Cited by 34Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsGrowth Hormone and Insulin-like Growth Factors

A historical perspective on the interactions of insulin at the blood‐brain barrier

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Rhea, Elizabeth M., Banks, William A.·2021·Journal of Neuroendocrinology

Abstract

Subsequent to the discovery of insulin in 1921, the role of insulin in the brain has been investigated throughly. The ability of insulin to act within the brain to regulate peripheral glucose levels helped evolve the research surrounding the ability of insulin to be transported into the brain. Investigations aiming to determine the transport of insulin into the brain from the circulation soon followed. Once it was established that insulin could enter the brain, the ability of insulin to bind brain microvessels and regulators of this process were determined. As technology advanced, quantitative measurements to specify the transport rate of insulin across the blood‐brain barrier (BBB) and the impact of physiological conditions and diseases were the logical next steps. Lastly, with the advent of genetic mouse models and high‐specificity antagonists, the specific role of the insulin receptor in mediating insulin transport could begin to be explored. In this review, we summarise the main findings throughout the decades regarding the interactions of insulin at the BBB.

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Authors
Rhea, E. M., & Banks, W. A.
Affiliations
University of Washington (US)
Corresponding author
Rhea, Elizabeth M.
Venue
Journal of Neuroendocrinology
Publisher
Wiley
Published
2021-01-12
Volume
33
Issue
4
Pages
e12929-e12929
ISSN
  • 0953-8194 (ISSN-L)
  • 1365-2826
OpenAlex
W3118467990
Cited by
34
References
85
Citations by year
2026: 7 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 5
FWCI
0.67
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Center for Scientific Review (RF1AG059088, RO1AG046619)
  • Diabetes Research Center, University of Washington
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
insulin, blood-brain barrier, insulin transport, insulin receptor, cerebral microvasculature, insulin binding, glucose regulation, insulin receptor antagonist, genetic mouse models
MeSH terms
Animals, Biological Transport, Blood-Brain Barrier, Brain, Humans, Insulin, Receptor, Insulin

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