges, D. F., & Goel, N. (2013) · Sleep · doi:10.5665/sleep.2792 · Cited by 457 · see citing works
Early Childhood Obesity Prevention Policies
(2011) · doi:10.17226/13124 · Cited by 452 · see citing works
Acute partial sleep deprivation increases food intake in healthy men
Brondel, L., Romer, M. A., Nougues, P. M., Touyarou, P., & Davenne, D. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28523 · Cited by 442 · see citing works
Sleep and the epidemic of obesity in children and adults
Van Cauter, E., & Knutson, K. L. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0298 · Cited by 427 · see citing works
Sleep and Circadian Rhythms in Humans
Czeisler, C. A., & Gooley, J. J. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.064 · Cited by 425 · see citing works
Boubekri, M., Cheung, I. N., Reid, K. J., Wang, C.-H., & Zee, P. C. (2014) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.3780 · Cited by 418 · see citing works
Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity
Balbo, M., Leproult, R., & Van Cauter, E. (2010) · International Journal of Endocrinology · doi:10.1155/2010/759234 · Cited by 408 · see citing works
Self-citationAssociation Between Sleep and Blood Pressure in Midlife: The CARDIA Sleep Study
Knutson, K. L., Van Cauter, E., Rathouz, P. J., Yan, L. L., Hulley, S. B., Liu, K., & Lauderdale, D. S. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.119 · Cited by 403 · see citing works
Schmid, S. M., Hallschmid, M., Jauch-Chara, K., Wilms, B., Benedict, C., Lehnert, H., Born, J., & Schultes, B. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27984 · Cited by 400 · see citing works
Insufficient Sleep Undermines Dietary Efforts to Reduce Adiposity
Nedeltcheva, A. V., Kilkus, J. M., Imperial, J., Schoeller, D. A., & Penev, P. D. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-153-7-201010050-00006 · Cited by 397 · see citing works
Self-citationChaput, J.-P., Després, J.-P., Bouchard, C., & Tremblay, A. (2008) · Sleep · doi:10.1093/sleep/31.4.517 · Cited by 390 · see citing works
Sleep as a Potential Fundamental Contributor to Disparities in Cardiovascular Health
Jackson, C. L., Redline, S., & Emmons, K. M. (2015) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031914-122838 · Cited by 388 · see citing works
Donga, E., van Dijk, M., van Dijk, J. G., Biermasz, N. R., Lammers, G.-J., van Kralingen, K. W., Corssmit, E. P. M., & Romijn, J. A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2430 · Cited by 387 · see citing works
Obesity and polycystic ovary syndrome
Barber, T. M., & Franks, S. (2021) · Clinical Endocrinology · doi:10.1111/cen.14421 · Cited by 385 · see citing works
Stamatakis, K. A., Kaplan, G. A., & Roberts, R. E. (2007) · Annals of Epidemiology · doi:10.1016/j.annepidem.2007.07.096 · Cited by 377 · see citing works
Disorders of glucose metabolism in sleep apnea
Punjabi, N. M., & Polotsky, V. Y. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00695.2005 · Cited by 373 · see citing works
SCHMID, S. M., HALLSCHMID, M., JAUCH‐CHARA, K., BORN, J., & SCHULTES, B. (2008) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00662.x · Cited by 370 · see citing works
Age and gender effects on the prevalence of poor sleep quality in the adult population
Madrid‐Valero, J. J., Martínez‐Selva, J. M., Couto, B. R. D., Sánchez-Romera, J. F., & Ordoñana, J. R. (2016) · Gaceta Sanitaria · doi:10.1016/j.gaceta.2016.05.013 · Cited by 366 · see citing works
Broussard, J. L., Ehrmann, D. A., Van Cauter, E., Tasali, E., & Brady, M. J. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-8-201210160-00005 · Cited by 364 · see citing works
“Both reduced leptin levels (32, 33) and elevated free fatty acid concentrations (13) have been observed in healthy persons after experimental sleep restriction and could conceivably contribute to increased risk for obesity and diabetes.”
