Daytime melatonin and light independently affect human alertness and body temperature
Open accessAbstract
Light significantly improves alertness during the night (Cajochen, Sleep Med Rev , 11, 2007 and 453; Ruger et al., AJP Regul Integr Comp Physiol , 290, 2005 and R1413), but results are less conclusive at daytime (Lok et al., J Biol Rhythms , 33, 2018 and 589). Melatonin and core body temperature levels at those times of day may contribute to differences in alerting effects of light. In this experiment, the combined effect of daytime exogenous melatonin administration and light intensity on alertness, body temperature, and skin temperature was studied. The goal was to assess whether (a) alerting effects of light are melatonin dependent, (b) soporific effects of melatonin are mediated via the thermoregulatory system, and (c) light can improve alertness after melatonin‐induced sleepiness during daytime. 10 subjects (5 females, 5 males) received melatonin (5 mg) in dim (10 lux) and, on a separate occasion, in bright polychromatic white light (2000 lux). In addition, they received placebo both under dim and bright light conditions. Subjects participated in all four conditions in a balanced order, yielding a balanced within‐subject design, lasting from noon to 04:00 pm . Alertness and performance were assessed half hourly, while body temperature and skin temperature were measured continuously. Saliva samples to detect melatonin concentrations were collected half hourly. Melatonin administration increased melatonin concentrations in all subjects. Subjective sleepiness and distal skin temperature increased after melatonin ingestion. Bright light exposure after melatonin administration did not change subjective alertness scores, but body temperature and proximal skin temperature increased, while distal skin temperature decreased. Light exposure did not significantly affect these parameters in the placebo condition. These results indicate that (a) exogenous melatonin administration during daytime increases subjective sleepiness, confirming a role for melatonin in sleepiness regulation, (b) bright light exposure after melatonin ingestion significantly affected thermoregulatory parameters without altering subjective sleepiness, therefore temperature changes seem nonessential for melatonin‐induced sleepiness, (c) subjective sleepiness was increased by melatonin ingestion, but bright light administration was not able to improve melatonin‐induced sleepiness feelings nor performance. Other (physiological) factors may therefore contribute to differences in alerting effects of light during daytime and nighttime.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This alerting effect-exposure timing dependence has further been reported in the context of absent alerting responses during daytime light exposures, suggesting a relationship to circadian features, such as the melatonin level.
“This alerting effect‐exposure timing dependence has further been reported in the context of absent alerting responses during daytime light exposures, suggesting a relationship to circadian features, such as the melatonin level 70.”
From The inner clock-Blue light sets the human rhythm (2019) · cites this paper as [70]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234 · see citing works
Subjective and objective sleepiness in the active individual
Åkerstedt, T., & Gillberg, M. (1990) · International Journal of Neuroscience · doi:10.3109/00207459008994241 · Cited by 3,088 · see citing works
Life between Clocks: Daily Temporal Patterns of Human Chronotypes
Roenneberg, T., Wirz-Justice, A., & Merrow, M. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730402239679 · Cited by 2,662 · see citing works
Dinges, D. F., & Powell, J. W. (1985) · Behavior Research Methods, Instruments, & Computers · doi:10.3758/bf03200977 · Cited by 1,750 · see citing works
Activation of ventrolateral preoptic neurons during sleep
Sherin, J. E., Shiromani, P. J., McCarley, R. W., & Saper, C. B. (1996) · Science · doi:10.1126/science.271.5246.216 · Cited by 1,111 · see citing works
A Phase Response Curve to Single Bright Light Pulses in Human Subjects
Khalsa, S. B. S., Jewett, M. E., Cajochen, C., & Czeisler, C. A. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.040477 · Cited by 1,040 · see citing works
Validation of the Karolinska sleepiness scale against performance and EEG variables
Kaida, K., Takahashi, M., Åkerstedt, T., Nakata, A., Otsuka, Y., Haratani, T., & Fukasawa, K. (2006) · Clinical Neurophysiology · doi:10.1016/j.clinph.2006.03.011 · Cited by 1,016 · see citing works
