Sleep–wake profiles predict longitudinal changes in manic symptoms and memory in young people with mood disorders
Abstract
Summary: Mood disorders are characterized by disabling symptoms and cognitive difficulties which may vary in intensity throughout the course of the illness. Sleep–wake cycles and circadian rhythms influence emotional regulation and cognitive functions. However, the relationships between the sleep–wake disturbances experienced commonly by people with mood disorders and the longitudinal changes in their clinical and cognitive profile are not well characterized. This study investigated associations between initial sleep–wake patterns and longitudinal changes in mood symptoms and cognitive functions in 50 young people (aged 13–33 years) with depression or bipolar disorder. Data were based on actigraphy monitoring conducted over approximately 2 weeks and clinical and neuropsychological assessment. As part of a longitudinal cohort study, these assessments were repeated after a mean follow‐up interval of 18.9 months. No significant differences in longitudinal clinical changes were found between the participants with depression and those with bipolar disorder. Lower sleep efficiency was predictive of longitudinal worsening in manic symptoms (P = 0.007). Shorter total sleep time (P = 0.043) and poorer circadian rhythmicity (P = 0.045) were predictive of worsening in verbal memory. These findings suggest that some sleep–wake and circadian disturbances in young people with mood disorders may be associated with less favourable longitudinal outcomes, notably for subsequent manic symptoms and memory difficulties.
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Circadian disruptions in adolescents at high risk of psychosis and in individuals with mood disorders predict worse prognosis and symptoms in longitudinal studies.
“circadian disruptions in adolescents who are at high risk of psychosis (that is, subthreshold symptoms of psychosis, social impairment and higher suspicion–paranoia)197 and individuals with mood disorders predict worse prognosis and symptoms in longitudinal studies198,199”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [199]
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- Authors
- Robillard, R., Hermens, D. F., Lee, R. S. C., Jones, A., Carpenter, J. S., White, D., Naismith, S. L., Southan, J., Whitwell, B., Scott, E. M., & Hickie, I. B.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Hickie, Ian B.
- ORCID
- Venue
- Journal of Sleep Research
- Publisher
- Wiley
- Published
- 2016-05-30
- Volume
- 25
- Issue
- 5
- Pages
- 549-555
- ISSN
- 0962-1105 (ISSN-L)
- 1365-2869
- OpenAlex
- W2416548158
- Cited by
- 26
- References
- 40
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 1
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Sleep Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council (464914)
- Fonds de Recherche du Québec - Santé
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep-wake patterns, circadian rhythm, mood disorders, depression, bipolar disorder, manic symptoms, sleep efficiency, total sleep time, circadian rhythmicity, verbal memory, youth, actigraphy
- MeSH terms
- Adolescent, Adult, Affect, Bipolar Disorder, Circadian Rhythm, Cognition, Depressive Disorder, Female, Follow-Up Studies, Humans, Language, Longitudinal Studies, Male, Memory, Neuropsychological Tests, Sleep, Sleep Wake Disorders, Time Factors, Wakefulness, Young Adult, Actigraphy
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