BackgroundStress and obesity: the role of the hypothalamic–pituitary–adrenal axis in metabolic disease
Bose, M., Oliván, B., & Laferrère, B. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32832fa137 · Cited by 364 · see citing works
Impact of Sleep and Sleep Loss on Neuroendocrine and Metabolic Function
van Cauter, E., Holmbäck, U., Knutson, K., Leproult, R., Miller, A., Nedeltcheva, A., Pannain, S., Penev, P., Tasali, E., & Spiegel, K. (2007) · Hormone Research in Paediatrics · doi:10.1159/000097543 · Cited by 353 · see citing works
Self-citationSelf-reported sleep quality is associated with the metabolic syndrome
Jennings, J. R., Muldoon, M. F., Hall, M., Buysse, D. J., & Manuck, S. B. (2007) · Sleep · doi:10.1093/sleep/30.2.219 · Cited by 344 · see citing works
The metabolic burden of sleep loss
Schmid, S. M., Hallschmid, M., & Schultes, B. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70012-9 · Cited by 328 · see citing works
Nedeltcheva, A. V., Kessler, L., Imperial, J., & Penev, P. D. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0483 · Cited by 323 · see citing works
Self-citationReutrakul, S., & Van Cauter, E. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12355 · Cited by 321 · see citing works
Lao, X. Q., Liu, X., Deng, H.-B., Chan, T.-C., Ho, K. F., Wang, F., Vermeulen, R., Tam, T., Wong, M. C. S., Tse, L. A., et al. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6894 · Cited by 317 · see citing works
The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms
Briançon‐Marjollet, A., Weiszenstein, M., Henri, M., Thomas, A., Godin‐Ribuot, D., & Polak, J. (2015) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-015-0018-3 · Cited by 317 · see citing works
McHill, A. W., & Wright, K. P. (2017) · Obesity Reviews · doi:10.1111/obr.12503 · Cited by 316 · see citing works
Leggio, M., Lombardi, M., Caldarone, E., Severi, P., D’Emidio, S., Armeni, M., Bravi, V., Bendini, M. G., & Mazza, A. (2017) · Hypertension Research · doi:10.1038/hr.2017.75 · Cited by 313 · see citing works
Grandner, M. A., Jackson, N., Gerstner, J. R., & Knutson, K. L. (2013) · Appetite · doi:10.1016/j.appet.2013.01.004 · Cited by 310 · see citing works
Sleep Quality and Elevated Blood Pressure in Adolescents
Javaheri, S., Storfer‐Isser, A., ROSEN, C. L., & Redline, S. S. (2008) · Circulation · doi:10.1161/circulationaha.108.766410 · Cited by 310 · see citing works
Sleep and Athletic Performance
Charest, J., & Grandner, M. A. (2020) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2019.11.005 · Cited by 307 · see citing works
Sleep deprivation and stress: a reciprocal relationship
Nollet, M., Wisden, W., & Franks, N. P. (2020) · Interface Focus · doi:10.1098/rsfs.2019.0092 · Cited by 307 · see citing works
Grandner, M. A., Chakravorty, S., Perlis, M. L., Oliver, L., & Gurubhagavatula, I. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2013.09.012 · Cited by 300 · see citing works
“Other potential pathways may involve insulin dysregulation [33,34,114–117], decreased leptin (a hormone secreted by adipocytes that contributes to satiety), and increased ghrelin (a hormone secreted by the stomach to stimulate hunger) [118,119].”
