The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Biofilm infections, their resilience to therapy and innovative treatment strategies
Open accessAbstract
Biofilm formation of microorganisms causes persistent tissue and foreign body infections resistant to treatment with antimicrobial agents. Up to 80% of human bacterial infections are biofilm associated; such infections are most frequently caused byS taphylococcus epidermidis,P seudomonas aeruginosa,S taphylococcus aureus and E nterobacteria such asE scherichia coli. The accurate diagnosis of biofilm infections is often difficult, which prevents the appropriate choice of treatment. As biofilm infections significantly contribute to patient morbidity and substantial healthcare costs, novel strategies to treat these infections are urgently required. Nucleotide second messengers, c‐di‐GMP, (p)pp G pp and potentially c‐di‐AMP, are major regulators of biofilm formation and associated antibiotic tolerance. Consequently, different components of these signalling networks might be appropriate targets for antibiofilm therapy in combination with antibiotic treatment strategies. In addition, cyclic di‐nucleotides are microbial‐associated molecular patterns with an almost universal presence. Their conserved structures sensed by the eukaryotic host have a widespread effect on the immune system. Thus, cyclic di‐nucleotides are also potential immunotherapeutic agents to treat antibiotic‐resistant bacterial infections.
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Cites
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STING is a direct innate immune sensor of cyclic di-GMP
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Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation
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d -Amino Acids Trigger Biofilm Disassembly
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Cited by
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence
Moradali, M. F., Ghods, S., & Rehm, B. H. A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00039 · Cited by 1,537
Pseudomonas aeruginosa Biofilms
Thi, M. T. T., Wibowo, D., & Rehm, B. H. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228671 · Cited by 911
de la Fuente-Núñez, C., Reffuveille, F., Fernández, L., & Hancock, R. E. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.013 · Cited by 801
Novel Strategies for the Prevention and Treatment of Biofilm Related Infections
Chen, M., Yu, Q., & Sun, H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140918488 · Cited by 429
Mechanisms of Candida Biofilm Drug Resistance
Taff, H. T., Mitchell, K. F., Edward, J. A., & Andes, D. R. (2013) · Future Microbiology · doi:10.2217/fmb.13.101 · Cited by 422
Metadata
- Authors
- Römling, U., & Balsalobre, C.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2012-10-29
- Volume
- 272
- Issue
- 6
- Pages
- 541-561
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W1989942811
- Cited by
- 865
- References
- 13
- FWCI
- 12.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