Cajochen, C., Münch, M., Kobialka, S., Kräuchi, K., Steiner, R., Oelhafen, P., Orgül, S., & Wirz-Justice, A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0957 · Cited by 939 · see citing works
Moore, R. Y. (1983) · PubMed · Cited by 687 · see citing works
Cajochen, C., Zeitzer, J. M., Czeisler, C. A., & Dijk, D.-J. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00236-9 · Cited by 653 · see citing works
Cajochen, C. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.009 · Cited by 652 · see citing works
Melatonin: The chemical expression of darkness
Reiter, R. J. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90087-9 · Cited by 634 · see citing works
Arendt, J., & Skene, D. J. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.05.002 · Cited by 629 · see citing works
Dollins, A. B., Zhdanova, I. V., Wurtman, R. J., Lynch, H. J., & Deng, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.5.1824 · Cited by 578 · see citing works
Chellappa, S. L., Steiner, R., Blattner, P., Oelhafen, P., Götz, T., & Cajochen, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016429 · Cited by 546 · see citing works
Aschoff, J., & Wever, R. (1981) · Springer eBooks · doi:10.1007/978-1-4615-6552-9_17 · Cited by 533 · see citing works
Hardeland, R., Tan, D., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00701.x · Cited by 474 · see citing works
Wyatt, J. K., Cecco, A. R.-D., Czeisler, C. A., & Dijk, D. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.4.r1152 · Cited by 473 · see citing works
Relationship between alertness, performance, and body temperature in humans
Wright, K. P., Hull, J. T., & Czeisler, C. A. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00205.2002 · Cited by 447 · see citing works
Bright light effects on body temperature, alertness, EEG and behavior
Badia, P., Myers, B. L., Boecker, M. R., Culpepper, J., & Harsh, J. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90549-4 · Cited by 437 · see citing works
Melatonin Synthesis in the Pineal Gland: Control by Light
Wurtman, R. J., Axelrod, J., & Phillips, L. S. (1963) · Science · doi:10.1126/science.142.3595.1071 · Cited by 433 · see citing works
Melatonin receptors step into the light: cloning and classification of subtypes
Reppart, S. M., Weaver, D. R., & Godson, C. (1996) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(96)10005-5 · Cited by 426 · see citing works
The efficacy and safety of exogenous melatonin for primary sleep disorders a meta-analysis
Buscemi, N., Vandermeer, B., Hooton, N., Pandya, R., Tjosvold, L., Hartling, L., Baker, G., Klassen, T. P., & Vohra, S. (2005) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2005.0243.x · Cited by 399 · see citing works
Warm feet promote the rapid onset of sleep
Kräuchi, K., Cajochen, C., Werth, E., & Wirz-Justice, A. (1999) · Nature · doi:10.1038/43366 · Cited by 398 · see citing works
Phipps-Nelson, J., Redman, J. R., Dijk, D.-J., & Rajaratnam, S. M. W. (2003) · Sleep · doi:10.1093/sleep/26.6.695 · Cited by 394 · see citing works
Melatonin receptors: role on sleep and circadian rhythm regulation
Dubocovich, M. L. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.10.007 · Cited by 364 · see citing works
Smolders, K. C. H. J., de Kort, Y. A. W., & Cluitmans, P. J. M. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.04.028 · Cited by 353 · see citing works
Daytime Light Exposure Dynamically Enhances Brain Responses
Vandewalle, G., Balteau, E., Phillips, C., Degueldre, C., Moreau, V., Sterpenich, V., Albouy, G., Darsaud, A., Desseilles, M., Dang-Vu, T. T., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.031 · Cited by 313 · see citing works
Smolders, K. C. H. J., & de Kort, Y. A. W. (2014) · Journal of Environmental Psychology · doi:10.1016/j.jenvp.2013.12.010 · Cited by 304 · see citing works
Acute alerting effects of light: A systematic literature review
Souman, J. L., Tinga, A. M., te Pas, S. F., van Ee, R., & Vlaskamp, B. N. S. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.016 · Cited by 293 · see citing works
Rüger, M., Gordijn, M. C. M., Beersma, D. G. M., de Vries, B., & Daan, S. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00121.2005 · Cited by 286 · see citing works
Self-citationIndividual Differences in the Amount and Timing of Salivary Melatonin Secretion
Burgess, H. J., & Fogg, L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003055 · Cited by 270 · see citing works
Effect of melatonin on jet lag after long haul flights.
