Facing emotions in narcolepsy with cataplexy: haemodynamic and behavioural responses during emotional stimulation
Open accessAbstract
Narcolepsy with cataplexy is a complex sleep disorder that affects the modulation of emotions: cataplexy, the key symptom of narcolepsy, is indeed strongly linked with emotions that usually trigger the episodes. Our study aimed to investigate haemodynamic and behavioural responses during emotional stimulation in narco-cataplexy. Twelve adult drug-naive narcoleptic patients (five males; age: 33.3 ± 9.4 years) and 12 healthy controls (five males; age: 30.9 ± 9.5 years) were exposed to emotional stimuli (pleasant, unpleasant and neutral pictures). Heart rate, arterial blood pressure and mean cerebral blood flow velocity of the middle cerebral arteries were continuously recorded using photoplethysmography and Doppler ultrasound. Ratings of valence and arousal and coping strategies were scored by the Self-Assessment Manikin and by questionnaires, respectively. Narcoleptic patients' haemodynamic responses to pictures overlapped with the data obtained from controls: decrease of heart rate and increase of mean cerebral blood flow velocity regardless of pictures' content, increase of systolic blood pressure during the pleasant condition, and relative reduction of heart rate during pleasant and unpleasant conditions. However, when compared with controls, narcoleptic patients reported lower arousal scores during the pleasant and neutral stimulation, and lower valence scores during the pleasant condition, respectively, and also a lower score at the 'focus on and venting of emotions' dimensions of coping. Our results suggested that adult narcoleptic patients, compared with healthy controls, inhibited their emotion-expressive behaviour to emotional stimulation, and that may be related to the development of adaptive cognitive strategies to face emotions avoiding cataplexy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
(1970) · Cited by 24,983 · see citing works
A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale
Johns, M. W. (1991) · Sleep · doi:10.1093/sleep/14.6.540 · Cited by 17,364 · see citing works
Assessing coping strategies: A theoretically based approach.
Carver, C. S., Scheier, M. F., & Weintraub, J. K. (1989) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.56.2.267 · Cited by 11,679 · see citing works
Assessing coping strategies: A theoretically based approach.
Carver, C. S., Scheier, M. F., & Weintraub, J. K. (1989) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.56.2.267 · Cited by 11,507 · see citing works
Gross, J. J. (1998) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.74.1.224 · Cited by 4,671 · cited 1× · see citing works
“Indeed in the general population, a diminished venting of emotions has been related to the concept of suppression, which is the attempt to decrease or inhibit ongoing emotion-expressive behaviour (Gross, 1998).”
BackgroundAutonomic nervous system activity in emotion: a review
Kreibig, S. D. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.03.010 · Cited by 3,188 · see citing works
Quantification of Sleepiness: A New Approach
Hoddes, E., Zarcone, V., Smythe, H., Phillips, R., & Dement, W. C. (1973) · Psychophysiology · doi:10.1111/j.1469-8986.1973.tb00801.x · Cited by 2,538 · see citing works
How brains beware: neural mechanisms of emotional attention
Vuilleumier, P. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.10.011 · Cited by 2,162 · see citing works
Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., et al. (2000) · Nature Medicine · doi:10.1038/79690 · Cited by 2,118 · see citing works
Lang, P. J., Bradley, M. M., & Cuthbert, B. N. (1999) · Cited by 1,664 · see citing works
Littner, M. R., Kushida, C., Wise, M., G. Davila, D., Morgenthaler, T., Lee-Chiong, T., Hirshkowitz, M., Loube, D. L., Bailey, D., Berry, R. B., et al. (2005) · Sleep · doi:10.1093/sleep/28.1.113 · Cited by 1,142 · see citing works
The Amygdala Response to Emotional Stimuli: A Comparison of Faces and Scenes
Hariri, A. R., Tessitore, A., Mattay, V. S., Fera, F., & Weinberger, D. R. (2002) · NeuroImage · doi:10.1006/nimg.2002.1179 · Cited by 984 · see citing works
The International Affective Picture System (IAPS) in the Study of Emotion and Attention
Bradley, M. M., & Lang, P. J. (2007) · Handbook of Emotion Elicitation and Assessment · doi:10.1093/oso/9780195169157.003.0003 · Cited by 915 · see citing works
Beck Depression Inventory-II (BDI-II)
Bortnick, K. (2024) · Routledge eBooks · doi:10.4324/9781003525288-77 · Cited by 496 · see citing works
Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System
Tsujino, N., & Sakurai, T. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001321 · Cited by 479 · see citing works
Patterns of appraisal and emotion related to taking an exam.