Mukherjee, S., Patel, S. R., Kales, S. N., Ayas, N., Strohl, K. P., Gozal, D., & Malhotra, A. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201504-0767st · Cited by 300 · see citing works
Grandner, M. A., Patel, N. P., Gehrman, P. R., Perlis, M. L., & Pack, A. I. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.08.001 · Cited by 291 · see citing works
Golley, R. K., Maher, C. A., Matricciani, L., & Olds, T. S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.212 · Cited by 286 · see citing works
Landsberg, L., Aronne, L. J., Beilin, L. J., Burke, V., Igel, L. I., Lloyd‐Jones, D. M., & Sowers, J. R. (2012) · Obesity · doi:10.1002/oby.20181 · Cited by 286 · see citing works
Role of sleep duration in the regulation of glucose metabolism and appetite
Morselli, L., Leproult, R., Balbo, M., & Spiegel, K. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.07.005 · Cited by 283 · see citing works
Self-citationSleep restriction leads to increased activation of brain regions sensitive to food stimuli
St-Onge, M.-P., McReynolds, A., Trivedi, Z. B., Roberts, A. L., Sy, M., & Hirsch, J. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.027383 · Cited by 277 · see citing works
Sleep and Metabolism: An Overview
Sharma, S., & Kavuru, M. S. (2010) · International Journal of Endocrinology · doi:10.1155/2010/270832 · Cited by 277 · see citing works
Changes in Children’s Sleep Duration on Food Intake, Weight, and Leptin
Hart, C. N., Carskadon, M. A., Considine, R. V., Fava, J. L., Lawton, J., Raynor, H. A., Jelalian, E., Owens, J., & Wing, R. (2013) · Pediatrics · doi:10.1542/peds.2013-1274 · Cited by 276 · see citing works
Obstructive sleep apnea and obesity: implications for public health
McFarlane, S. I. (2017) · Sleep Medicine and Disorders International Journal · doi:10.15406/smdij.2017.01.00019 · Cited by 270 · see citing works
Watanabe, M., Kikuchi, H., Tanaka, K., & Takahashi, M. (2010) · Sleep · doi:10.1093/sleep/33.2.161 · Cited by 263 · see citing works
Ding, D., Rogers, K. D., van der Ploeg, H. P., Stamatakis, E. A., & Bauman, A. E. (2015) · PLoS Medicine · doi:10.1371/journal.pmed.1001917 · Cited by 256 · see citing works
Katagiri, R., Asakura, K., Kobayashi, S., Suga, H., Sasaki, S., & the Three‐generation Study of Women on Diets and Health Study Group (2014) · Journal of Occupational Health · doi:10.1539/joh.14-0051-oa · Cited by 253 · see citing works
Sleep Deprivation and Neurological Disorders
Bishir, M., Bhat, A., Essa, M. M., Ekpo, O. E., Ihunwo, A. O., Veeraraghavan, V. P., Surapaneni, K. M., Mahalakshmi, A. M., Ray, B., Tuladhar, S., et al. (2020) · BioMed Research International · doi:10.1155/2020/5764017 · Cited by 253 · see citing works
Olds, T., Maher, C. A., & Matricciani, L. (2011) · SLEEP · doi:10.5665/sleep.1266 · Cited by 252 · see citing works
Sleep, Anesthesiology, and the Neurobiology of Arousal State Control
Lydic, R., & Baghdoyan, H. A. (2005) · Anesthesiology · doi:10.1097/00000542-200512000-00024 · Cited by 251 · see citing works
PERIOD3, circadian phenotypes, and sleep homeostasis
Dijk, D., & Archer, S. N. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.07.002 · Cited by 246 · see citing works
Acute sleep deprivation reduces energy expenditure in healthy men
Benedict, C., Hallschmid, M., Lassen, A., Mahnke, C., Schultes, B., Schiöth, H. B., Born, J., & Lange, T. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.006460 · Cited by 243 · see citing works
Foster, F., & Wulff, K. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1670 · Cited by 243 · see citing works
Shift work and cancer – considerations on rationale, mechanisms, and epidemiology
Costa, G., Haus, E., & Stevens, R. (2010) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.2899 · Cited by 241 · see citing works
- Authors
- Spiegel, K., Leproult, R., L’Hermite-Balériaux, M., Copinschi, G., Penev, P. D., & Van Cauter, E.
- Affiliations
- Université Libre de Bruxelles (BE)
- University of Chicago (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-11
- Volume
- 89
- Issue
- 11
- Pages
- 5762-5771
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2115505164
- Cited by
- 1,006
- References
- 69
- Citations by year
- 2026: 18 · 2025: 29 · 2024: 28 · 2023: 52 · 2022: 48 · 2021: 40 · 2020: 50 · 2019: 30 · 2018: 42 · 2017: 41 · 2016: 57 · 2015: 57 · 2014: 61 · 2013: 78 · 2012: 74
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- University of Chicago
- National Institutes of Health
- National Institute on Aging (P01AG011412, AG-11412)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 20595, DK-41814, R01DK041814)
- National Center for Research Resources (M01-RR 00055, M01RR000055)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- leptin, sleep duration, sleep restriction, sleep extension, sympathovagal balance, heart rate variability, cortisol, thyroid-stimulating hormone, glucose, insulin, HOMA, carbohydrate regulation, energy homeostasis, appetite regulation, neuroendocrine regulation, perceived stress
- MeSH terms
- Adult, Homeostasis, Humans, Hydrocortisone, Male, Sleep, Sympathetic Nervous System, Thyrotropin, Time Factors, Vagus Nerve, Leptin, Carbohydrate Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