Petrie, K. J., Conaglen, J. V., Thompson, L., & Chamberlain, K. (1989) · BMJ · doi:10.1136/bmj.298.6675.705 · Cited by 242 · see citing works
Kräuchi, K., Cajochen, C., & Wirz-Justice, A. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.1.134 · Cited by 227 · see citing works
Effects of melatonin on human mood and performance
Lieberman, H. R., Waldhauser, F., Garfield, G. S., Lynch, H. J., & Wurtman, R. J. (1984) · Brain Research · doi:10.1016/0006-8993(84)90290-7 · Cited by 217 · see citing works
Shanahan, T. L., & Czeisler, C. A. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-2-227 · Cited by 217 · see citing works
Deacon, S., & Arendt, J. (1995) · Brain Research · doi:10.1016/0006-8993(95)96872-i · Cited by 203 · see citing works
Diurnal Spectral Sensitivity of the Acute Alerting Effects of Light
Rahman, S. A., Flynn‐Evans, E. E., Aeschbach, D., Brainard, G. C., Czeisler, C. A., & Lockley, S. W. (2014) · SLEEP · doi:10.5665/sleep.3396 · Cited by 201 · see citing works
A three pulse phase response curve to three milligrams of melatonin in humans
Burgess, H. J., Revell, V. L., & Eastman, C. I. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.143180 · Cited by 176 · see citing works
Arendt, J., Borbély, A. A., Franey, C. S., & Wright, J. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90245-3 · Cited by 172 · see citing works
Decreased alertness due to sleep loss increases pain sensitivity in mice
Alexandre, C., Latrémolière, A., Ferreira, A. N., Miracca, G., Yamamoto, M., Scammell, T. E., & Woolf, C. J. (2017) · Nature Medicine · doi:10.1038/nm.4329 · Cited by 171 · see citing works
Light, Alertness, and Alerting Effects of White Light: A Literature Overview
Lok, R., Smolders, K. C. H. J., Beersma, D. G. M., & de Kort, Y. A. W. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418796443 · Cited by 169 · see citing works
Self-citationVaněček, J. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb01108.x · Cited by 167 · see citing works
MT2 Melatonin Receptors Are Present and Functional in Rat Caudal Artery
Masana, M. I., Doolen, S., Erşahin, Ç. H., Al‐Ghoul, W. M., DUCKLES, S. P., Dubocovich, M. L., & Krause, D. N. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.302.3.1295 · Cited by 162 · see citing works
Thermoregulatory effects of melatonin in relation to sleepiness
Kräuchi, K., Cajochen, C., Pache, M., Flammer, J., & Wirz‐Justice, A. (2006) · Chronobiology International · doi:10.1080/07420520500545854 · Cited by 152 · see citing works
Homeostatic versus Circadian Effects of Melatonin on Core Body Temperature in Humans
Cagnacci, A., Kräuchi, K., Wirz-Justice, A., & Volpe, A. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200604 · Cited by 151 · see citing works
Melatonin receptors: Current status, facts, and hypotheses
Stankov, B. M., & Reiter, R. J. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90020-r · Cited by 141 · see citing works
Daytime light exposure: Effects on biomarkers, measures of alertness, and performance
Sahin, L., Wood, B., Plitnick, B., & Figueiro, M. G. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.017 · Cited by 131 · see citing works
Cajochen, C., Kräuchi, K., Danilenko, K. V., & Wirz‐Justice, A. (1998) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1998.00106.x · Cited by 130 · see citing works
Melatonin and jet lag: Confirmatory result using a simplified protocol
Claustrat, B., Brun, J., David, M., Sassolas, G., & Chazot, G. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90300-o · Cited by 128 · see citing works
Sleepiness: evaluating and quantifying methods
Curcio, G., Casagrande, M., & Bertini, M. (2001) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(01)00138-6 · Cited by 122 · see citing works
Effect of pharmacological daytime doses of melatonin on human mood and performance
Dollins, A. B., Lynch, H. J., Wurtman, R. J., Deng, M., Kischka, K. U., Gleason, R. E., & Lieberman, H. R. (1993) · Psychopharmacology · doi:10.1007/bf02244899 · Cited by 120 · see citing works
Rahman, S. A., Hilaire, M. A. S., & Lockley, S. W. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.05.002 · Cited by 117 · see citing works
Huiberts, L., Smolders, K. C. H. J., & de Kort, Y. A. W. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.035 · Cited by 112 · see citing works
Endogenous and exogenous components in the circadian variation of core body temperature in humans
Hiddinga, A. E., BEERSMA, & van den Hoofdakker, R. H. (1997) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1997.00047.x · Cited by 105 · see citing works
The influence of light on thermal responses
te Kulve, M., Schellen, L., Schlangen, L. J. M., & van Marken Lichtenbelt, W. D. (2016) · Acta Physiologica · doi:10.1111/apha.12552 · Cited by 105 · see citing works
Intense illumination in the morning hours improved mood and alertness but not mental performance
Leichtfried, V., Mair-Raggautz, M., Schaeffer, V., Hammerer‐Lercher, A., Mair, G., Bartenbach, C., Canazei, M., & Schobersberger, W. (2014) · Applied Ergonomics · doi:10.1016/j.apergo.2014.07.001 · Cited by 97 · see citing works
Light at Night and Measures of Alertness and Performance
