The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Pathological bacterial translocation in cirrhosis: pathophysiology, diagnosis and clinical implications
Open accessAbstract
Bacterial translocation (BT) is defined by the passage of viable indigenous bacteria from the intestinal lumen to mesenteric lymph nodes (MLN s) and other territories, and its diagnostic criteria rely on the isolation of viable bacteria in MLN s. Small intestinal overgrowth, increased intestinal permeability and immunological alterations are the main factors involved in its pathogenesis. BT is obviously difficult to identify in patients with cirrhosis, and alternative methods have been proposed instead. Bacterial DNA detection and species identification in serum or ascitic fluid has been proposed as a reliable marker of BT. Bacterial products, such as endotoxin, or bacterial DNA can translocate to extra‐intestinal sites and promote an immunological response similar to that produced by viable bacteria. Therefore, pathological BT plays an important role in the pathogenesis of the complications of cirrhosis, not only in infections, but by exerting a profound inflammatory state and exacerbating the haemodynamic derangement. This may promote in turn the development of hepatorenal syndrome, hepatic encephalopathy and other portal hypertension‐related complications. Therapeutic approaches for the prevention of BT in experimental and human cirrhosis are summarized. Finally, new investigations are needed to better understand the pathogenesis and consequences of translocation by viable bacteria (able to grow in culture), or non‐viable BT (detection of bacterial fragments with negative culture) and open new therapeutic avenues in patients with cirrhosis.
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Self-citationA Systematic Review of Diagnostic Tests for Small Intestinal Bacterial Overgrowth
Khoshini, R., Dai, S.-C., Lezcano, S., & Pimentel, M. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-0065-1 · Cited by 323
Lorenzo-Zúñiga, V., Bartolí, R., Planas, R., Hofmann, A. F., Viñado, B., Hagey, L. R., Hernández, J. M., Mañé, J., Alvarez, M. A., Ausina, V., et al. (2003) · Hepatology · doi:10.1053/jhep.2003.50116 · Cited by 321
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Cited by
Interactions Between the Intestinal Microbiome and Liver Diseases
Schnabl, B., & Brenner, D. A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.020 · Cited by 971
Gut–kidney crosstalk in septic acute kidney injury
Zhang, J., Ankawi, G., Sun, J., Digvijay, K., Yin, Y., Rosner, M. H., & Ronco, C. (2018) · Critical Care · doi:10.1186/s13054-018-2040-y · Cited by 95
“The influx of toxin contents can directly enter the circulation [35, 36] and/or educate circulating im-”
BackgroundMarkers of bacterial translocation in end-stage liver disease
Koutsounas, I. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i20.2264 · Cited by 55
Targeting the Gut–Liver Axis in Cirrhosis: Antibiotics and Non-Selective β-Blockers
Madsen, B. S., Havelund, T., & Krag, A. (2013) · Advances in Therapy · doi:10.1007/s12325-013-0044-1 · Cited by 38
Agiasotelli, D., Alexopoulou, A., Vasilieva, L., Hadziyannis, E., Goukos, D., Daikos, G. L., & Dourakis, S. P. (2017) · Liver International · doi:10.1111/liv.13264 · Cited by 31
Metadata
- Authors
- Bellot, P., Francés, R., & Such, J.
- Venue
- Liver International
- Publisher
- Wiley
- Published
- 2012-11-04
- Volume
- 33
- Issue
- 1
- Pages
- 31-39
- ISSN
- 0106-9543 (ISSN-L)
- 1478-3223
- 1478-3231
- OpenAlex
- W1987038743
- Cited by
- 254
- References
- 7
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bellot, P., Francés, R., & Such, J. (2013). Pathological bacterial translocation in cirrhosis: pathophysiology, diagnosis and clinical implications. Liver International. https://doi.org/10.1111/liv.12021
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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