Cited by 114Menopause: Health Impacts and TreatmentsEstrogen and related hormone effectsSkin Protection and Aging

A review of the role of estrogen in dermal aging and facial attractiveness in women

Lephart, Edwin D·2018·Journal of Cosmetic Dermatology

Abstract

Summary: Estrogens are known to have protective and favorable influences on skin health; conversely, androgens oppose the actions of estrogens. Estrogen's chemical messages are transmitted via the classical nuclear hormone estrogen receptors (ER) alpha and beta and the rapid‐acting G‐coupled membrane estrogen receptor. Androgens [both testosterone and 5α‐dihydrotestosterone (5α‐DHT)] bind the same androgen receptor. Estrogen levels peak in the mid‐ to late 20s in women and then decline by 50% by 50 years of age and dramatically decrease further after menopause. The loss of estrogens with aging contributes to diminished dermal health, whereas estrogen hormone therapy [eg, oral conjugated equine estrogens (CEE)] restores skin health. Several reports suggest positive correlations between the levels of circulating estrogens and: (1) perceived age, (2) attractiveness, (3) enhanced skin health, and (4) facial coloration in women. Based upon a psychological dermato‐endocrine perspective, the positive correspondence of high estrogens levels with perceived age and facial attractiveness in women especially with aging demonstrates the importance of hormonal influences on observed dermal health and youthful appearance.

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Registry

Crossref · 10.1111/jocd.12508

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48 of 48 references verified0 citation errors · 0 not checkable

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Authors
Lephart, E. D.
Affiliations
Brigham Young University (US)
Corresponding author
Lephart, Edwin D
Venue
Journal of Cosmetic Dermatology
Publisher
Wiley
Published
2018-02-13
Volume
17
Issue
3
Pages
282-288
ISSN
  • 1473-2130 (ISSN-L)
  • 1473-2165
OpenAlex
W2792899004
Cited by
114
References
48
Citations by year
2026: 10 · 2025: 13 · 2024: 24 · 2023: 10 · 2022: 16 · 2021: 11 · 2020: 9 · 2019: 18 · 2018: 3
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cosmetic Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Brigham Young University
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
estrogen, facial attractiveness, women, estrogen receptor, androgen receptor, androgens, menopause, hormone replacement therapy, conjugated equine estrogens, perceived age, skin health, facial coloration
MeSH terms
Androgens, Beauty, Estrogens, Face, Female, Humans, Menopause, Receptors, Androgen, Receptors, Estrogen, Skin Pigmentation, Skin Aging, Estrogen Replacement Therapy

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