Figueiro, M. G., Sahin, L., Wood, B., & Plitnick, B. (2015) · Biological Research For Nursing · doi:10.1177/1099800415572873 · Cited by 97 · see citing works
Indoor Exposure to Natural Bright Light Prevents Afternoon Sleepiness
Kaida, K., Takahashi, M., Haratani, T., Otsuka, Y., Fukasawa, K., & Nakata, A. (2006) · SLEEP · doi:10.1093/sleep/29.4.462 · Cited by 87 · see citing works
Maierová, L., Borisuit, A., Scartezzini, J., Jaeggi, S. M., Schmidt, C., & Münch, M. Y. (2016) · Scientific Reports · doi:10.1038/srep33591 · Cited by 83 · see citing works
Melatonin receptors in the rat brain and pituitary
Williams, L. M., Hannah, L. T., Hastings, M. H., & Maywood, E. S. (1995) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1995.tb00186.x · Cited by 82 · see citing works
Sleep-anticipating effects of melatonin in the human brain
Gorfine, T., Assaf, Y., Goshen‐Gottstein, Y., Yeshurun, Y., & Zisapel, N. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.11.024 · Cited by 77 · see citing works
Smolders, K. C. H. J., Peeters, S., Vogels, I. M. L. C., & de Kort, Y. A. W. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418796438 · Cited by 77 · see citing works
Cajochen, C., Kräuchi, K., & Wirz‐Justice, A. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200619 · Cited by 74 · see citing works
Deacon, S., English, J., & Arendt, J. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90282-8 · Cited by 70 · see citing works
Paraventricular–subparaventricular hypothalamic lesions selectively affect circadian function
Moore, R. Y., & Danchenko, R. L. (2002) · Chronobiology International · doi:10.1081/cbi-120002876 · Cited by 69 · see citing works
Åkerstedt, T., Hallvig, D., & Kecklund, G. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12528 · Cited by 67 · see citing works
Kulve, M. T., Schlangen, L. J. M., Schellen, L., Frijns, A. A., & Lichtenbelt, W. D. V. M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.043 · Cited by 64 · see citing works
Huiberts, L., Smolders, K. C. H. J., & de Kort, Y. A. W. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1324471 · Cited by 61 · see citing works
van de Werken, M., Giménez, M. C., de Vries, B., Beersma, D. G. M., & Gordijn, M. C. M. (2013) · Chronobiology International · doi:10.3109/07420528.2013.773440 · Cited by 58 · see citing works
Self-citationBright Light during Nighttime: Effects on the Circadian Regulation of Alertness and Performance
Daurat, A., Foret, J., Benoit, O., & Mauco, G. (2000) · Neurosignals · doi:10.1159/000014654 · Cited by 58 · see citing works
Correlated colour temperature of morning light influences alertness and body temperature
Kulve, M. T., Schlangen, L. J. M., Schellen, L., Souman, J. L., & Lichtenbelt, W. D. V. M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.12.004 · Cited by 58 · see citing works
Melatonin and its relevance to jet lag
Brown, G. M., Pandi-Perumal, S. R., Trakht, I., & Cardinali, D. P. (2008) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2008.09.004 · Cited by 54 · see citing works
Effects of melatonin on the thermoregulatory responses to intermittent exercise
Atkinson, G., Holder, A., Robertson, C. V., Gant, N., Drust, B., Reilly, T. P., & Waterhouse, J. M. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00256.x · Cited by 51 · see citing works
Melatonin Secretion as a Mediator of Circadian Variations in Sleep and Sleepiness
Wurtman, R. J., & Lieberman, H. R. (1985) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1985.tb00647.x · Cited by 50 · see citing works
White Light During Daytime Does Not Improve Alertness in Well-rested Individuals
Lok, R., Woelders, T., Gordijn, M. C. M., Hut, R. A., & Beersma, D. G. M. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418796036 · Cited by 50 · see citing works
Self-citationIskra‐Golec, I., & Smith, L. (2008) · Chronobiology International · doi:10.1080/07420520802118103 · Cited by 35 · see citing works
Bright Light as a Sleepiness Prophylactic: A Laboratory Study of Subjective Ratings and EEG
Åkerstedt, T., Landström, U., Byström, M., Nordström, B., & Wibom, R. (2003) · Perceptual and Motor Skills · doi:10.2466/pms.2003.97.3.811 · Cited by 33 · see citing works
Naldi, I., Bisulli, F., Testa, C. M., Rizzo, G., Ferri, L., Gramegna, L. L., Licchetta, L., Lodi, R., Tonon, C., & Tinuper, P. (2017) · SLEEP · doi:10.1093/sleep/zsx115 · Cited by 25 · see citing works
Putilov, A. A., Donskaya, O. G., & Verevkin, E. G. (2012) · Chronobiology International · doi:10.3109/07420528.2012.667029 · Cited by 24 · see citing works
Borragán, G., Deliens, G., Peigneux, P., & Leproult, R. (2017) · Journal of Environmental Psychology · doi:10.1016/j.jenvp.2017.03.008 · Cited by 23 · see citing works
Pardi, D., Buman, M. P., Black, J. E., Lammers, G. J., & Zeitzer, J. M. (2016) · SLEEP · doi:10.1093/sleep/zsw039 · Cited by 21 · see citing works
Effect of Melatonin on the Human Electrocardiogram and Simple Reaction Time Responses
Wynn, V. T., & Arendt, J. (1988) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1988.tb00786.x · Cited by 20 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [53]Dinges DF, Powell JW. Microcomputer analyses of performance on a sustained operations. Behav Res Methods, Instruments Comput. 1985; 17(6): 652‐ 655.