Smith, C. A., & Ellsworth, P. C. (1987) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.52.3.475 · Cited by 402 · see citing works
Facial expressions and complex IAPS pictures: Common and differential networks
Britton, J. C., Taylor, S. F., Sudheimer, K. D., & Liberzon, I. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.12.050 · Cited by 392 · see citing works
Same situation--Different emotions: How appraisals shape our emotions.
Siemer, M., Mauss, I. B., & Gross, J. J. (2007) · Emotion · doi:10.1037/1528-3542.7.3.592 · Cited by 374 · see citing works
Blouin, A. M., Fried, I., Wilson, C. L., Staba, R. J., Behnke, E., Lam, H. A., Maidment, N. T., Karlsson, K. Æ., Lapierre, J. L., & Siegel, J. M. (2013) · Nature Communications · doi:10.1038/ncomms2461 · Cited by 237 · see citing works
Schwartz, S., Ponz, A., Poryazova, R., Werth, E., Boesiger, P., Khatami, R., & Bassetti, C. L. (2007) · Brain · doi:10.1093/brain/awm292 · Cited by 160 · see citing works
Sica, C., Magni, C., Ghisi, M., Altoè, G., Sighinolfi, C., Chiri, L. R., & Franceschini, S. (2008) · Padua Research Archive (University of Padova) · Cited by 146 · see citing works
Overeem, S., van Nues, S. J., van der Zande, W. L., Donjacour, C. E., van Mierlo, P., & Lammers, G. J. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2010.05.010 · Cited by 144 · see citing works
Functional transcranial Doppler sonography as a tool in psychophysiological research
Duschek, S., & Schandry, R. (2003) · Psychophysiology · doi:10.1111/1469-8986.00046 · Cited by 143 · see citing works
Clinical and polysomnographic course of childhood narcolepsy with cataplexy
Pizza, F., Franceschini, C., Peltola, H., Vandi, S., Finotti, E., Ingravallo, F., Nobili, L., Bruni, O., Lin, L., Edwards, M. J., et al. (2013) · Brain · doi:10.1093/brain/awt277 · Cited by 132 · see citing works
Self-citationAbnormal activity in reward brain circuits in human narcolepsy with cataplexy
Ponz, A., Khatami, R., Poryazova, R., Werth, E., Boesiger, P., Bassetti, C. L., & Schwartz, S. (2009) · Annals of Neurology · doi:10.1002/ana.21825 · Cited by 109 · see citing works
Amygdala lesions reduce cataplexy in orexin knock-out mice
Burgess, C. R., Oishi, Y., Mochizuki, T., Peever, J. H., & Scammell, T. E. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5632-12.2013 · Cited by 108 · see citing works
Regional brain responses to pleasant and unpleasant IAPS pictures: different networks.
