Melatonin and the health of menopausal women: A systematic review
Abstract
Melatonin is involved in multiple changes that characterize the aging and can potentially be a safe and effective treatment for menopausal women. The aim of this study was to carry out a systematic review of the medical literature on the health benefits of oral melatonin administration on menopausal women. The electronic databases PubMed, Scopus, and Web of Science were searched systematically on interventional studies that evaluated the association between oral melatonin administration and the health of menopausal women. Risk for bias was assessed for randomized, controlled studies by the RoB v.2 tool and for non‐randomized trials by the ROBINS‐I tool. Twenty‐four studies on melatonin treatment in various aspects of women's health were included in the final systematic review. The studies included 1,173 participants. No evidence was found for an independent effect of melatonin on hemodynamic measures or markers of glucose metabolism. There is some evidence that very low‐density lipoprotein and triglycerides levels increase during melatonin administration. There is a fair amount of evidence that melatonin treatment has a favorable effect on bone density and BMI. Melatonin treatment improves EEG patterns and subjective sleep quality in postmenopausal women with preexisting sleep impairment. In a dose of 3 mg and above, melatonin improves climacteric symptoms in one or more domains. The vast majority of the studies had a low risk for bias. In light of multiple health benefits and an excellent safety profile, melatonin administration should be considered in menopausal women.
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Clinical evidence reveals melatonin supplements did not have striking effects on weight and the results of various doses and times on weight are inconsistent.
“However, the clinical evidence reveals melatonin supplements did not have striking effects on weight and the results of various doses and times on weight are inconsistent. 39-42”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [41]
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Mesri Alamdari, N., Namazi Shabestari, A., Najafipour, F., & Mirmazhari, A. (2024) · Biomedicine Advances · doi:10.34172/bma.05 · Cited by 4 · see citing works
- Authors
- Treister‐Goltzman, Y., & Peleg, R.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- Corresponding author
- Treister‐Goltzman, Yulia
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2021-05-24
- Volume
- 71
- Issue
- 2
- Pages
- e12743-e12743
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W3161434686
- Cited by
- 36
- References
- 34
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 3
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pineal Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- melatonin, menopause, postmenopausal women, menopausal symptoms, sleep quality, bone mineral density, body mass index, lipid metabolism, glucose metabolism, aging
- MeSH terms
- Female, Humans, Melatonin, Menopause, Sleep, Bone Density
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