Cited by
Sorted by citations
The inner clock-Blue light sets the human rhythm
Wahl, S., Engelhardt, M., Schaupp, P., Lappe, C., & Ivanov, I. V. (2019) · Journal of Biophotonics · doi:10.1002/jbio.201900102 · Cited by 293 · see citing works
Visible light. Part I: Properties and cutaneous effects of visible light
Austin, E., Geisler, A. N., Nguyen, J. K., Kohli, I., Hamzavi, I. H., Lim, H. W., & Jagdeo, J. R. (2021) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2021.02.048 · Cited by 247 · see citing works
Sumsuzzman, D. M., Choi, J., Jin, Y., & Hong, Y. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.04.034 · Cited by 128 · see citing works
Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial
Wibrow, B. A., Martinez, F. E., Myers, E., Chapman, A., Litton, E., Ho, K. M., Regli, A., Hawkins, D., Ford, A. H., van Haren, F. M. P., et al. (2022) · Intensive Care Medicine · doi:10.1007/s00134-022-06638-9 · Cited by 104 · see citing works
Zhang, H., Zhang, Y., Li, Y., Wang, Y., Yan, S., Xu, S., Deng, Z., Yang, X., Xie, H., & Li, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.756550 · Cited by 97 · see citing works
Role of mitochondrial quality control in the pathogenesis of nonalcoholic fatty liver disease
Li, R., Toan, S., & Zhou, H. (2020) · Aging · doi:10.18632/aging.102972 · Cited by 90 · see citing works
Bai, Y., Chen, J., Zhang, S., Xu, G., Mao, Z., Ding, Y., & Wang, W. (2024) · Advanced Materials · doi:10.1002/adma.202310443 · Cited by 67 · see citing works
Zhou, Q., Lin, L., Li, H., Wang, H., Jiang, S., Huang, P., Lin, Q., Chen, X., & Deng, Y. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02568-7 · Cited by 65 · see citing works
Siraji, M. A., Kalavally, V., Schaefer, A., & Haque, S. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.765750 · Cited by 61 · see citing works
Temporal organization of pineal melatonin signaling in mammals
Gorman, M. R. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110687 · Cited by 57 · see citing works
Nie, J., Zhou, T., Chen, Z., Dang, W., Jiao, F., Zhan, J., Chen, Y., Chen, Y., Pan, Z., Kang, X., et al. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.139334 · Cited by 53 · see citing works
Kompier, M. E., Smolders, K. C. H. J., Kramer, R. P., Lichtenbelt, W. D. V. M., & de Kort, Y. A. W. (2022) · Building and Environment · doi:10.1016/j.buildenv.2022.108844 · Cited by 53 · see citing works
Moraes, M. N., de Assis, L. V. M., Provencio, I., & Castrucci, A. M. D. L. (2021) · Cell and Tissue Research · doi:10.1007/s00441-021-03500-0 · Cited by 47 · see citing works
Stefanov, B.-A., Teixeira, A. P., Mansouri, M., Bertschi, A., Krawczyk, K., Hamri, G. C.-E., Xue, S., & Fussenegger, M. (2021) · Advancement of science · doi:10.1002/advs.202101813 · Cited by 38 · see citing works
Zhu, H., Zhao, Z., Liu, H., Cai, J., Lu, Q., Ji, L., & Xu, J. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2191218 · Cited by 41 · see citing works
Yaw, A. M., McLane-Svoboda, A. K., & Hoffmann, H. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010324 · Cited by 37 · see citing works
Nie, J., Chen, Z., Jiao, F., Zhan, J., Chen, Y., Pan, Z., Deng, C., Xi, X., Kang, X., Wang, Y., et al. (2021) · Optics & Laser Technology · doi:10.1016/j.optlastec.2021.107463 · Cited by 32 · see citing works
Harmsen, J., Wefers, J., Doligkeit, D., Schlangen, L. J. M., Dautzenberg, B., Rense, P., van Moorsel, D., Joris Hoeks, J., Moonen‐Kornips, E., Gordijn, M. C. M., et al. (2022) · Diabetologia · doi:10.1007/s00125-021-05643-9 · Cited by 32 · see citing works
Self-citationBlume, C., Niedernhuber, M., Spitschan, M., Slawik, H. C., Meyer, M., Bekinschtein, T. A., & Cajochen, C. (2022) · SLEEP · doi:10.1093/sleep/zsac199 · Cited by 30 · see citing works
Sleep disorders in Alzheimer’s disease: the predictive roles and potential mechanisms
Kuang, H., Zhu, Y., Zhou, Z., Yang, M.-W., Hong, F.-F., & Yang, M.-W. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.308071 · Cited by 26 · see citing works
Melatonin Supplementation in Undetermined Pediatric Deaths
Bishop-Freeman, S. C., Young, K. A., Labay, L. M., Beuhler, M. C., & Hudson, J. S. (2022) · Journal of Analytical Toxicology · doi:10.1093/jat/bkac033 · Cited by 25 · see citing works