Aldhafeeri, F. M., Mackenzie, I., Kay, T., Alghamdi, J., & Sluming, V. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.01.064 · Cited by 96 · see citing works
Reduced amygdala activity during aversive conditioning in human narcolepsy
Ponz, A., Khatami, R., Poryazova, R., Werth, E., Boesiger, P., Schwartz, S., & Bassetti, C. L. (2009) · Annals of Neurology · doi:10.1002/ana.21881 · Cited by 89 · see citing works
Cerebral perfusion changes during cataplexy in narcolepsy patients
Hong, S. B., Tae, W. S., & Joo, E. Y. (2006) · Neurology · doi:10.1212/01.wnl.0000218205.72668.ab · Cited by 79 · see citing works
Anomalous Hypothalamic Responses to Humor in Cataplexy
Reiss, A. L., Hoeft, F., Tenforde, A. S., Chen, W., Mobbs, D., & Mignot, E. J.-M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002225 · Cited by 69 · see citing works
Amygdala dysfunction in narcolepsy‐cataplexy
Khatami, R., BIRKMANN, S., & Bassetti, C. L. (2007) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2007.00587.x · Cited by 47 · see citing works
Functional Imaging of Cataplexy During Status Cataplecticus
Chabas, D., Habert, M., Maksud, P., Tourbah, A., Minz, M., Willer, J. C., & Arnulf, I. (2007) · SLEEP · doi:10.1093/sleep/30.2.153 · Cited by 39 · see citing works
Evidence for Metabolic Hypothalamo-Amygdala Dysfunction in Narcolepsy
Poryazova, R., Schnepf, B., Werth, E., Khatami, R., Dydak, U., Meier, D., Boesiger, P., & Bassetti, C. L. (2009) · SLEEP · doi:10.1093/sleep/32.5.607 · Cited by 38 · see citing works
Emotional Information Processing in Patients with Narcolepsy: A Psychophysiologic Investigation
Tucci, V., Stegagno, L., Vandi, S., Ferrillo, F., Palomba, D., Vignatelli, L., Ferini‐Strambi, L., Montagna, P., & Plazzi, G. (2003) · SLEEP · doi:10.1093/sleep/26.5.558 · Cited by 33 · see citing works
Self-citationSympathetic and cardiovascular activity during cataplexy in narcolepsy
Donadio, V. A., Plazzi, G., Vandi, S., Franceschini, C., KARLSSON, T., Montagna, P., Vetrugno, R., Bugiardini, E., Mignot, E. J.-M., & Liguori, R. (2008) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00682.x · Cited by 33 · see citing works
Self-citationCerebral blood flow in essential hypotension during emotional activation
Stegagno, L., Patritti, D., Duschek, S., et al. (2007) · Psychophysiology · doi:10.1111/j.1469-8986.2007.00507.x · Cited by 19 · see citing works
Self-citationCataplexy: An affair of pleasure or an unpleasant affair?
Tucci, V., & Plazzi, G. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.11.060 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The Functional Role of Dreaming in Emotional Processes
Scarpelli, S., Bartolacci, C., D'Atri, A., Gorgoni, M., & De Gennaro, L. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00459 · Cited by 190 · see citing works
Mental Sleep Activity and Disturbing Dreams in the Lifespan
Scarpelli, S., Bartolacci, C., D’Atri, A., Gorgoni, M., & De Gennaro, L. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16193658 · Cited by 41 · see citing works
“In this respect, it is important to specify that one of the main symptoms in narcolepsy, such as the cataplexy, is usually triggered by events with a high emotional charge [178] and that such patients show an impairment in the limbic system (e.g., [179]).”
- Authors
- de Zambotti, M., Pizza, F., Covassin, N., Vandi, S., Cellini, N., Stegagno, L., & Plazzi, G.
- Affiliations
- Center for Health Sciences SRI International Menlo Park CA USA
- Istituto delle Scienze Neurologiche di Bologna (IT)
- University of Padua (IT)
- ORCID
- Venue
- Journal of Sleep Research
- Publisher
- Wiley
- Published
- 2014-02-21
- Volume
- 23
- Issue
- 4
- Pages
- 432-440
- ISSN
- 0962-1105 (ISSN-L)
- 1365-2869
- OpenAlex
- W2078114021
- Cited by
- 20
- References
- 37
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2016: 3 · 2015: 1 · 2014: 1
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Journal of Sleep Research (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- narcolepsy type 1, cataplexy, emotional stimulation, hemodynamic response, heart rate, blood pressure, cerebral blood flow velocity, emotion regulation, coping strategies, arousal, valence, emotional pictures
- MeSH terms
- Adaptation, Psychological, Adult, Affect, Arousal, Blood Pressure, Cataplexy, Emotions, Female, Heart Rate, Humans, Functional Laterality, Male, Middle Aged, Sleep, Case-Control Studies, Young Adult, Self Report
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
