Cited by 38Child and Adolescent Psychosocial and Emotional DevelopmentPersonality Disorders and PsychopathologyMental Health Research Topics

Clinical Staging for Youth Mental Disorders: Progress in Reforming Diagnosis and Clinical Care

McGorry, Patrick D., Mei, Cristina·2021·Annual Review of Developmental Psychology

Abstract

Current silo-based diagnostic systems for mental disorders lack utility and fail to fulfil a fundamental purpose of diagnosis: to guide treatment planning and predict outcomes. Diagnostic reform has gained momentum, and clinical staging has emerged as a promising framework to improve the precision of diagnosis, particularly in early illness stages, and fill current gaps in linking diagnosis to more personalized and effective intervention, prognosis, and neurobiological markers. Transdiagnostic clinical staging recognizes that the early development of mental ill-health is marked by substantial fluidity and that symptoms may, although not inevitably, evolve into more stable diagnosable syndromes. Staging facilitates the selection of interventions that are proportionate to the current need and risk of illness progression and provides an efficient framework to organize biomarker data and guide service delivery. Here, we provide an overview of transdiagnostic clinical staging and summarize key evidence supporting its ability to integrate biomarkers and guide mental health care.

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Crossref · 10.1146/annurev-devpsych-050620-030405

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Authors
McGorry, P. D., & Mei, C.
Affiliations
The University of Melbourne (AU)
Venue
Annual Review of Developmental Psychology
Published
2021-12-09
Volume
3
Issue
1
Pages
15-39
ISSN
2640-7922 (ISSN-L)
OpenAlex
W3185569264
Cited by
38
References
154
Citations by year
2026: 8 · 2025: 9 · 2024: 9 · 2023: 8 · 2022: 4
FWCI
0.70
Type
journal article
Language
en
Open access
closed
Locations
Annual Review of Developmental Psychology (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords
clinical staging, adolescent mental disorders, biomarkers, personalized interventions, prognosis, disease progression, service delivery, developmental psychopathology

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