Hilditch, C. J., Wong, L. R., Bathurst, N., Feick, N. H., Pradhan, S., Santamaria, A., Shattuck, N. L., & Flynn‐Evans, E. E. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13558 · Cited by 23 · see citing works
Melanopsin elevates locomotor activity during the wake state of the diurnal zebrafish
Dekens, M. P. S., Fontinha, B. M., Gallach, M., Pflügler, S., & Tessmar‐Raible, K. (2022) · EMBO Reports · doi:10.15252/embr.202051528 · Cited by 19 · see citing works
Systematic review: Acute thermal effects of artificial light in the daytime
Wang, N., Wang, J., & Feng, Y. (2022) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2022.112601 · Cited by 22 · see citing works
Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice
Xia, T., Wang, Z., Jin, S.-W., Liu, X., Liu, Y., Zhang, S., Pan, R., Jiang, N., Liao, Y., Yan, M., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1210393 · Cited by 21 · see citing works
Towards zero-carbon, resilient, and community-integrated smart schools and campuses: A review
Abulibdeh, A. O. (2024) · World Development Sustainability · doi:10.1016/j.wds.2024.100193 · Cited by 27 · see citing works
Zhu, M., Zhang, X., Chen, D., & Gong, Y. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.171970 · Cited by 20 · see citing works
Novel melatonin-trientine conjugate as potential therapeutic agents for Alzheimer’s disease
Li, L., Fan, Y., Wu, W., Bai, C., Jia, M., Hu, J.-P., Gao, H., Wang, T., Zhong, M., Huang, X., et al. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106100 · Cited by 20 · see citing works
Zhou, Y., Chen, Q., Luo, X., Li, L., Ru, T., & Zhou, G. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.652849 · Cited by 21 · see citing works
Luo, X., Ru, T., Chen, Q., Hsiao, F., Hung, C., Yang, C., & Zhou, G. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.771605 · Cited by 18 · see citing works
Hou, D., Lin, C., & Lin, Y. (2022) · Phenomics · doi:10.1007/s43657-021-00039-6 · Cited by 17 · see citing works
Wu, S., Wu, C., Wang, X., Fei, W., & Fu, Y. (2022) · Nursing Open · doi:10.1002/nop2.1322 · Cited by 17 · see citing works
Circadian Regulation of the Brain and Behavior: A Neuroendocrine Perspective
Karatsoreos, I. N. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_115 · Cited by 16 · see citing works
Circadian neurogenetics and its implications in neurophysiology, behavior, and chronomedicine
Naveed, M., Chao, O. Y.-H., Hill, J. W., Yang, Y., Huston, J. P., & Cao, R. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105523 · Cited by 15 · see citing works
Wang, X., Liu, T., Lv, X., Sun, N., Li, F., Luo, L., Zhuge, X., Huang, J., & Wang, L. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00047-23 · Cited by 13 · see citing works
Li, Y., Fang, W., Qiu, H., Dong, W., Wang, J., & Bao, H. (2023) · LEUKOS The Journal of the Illuminating Engineering Society of North America · doi:10.1080/15502724.2023.2279946 · Cited by 15 · see citing works
Lasauskaite, R., Wüst, L. N., Schöllhorn, I., Richter, M. M., & Cajochen, C. (2025) · LEUKOS The Journal of the Illuminating Engineering Society of North America · doi:10.1080/15502724.2025.2493669 · Cited by 12 · see citing works
Melatonin-Loaded Nanoparticles for Enhanced Antidepressant Effects and HPA Hormone Modulation
Si, M., Sun, Q., Ding, H., Cao, C., Huang, M., Wang, Q., Yang, H., & Yao, Y. (2020) · Advances in Polymer Technology · doi:10.1155/2020/4789475 · Cited by 12 · see citing works
Zhu, B., Zheng, S., Fan, W., Zhang, M., Xia, Z., Chen, X., & Zhao, A. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.1061141 · Cited by 11 · see citing works
Wang, Z., Zhang, Y., Dong, L., Zheng, Z., Zhong, D., Long, X., Cai, Q., Jian, W., Zhang, S., Wu, W., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201560 · Cited by 11 · see citing works
Afternoon to early evening bright light exposure reduces later melatonin production in adolescents
Lazar, R., Fazlali, F., Dourte, M., Epple, C., Stefani, O., Spitschan, M., & Cajochen, C. (2025) · npj Biological Timing and Sleep · doi:10.1038/s44323-025-00040-6 · Cited by 10 · see citing works
Nie, J., Chen, Z., Jiao, F., Chen, Y., Pan, Z., Deng, C., Zhang, H., Dong, B., Xi, X., Kang, X., et al. (2022) · Building and Environment · doi:10.1016/j.buildenv.2022.109767 · Cited by 9 · see citing works
Barnadas-Solé, C., Zerón-Rugerio, M. F., Corvinos, J. F., Dı́ez-Noguera, A., Cambras, T., & Izquierdo-Pulido, M. (2021) · Chronobiology International · doi:10.1080/07420528.2020.1866003 · Cited by 8 · see citing works
Aryani, S. M., Kusumawanto, A., Suryabrata, J. A., & Aırın, C. M. (2021) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/738/1/012028 · Cited by 10 · see citing works
Inferring Circadian Rhythms of Cognitive Performance in Everyday Life
Tag, B., Dingler, T., Vargo, A. W., & Kostakos, V. (2020) · IEEE Pervasive Computing · doi:10.1109/mprv.2020.2994914 · Cited by 8 · see citing works
Lok, R., Woelders, T., van Koningsveld, M. J., Oberman, K., Fuhler, S., Beersma, D. G. M., & Hut, R. A. (2022) · Journal of Biological Rhythms · doi:10.1177/07487304221096948 · Cited by 8 · see citing works
Self-citationWeng, M., Schöllhorn, I., Kazhura, M., Cardini, B. B., & Stefani, O. (2022) · Clocks & Sleep · doi:10.3390/clockssleep4040047 · Cited by 7 · see citing works
Dittmar, M., Stark, T., & Wedell, S. (2024) · Geriatrics · doi:10.3390/geriatrics9040102 · Cited by 7 · see citing works
The effects of small Water Cool(ing) Islands on body temperature
Rising, H. H., & Deng, L. (2023) · Journal of Urban Design · doi:10.1080/13574809.2023.2209023 · Cited by 7 · see citing works
The thermal consequences of primate birth hour and its evolutionary implications
McFarland, R., Henzi, S. P., Fuller, A., Hetem, R. S., Young, C., & Barrett, L. (2022) · Biology Letters · doi:10.1098/rsbl.2021.0574 · Cited by 7 · see citing works
Zhu, Y., Yan, A., Shu, B., Chen, X., Chen, Y., Duan, G., & Huang, H. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.810166 · Cited by 7 · see citing works
Visual Comfort and Acute Alerting Effects of Diurnal Intermittent Bright Light
Kompier, M. E., Smolders, K. C. H. J., Schlangen, L. J. M., & de Kort, Y. A. W. (2022) · LEUKOS The Journal of the Illuminating Engineering Society of North America · doi:10.1080/15502724.2022.2068573 · Cited by 7 · see citing works
Circadian Clock and Body Temperature
Miyake, T., Inoue, Y., Maekawa, Y., & Doi, M. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-981-97-4584-5_12 · Cited by 6 · see citing works
Exploring melatonin's signalling pathways in the protection against age-related skin deterioration
Taheri, M., Seirafianpour, F., Fallahian, A., Hosseinzadeh, A., Reiter, R. J., & Mehrzadi, S. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00699-5 · Cited by 6 · see citing works
Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing
Mousavi, S. M., Etemad, L., Yari, D., Hashemi, M., & Salmasi, Z. (2024) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575299255240422055203 · Cited by 5 · see citing works
Influence of Acute Melatonin Administration on Human Physical Performance: A Systematic Review
Faria, V. S., Messias, L. H. D., Pejon, T. M. M., & Beck, W. R. (2023) · Sports Health A Multidisciplinary Approach · doi:10.1177/19417381231155142 · Cited by 4 · see citing works
Martínez‐Cayuelas, E., Merino-Andreu, M., Pozo, R. L.-D., Gavela‐Pérez, T., Garcés, C., & Soriano‐Guillén, L. (2023) · Journal of Child Neurology · doi:10.1177/08830738231173606 · Cited by 4 · see citing works
Zhang, X., Hu, S., Liu, G., & Ma, H. (2021) · Journal of Building Engineering · doi:10.1016/j.jobe.2021.103484 · Cited by 4 · see citing works
Objective Measures of Immediate “Energizing” Effect of Light: Studies Review and Data Analysis
Danilenko, K. V. (2022) · Clocks & Sleep · doi:10.3390/clockssleep4040038 · Cited by 4 · see citing works
Rhythms of light: Understanding the role of circadian timing in alertness and cognitive performance
Lok, R. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-323-90918-1.00016-2 · Cited by 3 · see citing works
Self-citationBedtime electronic device use and sleep quality in Chinese young adults: a longitudinal study
Zhang, J., Wang, Z., Xu, W., Jiang, R., Zheng, W., Kang, W., Feng, M., Zhang, Y., & Lu, P. (2026) · BMC Public Health · doi:10.1186/s12889-025-26013-9 · Cited by 2 · see citing works
Albrethsen, J., Andreasen, J. K., Anton, J., Sennels, H. P., Jørgensen, H. L., Hannibal, J., Hermann, D. H., & Albrechtsen, N. J. W. (2026) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2026.2660758 · Cited by 2 · see citing works
Wong, K. T., Jayapalan, J. J., Subramanian, P., Ismail, M. N., & Abdul‐Rahman, P. S. (2023) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.22008 · Cited by 2 · see citing works
Nanoparticles and treatment of depression
Komane, P. P., Kumar, P., & Choonara, Y. E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23763-8.00083-x · Cited by 2 · see citing works
Qiu, Q., Song, X., Sun, C., Tan, Y., Xu, Y., Huang, G., Zhang, N., Li, Z., & Wei, W. (2021) · Europe PMC (PubMed Central) · doi:10.12122/j.issn.1673-4254.2021.01.19 · Cited by 2 · see citing works
Self-Aware AI-Enabled Medical System
Vadsaria, A. S., Raza, A., Hammad, M. Y., & Shahid, M. F. (2023) · International Bhurban Conference on Applied Sciences and Technology (IBCAST) · doi:10.1109/ibcast59916.2023.10712990 · Cited by 1 · see citing works
Zhu, J., Liu, M., Lu, Z., Dong, X., Zhou, Y., Kang, Y., Cheng, A. S. K., & Xie, J. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.12.027 · Cited by 2 · see citing works
Wang, N., Wang, J., Mundinger, J. J., Chang, A., Feng, Y., & Chen, C. (2026) · Energy and Buildings · doi:10.1016/j.enbuild.2026.117644 · Cited by 1 · see citing works
ACTIGRAFIA COMO FERRAMENTA PARA AVALIAR O RITMO DO CICLO SONO VIGÍLIA DURANTE A PANDEMIA COVID-19
Belenello, J. R., Bernardi, A. A. B. G., & de Mello, S. T. (2022) · Arquivos do Mudi · doi:10.4025/arqmudi.v27i2.62757 · Cited by 1 · see citing works
Interaction between Melatonin, Sleepiness-Alertness and Body Temperature
Naz, S. S., Shafiq, M. M., & Albreiki, M. S. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.112249 · Cited by 1 · see citing works
Sun, X., Yang, S., Ling, M., Xiang, Y., & Li, H. (2023) · Research Square · doi:10.21203/rs.3.rs-2996163/v1 · Cited by 1 · see citing works
Circadiane slaap-waakritmestoornissen
Gordijn, M. C. M., & Lancel, M. (2020) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-2524-5_7
Self-citationOkechukwu, C. E., & Okechukwu, C. E. (2022) · MGM Journal of Medical Sciences · doi:10.4103/mgmj.mgmj_7_22
FUNCIÓN PROTECTORA DE LA MELATONINA DURANTE EL EJERCICIO FÍSICO
GARCÍA, J. J. G., MARÍN, A. F., CAPÓN, E. M. M., Alcalde, I. G., LAPIEDRA, M. P. A., Zubero, E. E., & Pingarrón, L. L. (2021) · Dykinson eBooks · doi:10.2307/j.ctv2gz3t0r.22
Relationship between carbon monoxide level and daytime sleepiness in individuals aged 18–45
Uvacın, B. C., Çöme, O., & Mevsim, V. (2023) · Biological Rhythm Research · doi:10.1080/09291016.2023.2236613
Концептуальна модель людино-орієнтованої розумної системи освітлення
Petrenko, T., & Павлусенко, К. О. (2023) · Інформаційно-керуючі системи на залізничному транспорті · doi:10.18664/ikszt.v28i3.290100
A 24-hour perspective on insulin resistance
Harmsen, J. (2023) · doi:10.26481/dis.20231213jh
Hanafi, M. I., Laksana, Z. A., Ardiyan, C. N. I., Arifianti, A., Islamiyah, W. R., & Fidiana, F. (2026) · Sleep Medicine Research · doi:10.17241/smr.2026.03426
Melatonin and Neurobehavioral Functions
Ekimova, I. V., & Chesnokova, A. Y. (2026) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093026040058
Dozzani, I., Rodríguez‐Martín, M., Dashti, H. S., Vetter, C., Fernández‐Breis, J. T., Florez, J. C., Saxena, R., Scheer, F. A. J. L., & Garaulet, M. (2026) · International Journal of Obesity · doi:10.1038/s41366-026-02225-w
- Authors
- Lok, R., van Koningsveld, M. J., Gordijn, M. C. M., Beersma, D. G. M., & Hut, R. A.
- Affiliations
- University of Groningen (NL)
- Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences University of Groningen Groningen The Netherlands
- Corresponding author
- Lok, Renske
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2019-05-09
- Volume
- 67
- Issue
- 1
- Pages
- e12583-e12583
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- PMC
- PMC6767594
- OpenAlex
- W2943364943
- Cited by
- 81
- References
- 84
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 7 · 2023: 15 · 2022: 22 · 2021: 17 · 2020: 6 · 2019: 3
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Pineal Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
- Funders
- Rijksuniversiteit Groningen (01110939)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- melatonin, bright light exposure, alertness, daytime sleepiness, core body temperature, skin temperature, thermoregulation, circadian rhythm
- MeSH terms
- Adult, Body Temperature, Body Temperature Regulation, Circadian Rhythm, Female, Humans, Light, Male, Melatonin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
